Published in Genes Dev on November 01, 2013
Are we there yet? Initial targeting of the Male-Specific Lethal and Polycomb group chromatin complexes in Drosophila. Open Biol (2014) 0.96
Chromatin regulation: how complex does it get? Epigenetics (2014) 0.96
Yy1 gene dosage effect and bi-allelic expression of Peg3. PLoS One (2015) 0.91
Transcriptome response to heat stress in a chicken hepatocellular carcinoma cell line. Cell Stress Chaperones (2015) 0.85
Combinatorial interactions are required for the efficient recruitment of pho repressive complex (PhoRC) to polycomb response elements. PLoS Genet (2014) 0.83
Molecular basis of PRC1 targeting to Polycomb response elements by PhoRC. Genes Dev (2016) 0.79
Adaptive selection and coevolution at the proteins of the Polycomb repressive complexes in Drosophila. Heredity (Edinb) (2015) 0.76
Molecular architecture of polycomb repressive complexes. Biochem Soc Trans (2017) 0.75
SFMBT2 (Scm-like with four mbt domains 2) negatively regulates cell migration and invasion in prostate cancer cells. Oncotarget (2016) 0.75
PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52
Phaser crystallographic software. J Appl Crystallogr (2007) 108.34
XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46
Control of developmental regulators by Polycomb in human embryonic stem cells. Cell (2006) 28.21
Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature (2006) 25.90
A generic protein purification method for protein complex characterization and proteome exploration. Nat Biotechnol (1999) 25.13
Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science (2002) 24.31
A gene complex controlling segmentation in Drosophila. Nature (1978) 23.75
Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein. Genes Dev (2002) 13.08
Histone methyltransferase activity of a Drosophila Polycomb group repressor complex. Cell (2002) 13.05
Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. Cell (2002) 12.28
An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases. Proc Natl Acad Sci U S A (2007) 12.13
Defining the human deubiquitinating enzyme interaction landscape. Cell (2009) 11.39
A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science (2002) 7.33
P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster. Science (2006) 7.03
Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell (1999) 6.90
Genome-wide analysis of Polycomb targets in Drosophila melanogaster. Nat Genet (2006) 6.48
Role of Bmi-1 and Ring1A in H2A ubiquitylation and Hox gene silencing. Mol Cell (2005) 6.29
The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1. Mol Cell (1998) 5.79
Organizing activity of wingless protein in Drosophila. Cell (1993) 5.65
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature (2010) 5.23
Different EZH2-containing complexes target methylation of histone H1 or nucleosomal histone H3. Mol Cell (2004) 5.06
Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev (2006) 5.03
Chromatin compaction by a polycomb group protein complex. Science (2004) 4.95
Reconstitution of a functional core polycomb repressive complex. Mol Cell (2001) 4.39
The Polycomb and trithorax group proteins of Drosophila: trans-regulators of homeotic gene function. Annu Rev Genet (1995) 4.03
Genome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila melanogaster. Nat Genet (2006) 3.83
Hierarchical recruitment of polycomb group silencing complexes. Mol Cell (2004) 3.73
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev (2006) 3.49
Essential role of the glycosyltransferase sxc/Ogt in polycomb repression. Science (2009) 3.44
Chromosomal distribution of PcG proteins during Drosophila development. PLoS Biol (2006) 3.41
PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes. Mol Cell (2012) 3.28
Functional anatomy of polycomb and trithorax chromatin landscapes in Drosophila embryos. PLoS Biol (2009) 3.24
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. Mol Cell Biol (2002) 3.13
Elements of the Drosophila bithorax complex that mediate repression by Polycomb group products. Dev Biol (1993) 3.07
Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets. Mol Cell Biol (2006) 2.99
A Polycomb response element in the Ubx gene that determines an epigenetically inherited state of repression. EMBO J (1994) 2.91
Polycomb response elements and targeting of Polycomb group proteins in Drosophila. Curr Opin Genet Dev (2006) 2.76
Polycomb group proteins and heritable silencing of Drosophila Hox genes. Development (2001) 2.67
Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila. Dev Cell (2008) 2.41
The deubiquitinating enzyme BAP1 regulates cell growth via interaction with HCF-1. J Biol Chem (2009) 2.40
dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev (2008) 2.29
The DNA-binding polycomb group protein pleiohomeotic mediates silencing of a Drosophila homeotic gene. Development (1999) 2.24
Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator. Proc Natl Acad Sci U S A (1996) 2.16
The iab-7 polycomb response element maps to a nucleosome-free region of chromatin and requires both GAGA and pleiohomeotic for silencing activity. Mol Cell Biol (2001) 2.03
The ubiquitin carboxyl hydrolase BAP1 forms a ternary complex with YY1 and HCF-1 and is a critical regulator of gene expression. Mol Cell Biol (2010) 1.96
A conserved sequence motif in Polycomb-response elements. Mol Cell (1998) 1.94
The Drosophila pho-like gene encodes a YY1-related DNA binding protein that is redundant with pleiohomeotic in homeotic gene silencing. Development (2003) 1.94
Throwing the cancer switch: reciprocal roles of polycomb and trithorax proteins. Nat Rev Cancer (2010) 1.93
Polycomb recruitment to DNA in vivo by the YY1 REPO domain. Proc Natl Acad Sci U S A (2006) 1.82
The MCP silencer of the Drosophila Abd-B gene requires both Pleiohomeotic and GAGA factor for the maintenance of repression. Development (2001) 1.74
Pleiohomeotic can link polycomb to DNA and mediate transcriptional repression. Mol Cell Biol (2002) 1.74
Polycomb comes of age: genome-wide profiling of target sites. Curr Opin Cell Biol (2007) 1.72
Architecture of a polycomb nucleoprotein complex. Mol Cell (2006) 1.55
Synergistic recognition of an epigenetic DNA element by Pleiohomeotic and a Polycomb core complex. Genes Dev (2005) 1.52
Ectopic expression of homeotic genes caused by the elimination of the Polycomb gene in Drosophila imaginal epidermis. Development (1988) 1.50
Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt. EMBO J (2009) 1.42
Tissue- and stage-specific control of homeotic and segmentation gene expression in Drosophila embryos by the polyhomeotic gene. Development (1988) 1.40
Functional analysis of repressor binding sites in the iab-2 regulatory region of the abdominal-A homeotic gene. Dev Biol (2000) 1.40
Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg. EMBO Rep (2007) 1.36
L3MBTL2 protein acts in concert with PcG protein-mediated monoubiquitination of H2A to establish a repressive chromatin structure. Mol Cell (2011) 1.32
A TAD further: exogenous control of gene activation. ACS Chem Biol (2007) 1.27
Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners. Proc Natl Acad Sci U S A (2011) 1.17
Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells. Nucleic Acids Res (2011) 1.16
Chromosome silencing mechanisms in X-chromosome inactivation: unknown unknowns. Development (2011) 1.10
The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development. Cell Stem Cell (2012) 1.08
Structural studies of a four-MBT repeat protein MBTD1. PLoS One (2009) 1.03
SFMBT1 functions with LSD1 to regulate expression of canonical histone genes and chromatin-related factors. Genes Dev (2013) 0.97
Replacement of a Drosophila Polycomb response element core, and in situ analysis of its DNA motifs. Mol Genet Genomics (2008) 0.93
Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB. Nature (2010) 5.23
Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins. Genes Dev (2006) 5.03
The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat Struct Mol Biol (2008) 4.33
Multiplex human papillomavirus serology based on in situ-purified glutathione s-transferase fusion proteins. Clin Chem (2005) 4.18
Nuclear pore components are involved in the transcriptional regulation of dosage compensation in Drosophila. Mol Cell (2006) 3.98
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell (2004) 3.95
Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome. Science (2002) 3.59
The conserved Nup107-160 complex is critical for nuclear pore complex assembly. Cell (2003) 3.58
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities. Genes Dev (2006) 3.49
Essential role of the glycosyltransferase sxc/Ogt in polycomb repression. Science (2009) 3.44
Reverse genetics in the mosquito Anopheles gambiae: targeted disruption of the Defensin gene. EMBO Rep (2002) 3.43
WD40 proteins propel cellular networks. Trends Biochem Sci (2010) 3.17
