The role of macrophage polarization in infectious and inflammatory diseases.

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation. Front Immunol (2014) 2.03

Molecular mechanisms that influence the macrophage m1-m2 polarization balance. Front Immunol (2014) 1.62

MiRNA-Mediated Macrophage Polarization and its Potential Role in the Regulation of Inflammatory Response. Shock (2016) 0.86

Identification of Differentially Expressed Long Non-coding RNAs in Polarized Macrophages. Sci Rep (2016) 0.85

Nur77 deficiency leads to systemic inflammation in elderly mice. J Inflamm (Lond) (2015) 0.85

HDAC6 deacetylase activity is critical for lipopolysaccharide-induced activation of macrophages. PLoS One (2014) 0.85

Advanced Glycation End Products Enhance Macrophages Polarization into M1 Phenotype through Activating RAGE/NF-κB Pathway. Biomed Res Int (2015) 0.85

Mycobacterium tuberculosis-Induced Polarization of Human Macrophage Orchestrates the Formation and Development of Tuberculous Granulomas In Vitro. PLoS One (2015) 0.84

The early induction of suppressor of cytokine signaling 1 and the downregulation of toll-like receptors 7 and 9 induce tolerance in costimulated macrophages. Mol Cells (2014) 0.81

Differential Gene Expression Profiles Reflecting Macrophage Polarization in Aging and Periodontitis Gingival Tissues. Immunol Invest (2015) 0.80

NKp46(+) natural killer cells attenuate metabolism-induced hepatic fibrosis by regulating macrophage activation in mice. Hepatology (2016) 0.79

Macrophage Heterogeneity and Plasticity: Impact of Macrophage Biomarkers on Atherosclerosis. Scientifica (Cairo) (2015) 0.79

Brazilian Red Propolis Attenuates Inflammatory Signaling Cascade in LPS-Activated Macrophages. PLoS One (2015) 0.79

Gamma-tocotrienol attenuates high-fat diet-induced obesity and insulin resistance by inhibiting adipose inflammation and M1 macrophage recruitment. Int J Obes (Lond) (2014) 0.79

Gender differences in murine pulmonary responses elicited by cellulose nanocrystals. Part Fibre Toxicol (2016) 0.78

Fraxinus xanthoxyloides leaves reduced the level of inflammatory mediators during in vitro and in vivo studies. BMC Complement Altern Med (2016) 0.78

Spatiotemporal Cadence of Macrophage Polarisation in a Model of Light-Induced Retinal Degeneration. PLoS One (2015) 0.78

Scavenger Receptors: Emerging Roles in Cancer Biology and Immunology. Adv Cancer Res (2015) 0.77

Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression. PLoS One (2016) 0.77

Metformin Inhibits Advanced Glycation End Products-Induced Inflammatory Response in Murine Macrophages Partly through AMPK Activation and RAGE/NFκB Pathway Suppression. J Diabetes Res (2016) 0.77

Human newborn bacille Calmette-Guérin vaccination and risk of tuberculosis disease: a case-control study. BMC Med (2016) 0.77

Roles of endoplasmic reticulum stress-mediated apoptosis in M1-polarized macrophages during mycobacterial infections. Sci Rep (2016) 0.76

Expression of scavenger receptor-AI promotes alternative activation of murine macrophages to limit hepatic inflammation and fibrosis. Hepatology (2016) 0.76

Preclinical characterization of DUOC-01, a cell therapy product derived from banked umbilical cord blood for use as an adjuvant to umbilical cord blood transplantation for treatment of inherited metabolic diseases. Cytotherapy (2015) 0.76

AMPK-Activated Protein Kinase Suppresses Ccr2 Expression by Inhibiting the NF-κB Pathway in RAW264.7 Macrophages. PLoS One (2016) 0.76

Immunoregulatory Role of NK Cells in Tissue Inflammation and Regeneration. Front Immunol (2017) 0.75

