Published in Immunol Rev on May 01, 2014
Unbalanced recovery of regulatory and effector T cells after allogeneic stem cell transplantation contributes to chronic GVHD. Blood (2015) 0.98
Altered immunoregulation in rheumatoid arthritis: the role of regulatory T cells and proinflammatory th17 cells and therapeutic implications. Mediators Inflamm (2015) 0.92
Dynamic regulation of T follicular regulatory cell responses by interleukin 2 during influenza infection. Nat Immunol (2017) 0.80
Developmental Progression and Interrelationship of Central and Effector Regulatory T Cell Subsets. J Immunol (2016) 0.80
Beyond regulatory T cells: the potential role for IL-2 to deplete T-follicular helper cells and treat autoimmune diseases. Immunotherapy (2014) 0.78
Regulatory cells in health and disease. Immunol Rev (2014) 0.78
Marked in Vivo Donor Regulatory T Cell Expansion via Interleukin-2 and TL1A-Ig Stimulation Ameliorates Graft-versus-Host Disease but Preserves Graft-versus-Leukemia in Recipients after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant (2017) 0.77
The Involvement of Immune Semaphorins in the Pathogenesis of Inflammatory Bowel Diseases (IBDs). PLoS One (2015) 0.76
Notch Signaling Pathway Was Involved in Regulating Programmed Cell Death 1 Expression during Sepsis-Induced Immunosuppression. Mediators Inflamm (2015) 0.76
IBD. Regulatory T cells for treatment of Crohn's disease. Nat Rev Gastroenterol Hepatol (2015) 0.75
Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3 expression following acute flavivirus infection. Sci Rep (2017) 0.75
The Lower Limit of Regulatory CD4(+) Foxp3(+) TCRβ Repertoire Diversity Required To Control Autoimmunity. J Immunol (2017) 0.75
The Role of the Ikaros Family of Transcription Factors in Regulatory T cell Development and Function. J Clin Cell Immunol (2017) 0.75
Human Tregs Made Antigen Specific by Gene Modification: The Power to Treat Autoimmunity and Antidrug Antibodies with Precision. Front Immunol (2017) 0.75
Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cells highly induce regulatory T cells. Immunology (2017) 0.75
Control of regulatory T cell development by the transcription factor Foxp3. Science (2003) 40.32
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol (2003) 38.57
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J Immunol (1995) 29.42
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol (2004) 17.40
Induction of colonic regulatory T cells by indigenous Clostridium species. Science (2010) 16.71
A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med (2007) 15.17
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol (2006) 14.33
Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor. Immunity (2007) 12.98
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science (2007) 12.79
CTLA-4 control over Foxp3+ regulatory T cell function. Science (2008) 12.67
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat Immunol (2001) 12.00
Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med (2007) 11.82
Differentiation of effector CD4 T cell populations (*). Annu Rev Immunol (2010) 11.80
A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat Immunol (2005) 11.48
Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity (2008) 10.26
Inducing and expanding regulatory T cell populations by foreign antigen. Nat Immunol (2005) 9.91
Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces. Immunity (2008) 9.82
Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci U S A (2010) 9.81
Expression of Helios, an Ikaros transcription factor family member, differentiates thymic-derived from peripherally induced Foxp3+ T regulatory cells. J Immunol (2010) 9.72
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 9.71
Foxp3-dependent programme of regulatory T-cell differentiation. Nature (2007) 9.48
Mechanisms of foxp3+ T regulatory cell-mediated suppression. Immunity (2009) 9.28
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science (2009) 9.22
Suppressor effector function of CD4+CD25+ immunoregulatory T cells is antigen nonspecific. J Immunol (2000) 9.15
Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo. Nat Immunol (2009) 8.65
Bcl6 mediates the development of T follicular helper cells. Science (2009) 8.50
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol (2009) 8.32
CD4(+)CD25(+) immunoregulatory T cells: gene expression analysis reveals a functional role for the glucocorticoid-induced TNF receptor. Immunity (2002) 8.28
Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol (2007) 7.86
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity (2009) 7.69
Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol (2007) 7.64
Origin of regulatory T cells with known specificity for antigen. Nat Immunol (2002) 7.49
Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors. Immunity (2004) 6.89
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature (2010) 6.87
TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells. J Exp Med (2005) 6.87
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3. Nat Immunol (2007) 6.80
Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature (2013) 6.77
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature (2009) 6.65
Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature (2007) 6.58
Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med (2000) 6.57
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat Immunol (2007) 6.22
An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires. Nat Immunol (2006) 6.16
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science (2009) 6.14
All-trans retinoic acid mediates enhanced T reg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med (2007) 5.96
Transforming growth factor-beta controls development, homeostasis, and tolerance of T cells by regulatory T cell-dependent and -independent mechanisms. Immunity (2006) 5.91
Foxp3 occupancy and regulation of key target genes during T-cell stimulation. Nature (2007) 5.81
Peripheral education of the immune system by colonic commensal microbiota. Nature (2011) 5.80
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med (2007) 5.52
Regulatory T cell development in the absence of functional Foxp3. Nat Immunol (2007) 5.44
Coordination of early protective immunity to viral infection by regulatory T cells. Science (2008) 5.33
IL-2 receptor beta-dependent STAT5 activation is required for the development of Foxp3+ regulatory T cells. J Immunol (2007) 5.31
Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med (2004) 5.08
Foxp3+ follicular regulatory T cells control the germinal center response. Nat Med (2011) 4.83
Preferential generation of follicular B helper T cells from Foxp3+ T cells in gut Peyer's patches. Science (2009) 4.80
The biology of interleukin-2. Annu Rev Immunol (2008) 4.77
Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood (2007) 4.50
Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions. Nat Med (2011) 4.50
Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature (2012) 4.33
Developmental regulation of Foxp3 expression during ontogeny. J Exp Med (2005) 4.32
PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature (2012) 4.31
A two-step process for thymic regulatory T cell development. Immunity (2008) 4.29
Heterogeneity of natural Foxp3+ T cells: a committed regulatory T-cell lineage and an uncommitted minor population retaining plasticity. Proc Natl Acad Sci U S A (2009) 4.25
Selection of Foxp3+ regulatory T cells specific for self antigen expressed and presented by Aire+ medullary thymic epithelial cells. Nat Immunol (2007) 4.21
Role of alpha 4-integrins in lymphocyte homing to mucosal tissues in vivo. J Immunol (1994) 4.21
DNA methylation controls Foxp3 gene expression. Eur J Immunol (2008) 4.19
Origin and T cell receptor diversity of Foxp3+CD4+CD25+ T cells. Immunity (2006) 3.96
A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity (2011) 3.76
Oral tolerance in the absence of naturally occurring Tregs. J Clin Invest (2005) 3.73
Transforming growth factor-beta signaling curbs thymic negative selection promoting regulatory T cell development. Immunity (2010) 3.69
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire. Immunity (2008) 3.56
Adaptation of TCR repertoires to self-peptides in regulatory and nonregulatory CD4+ T cells. J Immunol (2007) 3.47
The transcription factors Blimp-1 and IRF4 jointly control the differentiation and function of effector regulatory T cells. Nat Immunol (2011) 3.44
Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as CD25- regulatory T cells. Proc Natl Acad Sci U S A (2002) 3.41
Neuropilin-1 distinguishes natural and inducible regulatory T cells among regulatory T cell subsets in vivo. J Exp Med (2012) 3.40
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation. Immunity (2011) 3.40
Regulatory T cells reinforce intestinal homeostasis. Immunity (2009) 3.27
Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflict. Cell (2012) 3.24
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage? Nat Rev Immunol (2009) 3.23
Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol (1999) 3.21
Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease. J Exp Med (2007) 3.17
Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature (1996) 3.11
Molecular mechanisms underlying FOXP3 induction in human T cells. J Immunol (2006) 3.09
Viral infections induce abundant numbers of senescent CD8 T cells. J Immunol (2001) 3.04
Oral tolerance. Immunol Rev (2011) 3.03
Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3+ T reg cells. J Exp Med (2012) 2.97
Response to self antigen imprints regulatory memory in tissues. Nature (2011) 2.96
Development of Foxp3(+) regulatory t cells is driven by the c-Rel enhanceosome. Immunity (2009) 2.84
A role for CD103 in the retention of CD4+CD25+ Treg and control of Leishmania major infection. J Immunol (2005) 2.81
Expression of Helios in peripherally induced Foxp3+ regulatory T cells. J Immunol (2011) 2.80
Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature (2013) 2.75
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues. J Immunol (2012) 2.70
CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa. J Clin Invest (2002) 2.63
