PubRank

R Higuchi

Author PubWeight™ 330.45‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 1988 220.77
2 Avoiding false positives with PCR. Nature 1989 30.66
3 Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques 1991 21.69
4 Effective amplification of long targets from cloned inserts and human genomic DNA. Proc Natl Acad Sci U S A 1994 4.86
5 In silico mapping of complex disease-related traits in mice. Science 2001 4.67
6 High-throughput SNP allele-frequency determination in pooled DNA samples by kinetic PCR. Genome Res 2000 4.55
7 DNA sequences from the quagga, an extinct member of the horse family. Nature 1984 3.86
8 A general method for cloning eukaryotic structural gene sequences. Proc Natl Acad Sci U S A 1976 2.84
9 High-resolution, high-throughput HLA genotyping by next-generation sequencing. Tissue Antigens 2009 2.64
10 Preferential PCR amplification of alleles: mechanisms and solutions. PCR Methods Appl 1992 2.47
11 Single-tube genotyping without oligonucleotide probes. Genome Res 1999 1.94
12 Complete mitochondrial genome amplification. Nat Genet 1994 1.58
13 Transcript quantitation in total yeast cellular RNA using kinetic PCR. Nucleic Acids Res 2000 1.53
14 HLA-DR, DQ and DP typing using PCR amplification and immobilized probes. Eur J Immunogenet 1991 1.50
15 Human ribosomal RNA gene spacer sequences are found interspersed elsewhere in the genome. Gene 1981 1.36
16 Epidemiological and outcome characteristics of major burns in Tokyo. Burns 2005 1.10
17 Template integrity is essential for PCR amplification of 20- to 30-kb sequences from genomic DNA. PCR Methods Appl 1995 1.07
18 Bioactive terpenoids from Octocorallia, I. Bioactive diterpenoids: litophynols A and B from the mucus of the soft coral Litophyton sp. J Nat Prod 1994 1.04
19 Recombinant DNA clones constructed from immunoglobulin kappa light chain messenger RNA. Nucleic Acids Res 1978 1.03
20 Cytotoxic lavandulyl flavanones from Sophora flavescens. J Nat Prod 2000 1.01
21 Pearson's marrow/pancreas syndrome: a histological and genetic study. Virchows Arch A Pathol Anat Histopathol 1993 0.95
22 Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression. J Immunol 2000 0.94
23 Quantification of human mitochondrial DNA in a real time PCR. Forensic Sci Int 2002 0.93
24 Multiple mucosal bridge formation in the esophagus in a patient with Crohn's disease. Endoscopy 1998 0.89
25 Preoperative diagnosis of ileal lipoma by endoscopic ultrasonography probe. J Clin Gastroenterol 2000 0.88
26 Nebulized vs. instilled exogenous surfactant in an adult lung injury model. J Appl Physiol (1985) 1991 0.87
27 Sedative activity of two flavonol glycosides isolated from the flowers of Albizzia julibrissin Durazz. J Ethnopharmacol 2000 0.87
28 Polymerase chain reaction (PCR) amplification and human leukocyte antigen (HLA)-DQ alpha oligonucleotide typing on biological evidence samples: casework experience. J Forensic Sci 1992 0.86
29 Anti-idiotypic antibodies in a patient with a functioning renal graft. Nature 1980 0.86
30 [Stabilization and reduction of irritant taste of anti-inflammatory drug pirprofen by beta-cyclodextrin complexation]. Yakugaku Zasshi 1984 0.84
31 Identification of a mislabeled fixed specimen by DNA analysis. Am J Surg Pathol 1990 0.84
32 Human parvovirus B19 capsid antigen in granulocytes in parvovirus-B19-induced pancytopenia after bone marrow transplantation. Acta Haematol 1998 0.83
33 Hyaluronidase inhibitory active 6H-dibenzo[b,d]pyran-6-ones from the feces of Trogopterus xanthipes. Planta Med 2000 0.81
34 In vitro inducible nitric oxide synthesis inhibitory active constituents from Fraxinus rhynchophylla. Planta Med 1999 0.81
35 Plasma angiotensin II concentrations in the early neonatal period. Arch Dis Child Fetal Neonatal Ed 2006 0.81
36 Rotundines A-C, three novel sesquiterpene alkaloids from Cyperus rotundus. J Nat Prod 2000 0.81
37 Bioactive diterpenoids from Octocorallia, 2. Deoxyxeniolide B, a novel ichthyotoxic diterpenoid from the soft coral Xenia elongata. J Nat Prod 1995 0.81
38 Report of the blind trial of the Cetus Amplitype HLA DQ alpha forensic deoxyribonucleic acid (DNA) amplification and typing kit. J Forensic Sci 1991 0.80
39 Constituents of holothuroidea. 10. Isolation and structure of a biologically active ganglioside molecular species from the sea cucumber Holothuria leucospilota. Chem Pharm Bull (Tokyo) 2001 0.80
40 Adenocarcinoma arising from a hyperplastic polyp with adenomatous foci. Endoscopy 1999 0.79