Loss of Ifnar1 in Pancreatic Acinar Cells Ameliorates the Disease Course of Acute Pancreatitis. PLoS One (2015) 0.75

Enhancement of Anti-Hypoxic Activity and Differentiation of Cardiac Stem Cells by Supernatant Fluids from Cultured Macrophages that Phagocytized Dead Mesenchymal Stem Cells. Int J Mol Sci (2016) 0.75

NMAAP1 Expressed in BCG-Activated Macrophage Promotes M1 Macrophage Polarization. Mol Cells (2015) 0.75

NLRP3 Inflammasome Expression and Signaling in Human Diabetic Wounds and in High Glucose Induced Macrophages. J Diabetes Res (2017) 0.75

Myeloperoxidase-Oxidized LDLs Enhance an Anti-Inflammatory M2 and Antioxidant Phenotype in Murine Macrophages. Mediators Inflamm (2016) 0.75

Double Roles of Macrophages in Human Neuroimmune Diseases and Their Animal Models. Mediators Inflamm (2016) 0.75

Attenuating immune pathology using a microbial-based intervention in a mouse model of cigarette smoke-induced lung inflammation. Respir Res (2017) 0.75

Protectin DX increases survival in a mouse model of sepsis by ameliorating inflammation and modulating macrophage phenotype. Sci Rep (2017) 0.75

Effects of IRF1 and IFN-β interaction on the M1 polarization of macrophages and its antitumor function. Int J Mol Med (2016) 0.75

Cholesterol reduction and macrophage function: role of paraoxonases. Curr Opin Lipidol (2017) 0.75

Intestinal hypoxia and hypoxia-induced signalling as therapeutic targets for IBD. Nat Rev Gastroenterol Hepatol (2017) 0.75

Comparative analysis of signature genes in PRRSV-infected porcine monocyte-derived cells to different stimuli. PLoS One (2017) 0.75

Pivotal regulators of tissue homeostasis and cancer: macrophages. Exp Hematol Oncol (2017) 0.75

Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest (2003) 41.22

Inflammation and metabolic disorders. Nature (2006) 33.33

Alternative activation of macrophages. Nat Rev Immunol (2003) 27.53

Exploring the full spectrum of macrophage activation. Nat Rev Immunol (2008) 26.08

Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 20.19

The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol (2004) 19.38

Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev (2002) 17.58

Clinical progression and viral load in a community outbreak of coronavirus-associated SARS pneumonia: a prospective study. Lancet (2003) 13.79

Macrophage plasticity and polarization: in vivo veritas. J Clin Invest (2012) 13.44

Steatohepatitis: a tale of two "hits"? Gastroenterology (1998) 13.21

Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol (2011) 12.21

Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res (2005) 11.88

Macrophages, inflammation, and insulin resistance. Annu Rev Physiol (2010) 11.77

Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol (2009) 11.63

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 11.59

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science (2001) 11.56

Macrophage activation and polarization. Front Biosci (2008) 11.17

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature (2012) 10.74

CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest (2005) 10.44

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm. Nat Immunol (2010) 9.59

The many faces of macrophage activation. J Leukoc Biol (2003) 8.95

Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest (2005) 8.58

A lineage of myeloid cells independent of Myb and hematopoietic stem cells. Science (2012) 8.42

Macrophage biology in development, homeostasis and disease. Nature (2013) 8.28

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nat Immunol (2012) 7.32

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature (1998) 6.69

M-1/M-2 macrophages and the Th1/Th2 paradigm. J Immunol (2000) 6.61

Evolving epidemiology of hepatitis C virus. Clin Microbiol Infect (2011) 6.48

Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol (2011) 6.34

Adipose tissue remodeling and obesity. J Clin Invest (2011) 6.12

Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes (2007) 6.08

Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab (2008) 5.53

Macrophages sequentially change their functional phenotype in response to changes in microenvironmental influences. J Immunol (2005) 5.20

