Axonal transport of TDP-43 mRNA granules is impaired by ALS-causing mutations.

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Published in Neuron on February 05, 2014

Authors

Nael H Alami1, Rebecca B Smith1, Monica A Carrasco2, Luis A Williams3, Christina S Winborn4, Steve S W Han3,5, Evangelos Kiskinis3, Brett Winborn1, Brian D Freibaum1, Anderson Kanagaraj1, Alison J Clare1, Nisha M Badders1, Bilada Bilican6, Edward Chaum4, Siddharthan Chandran6, Christopher E Shaw7, Kevin C Eggan3, Tom Maniatis2, J Paul Taylor1

Author Affiliations

1: Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
2: Department of Biochemistry and Molecular Biophysics, Columbia University Medical Center, New York, NY 10032, USA.
3: Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138.
4: Department of Ophthalmology, University of Tennessee Health Sciences Center, Memphis, TN 38163, USA.
5: Department of Neurology, Massachusetts General Hospital, Boston, MA 02114, USA.
6: Euan MacDonald Centre for Motor Neurone Disease Research, Medical Research Council Centre for Regenerative Medicine, Centre for Neuroregeneration, University of Edinburgh, Edinburgh EH16 4SB, UK.
7: Departments of Clinical Neuroscience and Neurodegeneration and Brain Injury, King's College London and King's Health Partners, MRC Centre for Neurodegeneration Research, London SE5 8AF, UK.

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