Effects of interventions on survival in acute respiratory distress syndrome: an umbrella review of 159 published randomized trials and 29 meta-analyses.

PubWeight™: 2.51‹?› | Rank: Top 2%

🔗 View Article (PMC 4031289)

Published in Intensive Care Med on March 26, 2014

Authors

Adriano R Tonelli1, Joe Zein, Jacob Adams, John P A Ioannidis

Author Affiliations

1: Department of Pulmonary, Allergy, and Critical Care Medicine, Respiratory Institute, Cleveland, OH, USA.

Articles citing this

The methodological quality of animal research in critical care: the public face of science. Ann Intensive Care (2014) 0.89

Clinical trials in patients with the acute respiratory distress syndrome: burn after reading. Intensive Care Med (2014) 0.85

Prone position ventilation in Acute Respiratory Distress Syndrome: An overview of the evidences. Indian J Anaesth (2015) 0.83

Year in review 2013: Critical Care--respirology. Crit Care (2014) 0.79

ARDS: rest the lungs or the ventilator? Intensive Care Med (2014) 0.78

Prediction model for critically ill patients with acute respiratory distress syndrome. PLoS One (2015) 0.78

Acute respiratory distress syndrome following cardiovascular surgery: current concepts and novel therapeutic approaches. Curr Opin Anaesthesiol (2016) 0.76

Influence of quality of care and individual patient characteristics on quality of life and return to work in survivors of the acute respiratory distress syndrome: protocol for a prospective, observational, multi-centre patient cohort study (DACAPO). BMC Health Serv Res (2015) 0.76

Characteristics and provision of care of patients with the acute respiratory distress syndrome: descriptive findings from the DACAPO cohort baseline and comparison with international findings. J Thorac Dis (2017) 0.75

Advances in the support of respiratory failure: putting all the evidence together. Crit Care (2015) 0.75

Efficacy of prone position in acute respiratory distress syndrome patients: A pathophysiology-based review. World J Crit Care Med (2016) 0.75

Ex Vivo Lung Perfusion Rehabilitates Sepsis-Induced Lung Injury. Ann Thorac Surg (2017) 0.75

Sepsis-related acute respiratory distress syndrome in children with cancer: the respiratory dynamics of a devastating condition. Rev Bras Ter Intensiva (2017) 0.75

From Berlin to Kigali: the sobering journey of acute respiratory distress syndrome. J Thorac Dis (2016) 0.75

What every intensivist should know about acute respiratory distress syndrome and diffuse alveolar damage. Rev Bras Ter Intensiva (2017) 0.75

[Acute respiratory distress syndrome : Basic principles and treatment]. Anaesthesist (2017) 0.75

Quality indicators in intensive care medicine for Germany - third edition 2017. Ger Med Sci (2017) 0.75

Surfactants in Acute Respiratory Distress Syndrome in Infants and Children: Past, Present and Future. Clin Drug Investig (2017) 0.75

Fifty Years of Research in ARDS. Cell Based Therapy for ARDS: Biology and Potential Therapeutic Value. Am J Respir Crit Care Med (2017) 0.75

Clinical effects of pulmonary surfactant in combination with nasal continuous positive airway pressure therapy on neonatal respiratory distress syndrome. Pak J Med Sci (2017) 0.75

Articles cited by this

Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network. N Engl J Med (2000) 48.03

Why most published research findings are false. PLoS Med (2005) 41.68

The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med (1994) 27.68

Acute respiratory distress syndrome: the Berlin Definition. JAMA (2012) 21.04

Comparison of two fluid-management strategies in acute lung injury. N Engl J Med (2006) 19.54

Prone positioning in severe acute respiratory distress syndrome. N Engl J Med (2013) 12.37

Higher versus lower positive end-expiratory pressures in patients with the acute respiratory distress syndrome. N Engl J Med (2004) 11.78

Why most discovered true associations are inflated. Epidemiology (2008) 11.22

Meta-analysis of acute lung injury and acute respiratory distress syndrome trials testing low tidal volumes. Am J Respir Crit Care Med (2002) 10.52

