Endogenous retroviruses and the development of cancer.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMC 3925786)

Published in J Immunol on February 15, 2014

Authors

George Kassiotis1

Author Affiliations

1: Division of Immunoregulation, Medical Research Council National Institute for Medical Research, London NW7 1AA, United Kingdom.

Articles citing this

The KRAB zinc finger protein ZFP809 is required to initiate epigenetic silencing of endogenous retroviruses. Genes Dev (2015) 1.00

Innate and Adaptive Immune Regulation During Chronic Viral Infections. Annu Rev Virol (2015) 0.89

Regulatory activities of transposable elements: from conflicts to benefits. Nat Rev Genet (2016) 0.87

Microarray analysis reveals global modulation of endogenous retroelement transcription by microbes. Retrovirology (2014) 0.86

Spotting the enemy within: Targeted silencing of foreign DNA in mammalian genomes by the Krüppel-associated box zinc finger protein family. Mob DNA (2015) 0.85

Activation of an endogenous retrovirus-associated long non-coding RNA in human adenocarcinoma. Genome Med (2015) 0.84

Human endogenous retroviruses sustain complex and cooperative regulation of gene-containing loci and unannotated megabase-sized regions. Retrovirology (2015) 0.84

Restricting retrotransposons: a review. Mob DNA (2016) 0.79

Endogenous retroviral promoter exaptation in human cancer. Mob DNA (2016) 0.78

Detecting endogenous retrovirus-driven tissue-specific gene transcription. Genome Biol Evol (2015) 0.77

CTRL+INSERT: retrotransposons and their contribution to regulation and innovation of the transcriptome. EMBO Rep (2016) 0.77

Transcriptional activity of human endogenous retroviruses in human peripheral blood mononuclear cells. Biomed Res Int (2015) 0.76

Human Endogenous Retroviruses as Pathogenic Factors in the Development of Schizophrenia. Front Psychiatry (2016) 0.76

Making a virtue of necessity: the pleiotropic role of human endogenous retroviruses in cancer. Philos Trans R Soc Lond B Biol Sci (2017) 0.76

Tumour virology in the era of high-throughput genomics. Philos Trans R Soc Lond B Biol Sci (2017) 0.75

Therapeutic potential of antiviral drugs targeting chemorefractory colorectal adenocarcinoma cells overexpressing endogenous retroviral elements. J Exp Clin Cancer Res (2015) 0.75

Expression of evolutionarily novel genes in tumors. Infect Agent Cancer (2016) 0.75

p53 in the game of transposons. Bioessays (2016) 0.75

DNA hypomethylation and aberrant expression of the human endogenous retrovirus ERVWE1/syncytin-1 in seminomas. Retrovirology (2017) 0.75

Evidence for the persistence of an active endogenous retrovirus (ERVE) in humans. Genetica (2014) 0.75

Dielectrophoresis for Biomedical Sciences Applications: A Review. Sensors (Basel) (2017) 0.75

New bioinformatic tool for quick identification of functionally relevant endogenous retroviral inserts in human genome. Cell Cycle (2015) 0.75

The effect of life history on retroviral genome invasions. PLoS One (2015) 0.75

A novel isoform of IL-33 revealed by screening for transposable element promoted genes in human colorectal cancer. PLoS One (2017) 0.75

Sarcoma eradication by doxorubicin and targeted TNF relies upon CD8+ T cell recognition of a retroviral antigen. Cancer Res (2017) 0.75

Friends-Enemies: Endogenous Retroviruses Are Major Transcriptional Regulators of Human DNA. Front Chem (2017) 0.75

IFITM1 suppresses expression of human endogenous retroviruses in human embryonic stem cells. FEBS Open Bio (2017) 0.75

Articles cited by this

Initial sequencing and analysis of the human genome. Nature (2001) 212.86

Initial sequencing and comparative analysis of the mouse genome. Nature (2002) 96.15

Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 34.13

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing. Cell (2012) 11.69

Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature (2007) 10.94

Trex1 prevents cell-intrinsic initiation of autoimmunity. Cell (2008) 9.59

Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol (2003) 9.30

Evolution and impact of subclonal mutations in chronic lymphocytic leukemia. Cell (2013) 9.24

The regulated retrotransposon transcriptome of mammalian cells. Nat Genet (2009) 5.79

