Published in J Innate Immun on November 01, 2013
Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol (2015) 0.90
Adjuvants: Classification, Modus Operandi, and Licensing. J Immunol Res (2016) 0.81
Hepatitis C Virus NS3 Mediated Microglial Inflammation via TLR2/TLR6 MyD88/NF-κB Pathway and Toll Like Receptor Ligand Treatment Furnished Immune Tolerance. PLoS One (2015) 0.79
Combination immunotherapy with TLR agonists and checkpoint inhibitors suppresses head and neck cancer. JCI Insight (2017) 0.75
Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity (2011) 11.15
Type 1 interferons and the virus-host relationship: a lesson in détente . Science (2006) 6.33
Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. Proc Natl Acad Sci U S A (2004) 3.61
The history of Toll-like receptors - redefining innate immunity. Nat Rev Immunol (2013) 3.59
Specific restrictions in the progression of Venezuelan equine encephalitis virus-induced disease resulting from single amino acid changes in the glycoproteins. Virology (1995) 2.14
Transmission of pandemic H1N1 influenza virus and impact of prior exposure to seasonal strains or interferon treatment. J Virol (2010) 1.92
Mechanism of neuroinvasion of Venezuelan equine encephalitis virus in the mouse. Virology (1995) 1.79
Imiquimod: mode of action. Br J Dermatol (2007) 1.70
The comparative pathology of experimental Venezuelan equine encephalomyelitis infection in different animal hosts. J Infect Dis (1962) 1.68
The role of neutrophils during mild and severe influenza virus infections of mice. PLoS One (2011) 1.61
Induction of MxA gene expression by influenza A virus requires type I or type III interferon signaling. J Virol (2007) 1.58
RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection. PLoS Negl Trop Dis (2011) 1.50
Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A (2010) 1.49
Effective mucosal immunity to anthrax: neutralizing antibodies and Th cell responses following nasal immunization with protective antigen. J Immunol (2003) 1.34
Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A (2007) 1.28
Activation of toll-like receptor signaling pathway for protection against influenza virus infection. Vaccine (2009) 1.24
Intranasal administration of alpha interferon reduces seasonal influenza A virus morbidity in ferrets. J Virol (2009) 1.22
Innate immune detection of microbial nucleic acids. Trends Microbiol (2013) 1.21
Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem (2009) 1.20
Toll-like receptor expression and induction of type I and type III interferons in primary airway epithelial cells. J Virol (2013) 1.18
Pegylated alpha interferon is an effective treatment for virulent venezuelan equine encephalitis virus and has profound effects on the host immune response to infection. J Virol (2000) 1.17
Spread of Venezuelan equine encephalitis virus in mice olfactory tract. Arch Virol (1995) 1.14
Therapy of human papillomavirus-related disease. Vaccine (2012) 1.11
Venezuelan equine encephalitis in BALB/c mice: kinetic analysis of central nervous system infection following aerosol or subcutaneous inoculation. Arch Pathol Lab Med (1996) 1.09
Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity. PLoS Pathog (2013) 1.07
Toll-like receptor pre-stimulation protects mice against lethal infection with highly pathogenic influenza viruses. Virol J (2011) 1.06
Protection from lethal influenza virus challenge by oral type 1 interferon. Biochem Biophys Res Commun (2007) 1.06
Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats. Antiviral Res (2006) 1.04
Surfactant phospholipid metabolism. Biochim Biophys Acta (2012) 1.03
Mast cell-dependent anorexia and hypothermia induced by mucosal activation of Toll-like receptor 7. Am J Physiol Regul Integr Comp Physiol (2008) 1.02
Protective effect of Toll-like receptor 4 in pulmonary vaccinia infection. PLoS Pathog (2008) 1.02
The role of the blood-brain barrier during Venezuelan equine encephalitis virus infection. J Virol (2011) 1.01
Synergistic TLR2/6 and TLR9 activation protects mice against lethal influenza pneumonia. PLoS One (2012) 1.00
Intranasal administration of the TLR2 agonist Pam2Cys provides rapid protection against influenza in mice. Mol Pharm (2012) 1.00
Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine. Antiviral Res (2008) 0.97
Toll like receptors in diseases of the lung. Int Immunopharmacol (2011) 0.97
An immunological profile of Balb/c mice protected from airborne challenge following vaccination with a live attenuated Venezuelan equine encephalitis virus vaccine. Vaccine (2000) 0.97
CpG-containing immunostimulatory DNA sequences elicit TNF-alpha-dependent toxicity in rodents but not in humans. J Clin Invest (2009) 0.96
Low-dose interferon Type I treatment is effective against H5N1 and swine-origin H1N1 influenza A viruses in vitro and in vivo. J Interferon Cytokine Res (2011) 0.96
A single-site mutant and revertants arising in vivo define early steps in the pathogenesis of Venezuelan equine encephalitis virus. Virology (2000) 0.95
Innate imprinting by the modified heat-labile toxin of Escherichia coli (LTK63) provides generic protection against lung infectious disease. J Immunol (2004) 0.93