Protein composition of human prespliceosomes isolated by a tobramycin affinity-selection method. Proc Natl Acad Sci U S A (2002) 3.14
Histone methylation by PRC2 is inhibited by active chromatin marks. Mol Cell (2011) 3.14
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathway. J Cell Biol (2005) 2.97
Suppression of non-specific binding in serological Luminex assays. J Immunol Methods (2005) 2.96
Cooperative binding of two acetylation marks on a histone tail by a single bromodomain. Nature (2009) 2.83
HURP is part of a Ran-dependent complex involved in spindle formation. Curr Biol (2006) 2.74
Genome-wide analysis of mRNAs regulated by the THO complex in Drosophila melanogaster. Nat Struct Mol Biol (2004) 2.70
The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms. PLoS Biol (2004) 2.59
HDAC6-p97/VCP controlled polyubiquitin chain turnover. EMBO J (2006) 2.52
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes. EMBO J (2007) 2.49
Dynamic regulation by polycomb group protein complexes controls pattern formation and the cell cycle in Drosophila. Dev Cell (2008) 2.41
Human papillomavirus infection and incidence of squamous cell and basal cell carcinomas of the skin. J Natl Cancer Inst (2006) 2.40
Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. EMBO J (2002) 2.39
RBM5/Luca-15/H37 regulates Fas alternative splice site pairing after exon definition. Mol Cell (2008) 2.39
The histone methyltransferases Trithorax and Ash1 prevent transcriptional silencing by Polycomb group proteins. EMBO Rep (2004) 2.36
A histone mutant reproduces the phenotype caused by loss of histone-modifying factor Polycomb. Science (2013) 2.31
Crystal structure and functional analysis of a nucleosome recognition module of the remodeling factor ISWI. Mol Cell (2003) 2.26
A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing. EMBO J (2004) 2.20
Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex. Mol Cell (2008) 2.09
RanGTP mediates nuclear pore complex assembly. Nature (2003) 2.08
Crystal structure of the M1 protein-binding domain of the influenza A virus nuclear export protein (NEP/NS2). EMBO J (2003) 1.95
Nucleosome binding and histone methyltransferase activity of Drosophila PRC2. EMBO Rep (2005) 1.95
Karyopherin flexibility in nucleocytoplasmic transport. Curr Opin Struct Biol (2006) 1.86
Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. Biochem J (2003) 1.74
Architecture of CRM1/Exportin1 suggests how cooperativity is achieved during formation of a nuclear export complex. Mol Cell (2004) 1.72
An efficient protein complex purification method for functional proteomics in higher eukaryotes. Nat Biotechnol (2002) 1.71
The nonspecific lethal complex is a transcriptional regulator in Drosophila. Mol Cell (2010) 1.68
Residues in the HIV-1 capsid assembly inhibitor binding site are essential for maintaining the assembly-competent quaternary structure of the capsid protein. J Biol Chem (2008) 1.61
A genetic screen identifies novel polycomb group genes in Drosophila. Genetics (2007) 1.60
Immunological responses in women with human papillomavirus type 16 (HPV-16)-associated anogenital intraepithelial neoplasia induced by heterologous prime-boost HPV-16 oncogene vaccination. Clin Cancer Res (2004) 1.51
Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A. Proc Natl Acad Sci U S A (2006) 1.48
Seroprevalence of 34 human papillomavirus types in the German general population. PLoS Pathog (2008) 1.44
A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae. Mol Syst Biol (2010) 1.43
Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt. EMBO J (2009) 1.42
Insights into transcription initiation and termination from the electron microscopy structure of yeast RNA polymerase III. Mol Cell (2007) 1.40
Crystal structure of the 14-subunit RNA polymerase I. Nature (2013) 1.40
MOF-regulated acetylation of MSL-3 in the Drosophila dosage compensation complex. Mol Cell (2003) 1.39
Nup155 regulates nuclear envelope and nuclear pore complex formation in nematodes and vertebrates. EMBO J (2005) 1.39
NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules. Mol Biol Cell (2006) 1.37
Recognition of 2'-O-methylated 3'-end of piRNA by the PAZ domain of a Piwi protein. Structure (2011) 1.37
Analysis of a polycomb group protein defines regions that link repressive activity on nucleosomal templates to in vivo function. Mol Cell Biol (2005) 1.36
Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg. EMBO Rep (2007) 1.36
Reactivity pattern of 92 monoclonal antibodies with 15 human papillomavirus types. J Gen Virol (2008) 1.35
