Molecular interactions between general anesthetics and the 5HT2B receptor.

PubWeight™: 0.76‹?›

🔗 View Article (PMID 24365264)

Published in J Biomol Struct Dyn on December 23, 2013

Authors

Felipe Matsunaga1, Lu Gao, Xi-Ping Huang, Jeffery G Saven, Bryan L Roth, Renyu Liu

Author Affiliations

1: a Department of Anesthesiology and Critical Care , Perelman School of Medicine, University of Pennsylvania , 336 John Morgan Building, 3620 Hamilton Walk, Philadelphia , PA 19104 , USA.

Articles citing this

Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review. Anesth Analg (2016) 0.79

Articles by these authors

Predicting new molecular targets for known drugs. Nature (2009) 9.71

Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand. Proc Natl Acad Sci U S A (2007) 7.96

Genome editing with RNA-guided Cas9 nuclease in zebrafish embryos. Cell Res (2013) 7.41

Functional selectivity and classical concepts of quantitative pharmacology. J Pharmacol Exp Ther (2006) 7.03

Relating protein pharmacology by ligand chemistry. Nat Biotechnol (2007) 6.61

Structure of the human κ-opioid receptor in complex with JDTic. Nature (2012) 5.18

Rapid, reversible activation of AgRP neurons drives feeding behavior in mice. J Clin Invest (2011) 5.12

Remote control of neuronal activity in transgenic mice expressing evolved G protein-coupled receptors. Neuron (2009) 4.98

Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem (2003) 4.36

Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual participant data. Lancet (2012) 4.16

The expanded biology of serotonin. Annu Rev Med (2009) 3.87

Aripiprazole, a novel atypical antipsychotic drug with a unique and robust pharmacology. Neuropsychopharmacology (2003) 3.78

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells. Nat Chem Biol (2011) 3.60

Generation of a synthetic memory trace. Science (2012) 3.55

Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization. Nat Neurosci (2010) 3.55

The human polyomavirus, JCV, uses serotonin receptors to infect cells. Science (2004) 3.54

Automated design of ligands to polypharmacological profiles. Nature (2012) 3.54

H1-histamine receptor affinity predicts short-term weight gain for typical and atypical antipsychotic drugs. Neuropsychopharmacology (2003) 3.35

Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron (2005) 3.30

Endocrine regulation of male fertility by the skeleton. Cell (2011) 3.20

Topoisomerase inhibitors unsilence the dormant allele of Ube3a in neurons. Nature (2011) 3.19

Structure of the human smoothened receptor bound to an antitumour agent. Nature (2013) 3.08

Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature (2012) 2.96

Remote control of neuronal signaling. Pharmacol Rev (2011) 2.66

Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell (2012) 2.62

Structural features for functional selectivity at serotonin receptors. Science (2013) 2.60

Engineering GPCR signaling pathways with RASSLs. Nat Methods (2008) 2.29

Ligand discovery from a dopamine D3 receptor homology model and crystal structure. Nat Chem Biol (2011) 2.10

Airway trauma in a high patient volume academic cardiac electrophysiology laboratory center. Anesth Analg (2012) 2.06

Inhibition of mediodorsal thalamus disrupts thalamofrontal connectivity and cognition. Neuron (2013) 2.01

DREADDs (designer receptors exclusively activated by designer drugs): chemogenetic tools with therapeutic utility. Annu Rev Pharmacol Toxicol (2014) 1.99

Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. Proc Natl Acad Sci U S A (2011) 1.98

Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations. J Pharmacol Exp Ther (2004) 1.97

Transcriptomic shock generates evolutionary novelty in a newly formed, natural allopolyploid plant. Curr Biol (2011) 1.94

Finding new tricks for old drugs: an efficient route for public-sector drug discovery. Nat Rev Drug Discov (2005) 1.93

Chemogenetic tools to interrogate brain functions. Annu Rev Neurosci (2014) 1.92

G-protein-coupled receptors at a glance. J Cell Sci (2003) 1.92

A chemical-genetic approach to study G protein regulation of beta cell function in vivo. Proc Natl Acad Sci U S A (2009) 1.90

An orally bioavailable chemical probe of the Lysine Methyltransferases EZH2 and EZH1. ACS Chem Biol (2013) 1.89

Evidence for the involvement of dopamine transporters in behavioral stimulant effects of modafinil. J Pharmacol Exp Ther (2009) 1.88

Structural basis for molecular recognition at serotonin receptors. Science (2013) 1.86

N-desalkylquetiapine, a potent norepinephrine reuptake inhibitor and partial 5-HT1A agonist, as a putative mediator of quetiapine's antidepressant activity. Neuropsychopharmacology (2007) 1.83

Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist. J Med Chem (2005) 1.78

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol (2013) 1.72

In vitro characterization of ephedrine-related stereoisomers at biogenic amine transporters and the receptorome reveals selective actions as norepinephrine transporter substrates. J Pharmacol Exp Ther (2003) 1.70

A pharmacological organization of G protein-coupled receptors. Nat Methods (2013) 1.65

Structural determinants for high 5-HT(2A) receptor affinity of spiro[9,10-dihydroanthracene]-9,3(')-pyrrolidine (SpAMDA). Bioorg Med Chem Lett (2004) 1.65