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature (2011) 5.28

Awakening guardian angels: drugging the p53 pathway. Nat Rev Cancer (2009) 5.12

Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome. Nature (1981) 4.77

Landscape of somatic retrotransposition in human cancers. Science (2012) 4.37

Retrotransposons revisited: the restraint and rehabilitation of parasites. Cell (2008) 4.19

Active human retrotransposons: variation and disease. Curr Opin Genet Dev (2012) 3.60

Transposable elements in mammals promote regulatory variation and diversification of genes with specialized functions. Trends Genet (2003) 3.49

Sequence-based characterization of structural variation in the mouse genome. Nature (2011) 3.48

Genomewide screening reveals high levels of insertional polymorphism in the human endogenous retrovirus family HERV-K(HML2): implications for present-day activity. J Virol (2005) 3.26

Retroviral elements and their hosts: insertional mutagenesis in the mouse germ line. PLoS Genet (2006) 3.07

Human RNA "rumor" viruses: the search for novel human retroviruses in chronic disease. Microbiol Mol Biol Rev (2008) 3.07

PSF and p54(nrb)/NonO--multi-functional nuclear proteins. FEBS Lett (2002) 3.06

Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53. Proc Natl Acad Sci U S A (2007) 3.00

Effects of retroviruses on host genome function. Annu Rev Genet (2008) 2.96

Why do viruses cause cancer? Highlights of the first century of human tumour virology. Nat Rev Cancer (2010) 2.68

Identification of endogenous retroviral reading frames in the human genome. Retrovirology (2004) 2.58

Identification of an infectious progenitor for the multiple-copy HERV-K human endogenous retroelements. Genome Res (2006) 2.55

Endogenous viruses: insights into viral evolution and impact on host biology. Nat Rev Genet (2012) 2.52

Reconstitution of an infectious human endogenous retrovirus. PLoS Pathog (2007) 2.52

An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. Nat Immunol (2009) 2.38

Nucleic acid-sensing Toll-like receptors are essential for the control of endogenous retrovirus viremia and ERV-induced tumors. Immunity (2012) 2.35

The immunodominant major histocompatibility complex class I-restricted antigen of a murine colon tumor derives from an endogenous retroviral gene product. Proc Natl Acad Sci U S A (1996) 2.24

Role of endogenous retroviruses as mutagens: the hairless mutation of mice. Cell (1988) 2.20

The discovery of endogenous retroviruses. Retrovirology (2006) 2.18

Endogenous retroviral LTRs as promoters for human genes: a critical assessment. Gene (2009) 2.13

Cell fusion: a hidden enemy? Cancer Cell (2003) 1.95

Studies of endogenous retroviruses reveal a continuing evolutionary saga. Nat Rev Microbiol (2012) 1.94

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma. Nat Med (2010) 1.93

Identification, phylogeny, and evolution of retroviral elements based on their envelope genes. J Virol (2001) 1.91

Murine endogenous retroviruses. Cell Mol Life Sci (2008) 1.85

Human transposon tectonics. Cell (2012) 1.81

Resurrection of endogenous retroviruses in antibody-deficient mice. Nature (2012) 1.81

Brief communication: C-type particles in normal human placentas. J Natl Cancer Inst (1973) 1.80

Identification, characterization, and comparative genomic distribution of the HERV-K (HML-2) group of human endogenous retroviruses. Retrovirology (2011) 1.80

An endogenous retrovirus derived from human melanoma cells. Cancer Res (2003) 1.76

Role of human noncoding RNAs in the control of tumorigenesis. Proc Natl Acad Sci U S A (2009) 1.76

Expression of human endogenous retrovirus K in melanomas and melanoma cell lines. Cancer Res (2005) 1.65

Tumor cells expressing a retroviral envelope escape immune rejection in vivo. Proc Natl Acad Sci U S A (1998) 1.60

From ancestral infectious retroviruses to bona fide cellular genes: role of the captured syncytins in placentation. Placenta (2012) 1.59

Regression of human kidney cancer following allogeneic stem cell transplantation is associated with recognition of an HERV-E antigen by T cells. J Clin Invest (2008) 1.58

Endogenous retroviruses and cancer. Cell Mol Life Sci (2008) 1.55

A human endogenous retroviral sequence encoding an antigen recognized on melanoma by cytolytic T lymphocytes. Cancer Res (2002) 1.51

Human endogenous retroviral elements as indicators of ectopic recombination events in the primate genome. Genetics (2005) 1.40