Neuromuscular blockers in early acute respiratory distress syndrome. N Engl J Med (2010) 10.44

Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome. N Engl J Med (1998) 10.22

Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med (2006) 9.52

Effect of prone positioning on the survival of patients with acute respiratory failure. N Engl J Med (2001) 8.74

Positive end-expiratory pressure setting in adults with acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA (2008) 8.13

Pulmonary-artery versus central venous catheter to guide treatment of acute lung injury. N Engl J Med (2006) 7.97

Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest (2007) 7.49

Mechanical ventilation guided by esophageal pressure in acute lung injury. N Engl J Med (2008) 7.26

Association between use of lung-protective ventilation with lower tidal volumes and clinical outcomes among patients without acute respiratory distress syndrome: a meta-analysis. JAMA (2012) 6.73

High-frequency oscillation in early acute respiratory distress syndrome. N Engl J Med (2013) 6.56

Ventilation strategy using low tidal volumes, recruitment maneuvers, and high positive end-expiratory pressure for acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. JAMA (2008) 6.39

Stopping randomized trials early for benefit and estimation of treatment effects: systematic review and meta-regression analysis. JAMA (2010) 5.90

A high positive end-expiratory pressure, low tidal volume ventilatory strategy improves outcome in persistent acute respiratory distress syndrome: a randomized, controlled trial. Crit Care Med (2006) 5.19

The efficacy and safety of prone positional ventilation in acute respiratory distress syndrome: updated study-level meta-analysis of 11 randomized controlled trials. Crit Care Med (2014) 5.11

Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med (2009) 4.90

Initial trophic vs full enteral feeding in patients with acute lung injury: the EDEN randomized trial. JAMA (2012) 4.67

Higher vs lower positive end-expiratory pressure in patients with acute lung injury and acute respiratory distress syndrome: systematic review and meta-analysis. JAMA (2010) 4.64

High-frequency oscillation for acute respiratory distress syndrome. N Engl J Med (2013) 4.52

Systematic review of the empirical evidence of study publication bias and outcome reporting bias - an updated review. PLoS One (2013) 4.38

Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial. JAMA (1998) 4.21

Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: a randomized controlled trial. JAMA (2003) 3.64

Overlapping meta-analyses on the same topic: survey of published studies. BMJ (2013) 3.57

Empirical evaluation of very large treatment effects of medical interventions. JAMA (2012) 3.48

High-frequency oscillatory ventilation for acute respiratory distress syndrome in adults: a randomized, controlled trial. Am J Respir Crit Care Med (2002) 3.43

Prone positioning in patients with moderate and severe acute respiratory distress syndrome: a randomized controlled trial. JAMA (2009) 3.35

The use of an inflammation-modulating diet in patients with acute lung injury or acute respiratory distress syndrome: a meta-analysis of outcome data. JPEN J Parenter Enteral Nutr (2008) 3.27

The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18

Effect of recombinant surfactant protein C-based surfactant on the acute respiratory distress syndrome. N Engl J Med (2004) 3.14

Tidal ventilation at low airway pressures can augment lung injury. Am J Respir Crit Care Med (1994) 3.13

The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation. Intensive Care Med (2011) 3.03

Evolution of mortality over time in patients receiving mechanical ventilation. Am J Respir Crit Care Med (2013) 2.95

Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis (1985) 2.90

Prone ventilation reduces mortality in patients with acute respiratory failure and severe hypoxemia: systematic review and meta-analysis. Intensive Care Med (2010) 2.88

Aerosolized surfactant in adults with sepsis-induced acute respiratory distress syndrome. Exosurf Acute Respiratory Distress Syndrome Sepsis Study Group. N Engl J Med (1996) 2.88

Causes and timing of death in patients with ARDS. Chest (2005) 2.72

Effect of neuromuscular blocking agents on gas exchange in patients presenting with acute respiratory distress syndrome. Crit Care Med (2004) 2.55

Effect of nitric oxide on oxygenation and mortality in acute lung injury: systematic review and meta-analysis. BMJ (2007) 2.33