Strategies to discover unexpected targets for drugs active at G protein-coupled receptors. Annu Rev Pharmacol Toxicol (2011) 1.61

Computational design and characterization of a monomeric helical dinuclear metalloprotein. J Mol Biol (2003) 1.60

Palmitoylation and polymerization of hepatitis C virus NS4B protein. J Virol (2006) 1.59

Genome-wide lethality screen identifies new PI4,5P2 effectors that regulate the actin cytoskeleton. EMBO J (2004) 1.59

Mining the receptorome. J Biol Chem (2004) 1.58

New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug). Mol Pharmacol (2008) 1.57

Molecular biology of serotonin receptors structure and function at the molecular level. Curr Top Med Chem (2002) 1.54

Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. J Clin Invest (2015) 1.53

Computational de novo design and characterization of a four-helix bundle protein that selectively binds a nonbiological cofactor. J Am Chem Soc (2005) 1.52

Strand transfer events during HIV-1 reverse transcription. Virus Res (2008) 1.51

Dickkopf-3 attenuates pressure overload-induced cardiac remodelling. Cardiovasc Res (2014) 1.49

3,4-methylenedioxymethamphetamine (MDMA, "Ecstasy") induces fenfluramine-like proliferative actions on human cardiac valvular interstitial cells in vitro. Mol Pharmacol (2003) 1.47

In silico molecular comparisons of C. elegans and mammalian pharmacology identify distinct targets that regulate feeding. PLoS Biol (2013) 1.47

PSD-95 is essential for hallucinogen and atypical antipsychotic drug actions at serotonin receptors. J Neurosci (2009) 1.46

Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader-Willi syndrome. Neurobiol Dis (2010) 1.46

Molecular targets for treating cognitive dysfunction in schizophrenia. Schizophr Bull (2007) 1.45

Parallel functional activity profiling reveals valvulopathogens are potent 5-hydroxytryptamine(2B) receptor agonists: implications for drug safety assessment. Mol Pharmacol (2009) 1.44

Salvinorin A: the "magic mint" hallucinogen finds a molecular target in the kappa opioid receptor. Trends Pharmacol Sci (2003) 1.42

Completely anonymous multi-recipient signcryption scheme with public verification. PLoS One (2013) 1.40

Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. Autophagy (2009) 1.39

CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling. Nat Neurosci (2010) 1.38

Chemical informatics and target identification in a zebrafish phenotypic screen. Nat Chem Biol (2011) 1.37

Engineered GPCRs as tools to modulate signal transduction. Physiology (Bethesda) (2008) 1.37

Caveolin-1 interacts with 5-HT2A serotonin receptors and profoundly modulates the signaling of selected Galphaq-coupled protein receptors. J Biol Chem (2004) 1.37

Characterization of duplicate gene evolution in the recent natural allopolyploid Tragopogon miscellus by next-generation sequencing and Sequenom iPLEX MassARRAY genotyping. Mol Ecol (2010) 1.37

Identifying mechanism-of-action targets for drugs and probes. Proc Natl Acad Sci U S A (2012) 1.36

Dementia before death in ageing societies--the promise of prevention and the reality. PLoS Med (2006) 1.34

A unitary anesthetic binding site at high resolution. J Biol Chem (2009) 1.34

Virus combinations and chemotherapy for the treatment of human cancers. Curr Opin Mol Ther (2008) 1.32

Computational design of water-soluble analogues of the potassium channel KcsA. Proc Natl Acad Sci U S A (2004) 1.31

Development of a rationally designed, low abuse potential, biogenic amine releaser that suppresses cocaine self-administration. J Pharmacol Exp Ther (2005) 1.29

A direct interaction of PSD-95 with 5-HT2A serotonin receptors regulates receptor trafficking and signal transduction. J Biol Chem (2003) 1.28

Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo. Psychopharmacology (Berl) (2009) 1.28

Massively parallel screening of the receptorome. Comb Chem High Throughput Screen (2008) 1.27

Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6. J Biol Chem (2002) 1.27

Directed molecular evolution of DREADDs: a generic approach to creating next-generation RASSLs. Nat Protoc (2010) 1.26

Effects of inflammatory factors on mesenchymal stem cells and their role in the promotion of tumor angiogenesis in colon cancer. J Biol Chem (2011) 1.26

Rapid modulation of spine morphology by the 5-HT2A serotonin receptor through kalirin-7 signaling. Proc Natl Acad Sci U S A (2009) 1.26

Theoretical and computational protein design. Annu Rev Phys Chem (2011) 1.26

Ultrafast folding of a computationally designed Trp-cage mutant: Trp2-cage. J Phys Chem B (2006) 1.26

Case report: Anti-N-methyl-D-aspartate receptor encephalitis and its anesthetic implications. Anesth Analg (2011) 1.25

Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. J Med Chem (2006) 1.24

Aripiprazole: a novel atypical antipsychotic drug with a uniquely robust pharmacology. CNS Drug Rev (2004) 1.24

Computational design of a protein crystal. Proc Natl Acad Sci U S A (2012) 1.23