PubRank

Jukka Hakkola

Author PubWeight™ 26.85‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Inhibition and induction of human cytochrome P450 enzymes: current status. Arch Toxicol 2008 2.02
2 Functional role of P-glycoprotein in the human blood-placental barrier. Clin Pharmacol Ther 2005 1.79
3 Expression and regulation of xenobiotic-metabolizing cytochrome P450 (CYP) enzymes in human lung. Crit Rev Toxicol 2002 1.28
4 Methylation of cytochrome P4501A1 promoter in the lung is associated with tobacco smoking. Cancer Res 2003 1.07
5 Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist. J Biol Chem 2011 0.96
6 Cytochrome P450-mediated pulmonary metabolism of carcinogens: regulation and cross-talk in lung carcinogenesis. Am J Respir Cell Mol Biol 2010 0.95
7 The plasma membrane carbonic anhydrase in murine hepatocytes identified as isozyme XIV. BMC Gastroenterol 2002 0.92
8 Regulation of CYP3A5 by glucocorticoids and cigarette smoke in human lung-derived cells. J Pharmacol Exp Ther 2003 0.92
9 Regulation of CYP2A5 gene by the transcription factor nuclear factor (erythroid-derived 2)-like 2. Drug Metab Dispos 2007 0.91
10 Cytochrome P450 2A5 constitutive expression and induction by heavy metals is dependent on redox-sensitive transcription factor Nrf2 in liver. Chem Res Toxicol 2010 0.91
11 Metformin induces PGC-1α expression and selectively affects hepatic PGC-1α functions. Br J Pharmacol 2014 0.88
12 Metformin reduces hepatic expression of SIRT3, the mitochondrial deacetylase controlling energy metabolism. PLoS One 2012 0.88
13 Metabolism of ophthalmic timolol: new aspects of an old drug. Basic Clin Pharmacol Toxicol 2011 0.88
14 Coactivator PGC-1alpha regulates the fasting inducible xenobiotic-metabolizing enzyme CYP2A5 in mouse primary hepatocytes. Toxicol Appl Pharmacol 2008 0.86
15 Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver. Curr Drug Metab 2013 0.85
16 Regulation of CYP3A genes in the human respiratory tract. Chem Biol Interact 2005 0.83
17 Energy sensing factors PGC-1α and SIRT1 modulate PXR expression and function. Biochem Pharmacol 2011 0.83
18 Aryl hydrocarbon receptor nuclear translocator and upstream stimulatory factor regulate Cytochrome P450 2a5 transcription through a common E-box site. J Mol Biol 2007 0.83
19 Regulation of the Cyp2a5 gene involves an aryl hydrocarbon receptor-dependent pathway. Mol Pharmacol 2005 0.82
20 Transcription factor binding to a putative double E-box motif represses CYP3A4 expression in human lung cells. Mol Pharmacol 2007 0.81
21 Regulation of Cyp2a5 transcription in mouse primary hepatocytes: roles of hepatocyte nuclear factor 4 and nuclear factor I. Biochem J 2004 0.79
22 Characterization of androgen-regulated expression of CYP3A5 in human prostate. Carcinogenesis 2006 0.78
23 Effects of selective serotonin reuptake inhibitors on timolol metabolism in human liver microsomes and cryo-preserved hepatocytes. Basic Clin Pharmacol Toxicol 2009 0.78
24 Pregnane X receptor (PXR)--a contributor to the diabetes epidemic? Drug Metabol Drug Interact 2014 0.78
25 Characterization of human cytochrome P450 induction by pesticides. Toxicology 2012 0.78
26 Heme and heme biosynthesis intermediates induce heme oxygenase-1 and cytochrome P450 2A5, enzymes with putative sequential roles in heme and bilirubin metabolism: different requirement for transcription factor nuclear factor erythroid- derived 2-like 2. Toxicol Sci 2012 0.77
27 Reactive metabolites in early drug development: predictive in vitro tools. Curr Med Chem 2015 0.76
28 Expression of cytochrome P450 (CYP) enzymes in human nonpigmented ciliary epithelial cells: induction of CYP1B1 expression by TCDD. Invest Ophthalmol Vis Sci 2009 0.76
29 Placental transfer of quetiapine in relation to P-glycoprotein activity. J Psychopharmacol 2007 0.76
30 Preservation, induction or incorporation of metabolism into the in vitro cellular system - views to current opportunities and limitations. Toxicol In Vitro 2012 0.75
31 Cytochromes P450, induction and cholesterol--what are the connections? Eur J Clin Pharmacol 2008 0.75