Published in Diabetes on December 02, 2013
Polygenic type 2 diabetes prediction at the limit of common variant detection. Diabetes (2014) 2.52
Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes. Diabetes (2014) 1.77
Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism. Proc Natl Acad Sci U S A (2014) 1.40
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. Nat Genet (2015) 1.39
Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity. Diabetes (2014) 1.26
Recent advances in understanding the genetic architecture of type 2 diabetes. Hum Mol Genet (2015) 1.16
Zinc transporter 8 (ZnT8) and β cell function. Trends Endocrinol Metab (2014) 1.14
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors. PLoS Genet (2015) 1.03
Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis. J Natl Cancer Inst (2015) 0.98
A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease. Nat Commun (2015) 0.97
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Inflammation, metaflammation and immunometabolic disorders. Nature (2017) 0.93
Association of physical activity with lower type 2 diabetes incidence is weaker among individuals at high genetic risk. Diabetologia (2014) 0.90
Identification of a regulatory variant that binds FOXA1 and FOXA2 at the CDC123/CAMK1D type 2 diabetes GWAS locus. PLoS Genet (2014) 0.89
An integrated cell purification and genomics strategy reveals multiple regulators of pancreas development. PLoS Genet (2014) 0.87
Genome-wide associations for birth weight and correlations with adult disease. Nature (2016) 0.87
Untangling the interplay of genetic and metabolic influences on beta-cell function: Examples of potential therapeutic implications involving TCF7L2 and FFAR1. Mol Metab (2014) 0.85
Loss-of-Function Mutations in the Cell-Cycle Control Gene CDKN2A Impact on Glucose Homeostasis in Humans. Diabetes (2015) 0.85
BMI as a Modifiable Risk Factor for Type 2 Diabetes: Refining and Understanding Causal Estimates Using Mendelian Randomization. Diabetes (2016) 0.84
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Association of variants in CDKN2A/2B and CDKAL1 genes with gestational insulin sensitivity and disposition in pregnant Han Chinese women. J Diabetes Investig (2015) 0.81
Protective alleles and modifier variants in human health and disease. Nat Rev Genet (2015) 0.81
Common type 2 diabetes risk variant in MTNR1B worsens the deleterious effect of melatonin on glucose tolerance in humans. Metabolism (2015) 0.80
Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants. Diabetes (2016) 0.80
Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series. Genome Med (2016) 0.80
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Using Drosophila to discover mechanisms underlying type 2 diabetes. Dis Model Mech (2016) 0.80
Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank. Diabetologia (2016) 0.80
The diabetes gene Zfp69 modulates hepatic insulin sensitivity in mice. Diabetologia (2015) 0.79
A cautionary tale: the non-causal association between type 2 diabetes risk SNP, rs7756992, and levels of non-coding RNA, CDKAL1-v1. Diabetologia (2015) 0.79
An epidemiological perspective of personalized medicine: the Estonian experience. J Intern Med (2015) 0.78
The potential use of DNA methylation biomarkers to identify risk and progression of type 2 diabetes. Front Endocrinol (Lausanne) (2015) 0.78
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An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. Diabetes (2017) 0.78
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Insights into islet development and biology through characterization of a human iPSC-derived endocrine pancreas model. Islets (2016) 0.77
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Insulin-degrading enzyme inhibition, a novel therapy for type 2 diabetes? Cell Metab (2014) 0.77
Physiology helps GWAS take a step closer to mechanism. Diabetes (2014) 0.77
Maternal Midpregnancy Glucose Levels and Risk of Congenital Heart Disease in Offspring. JAMA Pediatr (2015) 0.77
Lifestyle and Metformin Ameliorate Insulin Sensitivity Independently of the Genetic Burden of Established Insulin Resistance Variants in Diabetes Prevention Program Participants. Diabetes (2015) 0.77
Mechanisms of Type 2 Diabetes Risk Loci. Curr Diab Rep (2017) 0.76
MTNR1B Genetic Variability Is Associated with Gestational Diabetes in Czech Women. Int J Endocrinol (2014) 0.76
Q&A: insulin secretion and type 2 diabetes: why do β-cells fail? BMC Biol (2015) 0.76
The Importance of Context: Uncovering Species- and Tissue-Specific Effects of Genetic Risk Variants for Type 2 Diabetes. Front Endocrinol (Lausanne) (2016) 0.76
Risk Alleles in/near ADCY5, ADRA2A, CDKAL1, CDKN2A/B, GRB10, and TCF7L2 Elevate Plasma Glucose Levels at Birth and in Early Childhood: Results from the FAMILY Study. PLoS One (2016) 0.76
Islet biology, the CDKN2A/B locus and type 2 diabetes risk. Diabetologia (2016) 0.76
Assignment of Functional Relevance to Genes at Type 2 Diabetes-Associated Loci Through Investigation of β-Cell Mass Deficits. Mol Endocrinol (2016) 0.76
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci. Diabetes (2016) 0.76
Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China. Int J Environ Res Public Health (2016) 0.75
Genetic predisposition in nonalcoholic fatty liver disease. Clin Mol Hepatol (2017) 0.75
Decreased STARD10 Expression Is Associated with Defective Insulin Secretion in Humans and Mice. Am J Hum Genet (2017) 0.75
Human genetics as a model for target validation: finding new therapies for diabetes. Diabetologia (2017) 0.75
Transcriptional Regulation of the Pancreatic Islet: Implications for Islet Function. Curr Diab Rep (2015) 0.75
Obstacles to Translating Genotype-Phenotype Correlates in Metabolic Disease. Physiology (Bethesda) (2017) 0.75
