Pros and cons of GnRHa treatment for early puberty in girls.

PubWeight™: 1.01‹?› | Rank: Top 15%

🔗 View Article (PMID 24709660)

Published in Nat Rev Endocrinol on April 08, 2014

Authors

Ruben H Willemsen1, Daniela Elleri1, Rachel M Williams1, Ken K Ong2, David B Dunger1

Author Affiliations

1: Department of Paediatrics and Wellcome Trust-MRC Institute of Metabolic Science, Box 116, Level 8, Addenbrooke's Hospital, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, UK.
2: MRC Epidemiology Unit, Box 285, University of Cambridge, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0QQ, UK.

Articles cited by this

(truncated to the top 100)

Variations in pattern of pubertal changes in girls. Arch Dis Child (1969) 23.35

Secondary sexual characteristics and menses in young girls seen in office practice: a study from the Pediatric Research in Office Settings network. Pediatrics (1997) 9.24

Tables for predicting adult height from skeletal age: revised for use with the Greulich-Pyle hand standards. J Pediatr (1952) 6.03

Childhood obesity. Lancet (2010) 5.47

The timing of normal puberty and the age limits of sexual precocity: variations around the world, secular trends, and changes after migration. Endocr Rev (2003) 4.88

Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. Nat Genet (2010) 3.37

Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone. Science (1978) 3.15

Reexamination of the age limit for defining when puberty is precocious in girls in the United States: implications for evaluation and treatment. Drug and Therapeutics and Executive Committees of the Lawson Wilkins Pediatric Endocrine Society. Pediatrics (1999) 3.10

Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med (2013) 3.04

Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies. Lancet Oncol (2012) 2.95

Two-year results of treatment with depot leuprolide acetate for central precocious puberty. J Pediatr (1992) 2.93

Consensus statement on the use of gonadotropin-releasing hormone analogs in children. Pediatrics (2009) 2.67

Impact of timing of pubertal maturation on growth in black and white female adolescents: The National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr (2001) 2.59

A GPR54-activating mutation in a patient with central precocious puberty. N Engl J Med (2008) 2.53

Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev (1998) 2.39

Secular trends in growth. Proc Nutr Soc (2000) 2.32

Early age at menarche associated with cardiovascular disease and mortality. J Clin Endocrinol Metab (2009) 2.32

Prospective study of factors influencing the onset of natural menopause. J Clin Epidemiol (1998) 2.30

Onset of breast development in a longitudinal cohort. Pediatrics (2013) 2.03

Childhood obesity and the timing of puberty. Trends Endocrinol Metab (2009) 2.00

Common genetic influences on BMI and age at menarche. Hum Biol (1995) 1.93

Unsustained or slowly progressive puberty in young girls: initial presentation and long-term follow-up of 20 untreated patients. J Clin Endocrinol Metab (1999) 1.83

Reduction of baseline body mass index under gonadotropin-suppressive therapy in girls with idiopathic precocious puberty. Eur J Endocrinol (2004) 1.79

Evolution, development and timing of puberty. Trends Endocrinol Metab (2005) 1.75

Secondary sexual characteristics in boys: data from the Pediatric Research in Office Settings Network. Pediatrics (2012) 1.68

Age at natural menopause in a population-based screening cohort: the role of menarche, fecundity, and lifestyle factors. Fertil Steril (1997) 1.67

Activating Gsalpha mutations: analysis of 113 patients with signs of McCune-Albright syndrome--a European Collaborative Study. J Clin Endocrinol Metab (2004) 1.61

Polycystic ovaries and associated clinical and biochemical features in young women. Clin Endocrinol (Oxf) (1999) 1.60

Mutations of the KISS1 gene in disorders of puberty. J Clin Endocrinol Metab (2010) 1.54

Factors predicting adult height in girls with idiopathic central precocious puberty: implications for treatment. Clin Endocrinol (Oxf) (2002) 1.50

Familial central precocious puberty suggests autosomal dominant inheritance. J Clin Endocrinol Metab (2004) 1.49

Infancy weight gain predicts childhood body fat and age at menarche in girls. J Clin Endocrinol Metab (2009) 1.47

Pubertal timing and adult obesity and cardiometabolic risk in women and men: a systematic review and meta-analysis. Int J Obes (Lond) (2012) 1.43

Serum hormone levels in relation to reproductive and lifestyle factors in postmenopausal women (United States). Cancer Causes Control (1998) 1.43

