Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release.

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Published in Vaccine on March 01, 2014

Authors

Petr O Ilyinskii1, Christopher J Roy2, Conlin P O'Neil2, Erica A Browning2, Lynnelle A Pittet2, David H Altreuter2, Frank Alexis3, Elena Tonti4, Jinjun Shi3, Pamela A Basto5, Matteo Iannacone4, Aleksandar F Radovic-Moreno5, Robert S Langer5, Omid C Farokhzad3, Ulrich H von Andrian4, Lloyd P M Johnston2, Takashi Kei Kishimoto2

Author Affiliations

1: Selecta Biosciences, Watertown, MA 02472, USA. Electronic address: PIlyinskii@selectabio.com.
2: Selecta Biosciences, Watertown, MA 02472, USA.
3: Laboratory of Nanomedicine and Biomaterials, Brigham and Women's Hospital, Boston, MA 02115, USA.
4: Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA.
5: David H. Koch Institute for Integrative Cancer Research, Cambridge, MA 02139, USA; Harvard-MIT Division of Health Sciences and Technology, Cambridge, MA 02139, USA.

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