Published in J Biol Chem on March 05, 1986
Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice. Proc Natl Acad Sci U S A (2003) 3.53
Protein kinase A antagonizes platelet-derived growth factor-induced signaling by mitogen-activated protein kinase in human arterial smooth muscle cells. Proc Natl Acad Sci U S A (1993) 2.31
Increasing cAMP attenuates activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A (1993) 2.24
The insulin receptor and the molecular mechanism of insulin action. J Clin Invest (1988) 2.17
Serine phosphorylation of human P450c17 increases 17,20-lyase activity: implications for adrenarche and the polycystic ovary syndrome. Proc Natl Acad Sci U S A (1995) 1.44
Insulin receptor signaling in normal and insulin-resistant states. Cold Spring Harb Perspect Biol (2014) 1.38
Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. Biochem J (1994) 1.26
Two systems in vitro that show insulin-stimulated serine kinase activity towards the insulin receptor. Biochem J (1988) 1.10
Evidence that a novel serine kinase catalyses phosphorylation of the insulin receptor in an insulin-dependent and tyrosine kinase-dependent manner. Biochem J (1988) 1.01
Signalling pathways of insulin-like growth factor-I that are augmented by cAMP in FRTL-5 cells. Biochem J (2000) 0.97
Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor. EMBO J (1995) 0.95
Polycystic ovary syndrome in the pediatric population. Metab Syndr Relat Disord (2010) 0.93
Pathways leading to phosphorylation of p450c17 and to the posttranslational regulation of androgen biosynthesis. Endocrinology (2008) 0.92
Effect of cyclic AMP-dependent protein kinase on insulin receptor tyrosine kinase activity. Biochem J (1987) 0.88
Role of janus kinase-2 in insulin-mediated phosphorylation and inactivation of protein phosphatase-2A and its impact on upstream insulin signalling components. Biochem J (1999) 0.88
Insulin stimulates the tyrosyl phosphorylation and activation of the 52 kDa peripheral plasma-membrane cyclic AMP phosphodiesterase in intact hepatocytes. Biochem J (1989) 0.87
The interaction between the adenylate cyclase system and insulin-stimulated glucose transport. Evidence for the importance of both cyclic-AMP-dependent and -independent mechanisms. Biochem J (1987) 0.84
Insulin and insulin-like growth factor 1 stimulate the phosphorylation on tyrosine of a 160 kDa cytosolic protein in 3T3-L1 adipocytes. Biochem J (1988) 0.83
Identification of serines-967/968 in the juxtamembrane region of the insulin receptor as insulin-stimulated phosphorylation sites. Biochem J (1994) 0.83
The relationship between insulin binding, insulin activation of insulin-receptor tyrosine kinase, and insulin stimulation of glucose uptake in isolated rat adipocytes. Effects of isoprenaline. Biochem J (1991) 0.82
Phosphorylation of human cytochrome P450c17 by p38α selectively increases 17,20 lyase activity and androgen biosynthesis. J Biol Chem (2013) 0.82
Inhibitory effect of the D(3) dopamine receptor on insulin receptor expression and function in vascular smooth muscle cells. Am J Hypertens (2011) 0.82
Interaction between cAMP-dependent and insulin-dependent signal pathways in tyrosine phosphorylation in primary cultures of rat hepatocytes. Biochem J (1997) 0.81
Characterization of phorbol ester-stimulated serine phosphorylation of the human insulin receptor. Biochem J (1994) 0.77
Insulin receptor desensitization correlates with attenuation of tyrosine kinase activity, but not of receptor endocytosis. Biochem J (1987) 0.77
The insulin-like effect of growth hormone on insulin-like growth factor II receptors is opposed by cyclic AMP. Evidence for a common post-receptor pathway for growth hormone and insulin action. Biochem J (1990) 0.77
Regulation of cyclic AMP synthesis and degradation is modified in rat liver at late gestation. Biochem J (1992) 0.76
Cyclic AMP impairs the rapid effect of insulin to enhance cell-surface insulin-binding capacity in rat adipocytes. Biochem J (1992) 0.75
Impairment of the liver insulin receptor autoactivation cascade at full-term pregnancy in the rat. Biochem J (1995) 0.75
Studies on an insulin-stimulated insulin receptor serine kinase activity: separation of the kinase activity from the insulin receptor and its reconstitution back to the insulin receptor. Biochem J (1995) 0.75