Precocious puberty and statural growth. Hum Reprod Update (2004) 1.42

Age at puberty and the emerging obesity epidemic. PLoS One (2009) 1.37

Long-term observation of 87 girls with idiopathic central precocious puberty treated with gonadotropin-releasing hormone analogs: impact on adult height, body mass index, bone mineral content, and reproductive function. J Clin Endocrinol Metab (2007) 1.34

Epigenetic control of female puberty. Nat Neurosci (2013) 1.34

Gender-related psychological and behavioural correlates of pubertal timing in a national sample of Swiss adolescents. Mol Cell Endocrinol (2006) 1.33

Recent secular trends in pubertal timing: implications for evaluation and diagnosis of precocious puberty. Horm Res Paediatr (2012) 1.26

Pubertal timing and self-reported delinquency among male adolescents. J Adolesc (1999) 1.24

Pubertal development in Danish children: comparison of recent European and US data. Int J Androl (2006) 1.23

Pubertal development in Swiss girls. Helv Paediatr Acta (1983) 1.22

Diagnostic work-up of 449 consecutive girls who were referred to be evaluated for precocious puberty. J Clin Endocrinol Metab (2011) 1.22

Premature thelarche and central precocious puberty: the relationship between clinical presentation and the gonadotropin response to luteinizing hormone-releasing hormone. J Clin Endocrinol Metab (1988) 1.18

The efficacy and safety of gonadotropin-releasing hormone analog treatment in childhood and adolescence: a single center, long-term follow-up study. J Clin Endocrinol Metab (2009) 1.17

Therapeutic use of pituitary desensitization with a long-acting lhrh agonist: a potential new treatment for idiopathic precocious puberty. J Clin Endocrinol Metab (1981) 1.17

Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function. J Clin Endocrinol Metab (1999) 1.14

Growth pattern and final height after cessation of gonadotropin-suppressive therapy in girls with central sexual precocity. J Clin Endocrinol Metab (2007) 1.13

Effects of obesity on human sexual development. Nat Rev Endocrinol (2012) 1.13

Age at menarche and type 2 diabetes risk: the EPIC-InterAct study. Diabetes Care (2013) 1.13

Final height in central precocious puberty after long term treatment with a slow release GnRH agonist. Arch Dis Child (1996) 1.09

Final height after long-term treatment with triptorelin slow release for central precocious puberty: importance of statural growth after interruption of treatment. French study group of Decapeptyl in Precocious Puberty. J Clin Endocrinol Metab (1999) 1.08

Increased final height in precocious puberty after long-term treatment with LHRH agonists: the National Institutes of Health experience. J Clin Endocrinol Metab (2001) 1.08

Factors associated with early menarche: results from the French Health Behaviour in School-aged Children (HBSC) study. BMC Public Health (2010) 1.07

Randomised trial of LHRH analogue treatment on final height in girls with onset of puberty aged 7.5-8.5 years. Arch Dis Child (1999) 1.07

Metformin therapy during puberty delays menarche, prolongs pubertal growth, and augments adult height: a randomized study in low-birth-weight girls with early-normal onset of puberty. J Clin Endocrinol Metab (2006) 1.06

Disorders of pubertal development. Best Pract Res Clin Obstet Gynaecol (2003) 1.04

Results of long-term follow-up after treatment of central precocious puberty with leuprorelin acetate: evaluation of effectiveness of treatment and recovery of gonadal function. The TAP-144-SR Japanese Study Group on Central Precocious Puberty. J Clin Endocrinol Metab (2004) 1.03

Lack of effect of GnRH agonists on final height in girls with advanced puberty: a randomized long-term pilot study. J Clin Endocrinol Metab (1999) 1.02

Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty. J Clin Endocrinol Metab (1999) 1.01

Precocious puberty in adolescent girls: a biomarker of later psychosocial adjustment problems. Child Psychiatry Hum Dev (2005) 1.01

Increased risk of precocious puberty in internationally adopted children in Denmark. Pediatrics (2006) 1.00

Trends in puberty timing in humans and environmental modifiers. Mol Cell Endocrinol (2010) 0.99

Approach to the patient with hypogonadotropic hypogonadism. J Clin Endocrinol Metab (2013) 0.98

Long-term GnRH agonist treatment for female central precocious puberty does not impair reproductive function. Mol Cell Endocrinol (2006) 0.98

Bone mineral density and body composition before and during treatment with gonadotropin-releasing hormone agonist in children with central precocious and early puberty. J Clin Endocrinol Metab (1998) 0.97

Psychological assessments before and after treatment of early puberty in adopted children. Acta Paediatr (2001) 0.97

Longitudinal follow-up of bone density and body composition in children with precocious or early puberty before, during and after cessation of GnRH agonist therapy. J Clin Endocrinol Metab (2002) 0.97

