Published in J Proteomics on November 09, 2013
'Porosome' discovered nearly 20 years ago provides molecular insights into the kiss-and-run mechanism of cell secretion. J Cell Mol Med (2015) 0.79
The neuronal porosome complex in health and disease. Exp Biol Med (Maywood) (2015) 0.75
Functional Reconstitution of the Insulin-Secreting Porosome Complex in Live Cells. Endocrinology (2015) 0.75
Porosome in Cystic Fibrosis. Discoveries (Craiova) (2015) 0.75
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science (1989) 40.22
Mucus clearance as a primary innate defense mechanism for mammalian airways. J Clin Invest (2002) 5.94
Chloride impermeability in cystic fibrosis. Nature (1983) 3.98
CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP. Cell (1995) 3.46
Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol (2004) 3.43
New insights into cystic fibrosis: molecular switches that regulate CFTR. Nat Rev Mol Cell Biol (2006) 2.83
Calu-3: a human airway epithelial cell line that shows cAMP-dependent Cl- secretion. Am J Physiol (1994) 2.33
Surface dynamics in living acinar cells imaged by atomic force microscopy: identification of plasma membrane structures involved in exocytosis. Proc Natl Acad Sci U S A (1997) 2.09
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype. J Exp Med (2012) 2.08
MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: identification of glycoforms and C-terminal cleavage. Biochem J (1998) 2.05
Regulation of CFTR chloride channels by syntaxin and Munc18 isoforms. Nature (1997) 1.98
Assembly of functional CFTR chloride channels. Annu Rev Physiol (2005) 1.95
Different mucins are produced by the surface epithelium and the submucosa in human trachea: identification of MUC5AC as a major mucin from the goblet cells. Biochem J (1996) 1.94
Osmotic swelling of vesicles: its role in the fusion of vesicles with planar phospholipid bilayer membranes and its possible role in exocytosis. Annu Rev Physiol (1986) 1.93
A macromolecular complex of beta 2 adrenergic receptor, CFTR, and ezrin/radixin/moesin-binding phosphoprotein 50 is regulated by PKA. Proc Natl Acad Sci U S A (2002) 1.78
Neuronal fusion pore assembly requires membrane cholesterol. Cell Biol Int (2007) 1.67
Cystic fibrosis transmembrane conductance regulator inverts protein kinase A-mediated regulation of epithelial sodium channel single channel kinetics. J Biol Chem (1997) 1.61
Organellar proteomics: analysis of pancreatic zymogen granule membranes. Mol Cell Proteomics (2005) 1.49
Structure and dynamics of the fusion pores in live GH-secreting cells revealed using atomic force microscopy. Endocrinology (2002) 1.49
Is swelling of the secretory granule matrix the force that dilates the exocytotic fusion pore? Biophys J (1991) 1.40
Structure and composition of the fusion pore. Biophys J (2003) 1.38
Structure and dynamics of the fusion pore in live cells. Cell Biol Int (2002) 1.36
Structure, isolation, composition and reconstitution of the neuronal fusion pore. Cell Biol Int (2004) 1.36
Molecular assembly of cystic fibrosis transmembrane conductance regulator in plasma membrane. J Biol Chem (2004) 1.34
The role of osmotic forces in exocytosis from adrenal chromaffin cells. Annu Rev Physiol (1986) 1.32
Protein kinase A associates with cystic fibrosis transmembrane conductance regulator via an interaction with ezrin. J Biol Chem (2000) 1.31
Reversible condensation of mast cell secretory products in vitro. Biophys J (1991) 1.31
CFTR drives Na+-nHCO-3 cotransport in pancreatic duct cells: a basis for defective HCO-3 secretion in CF. Am J Physiol (1999) 1.26
Vesicle swelling regulates content expulsion during secretion. Cell Biol Int (2004) 1.26
The cytosolic termini of the beta- and gamma-ENaC subunits are involved in the functional interactions between cystic fibrosis transmembrane conductance regulator and epithelial sodium channel. J Biol Chem (2000) 1.23
Aquaporin 1 regulates GTP-induced rapid gating of water in secretory vesicles. Proc Natl Acad Sci U S A (2002) 1.20
Reconstituted fusion pore. Biophys J (2003) 1.19
Gi regulation of secretory vesicle swelling examined by atomic force microscopy. Proc Natl Acad Sci U S A (1997) 1.16
Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactions. J Biol Chem (2003) 1.14
Quantitative organellar proteomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas. J Proteome Res (2010) 1.11
New structure involved in transient membrane fusion and exocytosis. Ann N Y Acad Sci (2002) 1.11
Epithelial sodium channels regulate cystic fibrosis transmembrane conductance regulator chloride channels in Xenopus oocytes. J Biol Chem (2000) 1.09
Molecular machinery and mechanism of cell secretion. Exp Biol Med (Maywood) (2005) 1.08
Discovery of the Porosome: revealing the molecular mechanism of secretion and membrane fusion in cells. J Cell Mol Med (2004) 1.07
Global topology analysis of pancreatic zymogen granule membrane proteins. Mol Cell Proteomics (2008) 1.00
The cystic fibrosis transmembrane regulator forms macromolecular complexes with PDZ domain scaffold proteins. Proc Am Thorac Soc (2004) 1.00
Quantitative proteomics analysis of cell cycle-regulated Golgi disassembly and reassembly. J Biol Chem (2010) 0.94
Secretion machinery at the cell plasma membrane. Curr Opin Struct Biol (2007) 0.92
CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity. J Cell Sci (2012) 0.91
EM 3D contour maps provide protein assembly at the nanoscale within the neuronal porosome complex. J Microsc (2008) 0.91
Cholesterol is critical to the integrity of neuronal porosome/fusion pore. Ultramicroscopy (2006) 0.90
Neuronal porosome proteome: Molecular dynamics and architecture. J Proteomics (2012) 0.89
Involvement of vH(+)-ATPase in synaptic vesicle swelling. J Neurosci Res (2010) 0.87
3D organization and function of the cell: Golgi budding and vesicle biogenesis to docking at the porosome complex. Histochem Cell Biol (2012) 0.86
Applications of atomic force microscopy in biophysical chemistry of cells. J Phys Chem B (2010) 0.86
The interaction between syntaxin 1A and cystic fibrosis transmembrane conductance regulator Cl- channels is mechanistically distinct from syntaxin 1A-SNARE interactions. J Biol Chem (2002) 0.85
Quantitative proteomics analysis of pancreatic zymogen granule membrane proteins. Methods Mol Biol (2009) 0.84
Patch clamped single pancreatic zymogen granules: direct measurements of ion channel activities at the granule membrane. Pancreatology (2005) 0.83
Synergistic effects of cystic fibrosis transmembrane conductance regulator and aquaporin-9 in the rat epididymis. Biol Reprod (2002) 0.82
Porosome in astrocytes. J Cell Mol Med (2008) 0.81
Identification of the porosome complex in the hair cell. Cell Biol Int Rep (2010) (2011) 0.80
Involvement of β-adrenergic receptor in synaptic vesicle swelling and implication in neurotransmitter release. J Cell Mol Med (2011) 0.79
Involvement of cholesterol in synaptic vesicle swelling. Exp Biol Med (Maywood) (2010) 0.79
Aquaporin-assisted and ER-mediated mitochondrial fission: a hypothesis. Micron (2013) 0.78
Nanoscale 3D contour map of protein assembly within the astrocyte porosome complex. Cell Biol Int (2008) 0.77
Derlin-1 promotes ubiquitylation and degradation of the epithelial Na(+) channel, ENaC. J Cell Sci (2017) 0.76