Spironolactone decreases DOCA-salt-induced organ damage by blocking the activation of T helper 17 and the downregulation of regulatory T lymphocytes.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMID 24420551)

Published in Hypertension on January 13, 2014

Authors

Cristián A Amador1, Víctor Barrientos, Juan Peña, Andrés A Herrada, Magdalena González, Solange Valdés, Loreto Carrasco, Rodrigo Alzamora, Fernando Figueroa, Alexis M Kalergis, Luis Michea

Author Affiliations

1: Facultad de Medicina, Universidad de Chile, Independencia 1027, Santiago, Chile. lmichea@med.uchile.cl.

Articles citing this

Inflammation, immunity, and hypertensive end-organ damage. Circ Res (2015) 1.77

The immune system and hypertension. Immunol Res (2014) 1.10

Mineralocorticoid receptors in immune cells: emerging role in cardiovascular disease. Steroids (2014) 1.01

Dual opposing roles of adaptive immunity in hypertension. Eur Heart J (2014) 0.95

Mineralocorticoid receptor antagonism treats obesity-associated cardiac diastolic dysfunction. Hypertension (2015) 0.90

Sex differences in T cells in hypertension. Clin Ther (2014) 0.89

Inflammation and hypertension: new understandings and potential therapeutic targets. Curr Hypertens Rep (2015) 0.89

Female spontaneously hypertensive rats have a compensatory increase in renal regulatory T cells in response to elevations in blood pressure. Hypertension (2014) 0.89

Sodium chloride, SGK1, and Th17 activation. Pflugers Arch (2014) 0.86

Mineralocorticoid Receptors in the Pathophysiology of Vascular Inflammation and Atherosclerosis. Front Endocrinol (Lausanne) (2015) 0.84

Interleukin-17A Regulates Renal Sodium Transporters and Renal Injury in Angiotensin II-Induced Hypertension. Hypertension (2016) 0.82

Effects of Sodium Restriction on Activation of the Renin-Angiotensin-Aldosterone System and Immune Indices During HIV Infection. J Infect Dis (2016) 0.79

CXCR4 Antagonism Attenuates the Development of Diabetic Cardiac Fibrosis. PLoS One (2015) 0.78

Interfering with mineralocorticoid receptor activation: the past, present, and future. F1000Prime Rep (2014) 0.78

Novel Immune Mechanisms in Hypertension and Cardiovascular Risk. Curr Cardiovasc Risk Rep (2017) 0.77

Inhibition of Interleukin 17-A but not Interleukin-17F Signaling Lowers Blood Pressure and Reduces End-organ Inflammation in Angiotensin II-induced Hypertension. JACC Basic Transl Sci (2016) 0.77

Role of immune cells in salt-sensitive hypertension and renal injury. Curr Opin Nephrol Hypertens (2016) 0.76

Hypertension and immunity: mechanisms of T cell activation and pathways of hypertension. Curr Opin Nephrol Hypertens (2015) 0.76

Dysregulation of T cell subsets in the pathogenesis of hypertension. Curr Hypertens Rep (2015) 0.76

Interventional procedures and future drug therapy for hypertension. Eur Heart J (2017) 0.75

The Central Role of Neutrophil Gelatinase-Associated Lipocalin in Cardiovascular Fibrosis. Hypertension (2015) 0.75

Is immune system-related hypertension associated with ovarian hormone deficiency? Exp Physiol (2015) 0.75

Hydrogen sulfide alleviates hypertensive kidney dysfunction through an epigenetic mechanism. Am J Physiol Heart Circ Physiol (2017) 0.75

Potential Effects of Pomegranate on Lipid Peroxidation and Pro-inflammatory Changes in Daunorubicin-induced Cardiotoxicity in Rats. Int J Prev Med (2016) 0.75

Modulation of Immunity and Inflammation by the Mineralocorticoid Receptor and Aldosterone. Biomed Res Int (2015) 0.75

A salt-sensing kinase in T lymphocytes, SGK1, drives hypertension and hypertensive end-organ damage. JCI Insight (2017) 0.75

Abnormal CD161(+) Immune Cells and RORΓT Mediated Enhanced IL-17F Expression in Genetic Hypertension. J Allergy Clin Immunol (2017) 0.75

Mineralocorticoids modulate the expression of the beta-3 subunit of the Na(+),K(+)-ATPase in the renal collecting duct. Channels (Austin) (2017) 0.75

Dietary Salt Exacerbates Experimental Colitis. J Immunol (2017) 0.75

Articles by these authors

Activated TCRs remain marked for internalization after dissociation from pMHC. Nat Immunol (2002) 3.01