Structural basis of lytic cycle activation by the Epstein-Barr virus ZEBRA protein. Mol Cell (2006) 1.33
Conformational flexibility of RNA polymerase III during transcriptional elongation. EMBO J (2010) 1.32
The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription. EMBO J (2002) 1.30
Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis. Dev Cell (2005) 1.30
Splicing factors stimulate polyadenylation via USEs at non-canonical 3' end formation signals. EMBO J (2007) 1.27
Structure of the DNA-bound T-box domain of human TBX3, a transcription factor responsible for ulnar-mammary syndrome. Structure (2002) 1.24
Structure of an activated Dictyostelium STAT in its DNA-unbound form. Mol Cell (2004) 1.24
Immunological and clinical responses in women with vulval intraepithelial neoplasia vaccinated with a vaccinia virus encoding human papillomavirus 16/18 oncoproteins. Cancer Res (2003) 1.24
Hsp90 enables Ctf13p/Skp1p to nucleate the budding yeast kinetochore. Proc Natl Acad Sci U S A (2002) 1.23
Sex-lethal imparts a sex-specific function to UNR by recruiting it to the msl-2 mRNA 3' UTR: translational repression for dosage compensation. Genes Dev (2006) 1.22
Interaction of influenza virus proteins with nucleosomes. Virology (2005) 1.21
Structure of the GCM domain-DNA complex: a DNA-binding domain with a novel fold and mode of target site recognition. EMBO J (2003) 1.19
General transcriptional silencing by a Polycomb response element in Drosophila. Development (2004) 1.15
The histone octamer is invisible when NF-kappaB binds to the nucleosome. J Biol Chem (2004) 1.15
The role of the histone H2A ubiquitinase Sce in Polycomb repression. Development (2011) 1.14
Preprocessing of tandem mass spectrometric data to support automatic protein identification. Proteomics (2003) 1.14
Importin alpha associates with membranes and participates in nuclear envelope assembly in vitro. EMBO J (2004) 1.14
Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate. J Cell Biol (2008) 1.13
Human papillomavirus type 16 L1 capsomeres induce L1-specific cytotoxic T lymphocytes and tumor regression in C57BL/6 mice. J Virol (2003) 1.12
Combination of peptide OFFGEL fractionation and label-free quantitation facilitated proteomics profiling of extraocular muscle. Proteomics (2007) 1.12
Biochemical function of female-lethal (2)D/Wilms' tumor suppressor-1-associated proteins in alternative pre-mRNA splicing. J Biol Chem (2002) 1.11
The histone fold subunits of Drosophila CHRAC facilitate nucleosome sliding through dynamic DNA interactions. Mol Cell Biol (2005) 1.10
"De novo" sequencing of peptides recovered from in-gel digested proteins by nanoelectrospray tandem mass spectrometry. Mol Biotechnol (2002) 1.10
Dendritic cell-based tumor vaccine for cervical cancer II: results of a clinical pilot study in 15 individual patients. J Cancer Res Clin Oncol (2003) 1.10
Chromatin-modifying complex component Nurf55/p55 associates with histones H3 and H4 and polycomb repressive complex 2 subunit Su(z)12 through partially overlapping binding sites. J Biol Chem (2011) 1.10
DMSO enhances electrospray response, boosting sensitivity of proteomic experiments. Nat Methods (2013) 1.09
Development of AAVLP(HPV16/31L2) particles as broadly protective HPV vaccine candidate. PLoS One (2012) 1.08
Absence of SV40 antibodies or DNA fragments in prediagnostic mesothelioma serum samples. Int J Cancer (2007) 1.07
Structure of the Drosophila nucleosome core particle highlights evolutionary constraints on the H2A-H2B histone dimer. Proteins (2008) 1.07
The tumour suppressor L(3)mbt inhibits neuroepithelial proliferation and acts on insulator elements. Nat Cell Biol (2011) 1.05
Molecular and genetic analysis of the Polycomb group gene Sex combs extra/Ring in Drosophila. Mech Dev (2003) 1.05
The N-terminal region of the human papillomavirus L2 protein contains overlapping binding sites for neutralizing, cross-neutralizing and non-neutralizing antibodies. Virology (2010) 1.04
IRAG mediates NO/cGMP-dependent inhibition of platelet aggregation and thrombus formation. Blood (2006) 1.03
Structural basis of TBX5-DNA recognition: the T-box domain in its DNA-bound and -unbound form. J Mol Biol (2010) 1.02
The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase. Nat Struct Mol Biol (2012) 1.02
Quantitative proteomics profiling of sarcomere associated proteins in limb and extraocular muscle allotypes. Mol Cell Proteomics (2007) 1.01