Protein phosphorylation. Annu Rev Biochem (1975) 6.71
Development of hormone receptors and hormonal responsiveness in vitro. Insulin receptors and insulin sensitivity in the preadipocyte and adipocyte forms of 3T3-L1 cells. J Biol Chem (1978) 4.93
Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Proc Natl Acad Sci U S A (1986) 4.40
Human insulin receptors mutated at the ATP-binding site lack protein tyrosine kinase activity and fail to mediate postreceptor effects of insulin. J Biol Chem (1987) 4.32
Phosphorylation activates the insulin receptor tyrosine protein kinase. Proc Natl Acad Sci U S A (1983) 3.94
After insulin binds. Science (1987) 3.16
Effect of dibutyryladenosine 3':5'-cyclic monophosphate on growth and differentiation in Caulobacter crescentus. Proc Natl Acad Sci U S A (1972) 2.73
Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta. Proc Natl Acad Sci U S A (1982) 2.40
Organelle relationships in cultured 3T3-L1 preadipocytes. J Cell Biol (1980) 2.30
Acquisition of increased hormone sensitivity during in vitro adipocyte development. J Biol Chem (1977) 2.23
Fate of immunoprecipitable protein kinase C in GH3 cells treated with phorbol 12-myristate 13-acetate. J Biol Chem (1985) 2.15
Molecular forms and subunit composition of a cyclic adenosine 3',5'-monophosphate-dependent protein kinase purified from bovine heart muscle. J Biol Chem (1972) 1.99
Glucose transporters serve as water channels. Proc Natl Acad Sci U S A (1990) 1.95
Activation of S6 kinase activity in 3T3-L1 cells by insulin and phorbol ester. Proc Natl Acad Sci U S A (1985) 1.89
Glucose deprivation and hexose transporter polypeptides of murine fibroblasts. J Biol Chem (1986) 1.81
Cyclic adenosine 3',5'-monophosphate-dependent protein kinase of human erythrocyte membranes. J Biol Chem (1972) 1.80
Cyclic 3':5'-adenosine monophosphate in Escherichia coli during transient and catabolite repression. Proc Natl Acad Sci U S A (1974) 1.71
Transformation of rat fibroblasts by FSV rapidly increases glucose transporter gene transcription. Science (1987) 1.70
Purified rat brain calcium- and phospholipid-dependent protein kinase phosphorylates ribosomal protein S6. Proc Natl Acad Sci U S A (1983) 1.59
Description of a protein kinase derived from insulin-treated 3T3-L1 cells that catalyzes the phosphorylation of ribosomal protein S6 and casein. J Biol Chem (1983) 1.59
Purification and properties of the human placental insulin receptor. J Biol Chem (1981) 1.57
Autophosphorylation of the insulin receptor in vitro. Designation of phosphorylation sites and correlation with receptor kinase activation. J Biol Chem (1986) 1.54
Insulin-treated 3T3-L1 adipocytes and cell-free extracts derived from them incorporate 32P into ribosomal protein S6. Proc Natl Acad Sci U S A (1980) 1.53
Growth factors rapidly induce expression of the glucose transporter gene. J Biol Chem (1988) 1.53
The protein-tyrosine kinase activity of the insulin receptor is necessary for insulin-mediated receptor down-regulation. J Biol Chem (1987) 1.52
Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta. Proc Natl Acad Sci U S A (1984) 1.49
Characterization of antisera to a synthetic carboxyl-terminal peptide of the glucose transporter protein. J Biol Chem (1988) 1.42
Insulin-stimulated protein phosphorylation in 3T3-L1 preadipocytes. Proc Natl Acad Sci U S A (1979) 1.41
Phosphorylation of a cyclic adenosine 3':5'-monophosphate-dependent protein kinase from bovine cardiac muscle. J Biol Chem (1974) 1.40
Reversible autophosphorylation of a cyclic 3':5'-AMP-dependent protein kinase from bovine cardiac muscle. J Biol Chem (1975) 1.40
Soluble cyclic AMP-dependent protein kinases: review of the enzyme isolated from bovine cardiac muscle. Curr Top Cell Regul (1977) 1.37
Cyclic AMP-dependent protein kinase from bovine heart muscle. Methods Enzymol (1974) 1.35
The effect of nucleotides and a nondialyzable factor on the hydrolysis of cyclic AMP by a cyclic nucleotide phosphodiesterase from beef heart. Arch Biochem Biophys (1971) 1.32
Studies on the orientation of cyclic AMP-dependent protein kinase in human erythrocyte membranes. Proc Natl Acad Sci U S A (1973) 1.29
Immunochemical evidence that three protein kinase C isozymes increase in abundance during HL-60 differentiation induced by dimethyl sulfoxide and retinoic acid. J Biol Chem (1988) 1.29