Incidence and mortality of acute lung injury and the acute respiratory distress syndrome in three Australian States. Am J Respir Crit Care Med (2002) 2.28

Effect of prone positioning in patients with acute respiratory distress syndrome: a meta-analysis. Crit Care Med (2008) 2.27

Meta-analysis: ventilation strategies and outcomes of the acute respiratory distress syndrome and acute lung injury. Ann Intern Med (2009) 2.07

Benefit of an enteral diet enriched with eicosapentaenoic acid and gamma-linolenic acid in ventilated patients with acute lung injury. Crit Care Med (2006) 2.04

High frequency oscillation in patients with acute lung injury and acute respiratory distress syndrome (ARDS): systematic review and meta-analysis. BMJ (2010) 2.02

Recombinant surfactant protein C-based surfactant for patients with severe direct lung injury. Am J Respir Crit Care Med (2010) 1.94

Effects of systematic prone positioning in hypoxemic acute respiratory failure: a randomized controlled trial. JAMA (2004) 1.93

A universal definition of ARDS: the PaO2/FiO2 ratio under a standard ventilatory setting--a prospective, multicenter validation study. Intensive Care Med (2013) 1.89

A multicenter trial of prolonged prone ventilation in severe acute respiratory distress syndrome. Am J Respir Crit Care Med (2006) 1.84

Exogenous natural surfactant for treatment of acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med (2009) 1.83

Corticosteroids in the prevention and treatment of acute respiratory distress syndrome (ARDS) in adults: meta-analysis. BMJ (2008) 1.75

Integration of evidence from multiple meta-analyses: a primer on umbrella reviews, treatment networks and multiple treatments meta-analyses. CMAJ (2009) 1.73

Neutrophil elastase inhibition in acute lung injury: results of the STRIVE study. Crit Care Med (2004) 1.72

Does a higher positive end expiratory pressure decrease mortality in acute respiratory distress syndrome? A systematic review and meta-analysis. Anesthesiology (2009) 1.68

Randomized double-blind, multicenter study of prostaglandin E1 in patients with the adult respiratory distress syndrome. Prostaglandin E1 Study Group. Chest (1989) 1.67

Liposomal prostaglandin E1 (TLC C-53) in acute respiratory distress syndrome: a controlled, randomized, double-blind, multicenter clinical trial. TLC C-53 ARDS Study Group. Crit Care Med (1999) 1.65

Hyperoxia in the intensive care unit: why more is not always better. Curr Opin Crit Care (2007) 1.62

Higher PEEP in patients with acute lung injury: a systematic review and meta-analysis. Respir Care (2011) 1.59

Exogenous surfactant may improve oxygenation but not mortality in adult patients with acute lung injury/acute respiratory distress syndrome: a meta-analysis of 9 clinical trials. J Cardiothorac Vasc Anesth (2012) 1.47

High levels of PEEP may improve survival in acute respiratory distress syndrome: A meta-analysis. Respir Med (2009) 1.46

The impact of high-risk patients on the results of clinical trials. J Clin Epidemiol (1997) 1.46

Neuromuscular blocking agents decrease inflammatory response in patients presenting with acute respiratory distress syndrome. Crit Care Med (2006) 1.41

Dynamic alveolar mechanics and ventilator-induced lung injury. Crit Care Med (2005) 1.37

Neuromuscular blocking agents in acute respiratory distress syndrome: a systematic review and meta-analysis of randomized controlled trials. Crit Care (2013) 1.36

Is there a role for noninvasive ventilation in acute respiratory distress syndrome? A meta-analysis. Respir Med (2006) 1.29

Prospective randomized trial comparing pressure-controlled ventilation and volume-controlled ventilation in ARDS. For the Spanish Lung Failure Collaborative Group. Chest (2000) 1.26

Effect of neutrophil elastase inhibitor (sivelestat sodium) in the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis. Intern Med (2010) 1.25

The need to consider the wider agenda in systematic reviews and meta-analyses: breadth, timing, and depth of the evidence. BMJ (2010) 1.20

