Published in Front Immunol on December 26, 2013
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol (2006) 14.33
Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol (2005) 13.03
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol (2001) 12.00
How regulatory T cells work. Nat Rev Immunol (2008) 11.66
A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol (2005) 11.48
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol (2010) 9.72
Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol (2000) 9.15
FOXP3+ regulatory T cells in the human immune system. Nat Rev Immunol (2010) 8.73
Binding of immunogenic peptides to Ia histocompatibility molecules. Nature (1985) 8.39
Antigen presentation and T cell stimulation by dendritic cells. Annu Rev Immunol (2001) 6.20
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med (2007) 5.52
Regulatory T cells and infection: a dangerous necessity. Nat Rev Immunol (2007) 4.56
Complete but curtailed T-cell response to very low-affinity antigen. Nature (2009) 4.31
Nonself-antigens are the cognate specificities of Foxp3+ regulatory T cells. Immunity (2007) 3.98
Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J Exp Med (2008) 3.15
T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity (2006) 3.02
Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity (2000) 2.71
Naive T cell homeostasis: from awareness of space to a sense of place. Nat Rev Immunol (2009) 2.68
How virus induces a rapid or slow onset insulin-dependent diabetes mellitus in a transgenic model. Immunity (1994) 2.56
Selection of regulatory T cells in the thymus. Nat Rev Immunol (2012) 2.51
Multiple sclerosis. J Clin Invest (2012) 2.41
Understanding presentation of viral antigens to CD8+ T cells in vivo: the key to rational vaccine design. Annu Rev Immunol (2005) 2.39
Mechanisms maintaining peripheral tolerance. Nat Immunol (2009) 2.14
Understanding immunosenescence to improve responses to vaccines. Nat Immunol (2013) 2.09
Type 1 diabetes as a relapsing-remitting disease? Nat Rev Immunol (2007) 2.04
Competing feedback loops shape IL-2 signaling between helper and regulatory T lymphocytes in cellular microenvironments. Proc Natl Acad Sci U S A (2010) 1.71
Selective depletion of Foxp3+ regulatory T cells improves effective therapeutic vaccination against established melanoma. Cancer Res (2010) 1.66
Natural regulatory T cells and persistent viral infection. J Virol (2007) 1.62
Making regulatory T cells with defined antigen specificity: role in autoimmunity and cancer. Immunol Rev (2006) 1.50
Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper. Nat Rev Immunol (2009) 1.49
Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes. Nat Immunol (2012) 1.46
Tuning of activation thresholds explains flexibility in the selection and development of T cells in the thymus. Proc Natl Acad Sci U S A (1996) 1.44
Modulation of Fas-dependent apoptosis: a dynamic process controlling both the persistence and death of CD4 regulatory T cells and effector T cells. J Immunol (2002) 1.41
Avidity maturation of memory CD8 T cells is limited by self-antigen expression. J Exp Med (2008) 1.38
The three main stumbling blocks for anticancer T cells. Trends Immunol (2012) 1.38
Ablation of thymic export causes accelerated decay of naive CD4 T cells in the periphery because of activation by environmental antigen. Proc Natl Acad Sci U S A (2008) 1.32
Homeostasis and function of regulatory T cells in aging. Curr Opin Immunol (2012) 1.30
Hepatitis C virus immune escape via exploitation of a hole in the T cell repertoire. J Immunol (2008) 1.28
How thymic antigen presenting cells sample the body's self-antigens. Curr Opin Immunol (2010) 1.26
Transient depletion of regulatory T cells in transgenic mice reactivates virus-specific CD8+ T cells and reduces chronic retroviral set points. Proc Natl Acad Sci U S A (2011) 1.26
Autoreactive T cells bypass negative selection and respond to self-antigen stimulation during infection. J Exp Med (2012) 1.15
Dendritic cells induce regulatory T cell proliferation through antigen-dependent and -independent interactions. J Immunol (2010) 1.14
Amino acid similarity accounts for T cell cross-reactivity and for "holes" in the T cell repertoire. PLoS One (2008) 1.11
When three is not a crowd: a Crossregulation model of the dynamics and repertoire selection of regulatory CD4+ T cells. Immunol Rev (2007) 1.10
Autoreactive T cells promote post-traumatic healing in the central nervous system. J Neuroimmunol (2003) 1.08
The role of regulatory T cells in chronic and acute viral infections. Clin Infect Dis (2008) 1.06
Quorum-Sensing in CD4(+) T Cell Homeostasis: A Hypothesis and a Model. Front Immunol (2012) 0.99
Modelling T-cell-mediated suppression dependent on interactions in multicellular conjugates. J Theor Biol (2000) 0.97
Fratricide: a mechanism for T memory-cell homeostasis. Trends Immunol (2003) 0.97
Central tolerance: what have we learned from mice? Semin Immunopathol (2008) 0.97
Regulatory T cell adjustment of quorum growth thresholds and the control of local immune responses. J Theor Biol (2006) 0.96
Modeling regulation mechanisms in the immune system. J Theor Biol (2006) 0.95
Activation-threshold tuning in an affinity model for the T-cell repertoire. Proc Biol Sci (2004) 0.94
Recognition of HIV-1 peptides by host CTL is related to HIV-1 similarity to human proteins. PLoS One (2007) 0.92
Autoreactive T cells induce neurotrophin production by immune and neural cells in injured rat optic nerve: implications for protective autoimmunity. FASEB J (2002) 0.91
Age-related autoimmunity. BMC Med (2013) 0.91
A self-reactive TCR drives the development of Foxp3+ regulatory T cells that prevent autoimmune disease. J Immunol (2011) 0.91
The contributions of T-cell anergy to peripheral T-cell tolerance. Immunology (2001) 0.91
T cell avidity determines the level of CTL activation. Eur J Immunol (2004) 0.90
Massive peptide sharing between viral and human proteomes. Peptides (2008) 0.90
Regulatory T cells and viral infections. Front Biosci (2008) 0.82
Three-cell interactions in T cell-mediated suppression? A mathematical analysis of its quantitative implications. J Immunol (2001) 0.79
Bacterial peptides are intensively present throughout the human proteome. Self Nonself (2010) 0.79
Beneficial brain autoimmunity? Brain (2010) 0.78
Self-nonself discrimination due to immunological nonlinearities: the analysis of a series of models by numerical methods. IMA J Math Appl Med Biol (1987) 0.76