Mineralocorticoid receptor antagonism attenuates cardiac hypertrophy and prevents oxidative stress in uremic rats. Hypertension (2008) 2.21

Dynamic wait-listed designs for randomized trials: new designs for prevention of youth suicide. Clin Trials (2006) 2.12

Angiotensin-(1-9) reverses experimental hypertension and cardiovascular damage by inhibition of the angiotensin converting enzyme/Ang II axis. J Hypertens (2014) 2.04

Endothelial epithelial sodium channel inhibition activates endothelial nitric oxide synthase via phosphoinositide 3-kinase/Akt in small-diameter mesenteric arteries. Hypertension (2009) 1.62

T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell. Proc Natl Acad Sci U S A (2005) 1.49

High-salt diet inhibits expression of angiotensin type 2 receptor in resistance arteries. Hypertension (2005) 1.45

Gestational hypothyroidism increases the severity of experimental autoimmune encephalomyelitis in adult offspring. Thyroid (2013) 1.41

Salmonella escape from antigen presentation can be overcome by targeting bacteria to Fc gamma receptors on dendritic cells. J Immunol (2004) 1.33

Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells. Stem Cell Res Ther (2013) 1.26

Aldosterone promotes autoimmune damage by enhancing Th17-mediated immunity. J Immunol (2009) 1.22

Virulent Salmonella enterica serovar typhimurium evades adaptive immunity by preventing dendritic cells from activating T cells. Infect Immun (2006) 1.21

Vacuolar H+-ATPase apical accumulation in kidney intercalated cells is regulated by PKA and AMP-activated protein kinase. Am J Physiol Renal Physiol (2010) 1.20

AMP-activated protein kinase inhibits alkaline pH- and PKA-induced apical vacuolar H+-ATPase accumulation in epididymal clear cells. Am J Physiol Cell Physiol (2009) 1.20

T cell immunity evasion by virulent Salmonella enterica. Immunol Lett (2007) 1.19

Respiratory syncytial virus impairs T cell activation by preventing synapse assembly with dendritic cells. Proc Natl Acad Sci U S A (2008) 1.16

Human impacts on land cover and water balances in a coastal Mediterranean county. Environ Manage (2007) 1.15

cDNA array identification of genes regulated in rat renal medulla in response to vasopressin infusion. Am J Physiol Renal Physiol (2002) 1.14

Elevated expression of MeCP2 in cardiac and skeletal tissues is detrimental for normal development. Hum Mol Genet (2010) 1.13

Mesenchymal stem cells repress Th17 molecular program through the PD-1 pathway. PLoS One (2012) 1.10

Andrographolide interferes with T cell activation and reduces experimental autoimmune encephalomyelitis in the mouse. J Pharmacol Exp Ther (2004) 1.10

Female gender-specific inhibition of KCNQ1 channels and chloride secretion by 17beta-estradiol in rat distal colonic crypts. J Biol Chem (2007) 1.09

Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG. Proc Natl Acad Sci U S A (2008) 1.08

Aldosterone as a modulator of immunity: implications in the organ damage. J Hypertens (2011) 1.05

Opposing effect of mesenchymal stem cells on Th1 and Th17 cell polarization according to the state of CD4+ T cell activation. Immunol Lett (2010) 1.04

B cells from rheumatoid arthritis patients show important alterations in the expression of CD86 and FcgammaRIIb, which are modulated by anti-tumor necrosis factor therapy. Arthritis Res Ther (2010) 1.04

Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model. Clin Sci (Lond) (2011) 1.04

Drought tolerance and transplanting performance of holm oak (Quercus ilex) seedlings after drought hardening in the nursery. Tree Physiol (2004) 1.03

Inhibition of nuclear factor-kappa B enhances the capacity of immature dendritic cells to induce antigen-specific tolerance in experimental autoimmune encephalomyelitis. J Pharmacol Exp Ther (2006) 1.01

Host immunity during RSV pathogenesis. Int Immunopharmacol (2008) 1.01

Insulin-like growth factor-1 induces an inositol 1,4,5-trisphosphate-dependent increase in nuclear and cytosolic calcium in cultured rat cardiac myocytes. J Biol Chem (2003) 1.01

Modulation of T cell function by TCR/pMHC binding kinetics. Immunobiology (2006) 1.00

Stimulation of dopamine receptor D5 expressed on dendritic cells potentiates Th17-mediated immunity. J Immunol (2012) 0.99