An updated study-level meta-analysis of randomised controlled trials on proning in ARDS and acute lung injury. Crit Care (2011) 1.20

High versus low positive end-expiratory pressure (PEEP) levels for mechanically ventilated adult patients with acute lung injury and acute respiratory distress syndrome. Cochrane Database Syst Rev (2013) 1.18

Mechanical ventilation in ARDS: a state-of-the-art review. Chest (2007) 1.14

Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis. Crit Care (2006) 1.13

Prone positioning reduces mortality from acute respiratory distress syndrome in the low tidal volume era: a meta-analysis. Intensive Care Med (2014) 1.12

Do glucocorticoids decrease mortality in acute respiratory distress syndrome? A meta-analysis. Respirology (2007) 1.05

Corticosteroid therapy for acute lung injury, acute respiratory distress syndrome, and severe pneumonia: a meta-analysis of randomized controlled trials. J Crit Care (2009) 1.03

Practices and impact of primary outcome adjustment in randomized controlled trials: meta-epidemiologic study. BMJ (2013) 1.03

Pressure and volume limited ventilation for the ventilatory management of patients with acute lung injury: a systematic review and meta-analysis. PLoS One (2011) 1.02

Airway pressure release ventilation as a primary ventilatory mode in acute respiratory distress syndrome. Acta Anaesthesiol Scand (2004) 0.98

Efficacy of positive end-expiratory pressure titration after the alveolar recruitment manoeuvre in patients with acute respiratory distress syndrome. Crit Care (2009) 0.97

Prone positioning in hypoxemic respiratory failure: meta-analysis of randomized controlled trials. J Crit Care (2008) 0.96

Inhaled nitric oxide for acute respiratory distress syndrome and acute lung injury in adults and children: a systematic review with meta-analysis and trial sequential analysis. Anesth Analg (2011) 0.95

Raw data from clinical trials: within reach? Trends Pharmacol Sci (2013) 0.93

Efficacy of prone ventilation in adult patients with acute respiratory failure: a meta-analysis. J Crit Care (2008) 0.89

Calculating additive treatment effects from multiple randomized trials provides useful estimates of combination therapies. J Clin Epidemiol (2012) 0.81

β2 agonist for the treatment of acute lung injury: a systematic review and meta-analysis. Respir Care (2013) 0.79

Exogenous pulmonary surfactant for acute respiratory distress syndrome in adults: A systematic review and meta-analysis. Exp Ther Med (2012) 0.79

Claims for improved survival from systemic corticosteroids in diverse conditions: an umbrella review. Eur J Clin Invest (2011) 0.78

Articles by these authors

(truncated to the top 100)

Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nat Rev Genet (2008) 30.94

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ (2009) 22.18

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med (2009) 21.74

Power failure: why small sample size undermines the reliability of neuroscience. Nat Rev Neurosci (2013) 13.37

Systematic review of the empirical evidence of study publication bias and outcome reporting bias. PLoS One (2008) 13.32

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med (2009) 12.16

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol (2009) 11.80

The case of the misleading funnel plot. BMJ (2006) 8.26

Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. BMJ (2014) 7.21

Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials. BMJ (2011) 6.80

Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet (2008) 6.71

Sensitivity of between-study heterogeneity in meta-analysis: proposed metrics and empirical evaluation. Int J Epidemiol (2008) 5.88

Research grants: Conform and be funded. Nature (2012) 5.83

Correlation of quality measures with estimates of treatment effect in meta-analyses of randomized controlled trials. JAMA (2002) 5.81

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet (2012) 5.48

Assessment of claims of improved prediction beyond the Framingham risk score. JAMA (2009) 5.36

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies. Nat Genet (2009) 5.32

Why current publication practices may distort science. PLoS Med (2008) 5.09

Evaluation of networks of randomized trials. Stat Methods Med Res (2007) 4.70

Predictive ability of DNA microarrays for cancer outcomes and correlates: an empirical assessment. Lancet (2003) 4.58

Number of published systematic reviews and global burden of disease: database analysis. BMJ (2003) 4.53