Human macrophage activation programs induced by bacterial pathogens. Proc Natl Acad Sci U S A (2002) 5.18

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses. Nat Immunol (2011) 5.11

Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria. Proc Natl Acad Sci U S A (2004) 4.84

Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis. Hepatology (2010) 4.76

Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol (2011) 4.68

Macrophage polarization in bacterial infections. J Immunol (2008) 4.67

Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol (2012) 4.30

Staphylococcal biofilms. Curr Top Microbiol Immunol (2008) 4.26

The JAK/STAT signaling pathway. J Cell Sci (2004) 4.23

Insights into host responses against pathogens from transcriptional profiling. Nat Rev Microbiol (2005) 4.11

Tissue-resident macrophages. Nat Immunol (2013) 4.09

Functional plasticity of macrophages: reversible adaptation to changing microenvironments. J Leukoc Biol (2004) 4.05

Differential expression of FIZZ1 and Ym1 in alternatively versus classically activated macrophages. J Leukoc Biol (2002) 3.89

HRG inhibits tumor growth and metastasis by inducing macrophage polarization and vessel normalization through downregulation of PlGF. Cancer Cell (2011) 3.89

The liver as an immunological organ. Hepatology (2006) 3.86

A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation). Blood (2005) 3.85

Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Gastroenterology (2010) 3.52

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: a connection between endogenous alcohol and NASH. Hepatology (2013) 3.50

Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis. Hepatology (2009) 3.20

Mechanisms of Liver Injury. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol Gastrointest Liver Physiol (2006) 3.16

The phenotype of murine wound macrophages. J Leukoc Biol (2010) 3.13

Krüppel-like factor 4 regulates macrophage polarization. J Clin Invest (2011) 3.08

Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics. J Leukoc Biol (2008) 2.76

Arginase-1 and Ym1 are markers for murine, but not human, alternatively activated myeloid cells. J Immunol (2005) 2.75

IL-12 and IFN-gamma in host defense against mycobacteria and salmonella in mice and men. Curr Opin Immunol (1999) 2.69

Increased monocytic activity and biomarkers of inflammation in patients with type 1 diabetes. Diabetes (2006) 2.65

Morphologic findings of coronary atherosclerotic plaques in diabetics: a postmortem study. Arterioscler Thromb Vasc Biol (2004) 2.54

Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev Immunol (2010) 2.38

Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages. Blood (2007) 2.37

Plasticity of macrophage function during tumor progression: regulation by distinct molecular mechanisms. J Immunol (2008) 2.26

Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivo. J Immunol (2011) 2.16

Reactivation and persistence of human herpesvirus-8 infection in B cells and monocytes by Th-1 cytokines increased in Kaposi's sarcoma. Blood (1999) 2.10

Immunological complications of obesity. Nat Immunol (2012) 2.09

Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore. Hum Pathol (2003) 2.08

Constitutively activated Akt-1 is vital for the survival of human monocyte-differentiated macrophages. Role of Mcl-1, independent of nuclear factor (NF)-kappaB, Bad, or caspase activation. J Exp Med (2001) 2.06

Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2. Circ Res (2010) 2.04

Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. Hepatology (2011) 2.04

M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. J Immunol (2011) 2.02

The macrophage colony-stimulating factor 1 response signature in breast carcinoma. Clin Cancer Res (2009) 2.00

Akt1 and Akt2 protein kinases differentially contribute to macrophage polarization. Proc Natl Acad Sci U S A (2012) 1.97

Crosstalk among Jak-STAT, Toll-like receptor, and ITAM-dependent pathways in macrophage activation. J Leukoc Biol (2007) 1.94

Toll-like receptor signaling in the liver. Gastroenterology (2006) 1.94

A macrophage protein, Ym1, transiently expressed during inflammation is a novel mammalian lectin. J Biol Chem (2001) 1.88

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. Am J Physiol Gastrointest Liver Physiol (2012) 1.87