The half-life of the T-cell receptor/peptide-major histocompatibility complex interaction can modulate T-cell activation in response to bacterial challenge. Immunology (2007) 0.98

Functional gap junctions accumulate at the immunological synapse and contribute to T cell activation. J Immunol (2011) 0.97

Efficient lung recruitment of respiratory syncytial virus-specific Th1 cells induced by recombinant bacillus Calmette-Guérin promotes virus clearance and protects from infection. J Immunol (2010) 0.96

Functional regulation of the epithelial Na+ channel by IkappaB kinase-beta occurs via phosphorylation of the ubiquitin ligase Nedd4-2. J Biol Chem (2008) 0.95

The capacity of Salmonella to survive inside dendritic cells and prevent antigen presentation to T cells is host specific. Immunology (2008) 0.95

SGLT1, a novel cardiac glucose transporter, mediates increased glucose uptake in PRKAG2 cardiomyopathy. J Mol Cell Cardiol (2010) 0.95

Human mesenchymal stem cells derived from adipose tissue reduce functional and tissue damage in a rat model of chronic renal failure. Clin Sci (Lond) (2013) 0.95

A randomized, double-blind, placebo-controlled trial of spironolactone on carotid intima-media thickness in nondiabetic hemodialysis patients. Clin J Am Soc Nephrol (2010) 0.95

[Identifying bacteria using a matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometer. Comparison with routine methods used in clinical microbiology laboratories]. Enferm Infecc Microbiol Clin (2010) 0.94

Immune complex-induced enhancement of bacterial antigen presentation requires Fcgamma receptor III expression on dendritic cells. Proc Natl Acad Sci U S A (2007) 0.94

Research priorities for neglected infectious diseases in Latin America and the Caribbean region. PLoS Negl Trop Dis (2010) 0.94

Proliferation and osmotic tolerance of renal inner medullary epithelial cells in vivo and in cell culture. Am J Physiol Renal Physiol (2002) 0.92

Mechanisms used by virulent Salmonella to impair dendritic cell function and evade adaptive immunity. Immunology (2012) 0.92

Genomic priming of the antisecretory response to estrogen in rat distal colon throughout the estrous cycle. Mol Endocrinol (2009) 0.92

Advances in understanding respiratory syncytial virus infection in airway epithelial cells and consequential effects on the immune response. Microbes Infect (2012) 0.92

Rate of increase of osmolality determines osmotic tolerance of mouse inner medullary epithelial cells. Am J Physiol Renal Physiol (2002) 0.91

Regulation of the creatine transporter by AMP-activated protein kinase in kidney epithelial cells. Am J Physiol Renal Physiol (2010) 0.91

Interplay between thermal and immune ecology: effect of environmental temperature on insect immune response and energetic costs after an immune challenge. J Insect Physiol (2011) 0.90

The duration of TCR/pMHC interactions regulates CTL effector function and tumor-killing capacity. Eur J Immunol (2009) 0.90

Nongenomic effect of aldosterone on Na+,K+-adenosine triphosphatase in arterial vessels. Endocrinology (2003) 0.90

Infection of human monocyte-derived dendritic cells by ANDES Hantavirus enhances pro-inflammatory state, the secretion of active MMP-9 and indirectly enhances endothelial permeability. Virol J (2011) 0.89

Local cytokine response upon respiratory syncytial virus infection. Immunol Lett (2010) 0.89

Excision of an unstable pathogenicity island in Salmonella enterica serovar Enteritidis is induced during infection of phagocytic cells. PLoS One (2011) 0.89

Gap junctions at the dendritic cell-T cell interface are key elements for antigen-dependent T cell activation. J Immunol (2009) 0.89

Respiratory syncytial virus infection and immunity. Rev Med Virol (2012) 0.88

The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling. Biochem Biophys Res Commun (2009) 0.88

Molecular interactions between dendritic cells and Salmonella: escape from adaptive immunity and implications on pathogenesis. Crit Rev Immunol (2005) 0.88

E Prostanoid-1 receptor regulates renal medullary alphaENaC in rats infused with angiotensin II. Biochem Biophys Res Commun (2009) 0.88

Melanocortin 1 receptor is expressed by uveal malignant melanoma and can be considered a new target for diagnosis and immunotherapy. Invest Ophthalmol Vis Sci (2007) 0.88

Interstitial granulomatous dermatitis with histiocytic pseudorosettes: a new histopathologic pattern in cutaneous borreliosis. Detection of Borrelia burgdorferi DNA sequences by a highly sensitive PCR-ELISA. J Am Acad Dermatol (2003) 0.87