The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med (2015) 4.49

Neoadjuvant versus adjuvant systemic treatment in breast cancer: a meta-analysis. J Natl Cancer Inst (2005) 4.48

Heterogeneity testing in meta-analysis of genome searches. Genet Epidemiol (2005) 4.45

Public availability of published research data in high-impact journals. PLoS One (2011) 4.41

Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database. PLoS Genet (2012) 4.27

Relative citation impact of various study designs in the health sciences. JAMA (2005) 4.19

Comparisons of established risk prediction models for cardiovascular disease: systematic review. BMJ (2012) 4.16

Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial. J Clin Epidemiol (2010) 4.10

The emergence of translational epidemiology: from scientific discovery to population health impact. Am J Epidemiol (2010) 4.04

Methods for meta-analysis in genetic association studies: a review of their potential and pitfalls. Hum Genet (2007) 3.92

Predicting death: an empirical evaluation of predictive tools for mortality. Arch Intern Med (2011) 3.81

Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81

Relation between burden of disease and randomised evidence in sub-Saharan Africa: survey of research. BMJ (2002) 3.78

Translation of highly promising basic science research into clinical applications. Am J Med (2003) 3.74

Influence of reported study design characteristics on intervention effect estimates from randomized, controlled trials. Ann Intern Med (2012) 3.63

Overlapping meta-analyses on the same topic: survey of published studies. BMJ (2013) 3.57

Empirical evaluation of very large treatment effects of medical interventions. JAMA (2012) 3.48

Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet (2012) 3.48

Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal. Trials (2010) 3.45

Selective reporting biases in cancer prognostic factor studies. J Natl Cancer Inst (2005) 3.41

Meta-analysis in genome-wide association studies. Pharmacogenomics (2009) 3.39

Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study. Lancet Neurol (2011) 3.36

Differential effects of NOD2 variants on Crohn's disease risk and phenotype in diverse populations: a metaanalysis. Am J Gastroenterol (2004) 3.28

Medicine. Life cycle of translational research for medical interventions. Science (2008) 3.12

The Scientific Foundation for personal genomics: recommendations from a National Institutes of Health-Centers for Disease Control and Prevention multidisciplinary workshop. Genet Med (2009) 2.91

Survival with aromatase inhibitors and inactivators versus standard hormonal therapy in advanced breast cancer: meta-analysis. J Natl Cancer Inst (2006) 2.91

HEGESMA: genome search meta-analysis and heterogeneity testing. Bioinformatics (2005) 2.81

Collaborative meta-analysis: associations of 150 candidate genes with osteoporosis and osteoporotic fracture. Ann Intern Med (2009) 2.80

The association between common vitamin D receptor gene variations and osteoporosis: a participant-level meta-analysis. Ann Intern Med (2006) 2.74

Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis (TRIPOD): explanation and elaboration. Ann Intern Med (2015) 2.71

Evaluation of excess significance bias in animal studies of neurological diseases. PLoS Biol (2013) 2.70

Extended-interval aminoglycoside administration for children: a meta-analysis. Pediatrics (2004) 2.60

Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. J Allergy Clin Immunol (2005) 2.59

Meta-analysis methods for genome-wide association studies and beyond. Nat Rev Genet (2013) 2.58

Reporting and interpretation of SF-36 outcomes in randomised trials: systematic review. BMJ (2009) 2.57

Transforming epidemiology for 21st century medicine and public health. Cancer Epidemiol Biomarkers Prev (2013) 2.56

Comparative effectiveness of exercise and drug interventions on mortality outcomes: metaepidemiological study. BMJ (2013) 2.52

Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis. JAMA (2008) 2.52

Origin and funding of the most frequently cited papers in medicine: database analysis. BMJ (2006) 2.47

Large-scale analysis of association between GDF5 and FRZB variants and osteoarthritis of the hip, knee, and hand. Arthritis Rheum (2009) 2.47

Claims of sex differences: an empirical assessment in genetic associations. JAMA (2007) 2.46

Almost all articles on cancer prognostic markers report statistically significant results. Eur J Cancer (2007) 2.46