41 Scopoletin: an inducible nitric oxide synthesis inhibitory active constituent from Artemisia feddei. Planta Med 1999 0.79
42 Human error in forensic DNA typing. Am J Hum Genet 1991 0.79
43 Determination of globin mRNA sequences and their insertion into bacterial plasmids. Prog Nucleic Acid Res Mol Biol 1976 0.78
44 A new concept of basal cell epitheliomas based on the three-dimensional growth pattern of the superficial multicentric type. Am J Pathol 1987 0.78
45 Characterization of the cytochrome P-450IID subfamily in bovine liver. Nucleotide sequences and microheterogeneity. Eur J Biochem 1992 0.78
46 A prospective clinical study on inhaled nitric oxide therapy for neonates in Japan. Pediatr Int 2001 0.78
47 Structures of four new triterpenoid oligoglycosides: DS-penaustrosides A, B, C, and D from the sea cucumber Pentacta australis. J Nat Prod 1992 0.78
48 Norlignans with Hyaluronidase Inhibitory Activity from Anemarrhena asphodeloides. Planta Med 1999 0.77
49 Constituents of ophiuroidea. 1. Isolation and structure of three ganglioside molecular species from the brittle star Ophiocoma scolopendrina. Chem Pharm Bull (Tokyo) 2001 0.76
50 Glyceroglycolipids preventing tert-butylhydroperoxide-induced cell death from Microbacterium sp. and Corynebacterium aquaticum strains. J Biosci Bioeng 2000 0.76
51 Multiple dermoid cysts on the forehead. Case report. Scand J Plast Reconstr Surg Hand Surg 1996 0.76
52 A patient with undifferentiated carcinoma of gallbladder presenting with hemobilia. J Gastroenterol 2000 0.76
53 Constituents of holothuroidea.9. Isolation and structure of a new ganglioside molecular species from the sea cucumber Holothuria pervicax. Chem Pharm Bull (Tokyo) 2000 0.76
54 [A case of Crohn's disease with left iliopsoas abscess]. Nihon Shokakibyo Gakkai Zasshi 1997 0.75
55 Biologically active quinolone alkaloids from Evodia rutaecarpa on Artemia salina. Planta Med 1998 0.75
56 Negative ion fast atom bombardment mass spectrometry for native gangliosides using a neutral matrix. Anal Biochem 1989 0.75
57 Endoscopic therapy for multiple mucosal bridges in the esophagus of a patient with Crohn's disease. Gastrointest Endosc 1999 0.75
58 Hyperthermic effects in vitro on the peripheral lymphocytes isolated from three cases of malignant lymphoma/leukemia. J Dermatol 1989 0.75
59 [A case of hereditary sensory and autonomic neuropathy type IV diagnosed following the development of acute encephalopathy due to heat stroke]. No To Hattatsu 1997 0.75
60 Influenza A virus-binding activity of glycoglycerolipids of aquatic bacteria. J Biochem 2000 0.75
61 Three-pion interferometry results from central Pb+Pb collisions at 158A GeV/c. Phys Rev Lett 2000 0.75
62 Structural elucidation of the ceramide moiety of starfish gangliosides by collision-induced dissociation of the sodium ion complex. Chem Pharm Bull (Tokyo) 1999 0.75
63 Possible new DR antigens: Cy6.1 and its variants. Transplant Proc 1981 0.75
64 Constituents of crinoidea. 2. Isolation and structure of the novel type gangliosides from the feather star Comanthus japonica. Chem Pharm Bull (Tokyo) 2001 0.75
65 A family with haemolytic anaemia and three beta-globins: the deletion in haemoglobin Atlanta-Coventry (beta 75 Leu----Pro, 141 Leu deleted) is not present at the nucleotide level. Br J Haematol 1992 0.75
66 Negative-ion fast-atom-bombardment mass spectrometry of native gangliosides using a high-polar matrix system. Carbohydr Res 1992 0.75
67 Bw46 and its association with Cw1, Cw3, and DRw8. Transplant Proc 1981 0.75
68 Cloning of chicken globin cDNA in bacterial plasmids. Gene 1981 0.75
69 Reliability of the HLA-DQ alpha PCR-based oligonucleotide typing system. J Forensic Sci 1990 0.75
70 Intractable diaper dermatitis as an early sign of biotin deficiency. Acta Paediatr 1998 0.75
71 On the remarkable inhibition of baker's yeast respiration with co-existence of sorbic acid and thiamine or its derivative. J Vitaminol (Kyoto) 1969 0.75
72 A case of abscess formation in a remnant common bile duct after Roux-en-Y hepaticojejunostomy. Endoscopy 1999 0.75
73 [Management of a patient with insuloma]. Masui 1973 0.75
74 HLA-DR antigens in pemphigus among Japanese. Tissue Antigens 1981 0.75
75 [Ultrasonographic evaluation of the development of the brain sulcus]. No To Hattatsu 1986 0.75
76 [Radioimmunoassay of human blood TSH with cretin TSH kit "Daiichi" (author's transl)]. Horumon To Rinsho 1981 0.75