Published in Nat Genet on March 02, 2014
BET inhibitor resistance emerges from leukaemia stem cells. Nature (2015) 1.88
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature (2015) 1.75
Functions of BET proteins in erythroid gene expression. Blood (2015) 1.50
Chromatin signatures of cancer. Genes Dev (2015) 1.20
Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T cell acute lymphoblastic leukemia. Nat Med (2015) 1.19
Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proc Natl Acad Sci U S A (2014) 1.15
BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget (2015) 1.12
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet (2016) 1.06
Poised epigenetic states and acquired drug resistance in cancer. Nat Rev Cancer (2014) 1.05
Episensitization: Defying Time's Arrow. Front Oncol (2015) 1.04
Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes. Sci Transl Med (2014) 1.00
Exploiting the Epigenome to Control Cancer-Promoting Gene-Expression Programs. Cancer Cell (2016) 0.98
BET protein inhibitor JQ1 attenuates Myc-amplified MCC tumor growth in vivo. Cancer Res (2014) 0.98
The BET bromodomain inhibitor JQ1 suppresses growth of pancreatic ductal adenocarcinoma in patient-derived xenograft models. Oncogene (2015) 0.97
Infiltrating neutrophils promote renal cell carcinoma progression via VEGFa/HIF2α and estrogen receptor β signals. Oncotarget (2015) 0.89
New Approaches to Target T-ALL. Front Oncol (2014) 0.88
Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome. Elife (2015) 0.86
JQ1 suppresses tumor growth via PTEN/PI3K/AKT pathway in endometrial cancer. Oncotarget (2016) 0.86
Therapeutic targeting of BET bromodomain protein, Brd4, delays cyst growth in ADPKD. Hum Mol Genet (2015) 0.84
Disrupting NOTCH Slows Diffuse Intrinsic Pontine Glioma Growth, Enhances Radiation Sensitivity, and Shows Combinatorial Efficacy With Bromodomain Inhibition. J Neuropathol Exp Neurol (2015) 0.82
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. Cell Stem Cell (2016) 0.82
Notch signaling deregulation in multiple myeloma: A rational molecular target. Oncotarget (2015) 0.81
Drugging Chromatin in Cancer: Recent Advances and Novel Approaches. Mol Cell (2015) 0.81
Notch signaling in the malignant bone marrow microenvironment: implications for a niche-based model of oncogenesis. Ann N Y Acad Sci (2014) 0.80
Enhancer alterations in cancer: a source for a cell identity crisis. Genome Med (2014) 0.80
The Chromatin Regulator CHD8 Is a Context-Dependent Mediator of Cell Survival in Murine Hematopoietic Malignancies. PLoS One (2015) 0.79
Gamma secretase inhibitors enhance vincristine-induced apoptosis in T-ALL in a NOTCH-independent manner. Apoptosis (2014) 0.78
Twist-BRD4 complex: potential drug target for basal-like breast cancer. Curr Pharm Des (2015) 0.78
Targeting Suppressor of Variegation 3-9 Homologue 2 (SUV39H2) in Acute Lymphoblastic Leukemia (ALL). Transl Oncol (2015) 0.78
The challenge of targeting notch in hematologic malignancies. Front Pediatr (2014) 0.78
Epigenetic reader BRD4 inhibition as a therapeutic strategy to suppress E2F2-cell cycle regulation circuit in liver cancer. Oncotarget (2016) 0.78
Senescent stromal cell-induced divergence and therapeutic resistance in T cell acute lymphoblastic leukemia/lymphoma. Oncotarget (2016) 0.77
Inhibition of Bromodomain and Extraterminal Domain Family Proteins Ameliorates Experimental Renal Damage. J Am Soc Nephrol (2016) 0.77
Histone H4 acetylation and the epigenetic reader Brd4 are critical regulators of pluripotency in embryonic stem cells. BMC Genomics (2016) 0.77
Enhancer deregulation in cancer and other diseases. Bioessays (2016) 0.76
CDK6-mediated repression of CD25 is required for induction and maintenance of Notch1-induced T-cell acute lymphoblastic leukemia. Leukemia (2015) 0.76
Epigenetic polypharmacology: from combination therapy to multitargeted drugs. Clin Epigenetics (2016) 0.76
HSP90 inhibition leads to degradation of the TYK2 kinase and apoptotic cell death in T-cell acute lymphoblastic leukemia. Leukemia (2015) 0.76
Transient resistance to DNA damaging agents is associated with expression of microRNAs-135b and -196b in human leukemia cell lines. Int J Biochem Mol Biol (2016) 0.75
Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia. Leuk Res (2017) 0.75
γ-Secretase inhibitor-resistant glioblastoma stem cells require RBPJ to propagate. J Clin Invest (2016) 0.75
Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts. EMBO Mol Med (2017) 0.75
Targeting NOTCH1 in T-ALL: Starving the dragon. Cell Cycle (2016) 0.75
CK2 inhibitor CX-4945 destabilizes NOTCH1 and synergizes with JQ1 against human T-acute lymphoblastic leukemic cells. Haematologica (2016) 0.75
Embryonic Stem Cell (ES)-Specific Enhancers Specify the Expression Potential of ES Genes in Cancer. PLoS Genet (2016) 0.75
Oncogenic Notch signaling in T-cell and B-cell lymphoproliferative disorders. Curr Opin Hematol (2016) 0.75
Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma. Genome Med (2016) 0.75
The relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemia. Haematologica (2016) 0.75
High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia. Blood (2016) 0.75
The MAPK pathway regulates intrinsic resistance to BET inhibitors in colorectal cancer. Clin Cancer Res (2016) 0.75