Activating and inhibitory Fcgamma receptors can differentially modulate T cell-mediated autoimmunity. Eur J Immunol (2008) 0.87

Modulation of the dendritic cell-T-cell synapse to promote pathogen immunity and prevent autoimmunity. Immunotherapy (2011) 0.87

Impairment of T cell immunity by the respiratory syncytial virus: targeting virulence mechanisms for therapy and prophylaxis. Curr Med Chem (2009) 0.87

Nitric oxide production by endothelial cells derived from blood progenitors cultured on NaOH-treated polycaprolactone films: A biofunctionality study. Acta Biomater (2009) 0.86

Tolerogenic dendritic cells as a therapy for treating lupus. Clin Immunol (2013) 0.86

Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells. Eur J Immunol (2013) 0.86

Impaired learning resulting from respiratory syncytial virus infection. Proc Natl Acad Sci U S A (2013) 0.86

Estradiol-induced expression of N(+)-K(+)-ATPase catalytic isoforms in rat arteries: gender differences in activity mediated by nitric oxide donors. Am J Physiol Heart Circ Physiol (2004) 0.85

Modulation of immunological synapse by membrane-bound and soluble ligands. Cytokine Growth Factor Rev (2007) 0.85

T-cell antagonism by short half-life pMHC ligands can be mediated by an efficient trapping of T-cell polarization toward the APC. Proc Natl Acad Sci U S A (2009) 0.85

11β-Hydroxysteroid dehydrogenase type-2 and type-1 (11β-HSD2 and 11β-HSD1) and 5β-reductase activities in the pathogenia of essential hypertension. Endocrine (2009) 0.84

Bone marrow stromal cells modulate mouse ENT1 activity and protect leukemia cells from cytarabine induced apoptosis. PLoS One (2012) 0.84

Deletion of a prophage-like element causes attenuation of Salmonella enterica serovar Enteritidis and promotes protective immunity. Vaccine (2010) 0.84

FcγRIIb and BAFF differentially regulate peritoneal B1 cell survival. J Immunol (2012) 0.84

Thyroid hormone administration induces rat liver Nrf2 activation: suppression by N-acetylcysteine pretreatment. Thyroid (2011) 0.84

Interplay between behavioural thermoregulation and immune response in mealworms. J Insect Physiol (2012) 0.84

Influence of glucose metabolism on vascular smooth muscle cell proliferation. Vasa (2013) 0.83

Use of genetically modified bacteria to modulate adaptive immunity. Curr Gene Ther (2009) 0.83

Salmonella pathogenicity island 1 differentially modulates bacterial entry to dendritic and non-phagocytic cells. Immunology (2010) 0.83

Injury of skeletal muscle and specific cytokines induce the expression of gap junction channels in mouse dendritic cells. J Cell Physiol (2007) 0.82

Resveratrol inhibits the epithelial sodium channel via phopshoinositides and AMP-activated protein kinase in kidney collecting duct cells. PLoS One (2013) 0.82

Disease activity in systemic lupus erythematosus is associated with an altered expression of low-affinity Fc gamma receptors and costimulatory molecules on dendritic cells. Immunology (2009) 0.82

NFAT5 is activated by hypoxia: role in ischemia and reperfusion in the rat kidney. PLoS One (2012) 0.82

Immunization with a recombinant bacillus Calmette-Guerin strain confers protective Th1 immunity against the human metapneumovirus. J Immunol (2013) 0.82

IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction. Biol Res (2012) 0.81

Rapid responses to steroid hormones: from frog skin to human colon. A homage to Hans Ussing. Biochim Biophys Acta (2002) 0.81

A novel adrenocorticotropin receptor mutation alters its structure and function, causing familial glucocorticoid deficiency. J Clin Endocrinol Metab (2008) 0.81

Chloracne: histopathologic findings in one case. J Cutan Pathol (2002) 0.81

Increased urinary glucocorticoid metabolites are associated with metabolic syndrome, hypoadiponectinemia, insulin resistance and β cell dysfunction. Steroids (2011) 0.81

Effect of spironolactone on K(+) homeostasis and ENaC expression in lymphocytes from chronic hemodialysis patients. Kidney Int (2004) 0.80

Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system. Clin Sci (Lond) (2014) 0.80

Rapid responses to aldosterone in the kidney and colon. J Steroid Biochem Mol Biol (2007) 0.80

The dendritic cell-T cell synapse as a determinant of autoimmune pathogenesis. Curr Pharm Des (2006) 0.80

Carbon monoxide exposure improves immune function in lupus-prone mice. Immunology (2013) 0.80