cAMP and Ca²⁺ signaling in secretory epithelia: crosstalk and synergism.

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Published in Cell Calcium on February 07, 2014

Authors

Malini Ahuja1, Archana Jha2, Jozsef Maléth2, Seonghee Park3, Shmuel Muallem4

Author Affiliations

1: Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, MD 20892, United States. Electronic address: Malini.ahuja@nih.gov.
2: Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, MD 20892, United States.
3: Department of Physiology, School of Medicine, Ewha Womans University, 911-1 Mok-6-dong, Yang Chun-gu, Seoul 158-710, Republic of Korea.
4: Epithelial Signaling and Transport Section, Molecular Physiology and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institute of Health, Bethesda, MD 20892, United States. Electronic address: Shmuel.muallem@nih.gov.

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The WNK/SPAK and IRBIT/PP1 pathways in epithelial fluid and electrolyte transport. Physiology (Bethesda) (2012) 0.94

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Differential regulation of the apical plasma membrane Ca(2+) -ATPase by protein kinase A in parotid acinar cells. J Biol Chem (2007) 0.92

Regulatory interaction between calmodulin and ATP on the red cell Ca2+ pump. Biochim Biophys Acta (1980) 0.91

Functional cross talk after activation of P2 and P1 receptors in oviductal ciliated cells. Am J Physiol Cell Physiol (2000) 0.91

Identification of inhibitory and calmodulin-binding domains of the PDE1A1 and PDE1A2 calmodulin-stimulated cyclic nucleotide phosphodiesterases. J Biol Chem (1995) 0.91

Kinetic properties of Ca2+/calmodulin-dependent phosphodiesterase isoforms dictate intracellular cAMP dynamics in response to elevation of cytosolic Ca2+. Cell Signal (2008) 0.90

Ca2+ potentiates cAMP-dependent expression of urokinase-type plasminogen activator gene through a calmodulin- and protein kinase C-independent mechanism. J Biol Chem (1990) 0.90

Mucus secretion from individual submucosal glands of the ferret trachea. Am J Physiol Lung Cell Mol Physiol (2010) 0.90

Thapsigargin potentiates histamine-stimulated HCl secretion in gastric parietal cells but does not mimic cholinergic responses. Cell Regul (1991) 0.90

Cav1.3 and Cav1.2 channels of adrenal chromaffin cells: emerging views on cAMP/cGMP-mediated phosphorylation and role in pacemaking. Biochim Biophys Acta (2012) 0.89

Cellular mechanism for potentiation of Ca2+-mediated Cl- secretion by the flavonoid baicalein in intestinal epithelia. J Biol Chem (2004) 0.89

Ca2+-dependent protein kinase--a modulation of the plasma membrane Ca2+-ATPase in parotid acinar cells. J Biol Chem (2002) 0.88

Na+, K+, and Cl- transport in resting pancreatic acinar cells. J Gen Physiol (1995) 0.88

Phospholamban and cardiac function: a comparative perspective in vertebrates. Acta Physiol (Oxf) (2012) 0.86