Innate immune sensing of HIV-1 by dendritic cells. Cell Host Microbe (2012) 1.35

Paleovirology of 'syncytins', retroviral env genes exapted for a role in placentation. Philos Trans R Soc Lond B Biol Sci (2013) 1.30

Characterization of human endogenous retroviral elements in the blood of HIV-1-infected individuals. J Virol (2011) 1.26

The full-length envelope of an HERV-H human endogenous retrovirus has immunosuppressive properties. J Gen Virol (2001) 1.26

Syncytin is involved in breast cancer-endothelial cell fusions. Cell Mol Life Sci (2006) 1.22

Virus-like particles in placentas from normal individuals and patients with systemic lupus erythematosus. J Natl Cancer Inst (1977) 1.20

Loss of epigenetic silencing in tumors preferentially affects primate-specific retroelements. Gene (2009) 1.19

Human endogenous retrovirus rec interferes with germ cell development in mice and may cause carcinoma in situ, the predecessor lesion of germ cell tumors. Oncogene (2005) 1.18

Distinct roles for LINE-1 and HERV-K retroelements in cell proliferation, differentiation and tumor progression. Oncogene (2007) 1.17

Molecular basis of DNA recognition in the immune system. J Immunol (2013) 1.13

Additional evidence of type-C particles in human placentas. J Natl Cancer Inst (1974) 1.11

Env-less endogenous retroviruses are genomic superspreaders. Proc Natl Acad Sci U S A (2012) 1.11

Retroviral promoters in the human genome. Bioinformatics (2008) 1.10

Insertional oncogenesis by non-acute retroviruses: implications for gene therapy. Viruses (2011) 1.09

Classification and nomenclature of endogenous retroviral sequences (ERVs): problems and recommendations. Gene (2009) 1.09

SINEs. Wiley Interdiscip Rev RNA (2011) 1.06

Immunization against endogenous retroviral tumor-associated antigens. Cancer Res (2001) 1.05

Sequence and insertion sites of murine melanoma-associated retrovirus. J Virol (1999) 1.03

Mouse mammary tumor virus molecular biology and oncogenesis. Viruses (2010) 1.03

Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic. J Immunol (2012) 1.01

Human endogenous retroviruses and cancer prevention: evidence and prospects. BMC Cancer (2013) 0.99

Endogenous retroviruses: acquisition, amplification and taming of genome invaders. Curr Opin Virol (2013) 0.99

Are human endogenous retroviruses pathogenic? An approach to testing the hypothesis. Bioessays (2013) 0.98

Recombinant origin, contamination, and de-discovery of XMRV. Curr Opin Virol (2012) 0.96

Association of endogenous retroviruses and long terminal repeats with human disorders. Front Oncol (2013) 0.96

Mobility and integration sites of a murine C57BL/6 melanoma endogenous retrovirus involved in tumor progression in vivo. Int J Cancer (2006) 0.95

Negative selection by an endogenous retrovirus promotes a higher-avidity CD4+ T cell response to retroviral infection. PLoS Pathog (2012) 0.95

Endogenous retrovirus expression is required for murine melanoma tumor growth in vivo. Cancer Res (2005) 0.94

On the concept and elucidation of endogenous retroviruses. Philos Trans R Soc Lond B Biol Sci (2013) 0.91

C. C. Little, cancer and inbred mice. Genetics (2002) 0.88

Role of endogenous retroviruses in murine SLE. Autoimmun Rev (2010) 0.87

A recombinant endogenous retrovirus amplified in a mouse neuroblastoma is involved in tumor growth in vivo. Int J Cancer (2006) 0.83

A compendium of the mouse mammary tumor biologist: from the initial observations in the house mouse to the development of genetically engineered mice. Cold Spring Harb Perspect Biol (2011) 0.82

Risks linked to endogenous retroviruses for vaccine production: a general overview. Biologicals (2010) 0.81

The mouse mammary tumor virus env gene is the source of a CD8+ T-cell-stimulating peptide presented by a major histocompatibility complex class I molecule in a murine thymoma. Proc Natl Acad Sci U S A (1996) 0.79

Immune abnormalities induced by human endogenous retroviral peptides: with reference to the pathogenesis of systemic lupus erythematosus. J Clin Immunol (2003) 0.79

A. E. C. Lathrop (1868-1918): Mouse Woman of Granby. Cancer Res (1975) 0.79

Murine Vbeta3+ and Vbeta7+ T cell subsets are specific targets for the HERV-K18 Env superantigen. J Immunol (2006) 0.78