Emergence of the Noncoding Cancer Genome: A Target of Genetic and Epigenetic Alterations. Cancer Discov (2016) 0.75
The Role of Histone Protein Modifications and Mutations in Histone Modifiers in Pediatric B-Cell Progenitor Acute Lymphoblastic Leukemia. Cancers (Basel) (2017) 0.75
Retinoblastoma Binding Protein 4 Modulates Temozolomide Sensitivity in Glioblastoma by Regulating DNA Repair Proteins. Cell Rep (2016) 0.75
Elevated Cellular PD1/PD-L1 Expression Confers Acquired Resistance to Cisplatin in Small Cell Lung Cancer Cells. PLoS One (2016) 0.75
Controlling the Master: Chromatin Dynamics at the MYC Promoter Integrate Developmental Signaling. Genes (Basel) (2017) 0.75
Pharmacologic targeting of drug-induced enhancers. Oncoscience (2017) 0.75
Uncovering BRD4 hyperphosphorylation associated with cellular transformation in NUT midline carcinoma. Proc Natl Acad Sci U S A (2017) 0.75
Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer. Elife (2017) 0.75
Leukemia-Initiating Cells in T-Cell Acute Lymphoblastic Leukemia. Front Oncol (2017) 0.75
Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4. Oncogene (2017) 0.75
Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors. Cell Rep (2017) 0.75
Epigenetics and Cancer Stem Cells: Unleashing, Hijacking, and Restricting Cellular Plasticity. Trends Cancer (2017) 0.75
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A (2005) 167.46
An integrated encyclopedia of DNA elements in the human genome. Nature (2012) 64.73
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat Genet (2003) 53.59
SOAP2: an improved ultrafast tool for short read alignment. Bioinformatics (2009) 39.47
GenePattern 2.0. Nat Genet (2006) 29.07
Mapping and analysis of chromatin state dynamics in nine human cell types. Nature (2011) 24.37
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell (2006) 18.81
Selective inhibition of BET bromodomains. Nature (2010) 18.79
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature (2011) 11.44
Treatment of acute lymphoblastic leukemia. N Engl J Med (2006) 11.30
A chromatin-mediated reversible drug-tolerant state in cancer cell subpopulations. Cell (2010) 11.20
Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet (2008) 11.17
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell (1991) 10.06
Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell (2013) 9.55
Suppression of inflammation by a synthetic histone mimic. Nature (2010) 8.80
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature (2011) 8.29
Cancer epigenetics: from mechanism to therapy. Cell (2012) 7.74
Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell (2007) 7.60
Highly parallel identification of essential genes in cancer cells. Proc Natl Acad Sci U S A (2008) 7.45
Charting histone modifications and the functional organization of mammalian genomes. Nat Rev Genet (2010) 7.39
NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A (2006) 6.80
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med (2007) 6.55
c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev (2006) 6.19
Statistical practice in high-throughput screening data analysis. Nat Biotechnol (2006) 5.85
Genome-scale loss-of-function screening with a lentiviral RNAi library. Nat Methods (2006) 4.12
Genome-wide chromatin state transitions associated with developmental and environmental cues. Cell (2013) 3.83
High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood (2009) 3.02
Gene bookmarking accelerates the kinetics of post-mitotic transcriptional re-activation. Nat Cell Biol (2011) 2.85
Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc. Mol Cell Biol (2006) 2.85
The Notch signalling system: recent insights into the complexity of a conserved pathway. Nat Rev Genet (2012) 2.77
The requirement for cyclin D function in tumor maintenance. Cancer Cell (2012) 2.49
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Blood (2007) 2.29
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesis. Cell Stem Cell (2012) 2.06
The evolving war on cancer. Cell (2011) 2.02
Monoubiquitylation of H2A.Z distinguishes its association with euchromatin or facultative heterochromatin. Mol Cell Biol (2007) 1.78
Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells. Cancer Res (2009) 1.54
Immunohistochemical detection of MYC-driven diffuse large B-cell lymphomas. PLoS One (2012) 1.35
Therapeutic targeting of NOTCH1 signaling in T-cell acute lymphoblastic leukemia. Clin Lymphoma Myeloma (2009) 1.13
BRD4 jump-starts transcription after mitotic silencing. Genome Biol (2011) 0.86
Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation. Nat Biotechnol (2014) 3.66
Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med (2016) 2.15
Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9. Nat Biotechnol (2016) 2.05
The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nat Immunol (2015) 1.56
An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma. Nat Genet (2016) 1.06
Efficient and Targeted Transduction of Nonhuman Primate Liver With Systemically Delivered Optimized AAV3B Vectors. Mol Ther (2015) 1.02
Repression of BIM mediates survival signaling by MYC and AKT in high-risk T-cell acute lymphoblastic leukemia. Leukemia (2014) 0.85
Computational correction of copy number effect improves specificity of CRISPR-Cas9 essentiality screens in cancer cells. Nat Genet (2017) 0.75