C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis. Diabetes (2010) 1.86

Monocytes from patients with type 1 diabetes spontaneously secrete proinflammatory cytokines inducing Th17 cells. J Immunol (2009) 1.83

A potential role of macrophage activation in the treatment of cancer. Crit Rev Oncol Hematol (2002) 1.81

Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization. Nat Immunol (2012) 1.81

Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production. J Biol Chem (2012) 1.75

M2-polarized tumor-associated macrophages promoted epithelial-mesenchymal transition in pancreatic cancer cells, partially through TLR4/IL-10 signaling pathway. Lab Invest (2013) 1.75

Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages. J Immunol (2008) 1.74

SOCS3 deficiency promotes M1 macrophage polarization and inflammation. J Immunol (2012) 1.71

Differentiation and heterogeneity in the mononuclear phagocyte system. Mucosal Immunol (2008) 1.70

Human cytomegalovirus induces monocyte differentiation and migration as a strategy for dissemination and persistence. J Virol (2004) 1.66

The role of IFN-gamma in the outcome of chlamydial infection. Curr Opin Immunol (2002) 1.65

Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int J Cancer (2009) 1.62

The TSC-mTOR pathway regulates macrophage polarization. Nat Commun (2013) 1.57

Macrophage polarization and function with emphasis on the evolving roles of coordinated regulation of cellular signaling pathways. Cell Signal (2013) 1.56

Zoledronic acid repolarizes tumour-associated macrophages and inhibits mammary carcinogenesis by targeting the mevalonate pathway. J Cell Mol Med (2010) 1.52

Transcriptome analysis reveals human cytomegalovirus reprograms monocyte differentiation toward an M1 macrophage. J Immunol (2008) 1.48

Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. Hepatology (2013) 1.48

Macrophage plasticity and polarization in liver homeostasis and pathology. Hepatology (2014) 1.48

Autophagy and apoptosis dysfunction in neurodegenerative disorders. Prog Neurobiol (2013) 1.46

Macrophage polarization in health and disease. ScientificWorldJournal (2011) 1.46

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications. Ann Rheum Dis (2008) 1.42

Salmonella require the fatty acid regulator PPARδ for the establishment of a metabolic environment essential for long-term persistence. Cell Host Microbe (2013) 1.41

Signal transducer and activator of transcription-3/suppressor of cytokine signaling-3 (STAT3/SOCS3) axis in myeloid cells regulates neuroinflammation. Proc Natl Acad Sci U S A (2012) 1.40

BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature (2007) 4.36

Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol (2002) 4.29

Dock180 and ELMO1 proteins cooperate to promote evolutionarily conserved Rac-dependent cell migration. J Biol Chem (2003) 2.04

Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP). J Biol Chem (2001) 1.86

Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production. J Biol Chem (2012) 1.75

CXCR4 acts as a costimulator during thymic beta-selection. Nat Immunol (2009) 1.42

PH domain of ELMO functions in trans to regulate Rac activation via Dock180. Nat Struct Mol Biol (2004) 1.36

Myeloid suppressor cells induced by hepatitis C virus suppress T-cell responses through the production of reactive oxygen species. Hepatology (2012) 1.36

Direct binding of hepatitis C virus core to gC1qR on CD4+ and CD8+ T cells leads to impaired activation of Lck and Akt. J Virol (2004) 1.34

Blockade of PD-1/B7-H1 interaction restores effector CD8+ T cell responses in a hepatitis C virus core murine model. J Immunol (2008) 1.27

Hepatitis C virus core selectively suppresses interleukin-12 synthesis in human macrophages by interfering with AP-1 activation. J Biol Chem (2004) 1.25

Intrahepatic IL-10 maintains NKG2A+Ly49- liver NK cells in a functionally hyporesponsive state. J Immunol (2010) 1.22

Extracellular hepatitis C virus core protein activates STAT3 in human monocytes/macrophages/dendritic cells via an IL-6 autocrine pathway. J Biol Chem (2011) 1.22

