Immune-checkpoint blockade and active immunotherapy for glioma.

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Published in Cancers (Basel) on November 01, 2013

Authors

Brian J Ahn1, Ian F Pollack, Hideho Okada

Author Affiliations

1: Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. okadah@upmc.edu.

Associated clinical trials:

Study of a Drug [DCVax®-L] to Treat Newly Diagnosed GBM Brain Cancer (GBM) | NCT00045968

Phase III Study of Rindopepimut/GM-CSF in Patients With Newly Diagnosed Glioblastoma (ACT IV) | NCT01480479

A Study of ICT-107 Immunotherapy in Glioblastoma Multiforme (GBM) | NCT01280552

Dendritic Cell Vaccine for Patients With Brain Tumors | NCT01204684

A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma (ReACT) | NCT01498328

Vaccine Therapy With Bevacizumab Versus Bevacizumab Alone in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery | NCT01814813

Study of DC Vaccination Against Glioblastoma | NCT01567202

Safe Study of Dendritic Cell (DC) Based Therapy Targeting Tumor Stem Cells in Glioblastoma | NCT00846456

Phase 1b Study of AdV-tk + Valacyclovir Combined With Radiation Therapy for Malignant Gliomas (BrTK01) | NCT00751270

Vaccine Therapy in Treating Patients Undergoing Surgery for Recurrent Glioblastoma Multiforme | NCT00890032

Peptide-based Glioma Vaccine IMA950 in Patients With Glioblastoma | NCT01403285

Dendritic Cell (DC) Vaccine for Malignant Glioma and Glioblastoma | NCT01808820

Chemotherapy, Radiation Therapy, and Vaccine Therapy With Basiliximab in Treating Patients With Glioblastoma Multiforme That Has Been Removed by Surgery (ZAP IT) | NCT00626015

HSPPC-96 Vaccine With Temozolomide in Patients With Newly Diagnosed GBM (HeatShock) | NCT00905060

GP96 Heat Shock Protein-Peptide Complex Vaccine in Treating Patients With Recurrent or Progressive Glioma | NCT00293423

Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor (Re-MATCH) | NCT01326104

Vaccine Therapy and Sargramostim in Treating Patients With Malignant Glioma | NCT01250470

Vaccine Therapy, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme | NCT01222221

Imiquimod/Brain Tumor Initiating Cell (BTIC) Vaccine in Brain Stem Glioma | NCT01400672

Dendritic Cell Cancer Vaccine for High-grade Glioma (GBM-Vax) | NCT01213407

Phase I Rindopepimut After Conventional Radiation in Children w/ Diffuse Intrinsic Pontine Gliomas | NCT01058850

Phase I/II Study To Test The Safety and Efficacy of TVI-Brain-1 As A Treatment For Recurrent Grade IV Glioma | NCT01081223

Study To Test the Safety and Efficacy of TVI-Brain-1 As A Treatment for Recurrent Grade IV Glioma | NCT01290692

Study of Peptide Vaccination With Tumor Associated Antigens Mixed With Montanide in Patients With CNS Tumors | NCT00935545

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