FimH, a TLR4 ligand, induces innate antiviral responses in the lung leading to protection against lethal influenza infection in mice. Antiviral Res (2011) 0.92
Modulation of cytokine production and enhancement of cell viability by TLR7 and TLR9 ligands during anthrax infection of macrophages. FEMS Immunol Med Microbiol (2006) 0.91
Venezuelan equine encephalitis virus propagation in the olfactory tract of normal and immunized mice. Biomed Sci (1991) 0.90
The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system. Expert Rev Clin Pharmacol (2011) 0.88
Prophylactic treatment with Toll-like receptor ligands enhances host immunity to avian influenza virus in chickens. Vaccine (2012) 0.87
Strong mucosal and systemic immunities induced by nasal immunization with anthrax protective antigen protein incorporated in liposome-protamine-DNA particles. Pharm Res (2006) 0.86
TLR2, but not TLR4, is required for effective host defence against Chlamydia respiratory tract infection in early life. PLoS One (2012) 0.85
Toll-like receptor-4 agonist in post-haemorrhage pneumonia: role of dendritic and natural killer cells. Eur Respir J (2013) 0.84
The TLR4-TRIF pathway protects against H5N1 influenza virus infection. J Virol (2011) 0.84
Exacerbation of influenza virus infections in mice by intranasal treatments and implications for evaluation of antiviral drugs. Antimicrob Agents Chemother (2012) 0.83
Interferon protects mice against inhalation anthrax. J Interferon Cytokine Res (2008) 0.81
Stimulation of pulmonary immune responses by the TLR2/6 agonist MALP-2 and effect on melanoma metastasis to the lung. Exp Dermatol (2011) 0.78
Reports of immunologic reactions to imiquimod: an assessment of actinic keratoses and treatment concerns in this era of litigation lotto. Dermatol Online J (2005) 0.77
Imiquimod. Drugs Today (Barc) (1999) 0.77
Pandemic 2009 H1N1 influenza virus is resistant to the antiviral activity of several interferon alpha subtypes. J Interferon Cytokine Res (2011) 0.76
HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 9.12
Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology (2004) 6.47
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature (2004) 3.18
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A (2003) 2.91
Oxidation-specific epitopes are dominant targets of innate natural antibodies in mice and humans. J Clin Invest (2009) 2.75
Sialidase fusion protein as a novel broad-spectrum inhibitor of influenza virus infection. Antimicrob Agents Chemother (2006) 2.69
Activation of the Wnt signaling pathway in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (2004) 2.60
The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant (2010) 2.59
IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis. J Clin Invest (2004) 2.56
Retracted Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity (2006) 2.49
Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a. Proc Natl Acad Sci U S A (2008) 2.41
Bacterial peptidoglycans but not CpG oligodeoxynucleotides activate synovial fibroblasts by toll-like receptor signaling. Arthritis Rheum (2003) 2.21
Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis. Gastroenterology (2002) 2.19
Caspase 1-independent activation of interleukin-1beta in neutrophil-predominant inflammation. Arthritis Rheum (2009) 2.16
Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci U S A (2004) 2.16
Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A (2011) 2.12
Intravesical Toll-like receptor 7 agonist R-837: optimization of its formulation in an orthotopic mouse model of bladder cancer. Int J Urol (2010) 2.10
ERK activation drives intestinal tumorigenesis in Apc(min/+) mice. Nat Med (2010) 2.09
A subset of Toll-like receptor ligands induces cross-presentation by bone marrow-derived dendritic cells. J Immunol (2003) 2.04
Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice. Antimicrob Agents Chemother (2006) 2.00
Interleukin 1 receptor dependence of serum transferred arthritis can be circumvented by toll-like receptor 4 signaling. J Exp Med (2003) 1.99
Inhibition of experimental asthma by indoleamine 2,3-dioxygenase. J Clin Invest (2004) 1.98
The effectiveness of passive stretching in children with cerebral palsy. Dev Med Child Neurol (2006) 1.88
Triple combination of amantadine, ribavirin, and oseltamivir is highly active and synergistic against drug resistant influenza virus strains in vitro. PLoS One (2010) 1.86
PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrob Agents Chemother (2010) 1.84
T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res (2009) 1.82
Favipiravir (T-705), a novel viral RNA polymerase inhibitor. Antiviral Res (2013) 1.79
BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-kappaB pathway. Blood (2006) 1.76
Characterization of monospecies biofilm formation by Helicobacter pylori. J Bacteriol (2004) 1.72
Identification of active antiviral compounds against a New York isolate of West Nile virus. Antiviral Res (2002) 1.71
The role of FcgammaR signaling in the K/B x N serum transfer model of arthritis. J Immunol (2002) 1.70
The KRN mouse model of inflammatory arthritis. Springer Semin Immunopathol (2003) 1.67
