Ticagrelor effects on myocardial infarction and the impact of event adjudication in the PLATO (Platelet Inhibition and Patient Outcomes) trial.

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Published in J Am Coll Cardiol on February 19, 2014

Authors

Kenneth W Mahaffey1, Claes Held2, Daniel M Wojdyla3, Stefan K James2, Hugo A Katus4, Steen Husted5, Philippe Gabriel Steg6, Christopher P Cannon7, Richard C Becker3, Robert F Storey8, Nardev S Khurmi9, José C Nicolau10, Cheuk-Man Yu11, Diego Ardissino12, Andrzej Budaj13, Joao Morais14, Debra Montgomery3, Anders Himmelmann15, Robert A Harrington16, Lars Wallentin2, PLATO Investigators

Author Affiliations

1: Duke Clinical Research Institute, Duke University, Durham, North Carolina; Department of Medicine, Stanford University, Stanford, California. Electronic address: kenneth.mahaffey@stanford.edu.
2: Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
3: Duke Clinical Research Institute, Duke University, Durham, North Carolina.
4: Medizinishe Klinik, University of Heidelberg, Heidelberg, Germany.
5: Medical Department, Hospital Unit West, Herning/Holstbro, Denmark.
6: INSERM-Unité 698, Paris, France; Assistance Publique-Hôpitaux de Paris, Département Hospitalo-Universitaire FIRE, Hôpital Bichat, Paris, France; Université Paris-Diderot, Sorbonne-Paris Cité, Paris, France.
7: TIMI Study Group, Brigham and Women's Hospital, Boston, Massachusetts.
8: Department of Cardiovascular Science, University of Sheffield, Sheffield, United Kingdom.
9: AstraZeneca Research and Development, Wilmington, Delaware.
10: Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil.
11: Prince of Wales Hospital, Institute of Vascular Medicine, the Chinese University of Hong Kong, Hong Kong.
12: Azienda Ospedaliero Universitaria di Parma, Parma, Italy.
13: Postgraduate Medical School, Grochowski Hospital, Warsaw, Poland.
14: Santo Andrés Hospital, Leiria, Portugal.
15: AstraZeneca Research and Development, Mölndal, Sweden.
16: Department of Medicine, Stanford University, Stanford, California.

Associated clinical trials:

A Comparison of Ticagrelor (AZD6140) and Clopidogrel in Patients With Acute Coronary Syndrome (PLATO) | NCT00391872

Use of Ticagrelor in Korean ACS Patients: The BRILIANT KOREA Registry | NCT02521038

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