HCV core protein interaction with gC1q receptor inhibits Th1 differentiation of CD4+ T cells via suppression of dendritic cell IL-12 production. J Leukoc Biol (2007) 1.17

Hepatitis C virus core protein suppresses NF-kappaB activation and cyclooxygenase-2 expression by direct interaction with IkappaB kinase beta. J Virol (2005) 1.16

gC1q receptor ligation selectively down-regulates human IL-12 production through activation of the phosphoinositide 3-kinase pathway. J Immunol (2005) 1.15

Chronically inflamed livers up-regulate expression of inhibitory B7 family members. Hepatology (2009) 1.15

Host and viral factors in the immunopathogenesis of primary hepatitis C virus infection. Immunol Cell Biol (2006) 1.14

HCV core/gC1qR interaction arrests T cell cycle progression through stabilization of the cell cycle inhibitor p27Kip1. Virology (2003) 1.10

Myeloid-derived suppressor cells: the dark knight or the joker in viral infections? Immunol Rev (2013) 1.05

Group 2 innate lymphoid cell production of IL-5 is regulated by NKT cells during influenza virus infection. PLoS Pathog (2013) 1.05

Hepatitis C virus core protein leads to immune suppression and liver damage in a transgenic murine model. J Virol (2002) 1.05

HCV+ hepatocytes induce human regulatory CD4+ T cells through the production of TGF-beta. PLoS One (2010) 1.01

Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes. Hepatology (2013) 0.95

Role of complement in immune regulation and its exploitation by virus. Viral Immunol (2007) 0.95

Retracted SOCS1 and SOCS3 are targeted by hepatitis C virus core/gC1qR ligation to inhibit T-cell function. J Virol (2005) 0.94

Regulation of NK cell repertoire and function in the liver. Crit Rev Immunol (2011) 0.93

Increased Fas ligand expression of CD4+ T cells by HCV core induces T cell-dependent hepatic inflammation. J Leukoc Biol (2005) 0.89

Fas ligand is responsible for CXCR3 chemokine induction in CD4+ T cell-dependent liver damage. J Immunol (2006) 0.88

Transcriptional regulation of IFN-λ genes in hepatitis C virus-infected hepatocytes via IRF-3·IRF-7·NF-κB complex. J Biol Chem (2014) 0.88

Liver-primed CD8+ T cells suppress antiviral adaptive immunity through galectin-9-independent T-cell immunoglobulin and mucin 3 engagement of high-mobility group box 1 in mice. Hepatology (2014) 0.86

The molecular basis of HCV-mediated immune dysregulation. Clin Immunol (2004) 0.86

The C-terminal region of hepatitis C core protein is required for Fas-ligand independent apoptosis in Jurkat cells by facilitating Fas oligomerization. Virology (2003) 0.86

Liver is able to activate naïve CD8+ T cells with dysfunctional anti-viral activity in the murine system. PLoS One (2009) 0.86

Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection. Clin Immunol (2009) 0.83

Lipidoid Nanoparticles Containing PD-L1 siRNA Delivered In Vivo Enter Kupffer Cells and Enhance NK and CD8(+) T Cell-mediated Hepatic Antiviral Immunity. Mol Ther Nucleic Acids (2013) 0.82

Retracted gC1qR expression in chimpanzees with resolved and chronic infection: potential role of HCV core/gC1qR-mediated T cell suppression in the outcome of HCV infection. Virology (2005) 0.79

Immunity to viruses. Immunol Rev (2013) 0.78

The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil. Hepatology (2012) 0.77

Site-specific fatty acid-conjugation to prolong protein half-life in vivo. J Control Release (2013) 0.77

Functional characterization of core genes from patients with acute hepatitis C virus infection. J Infect Dis (2010) 0.76

SOCS1 and SOCS3 are targeted by hepatitis C virus core/gC1qR ligation to inhibit T-cell function. J Virol (2006) 0.75