The role of natural antibodies in atherogenesis. J Lipid Res (2005) 1.65
Detection of low prevalence somatic mutations in solid tumors with ultra-deep targeted sequencing. Genome Biol (2011) 1.60
Effect of interferon-alpha and interferon-inducers on West Nile virus in mouse and hamster animal models. Antivir Chem Chemother (2004) 1.60
Platelet-derived growth factor and transforming growth factor beta synergistically potentiate inflammatory mediator synthesis by fibroblast-like synoviocytes. Arthritis Res Ther (2010) 1.59
Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A (2006) 1.59
Roles of B cells in rheumatoid arthritis. Arthritis Res Ther (2003) 1.57
Development and validation of a novel patient educational booklet to enhance colonoscopy preparation. Am J Gastroenterol (2011) 1.52
Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax. Proc Natl Acad Sci U S A (2010) 1.49
Portable two-color in vivo flow cytometer for real-time detection of fluorescently-labeled circulating cells. J Biomed Opt (2007) 1.46
TLR4 signaling in effector CD4+ T cells regulates TCR activation and experimental colitis in mice. J Clin Invest (2010) 1.45
Goldenhar phenotype in a child with distal 22q11.2 deletion and intracranial atypical teratoid rhabdoid tumor. Am J Med Genet A (2009) 1.45
Maternal infection leads to abnormal gene regulation and brain atrophy in mouse offspring: implications for genesis of neurodevelopmental disorders. Schizophr Res (2008) 1.42
The JAK inhibitor CP-690,550 (tofacitinib) inhibits TNF-induced chemokine expression in fibroblast-like synoviocytes: autocrine role of type I interferon. Ann Rheum Dis (2011) 1.42
Viruses of the Bunya- and Togaviridae families: potential as bioterrorism agents and means of control. Antiviral Res (2003) 1.40
Activity of T-705 in a hamster model of yellow fever virus infection in comparison with that of a chemically related compound, T-1106. Antimicrob Agents Chemother (2008) 1.40
Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J Immunol (2009) 1.39
Efficacy of orally administered T-705 pyrazine analog on lethal West Nile virus infection in rodents. Antiviral Res (2008) 1.38
Triple combination of oseltamivir, amantadine, and ribavirin displays synergistic activity against multiple influenza virus strains in vitro. Antimicrob Agents Chemother (2009) 1.37
Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis. Proc Natl Acad Sci U S A (2006) 1.37
Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene (2002) 1.37
Salmonella secreted factor L deubiquitinase of Salmonella typhimurium inhibits NF-kappaB, suppresses IkappaBalpha ubiquitination and modulates innate immune responses. J Immunol (2008) 1.36
Identification and characterization of the genes encoding a unique surface (S-) layer of Tannerella forsythia. Gene (2006) 1.36
Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Proc Natl Acad Sci U S A (2007) 1.35
Catheter-induced coronary artery dissection: risk factors, prevention and management. J Invasive Cardiol (2006) 1.34
Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines. J Immunol (2005) 1.34
Coronary air embolism: a case report and review of the literature. Catheter Cardiovasc Interv (2006) 1.33
Repression of beta-catenin function in malignant cells by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A (2005) 1.32
Treatment of late stage disease in a model of arenaviral hemorrhagic fever: T-705 efficacy and reduced toxicity suggests an alternative to ribavirin. PLoS One (2008) 1.32
Steroid profiles using liquid chromatography-tandem mass spectrometry with atmospheric pressure photoionization source. Arch Pathol Lab Med (2004) 1.31
IFN-alpha beta promote priming of antigen-specific CD8+ and CD4+ T lymphocytes by immunostimulatory DNA-based vaccines. J Immunol (2002) 1.30
Defining limits of treatment with humanized neutralizing monoclonal antibody for West Nile virus neurological infection in a hamster model. Antimicrob Agents Chemother (2007) 1.30
Anthrax toxins inhibit neutrophil signaling pathways in brain endothelium and contribute to the pathogenesis of meningitis. PLoS One (2008) 1.29
Immunotherapeutic activity of a conjugate of a Toll-like receptor 7 ligand. Proc Natl Acad Sci U S A (2007) 1.28
Wnt signaling antagonists are potential prognostic biomarkers for the progression of radiographic hip osteoarthritis in elderly Caucasian women. Arthritis Rheum (2007) 1.28
T-705 (favipiravir) inhibition of arenavirus replication in cell culture. Antimicrob Agents Chemother (2010) 1.27
Regulation of arthritis by p53: critical role of adaptive immunity. Arthritis Rheum (2005) 1.26
Vaccination with irradiated Listeria induces protective T cell immunity. Immunity (2006) 1.23
Genes in the Salmonella pathogenicity island 2 and the Salmonella virulence plasmid are essential for Salmonella-induced apoptosis in intestinal epithelial cells. Cell Microbiol (2002) 1.22
Potent anti-influenza activity of cyanovirin-N and interactions with viral hemagglutinin. Antimicrob Agents Chemother (2003) 1.21
WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheum (2004) 1.21
Synthesis and immunological characterization of toll-like receptor 7 agonistic conjugates. Bioconjug Chem (2009) 1.20