Current and potential immune therapies and vaccines in the management of psoriasis.

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Published in Hum Vaccin Immunother on February 03, 2014

Authors

Benjamin H Kaffenberger1, Grace L Lee1, Kelly Tyler1, Derek V Chan1, Wael Jarjour2, Maria E Ariza3, Marshall V Williams3, Henry K Wong1

Author Affiliations

1: Division of Dermatology; Department of Internal Medicine; Ohio State University Wexner Medical Center; Columbus, OH USA.
2: Division of Rheumatology; Department of Internal Medicine; Ohio State University Wexner Medical Center; Columbus, OH USA.
3: Department of Medical Virology, Immunology, and Molecular Genetics; Ohio State University Wexner Medical Center; Columbus, OH USA.

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Evolutionary analyses of the human genome. Nature (2001) 4.13

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity. Nat Genet (2012) 4.13

Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J Exp Med (2005) 4.04

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Human 60-kDa heat-shock protein: a danger signal to the innate immune system. J Immunol (1999) 2.01

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IL-10 is a key cytokine in psoriasis. Proof of principle by IL-10 therapy: a new therapeutic approach. J Clin Invest (1998) 1.40

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IPEX and FOXP3: clinical and research perspectives. J Autoimmun (2005) 1.21

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Comparison of expression of heat-shock protein 60, Toll-like receptors 2 and 4, and T-cell receptor gammadelta in plaque and guttate psoriasis. J Cutan Pathol (2007) 1.15

The genetics of psoriasis 2001: the odyssey continues. Arch Dermatol (2001) 1.14