Direct T cell activation via CD40 ligand generates high avidity CD8+ T cells capable of breaking immunological tolerance for the control of tumors.

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Published in PLoS One on March 24, 2014

Authors

Ruey-Shyang Soong1, Liwen Song2, Janson Trieu3, Sung Yong Lee4, Liangmei He5, Ya-Chea Tsai5, T-C Wu6, Chien-Fu Hung7

Author Affiliations

1: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America; Department of General Surgery, Chang Gung Memorial Hospital at Keelung, Keelung City, Taiwan; Chang Gung University, College of Medicine, Taoyuan, Taiwan.
2: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America; Pharmacy School of Fudan University, Shanghai, China; Department of Pharmacology and Toxicology, Shanghai Institute of Planned Parenthood Research, Shanghai, China; Department of Obstetrics and Gynecology, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China.
3: Johns Hopkins University, Baltimore, Maryland, United States of America.
4: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America; Department of Internal Medicine, Korea University Medical Center, Seoul, South Korea.
5: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America.
6: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America; Department of Obstetrics and Gynecology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America; Department of Molecular Microbiology and Immunology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America.
7: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America; Department of Oncology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States of America.

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