Published in Proc Natl Acad Sci U S A on December 01, 1988
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Analysis of gene expression in single live neurons. Proc Natl Acad Sci U S A (1992) 6.15
Prevention of pre-PCR mis-priming and primer dimerization improves low-copy-number amplifications. Nucleic Acids Res (1992) 5.98
Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol Cell Biol (1995) 5.71
Identification and cloning of unc-119, a gene expressed in the Caenorhabditis elegans nervous system. Genetics (1995) 5.33
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A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta. Proc Natl Acad Sci U S A (1998) 2.88
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The trithorax gene, a trans-acting regulator of the bithorax complex in Drosophila, encodes a protein with zinc-binding domains. Proc Natl Acad Sci U S A (1990) 2.85
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The Epstein-Barr virus nuclear protein encoded by the leader of the EBNA RNAs is important in B-lymphocyte transformation. J Virol (1991) 2.81
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A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit. Proc Natl Acad Sci U S A (1991) 2.60
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PCR-based cDNA library construction: general cDNA libraries at the level of a few cells. Nucleic Acids Res (1989) 2.48
Mapping the 5' and 3' ends of Tetrahymena thermophila mRNAs using RNA ligase mediated amplification of cDNA ends (RLM-RACE). Nucleic Acids Res (1993) 2.48
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Silicatein alpha: cathepsin L-like protein in sponge biosilica. Proc Natl Acad Sci U S A (1998) 2.46
Positive selection of candidate tumor-suppressor genes by subtractive hybridization. Proc Natl Acad Sci U S A (1991) 2.43
cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol (1996) 2.42
Isolation of a gene encoding a functional zinc finger protein homologous to erythroid Krüppel-like factor: identification of a new multigene family. Mol Cell Biol (1995) 2.41
Exclusive expression of Epstein-Barr virus nuclear antigen 1 in Burkitt lymphoma arises from a third promoter, distinct from the promoters used in latently infected lymphocytes. Proc Natl Acad Sci U S A (1991) 2.40
Molecular analysis of NOZZLE, a gene involved in pattern formation and early sporogenesis during sex organ development in Arabidopsis thaliana. Proc Natl Acad Sci U S A (1999) 2.35
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Functional analysis of the LACERATA gene of Arabidopsis provides evidence for different roles of fatty acid omega -hydroxylation in development. Proc Natl Acad Sci U S A (2001) 2.34
The Lateral suppressor (Ls) gene of tomato encodes a new member of the VHIID protein family. Proc Natl Acad Sci U S A (1999) 2.34
Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase. Proc Natl Acad Sci U S A (1991) 2.34
Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible. Proc Natl Acad Sci U S A (1999) 2.33
NuMA: an unusually long coiled-coil related protein in the mammalian nucleus. J Cell Biol (1992) 2.33
Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor. Proc Natl Acad Sci U S A (1990) 2.31
Neurospora crassa A mating-type region. Proc Natl Acad Sci U S A (1990) 2.31
Distinct cis-acting signals enhance 3' endpoint formation of CYC1 mRNA in the yeast Saccharomyces cerevisiae. EMBO J (1991) 2.30
The human CCG1 gene, essential for progression of the G1 phase, encodes a 210-kilodalton nuclear DNA-binding protein. Mol Cell Biol (1991) 2.30
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A novel WRKY transcription factor, SUSIBA2, participates in sugar signaling in barley by binding to the sugar-responsive elements of the iso1 promoter. Plant Cell (2003) 2.28
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N-myc mRNA forms an RNA-RNA duplex with endogenous antisense transcripts. Mol Cell Biol (1990) 2.24
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Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras. Proc Natl Acad Sci U S A (1992) 2.23
A gene controlling variation in Arabidopsis glucosinolate composition is part of the methionine chain elongation pathway. Plant Physiol (2001) 2.22
A phylogeny of caenorhabditis reveals frequent loss of introns during nematode evolution. Genome Res (2004) 2.21
Protein splicing removes intervening sequences in an archaea DNA polymerase. Nucleic Acids Res (1992) 2.20
Coordinate induction of two antibiotic genes in tracheal epithelial cells exposed to the inflammatory mediators lipopolysaccharide and tumor necrosis factor alpha. Infect Immun (1996) 2.20
Two forms of the basic fibroblast growth factor receptor-like mRNA are expressed in the developing mouse brain. Proc Natl Acad Sci U S A (1990) 2.17
MADS-box genes reveal that gnetophytes are more closely related to conifers than to flowering plants. Proc Natl Acad Sci U S A (1999) 2.15
Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells. Proc Natl Acad Sci U S A (2003) 2.14
Targeted gene walking polymerase chain reaction. Nucleic Acids Res (1991) 2.14
Identification, cloning, and characterization of PWL2, a gene for host species specificity in the rice blast fungus. Plant Cell (1995) 2.12
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Sex-lethal autoregulation requires multiple cis-acting elements upstream and downstream of the male exon and appears to depend largely on controlling the use of the male exon 5' splice site. Mol Cell Biol (1993) 2.10