Clinical Considerations for Use of Initial Combination Therapy in Type 2 Diabetes. Diabetes Care (2016) 0.75
CDC123/CAMK1D gene rs12779790 polymorphism and rs10811661 polymorphism upstream of the CDKN2A/2B gene in women with gestational diabetes. J Perinatol (2017) 0.75
Genome-edited human stem cell-derived beta cells: a powerful tool for drilling down on type 2 diabetes GWAS biology. F1000Res (2016) 0.75
Erchen Decoction Prevents High-Fat Diet Induced Metabolic Disorders in C57BL/6 Mice. Evid Based Complement Alternat Med (2015) 0.75
Allelic expression imbalance: tipping the scales to elucidate the function of type 2 diabetes-associated loci. Diabetes (2015) 0.75
How Can Genetic Studies Help Us to Understand Links Between Birth Weight and Type 2 Diabetes? Curr Diab Rep (2017) 0.75
The Metabolic Syndrome in Men study: a resource for studies of metabolic and cardiovascular diseases. J Lipid Res (2017) 0.75
Molecular correlates of fat mass expansion in C57BL/6J mice after short-term exposure to dietary fat. Ann N Y Acad Sci (2015) 0.75
Painting a new picture of personalised medicine for diabetes. Diabetologia (2017) 0.75
Genetics of Type 2 Diabetes: It Matters From Which Parent We Inherit the Risk. Rev Diabet Stud (2016) 0.75
Genome-wide association study identifies 112 new loci for body mass index in the Japanese population. Nat Genet (2017) 0.75
A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. Diabetes (2017) 0.75
Prioritising Causal Genes at Type 2 Diabetes Risk Loci. Curr Diab Rep (2017) 0.75
Type 2 Diabetes Prevention: Implications of Hemoglobin A1c Genetics. Rev Diabet Stud (2016) 0.75
Mining the Genome for Therapeutic Targets. Diabetes (2017) 0.75
Gene Editing and Human Pluripotent Stem Cells: Tools for Advancing Diabetes Disease Modeling and Beta-Cell Development. Curr Diab Rep (2017) 0.75
An alternative effector gene at the type 2 diabetes-associated TCF7L2 locus? Diabetologia (2016) 0.75
Genetic risk scores in the prediction of plasma glucose, impaired insulin secretion, insulin resistance and incident type 2 diabetes in the METSIM study. Diabetologia (2017) 0.75
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A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
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New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet (2010) 17.89
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis. Nat Genet (2010) 16.96
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Variants in MTNR1B influence fasting glucose levels. Nat Genet (2008) 10.85
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Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet (2007) 5.88
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion. Nat Genet (2008) 4.84
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nat Genet (2012) 4.37
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Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion. Diabetologia (2008) 2.57
Detailed physiologic characterization reveals diverse mechanisms for novel genetic Loci regulating glucose and insulin metabolism in humans. Diabetes (2010) 2.44
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Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response. Diabetologia (2009) 1.13
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The diabetogenic VPS13C/C2CD4A/C2CD4B rs7172432 variant impairs glucose-stimulated insulin response in 5,722 non-diabetic Danish individuals. Diabetologia (2011) 0.93
Type 2 diabetes risk allele near CENTD2 is associated with decreased glucose-stimulated insulin release. Diabetologia (2011) 0.91
The effect of FOXA2 rs1209523 on glucose-related phenotypes and risk of type 2 diabetes in Danish individuals. BMC Med Genet (2012) 0.83
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Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet (2011) 3.92
New genetic loci link adipose and insulin biology to body fat distribution. Nature (2015) 3.38
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes. Nat Genet (2011) 3.20
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet (2013) 2.83
Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. Diabetes Care (2010) 2.14
Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms. Diabetes Care (2010) 2.06
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The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. PLoS Genet (2015) 1.87
Genetic evidence for a normal-weight "metabolically obese" phenotype linking insulin resistance, hypertension, coronary artery disease, and type 2 diabetes. Diabetes (2014) 1.77
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Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes. Diabetes (2013) 1.06
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A central role for GRB10 in regulation of islet function in man. PLoS Genet (2014) 1.01
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Markers of tissue-specific insulin resistance predict the worsening of hyperglycemia, incident type 2 diabetes and cardiovascular disease. PLoS One (2014) 0.84
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Pathways targeted by antidiabetes drugs are enriched for multiple genes associated with type 2 diabetes risk. Diabetes (2014) 0.83
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The type 2 diabetes risk allele of TMEM154-rs6813195 associates with decreased beta cell function in a study of 6,486 Danes. PLoS One (2015) 0.78
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Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci. Diabetes (2016) 0.76
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A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes (2017) 0.75
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A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants. Diabetes (2017) 0.75
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