Dissociation and reassociation of the phosphorylated and nonphosphorylated forms of adenosine 3':5' -monophosphate-dependent protein kinase from bovine cardiac muscle. J Biol Chem (1976) 1.28
Phosphorylation of exogenous substrates by the insulin receptor-associated protein kinase. J Biol Chem (1983) 1.28
Phorbol ester- and protein kinase C-mediated phosphorylation of the cellular Kirsten ras gene product. J Biol Chem (1987) 1.26
Purification and properties of a specific fructose 1,6-diphosphatase from Candida utilis. Arch Biochem Biophys (1965) 1.25
Properties of an adenyl cyclase partially purified from frog erythrocytes. Arch Biochem Biophys (1969) 1.24
Development of hormone receptors and hormone responsiveness in vitro. Effect of prolonged insulin treatment on hexose uptake in 3T3-L1 adipocytes. J Biol Chem (1978) 1.23
Biosynthetic precursors and in vitro translation products of the glucose transporter of human hepatocarcinoma cells, human fibroblasts, and murine preadipocytes. J Biol Chem (1985) 1.22
Interconversion of cyclic nucleotide-activated and cyclic nucleotide-independent forms of a protein kinase from beef heart. Proc Natl Acad Sci U S A (1971) 1.20
Tunicamycin-mediated depletion of insulin receptors in 3T3-L1 adipocytes. J Cell Physiol (1979) 1.19
Physical properties of a purified cyclic adenosine 3':5'-monophosphate-dependent protein kinase from bovine heart muscle. J Biol Chem (1973) 1.17
Phosphorylation of synthetic insulin receptor peptides by the insulin receptor kinase and evidence that the preferred sequence containing Tyr-1150 is phosphorylated in vivo. J Biol Chem (1986) 1.17
Purification of a bovine liver S6 kinase. Biochem Biophys Res Commun (1987) 1.16
Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody. Proc Natl Acad Sci U S A (1986) 1.15
Purification of a phosphoinositide-specific phospholipase C from bovine brain. J Biol Chem (1987) 1.15
The role of cyclic AMP in the phosphorylation of proteins in human erythrocyte membranes. Biochem Biophys Res Commun (1973) 1.15
Functional expression of mammalian glucose transporters in Xenopus laevis oocytes: evidence for cell-dependent insulin sensitivity. Mol Cell Biol (1989) 1.14
Retention of endocrine function by an insulin-secreting pancreatic islet cell tumour from Syrain hamster through serial transplantation in nude mice. J Cell Sci (1975) 1.14
Purification of phosphoprotein phosphatase from bovine cardiac muscle that catalyzes dephosphorylation of cyclic AMP-binding protein component of protein kinase. J Biol Chem (1977) 1.14
Regulation of fatty acid synthetase concentration and activity during adipocyte differentiation. Studies on 3T3-L1 cells. J Biol Chem (1980) 1.13
Synthesis, purification, and characterization of the cytoplasmic domain of the human insulin receptor using a baculovirus expression system. J Biol Chem (1988) 1.12
Recent studies of the 3T3-L1 adipocyte-like cell line. Recent Prog Horm Res (1979) 1.12
Acquisition of insulin-dependent protein tyrosine kinase activity during Drosophila embryogenesis. J Biol Chem (1985) 1.12
An antipeptide antibody that specifically inhibits insulin receptor autophosphorylation and protein kinase activity. Proc Natl Acad Sci U S A (1985) 1.11
Latent insulin receptors and possible receptor precursors in 3T3-L1 adipocytes. Proc Natl Acad Sci U S A (1983) 1.11
Insulin and insulinlike growth factor 1 (IGF-1) receptors during central nervous system development: expression of two immunologically distinct IGF-1 receptor beta subunits. Mol Cell Biol (1989) 1.10
Structure and ligand specificity of the Drosophila melanogaster insulin receptor. Mol Cell Biol (1987) 1.10
Preparation and properties of a cyclic 3',5'-nucleotide phosphodiesterase isolated from frog erythrocytes. Arch Biochem Biophys (1970) 1.10
Trifluoperazine inhibits phagocytosis in a macrophagelike cultured cell line. J Cell Biol (1981) 1.06
Identification and characterization of a latent pool of insulin receptors in 3T3-L1 adipocytes. J Biol Chem (1982) 1.05
Purification and properties of a cyclic nucleotide phosphodiesterase from bovine heart. Arch Biochem Biophys (1972) 1.05
Resolution of the phosphorylated and dephosphorylated cAMP-binding proteins of bovine cardiac muscle by affinity labeling and two-dimensional electrophoresis. J Biol Chem (1979) 1.05
