Published in Cells on January 14, 2013
Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases. F1000Res (2016) 0.81
The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect? Genes (Basel) (2016) 0.79
Telomeres shorten during ageing of human fibroblasts. Nature (1990) 23.97
Extension of life-span by introduction of telomerase into normal human cells. Science (1998) 20.48
Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19
Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J (1992) 10.97
Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A (1992) 10.19
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature (2010) 4.36
Telomeres and telomerase in cancer. Carcinogenesis (2009) 4.28
Activation of telomerase in human lymphocytes and hematopoietic progenitor cells. J Immunol (1995) 3.20
Shortened telomeres in clonally expanded CD28-CD8+ T cells imply a replicative history that is distinct from their CD28+CD8+ counterparts. J Immunol (1996) 3.03
Human naive and memory T lymphocytes differ in telomeric length and replicative potential. Proc Natl Acad Sci U S A (1995) 2.77
Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clin Immunol (2002) 1.97
Telomerase levels control the lifespan of human T lymphocytes. Blood (2003) 1.59
Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization. J Immunol (2004) 1.58
The telomerase activator TA-65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell (2011) 1.55
Immortalization of human CD8+ T cell clones by ectopic expression of telomerase reverse transcriptase. J Immunol (2000) 1.45
Telomerase-based pharmacologic enhancement of antiviral function of human CD8+ T lymphocytes. J Immunol (2008) 1.34
A natural product telomerase activator as part of a health maintenance program. Rejuvenation Res (2010) 1.30
Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lymphocytes. J Clin Immunol (2010) 1.10
Ectopic human telomerase catalytic subunit expression maintains telomere length but is not sufficient for CD8+ T lymphocyte immortalization. J Immunol (2000) 1.03
Regulation of inflammatory gene expression in PBMCs by immunostimulatory botanicals. PLoS One (2010) 1.03
Centromeres and telomeres. Curr Opin Cell Biol (1992) 0.96
Astragalus saponins modulate mTOR and ERK signaling to promote apoptosis through the extrinsic pathway in HT-29 colon cancer cells. Int J Mol Med (2010) 0.93
A ten-year audit of traditional Chinese medicine and other natural product research published in the Chinese Medical Journal (2000-2009). Chin Med J (Engl) (2011) 0.82