Secular trends in age at menarche in women in the UK born 1908-93: results from the Breakthrough Generations Study. Paediatr Perinat Epidemiol (2011) 0.96

Is obesity an outcome of gonadotropin-releasing hormone agonist administration? Analysis of growth and body composition in 110 patients with central precocious puberty. J Clin Endocrinol Metab (1999) 0.95

Central precocious puberty in children living in Spain: incidence, prevalence, and influence of adoption and immigration. J Clin Endocrinol Metab (2010) 0.95

Analysis of the factors affecting auxological response to GnRH agonist treatment and final height outcome in girls with idiopathic central precocious puberty. Eur J Endocrinol (1999) 0.94

Idiopathic precocious puberty in girls: long-term effects on adolescent behavior. Acta Endocrinol Suppl (Copenh) (1986) 0.94

The timing of sexual maturation in a group of US white youths. J Pediatr Endocrinol Metab (1995) 0.94

Effect of central precocious puberty and gonadotropin-releasing hormone analogue treatment on peak bone mass and final height in females. Eur J Pediatr (1998) 0.93

Pubertal timing and its link to behavioral and emotional problems among 'at-risk' African American adolescent girls. J Adolesc (2008) 0.93

Efficacy of Leuprolide Acetate 1-Month Depot for Central Precocious Puberty (CPP): Growth Outcomes During a Prospective, Longitudinal Study. Int J Pediatr Endocrinol (2011) 0.93

Higher levels of IGF-I and adrenal androgens at age 8 years are associated with earlier age at menarche in girls. J Clin Endocrinol Metab (2012) 0.92

Final height, gonadal function and bone mineral density of adolescent males with central precocious puberty after therapy with gonadotropin-releasing hormone analogues. Eur J Pediatr (2000) 0.92

Outcome after depot gonadotrophin-releasing hormone agonist treatment for central precocious puberty: effects on body mass index and final height. Eur J Endocrinol (2005) 0.92

Insulin sensitivity and lipid profiles in girls with central precocious puberty before and during gonadal suppression. J Clin Endocrinol Metab (2010) 0.91

Bone mineral density during treatment of central precocious puberty. J Pediatr (1995) 0.90

Does early physical maturity influence breast cancer risk? Acta Oncol (1994) 0.90

Deciphering puberty: novel partners, novel mechanisms. Eur J Endocrinol (2012) 0.89

Treatment of central precocious puberty by subcutaneous injections of leuprorelin 3-month depot (11.25 mg). J Clin Endocrinol Metab (2002) 0.88

Treated and untreated women with idiopathic precocious puberty: long-term follow-up and reproductive outcome between the third and fifth decades. Clin Endocrinol (Oxf) (2013) 0.88

Determinants of growth during gonadotropin-releasing hormone analog therapy for precocious puberty. J Clin Endocrinol Metab (2004) 0.88

Reproductive outcome in patients treated and not treated for idiopathic early puberty: long-term results of a randomized trial in adults. J Pediatr (2006) 0.87

Are pubertal changes in girls before age 8 benign? Pediatrics (2003) 0.87

Longitudinal study of behavioral and affective patterns in girls with central precocious puberty during long-acting triptorelin therapy. Acta Paediatr (1997) 0.86

Final height in girls with central precocious puberty: comparison of two different luteinizing hormone-releasing hormone agonist treatments. Acta Paediatr (1994) 0.86

Predicting the adult height of girls with central precocious puberty. Med Sci Monit (2011) 0.86

Resumption of puberty after long term luteinizing hormone-releasing hormone agonist treatment of central precocious puberty. J Clin Endocrinol Metab (1988) 0.86

Changes in growth and serum growth hormone and plasma somatomedin-C levels during suppression of gonadal sex steroid secretion in girls with central precocious puberty. J Clin Endocrinol Metab (1988) 0.85

Early puberty in adopted children. Horm Res (2002) 0.85

Bone mineral density and body composition in girls with idiopathic central precocious puberty before and after treatment with a gonadotropin-releasing hormone agonist. Clinics (Sao Paulo) (2012) 0.85

Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist. J Clin Endocrinol Metab (1985) 0.84

Suppression of the pituitary-gonadal axis in children with central precocious puberty: effects on growth, growth hormone, insulin-like growth factor-I, and prolactin secretion. J Clin Endocrinol Metab (1991) 0.84

The effect of gonadotrophin-releasing hormone agonist treatment over 3 years on bone mineral density and body composition in girls with central precocious puberty. Clin Endocrinol (Oxf) (2012) 0.84