Complete activation of protein kinase C by an antipeptide antibody directed against the pseudosubstrate prototope. J Biol Chem (1989) 1.04
Tissue localization of Drosophila melanogaster insulin receptor transcripts during development. Mol Cell Biol (1988) 1.03
Genetic analysis of the role of cAMP in mediating effects of interferon. Proc Natl Acad Sci U S A (1982) 1.01
Modulation of Fc-mediated phagocytosis by cyclic AMP and insulin in a macrophage-like cell line. J Immunol (1977) 1.00
Cyclic adenosine 3':5'-monophosphate-mediated insulin secretion and ribosomal protein phosphorylation in a hamster islet cell tumor. J Biol Chem (1977) 1.00
Reconstitution of an insulin signaling pathway in Xenopus laevis oocytes: coexpression of a mammalian insulin receptor and three different mammalian hexose transporters. Mol Cell Biol (1990) 0.99
Chemical modification of the allosteric and catalytic sites of fructose 1,6-diphosphatase. Proc Natl Acad Sci U S A (1966) 0.99
Another version of the human insulin receptor kinase domain: expression, purification, and characterization. Proc Natl Acad Sci U S A (1989) 0.99
Insulin stimulates the phosphorylation of ribosomal protein S6 in a cell-free system derived from 3T3-L1 adipocytes. J Biol Chem (1981) 0.98
Ultrastructural analysis of the organization and distribution of insulin receptors on the surface of 3T3-L1 adipocytes: rapid microaggregation and migration of occupied receptors. J Cell Physiol (1985) 0.98
Lipolytic stimulation modulates the subcellular distribution of hormone-sensitive lipase in 3T3-L1 cells. J Lipid Res (1984) 0.98
A specific cyclic guanosine 3':5'-monophosphate-binding protein in Caulobacter crescentus. J Biol Chem (1975) 0.96
Properties of protein kinase and adenylate cyclase-deficient variants of a macrophage-like cell line. J Cell Physiol (1979) 0.96
The role of insulin receptor autophosphorylation in signal transduction. J Biol Chem (1991) 0.95
Hormonal regulation of the phosphorylation of ATP citrate lyase in 3T3-L1 adipocytes. Effects of insulin and isoproterenol. J Biol Chem (1982) 0.95
Dexamethasone regulates the beta-adrenergic receptor subtype expressed by 3T3 L1 preadipocytes and adipocytes. J Biol Chem (1982) 0.95
Antibodies to deduced sequences of the insulin receptor distinguish conserved and nonconserved regions in the IGF-I receptor. J Biol Chem (1986) 0.94
Radioimmunoassay of bovine heart protein kinase. Proc Natl Acad Sci U S A (1976) 0.94
A bacterial activator of frog erythrocyte adenyl cyclase. Arch Biochem Biophys (1970) 0.92
Reversible autophosphorylation of type II cAMP-dependent protein kinase: distinction between intramolecular and intermolecular reactions. Methods Enzymol (1983) 0.92
Factors which influence cyclic AMP formation and degradation in an islet cell tumor of the Syrian hamster. Arch Biochem Biophys (1971) 0.92
Mn2(+)-binding properties of a recombinant protein-tyrosine kinase derived from the human insulin receptor. Proc Natl Acad Sci U S A (1990) 0.92
Measurement of cyclic 3',5'-adenosine monophosphate synthesis in growing Escherichia coli. Biochem Biophys Res Commun (1975) 0.92
Autophosphorylation of cGMP-dependent protein kinase. J Biol Chem (1981) 0.92
The insulin receptor and tyrosine protein kinase activity. Biochim Biophys Acta (1984) 0.91
Stimulation of polyphosphoinositide hydrolysis by thrombin in membranes from human fibroblasts. Biochem J (1987) 0.91
Reevaluation of the evidence that an antibody to the insulin receptor is insulinmimetic without activating the protein tyrosine kinase activity of the receptor. J Biol Chem (1987) 0.90
Differentiation-dependent expression of catecholamine-stimulated adenylate cyclase. Roles of the beta-receptor and G/F protein in differentiating 3T3-L1 adipocytes. J Biol Chem (1981) 0.90
Biochemical analysis of mutants of a macrophage cell line resistant to the growth-inhibitory activity of interferon. J Cell Biol (1984) 0.90
Mechanism of self-phosphorylation of adenosine 3':5'-monophosphate-dependent protein kinase from bovine cardiac muscle. J Biol Chem (1976) 0.90
Inhibition of plasminogen activator secretion by cyclic AMP in a macrophage-like cell line. J Cyclic Nucleotide Res (1978) 0.90
Molecular structure and characterization of bovine heart protein kinase. Adv Cyclic Nucleotide Res (1975) 0.90