Strengthening the reporting of genetic association studies (STREGA): an extension of the strengthening the reporting of observational studies in epidemiology (STROBE) statement. J Clin Epidemiol (2009) 2.45

Systematic evaluation of environmental factors: persistent pollutants and nutrients correlated with serum lipid levels. Int J Epidemiol (2012) 2.42

Sources of funding for Nobel Prize-winning work: public or private? FASEB J (2010) 2.42

Comparison of evidence on harms of medical interventions in randomized and nonrandomized studies. CMAJ (2006) 2.40

STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement. PLoS Med (2009) 2.39

18F-fluorodeoxyglucose positron emission tomography to evaluate cervical node metastases in patients with head and neck squamous cell carcinoma: a meta-analysis. J Natl Cancer Inst (2008) 2.32

International ranking systems for universities and institutions: a critical appraisal. BMC Med (2007) 2.31

Can trial sequential monitoring boundaries reduce spurious inferences from meta-analyses? Int J Epidemiol (2008) 2.31

Treating anemia early in renal failure patients slows the decline of renal function: a randomized controlled trial. Kidney Int (2004) 2.30

A field synopsis on low-penetrance variants in DNA repair genes and cancer susceptibility. J Natl Cancer Inst (2008) 2.29

How to use an article reporting a multiple treatment comparison meta-analysis. JAMA (2012) 2.28

STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology STROBE-ME: an extension of the STROBE statement. J Clin Epidemiol (2011) 2.24

Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis. Ann Rheum Dis (2012) 2.21

Hardy-Weinberg equilibrium in genetic association studies: an empirical evaluation of reporting, deviations, and power. Eur J Hum Genet (2005) 2.21

Survival and disease-progression benefits with treatment regimens for advanced colorectal cancer: a meta-analysis. Lancet Oncol (2007) 2.19

A nutrient-wide association study on blood pressure. Circulation (2012) 2.19

Local literature bias in genetic epidemiology: an empirical evaluation of the Chinese literature. PLoS Med (2005) 2.18

Large-scale replication and heterogeneity in Parkinson disease genetic loci. Neurology (2012) 2.18

Genome-wide association studies, field synopses, and the development of the knowledge base on genetic variation and human diseases. Am J Epidemiol (2009) 2.15

Multiple-treatments meta-analysis of chemotherapy and targeted therapies in advanced breast cancer. J Natl Cancer Inst (2008) 2.15

Effectiveness of antipsychotic treatments in a nationwide cohort of patients in community care after first hospitalisation due to schizophrenia and schizoaffective disorder: observational follow-up study. BMJ (2006) 2.14

What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations. Int J Epidemiol (2011) 2.13

Modern health care as a game theory problem. Eur J Clin Invest (2015) 2.09

Percutaneous coronary intervention versus conservative therapy in nonacute coronary artery disease: a meta-analysis. Circulation (2005) 2.06

Ensuring the integrity of clinical practice guidelines: a tool for protecting patients. BMJ (2013) 2.06

US studies may overestimate effect sizes in softer research. Proc Natl Acad Sci U S A (2013) 2.06

A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum (2010) 2.02

Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet (2011) 1.98

Prognostic effect size of cardiovascular biomarkers in datasets from observational studies versus randomised trials: meta-epidemiology study. BMJ (2011) 1.97

Exploring the geometry of treatment networks. Ann Intern Med (2008) 1.95

Lack of replication of thirteen single-nucleotide polymorphisms implicated in Parkinson's disease: a large-scale international study. Lancet Neurol (2006) 1.92

Optimal timing of coronary angiography and potential intervention in non-ST-elevation acute coronary syndromes. Eur Heart J (2010) 1.91

Persistence of contradicted claims in the literature. JAMA (2007) 1.90

Replication in genome-wide association studies. Stat Sci (2009) 1.89

Meta-analysis: test performance of ultrasonography for giant-cell arteritis. Ann Intern Med (2005) 1.88

Demystifying trial networks and network meta-analysis. BMJ (2013) 1.87

Limited benefit of antiretroviral resistance testing in treatment-experienced patients: a meta-analysis. AIDS (2004) 1.87