The helicase HAGE prevents interferon-α-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1.

PubWeight™: 0.78‹?›

🔗 View Article (PMC 3944245)

Published in Cell Death Dis on February 13, 2014

Authors

M G Mathieu1, A K Miles1, M Ahmad1, M E Buczek1, A G Pockley1, R C Rees1, T Regad1

Author Affiliations

1: The John van Geest Cancer Research Centre, School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham, UK.

Articles cited by this

Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML. Cell (1991) 9.40

Identification of cells initiating human melanomas. Nature (2008) 8.28

A new protein containing an SH2 domain that inhibits JAK kinases. Nature (1997) 6.28

The DEAD-box protein family of RNA helicases. Gene (2005) 6.10

A road map for those who don't know JAK-STAT. Science (2002) 5.67

The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus. Nature (1990) 5.24

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families. Genes Dev (1998) 4.29

PML targeting eradicates quiescent leukaemia-initiating cells. Nature (2008) 3.75

Molecular analysis of acute promyelocytic leukemia breakpoint cluster region on chromosome 17. Science (1990) 3.34

The role of PML in tumor suppression. Cell (2002) 3.28

Dead-box proteins: a family affair--active and passive players in RNP-remodeling. Nucleic Acids Res (2006) 3.26

Loss of the tumor suppressor PML in human cancers of multiple histologic origins. J Natl Cancer Inst (2004) 3.17

The acute promyelocytic leukaemia-associated PML gene is induced by interferon. Oncogene (1995) 2.80

Role and fate of PML nuclear bodies in response to interferon and viral infections. Oncogene (2001) 2.52

Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene (1995) 2.50

PML nuclear bodies. Cold Spring Harb Perspect Biol (2010) 2.44

Does adjuvant interferon-alpha for high-risk melanoma provide a worthwhile benefit? A meta-analysis of the randomised trials. Cancer Treat Rev (2003) 2.08

Induction of the PML protein by interferons in normal and APL cells. Leukemia (1995) 2.05

Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1. Mol Cell Biol (2002) 1.92

Inteferons pen the JAK-STAT pathway. Semin Cell Dev Biol (2008) 1.79

Role of promyelocytic leukemia protein in host antiviral defense. J Interferon Cytokine Res (2011) 1.66

VEGFR-1 expressed by malignant melanoma-initiating cells is required for tumor growth. Cancer Res (2011) 1.62

Characterization of endogenous human promyelocytic leukemia isoforms. Cancer Res (2006) 1.52

Regulation of calcium/calmodulin-dependent kinase IV by O-GlcNAc modification. J Biol Chem (2009) 1.45

The tumor suppressor Pml regulates cell fate in the developing neocortex. Nat Neurosci (2009) 1.30

ABCB5 identifies a therapy-refractory tumor cell population in colorectal cancer patients. Cancer Res (2011) 1.23

Suppressor of cytokine signaling (SOCS) 1 inhibits type I interferon (IFN) signaling via the interferon alpha receptor (IFNAR1)-associated tyrosine kinase Tyk2. J Biol Chem (2011) 1.17

The RNA helicase database. Nucleic Acids Res (2010) 1.15

IFN-α in the treatment of melanoma. J Immunol (2012) 1.12

Expression of SOCS-1, suppressor of cytokine signalling-1, in human melanoma. J Invest Dermatol (2004) 1.11

The nuclear bodies inside out: PML conquers the cytoplasm. Curr Opin Cell Biol (2011) 1.01

Respiratory syncytial virus limits alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) phosphorylation to maintain translation and viral replication. J Biol Chem (2010) 0.95

The helicase HAGE expressed by malignant melanoma-initiating cells is required for tumor cell proliferation in vivo. J Biol Chem (2012) 0.94

Molecular and cellular pathogenesis of melanoma initiation and progression. Cell Mol Life Sci (2013) 0.90

Modulation of SOCS protein expression influences the interferon responsiveness of human melanoma cells. BMC Cancer (2010) 0.88