The 5' ends of Hantaan virus (Bunyaviridae) RNAs suggest a prime-and-realign mechanism for the initiation of RNA synthesis. J Virol (1995) 2.10
Isolation and characterization of the cDNA encoding human DNA methyltransferase. Nucleic Acids Res (1992) 2.10
The Arabidopsis dwarf mutant shi exhibits reduced gibberellin responses conferred by overexpression of a new putative zinc finger protein. Plant Cell (1999) 2.08
Structural organization, expression, and functional characterization of the murine cytomegalovirus immediate-early gene 3. J Virol (1992) 2.08
Defective pro alpha 2(I) collagen synthesis in a recessive mutation in mice: a model of human osteogenesis imperfecta. Proc Natl Acad Sci U S A (1993) 2.07
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A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med (1997) 2.05
Sparse linear modeling of next-generation mRNA sequencing (RNA-Seq) data for isoform discovery and abundance estimation. Proc Natl Acad Sci U S A (2011) 2.05
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science (1988) 220.77
A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res (1979) 214.95
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (1985) 95.08
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A simple and very efficient method for generating cDNA libraries. Gene (1983) 55.36
An improved method for prenatal diagnosis of genetic diseases by analysis of amplified DNA sequences. Application to hemophilia A. N Engl J Med (1987) 14.37
A method for isolation of intact, translationally active ribonucleic acid. DNA (1983) 13.67
DNA amplification for direct detection of HIV-1 in DNA of peripheral blood mononuclear cells. Science (1988) 13.46
The primary structure of rabbit beta-globin mRNA as determined from cloned DNA. Cell (1977) 11.05
HMG CoA reductase: a negatively regulated gene with unusual promoter and 5' untranslated regions. Cell (1984) 7.66
A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine. Cell (1987) 7.25
Hormonal induction of differentiation in teratocarcinoma stem cells: generation of parietal endoderm by retinoic acid and dibutyryl cAMP. Cell (1980) 6.72
Structure, expression, and mutation of the hypoxanthine phosphoribosyltransferase gene. Proc Natl Acad Sci U S A (1984) 6.48
Generation of cDNA probes directed by amino acid sequence: cloning of urate oxidase. Science (1988) 5.72
High-efficiency cloning of full-length cDNA; construction and screening of cDNA expression libraries for mammalian cells. Methods Enzymol (1987) 5.08
Sequence, topography and protein coding potential of mouse int-2: a putative oncogene activated by mouse mammary tumour virus. EMBO J (1986) 4.08
Detection of minimal residual cells carrying the t(14;18) by DNA sequence amplification. Science (1987) 4.02
Promoter region of the human Harvey ras proto-oncogene: similarity to the EGF receptor proto-oncogene promoter. Science (1985) 3.59
Rapid prenatal diagnosis of sickle cell anemia by a new method of DNA analysis. N Engl J Med (1987) 3.44
Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development. Proc Natl Acad Sci U S A (1986) 3.34
Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell (1985) 3.30
Four classes of mRNA are expressed from the mouse int-2 gene, a member of the FGF gene family. EMBO J (1988) 2.51
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A method for cloning full-length cDNA in plasmid vectors. Methods Enzymol (1987) 2.02
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A (1981) 18.96
Laminin--a glycoprotein from basement membranes. J Biol Chem (1979) 12.49
A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res (1987) 7.43
International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol Rev (1994) 7.11
Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma. Biochemistry (1982) 6.87
Basement membrane complexes with biological activity. Biochemistry (1986) 6.79
An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination. Nat Genet (1998) 5.95
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Zp3-cre, a transgenic mouse line for the activation or inactivation of loxP-flanked target genes specifically in the female germ line. Curr Biol (1997) 4.46
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Role of laminin in the attachment of PAM 212 (epithelial) cells to basement membrane collagen. Cell (1980) 4.13
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Vertebrate Sprouty genes are induced by FGF signaling and can cause chondrodysplasia when overexpressed. Development (1999) 3.84
Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev (1997) 3.75
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Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein. Lab Invest (1980) 3.64
Isolation of a heparan sulfate-containing proteoglycan from basement membrane. Proc Natl Acad Sci U S A (1980) 3.57
Virus infection of murine teratocarcinoma stem cell lines. Cell (1977) 3.54
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Cre-mediated chromosome loss in mice. Nat Genet (1997) 3.36
Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development. Proc Natl Acad Sci U S A (1986) 3.34
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Enzyme-linked immunoassay (ELISA) for connective tissue components. Anal Biochem (1980) 3.28
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Collagenase production by endotoxin-activated macrophages. Proc Natl Acad Sci U S A (1974) 3.05
Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro. Cell (1989) 3.00
Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation. Cell (1987) 2.95
Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity. Nature (1986) 2.94
A murine tumor producing a matrix of basement membrane. J Exp Med (1977) 2.89
Patients with Ehlers-Danlos syndrome type IV lack type III collagen. Proc Natl Acad Sci U S A (1975) 2.88
Enhanced tumor growth of both primary and established human and murine tumor cells in athymic mice after coinjection with Matrigel. J Natl Cancer Inst (1991) 2.86
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A new nomenclature for the laminins. Matrix Biol (1994) 2.82
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Defect in conversion of procollagen to collagen in a form of Ehlers-Danlos syndrome. Science (1973) 2.74
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Comparative anatomy of the human APRT gene and enzyme: nucleotide sequence divergence and conservation of a nonrandom CpG dinucleotide arrangement. Proc Natl Acad Sci U S A (1987) 2.49
Role of laminin in the attachment and metastasis of murine tumor cells. Cancer Res (1982) 2.49
Fgf-4 expression during gastrulation, myogenesis, limb and tooth development in the mouse. Development (1992) 2.45
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Cre-mediated gene inactivation demonstrates that FGF8 is required for cell survival and patterning of the first branchial arch. Genes Dev (1999) 2.42
Abnormal collagen metabolism in cultured cells in osteogenesis imperfecta. Proc Natl Acad Sci U S A (1975) 2.36
Nature of the collagenous protein in a tumor basement membrane. Eur J Biochem (1978) 2.35
Production of procollagen by human fibroblasts in culture. Proc Natl Acad Sci U S A (1972) 2.30
Preferential digestion of basement membrane collagen by an enzyme derived from a metastatic murine tumor. Proc Natl Acad Sci U S A (1979) 2.25
Ganglioside inhibition of fibronectin-mediated cell adhesion to collagen. Proc Natl Acad Sci U S A (1979) 2.24
Roles for FGF8 in the induction, initiation, and maintenance of chick limb development. Cell (1996) 2.22
Platelet-derived growth factor is a chemoattractant for vascular smooth muscle cells. J Cell Physiol (1982) 2.20
FGF-4 replaces the apical ectodermal ridge and directs outgrowth and patterning of the limb. Cell (1993) 2.18
A synthetic peptide containing the IKVAV sequence from the A chain of laminin mediates cell attachment, migration, and neurite outgrowth. J Biol Chem (1989) 2.17
Nucleotide sequence and organization of the mouse adenine phosphoribosyltransferase gene: presence of a coding region common to animal and bacterial phosphoribosyltransferases that has a variable intron/exon arrangement. Proc Natl Acad Sci U S A (1985) 2.17
Effects of inhibitors of plasminogen activator, serine proteinases, and collagenase IV on the invasion of basement membranes by metastatic cells. Cancer Res (1988) 2.17
5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries. Cardiovasc Res (1990) 2.16
BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo. Development (1999) 2.16
En-1 and En-2, two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis. Genes Dev (1987) 2.16
Antibodies to laminin in Chagas' disease. J Exp Med (1982) 2.11
Localization of type IV collagen, laminin, heparan sulfate proteoglycan, and fibronectin to the basal lamina of basement membranes. J Cell Biol (1982) 2.04
Biological activities of laminin. J Cell Biochem (1985) 2.03
Midbrain development induced by FGF8 in the chick embryo. Nature (1996) 2.03
Spatially restricted expression of Dlx-1, Dlx-2 (Tes-1), Gbx-2, and Wnt-3 in the embryonic day 12.5 mouse forebrain defines potential transverse and longitudinal segmental boundaries. J Neurosci (1993) 2.02
Incorporation of teratocarcinoma stem cells into blastocysts by aggregation with cleavage-stage embryos. Dev Biol (1980) 2.00
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Simultaneous synthesis of types I and III collagen by fibroblasts in culture. Proc Natl Acad Sci U S A (1976) 1.97
A pentapeptide from the laminin B1 chain mediates cell adhesion and binds the 67,000 laminin receptor. Biochemistry (1987) 1.95
Preparation of type III procollagen and collagen from rat skin. Biochemistry (1974) 1.92
Epidermal cells adhere preferentially to type IV (basement membrane) collagen. J Cell Biol (1979) 1.86
YIGSR, a synthetic laminin pentapeptide, inhibits experimental metastasis formation. Science (1987) 1.82
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Spontaneous expression of the c-sis gene and release of a platelet-derived growth factorlike molecule by human alveolar macrophages. J Clin Invest (1986) 1.80
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Stimulation of granulation tissue formation by platelet-derived growth factor in normal and diabetic rats. J Clin Invest (1985) 1.79
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Expression of N-myc in teratocarcinoma stem cells and mouse embryos. Nature (1985) 1.72
Adenovirus type 2 assembly analyzed by reversible cross-linking of labile intermediates. J Virol (1978) 1.72
Isolation of the mouse Hox-2.9 gene; analysis of embryonic expression suggests that positional information along the anterior-posterior axis is specified by mesoderm. Development (1990) 1.71
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