The role of beta7 integrins in CD8 T cell trafficking during an antiviral immune response. J Exp Med (1999) 2.62
Generation of CD4(+)CD25(+) regulatory T cells from autoreactive T cells simultaneously with their negative selection in the thymus and from nonautoreactive T cells by endogenous TCR expression. J Immunol (2002) 2.56
Helios expression is a marker of T cell activation and proliferation. PLoS One (2011) 2.55
The cytokines interleukin 27 and interferon-γ promote distinct Treg cell populations required to limit infection-induced pathology. Immunity (2012) 2.52
Nuclear factor-kappaB modulates regulatory T cell development by directly regulating expression of Foxp3 transcription factor. Immunity (2009) 2.35
Genomic definition of multiple ex vivo regulatory T cell subphenotypes. Proc Natl Acad Sci U S A (2010) 2.30
Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells. J Immunol (2011) 2.27
Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3⁺ regulatory T cells. Nat Immunol (2013) 2.21
Cytokine-dependent Blimp-1 expression in activated T cells inhibits IL-2 production. J Immunol (2007) 2.18
Essential role for interleukin-2 for CD4(+)CD25(+) T regulatory cell development during the neonatal period. J Exp Med (2005) 2.12
Distinct activation signals determine whether IL-21 induces B cell costimulation, growth arrest, or Bim-dependent apoptosis. J Immunol (2004) 2.07
Function of the IL-2R for thymic and peripheral CD4+CD25+ Foxp3+ T regulatory cells. J Immunol (2007) 2.01
A low interleukin-2 receptor signaling threshold supports the development and homeostasis of T regulatory cells. Immunity (2009) 1.72
T-cell tolerance and the multi-functional role of IL-2R signaling in T-regulatory cells. Immunol Rev (2011) 1.69
Initial antigen encounter programs CD8+ T cells competent to develop into memory cells that are activated in an antigen-free, IL-7- and IL-15-rich environment. J Immunol (2004) 1.54
A function for IL-7R for CD4+CD25+Foxp3+ T regulatory cells. J Immunol (2008) 1.52
Therapeutic Treg expansion in mice by TNFRSF25 prevents allergic lung inflammation. J Clin Invest (2010) 1.50
Selective availability of IL-2 is a major determinant controlling the production of CD4+CD25+Foxp3+ T regulatory cells. J Immunol (2006) 1.30
Efficient induction of primary and secondary T cell-dependent immune responses in vivo in the absence of functional IL-2 and IL-15 receptors. J Immunol (2003) 1.23
Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity. J Clin Invest (2014) 1.22
IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells. J Immunol (2012) 1.21
Modeling the CD8+ T effector to memory transition in adoptive T-cell antitumor immunotherapy. Cancer Res (2008) 1.08
IL-2R signaling is essential for functional maturation of regulatory T cells during thymic development. J Immunol (2013) 1.07
The basis of distinctive IL-2- and IL-15-dependent signaling: weak CD122-dependent signaling favors CD8+ T central-memory cell survival but not T effector-memory cell development. J Immunol (2011) 1.06
Cutting edge: allogeneic CD4+CD25+Foxp3+ T regulatory cells suppress autoimmunity while establishing transplantation tolerance. J Immunol (2006) 1.06
Long-term islet allograft survival in nonobese diabetic mice treated with tacrolimus, rapamycin, and anti-interleukin-2 antibody. Transplantation (2003) 1.05
CD4(+) CD25(+) Foxp3(+) T regulatory cells with limited TCR diversity in control of autoimmunity. J Immunol (2009) 1.04
T helper cells, IL-2 and the generation of cytotoxic T-cell responses. Trends Immunol (2002) 1.00
Allogeneic T regulatory cell-mediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance. Blood (2009) 0.99
Non-redundant role for IL-7R signaling for the survival of CD8+ memory T cells. Eur J Immunol (2007) 0.96
Host CD4+CD25+ T cells can expand and comprise a major component of the Treg compartment after experimental HCT. Blood (2008) 0.95
The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation. Immunol Res (2013) 0.94
Cellular and molecular determinants for the development of natural and induced regulatory T cells. Hum Immunol (2012) 0.88
Structural basis for binding multiple ligands by the common cytokine receptor gamma-chain. J Biol Chem (2002) 0.88
On CD28/CD40 ligand costimulation, common gamma-chain signals, and the alloimmune response. J Immunol (2002) 0.86
Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis. J Clin Invest (2015) 0.84
IL7Rα contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages. J Immunol (2013) 0.84
Quantitative assessment concerning the contribution of IL-2Rbeta for superantigen-mediated T cell responses in vivo. Int Immunol (2006) 0.82
Transient enhanced IL-2R signaling early during priming rapidly amplifies development of functional CD8+ T effector-memory cells. J Immunol (2012) 0.82
Screening of an antigen target for immunocontraceptives from cross-reactive antigens between human sperm and Ureaplasma urealyticum. Infect Immun (2007) 0.79
Redundant and unique regulation of activated mouse B lymphocytes by IL-4 and IL-21. J Leukoc Biol (2006) 0.79
Low-dose IL-2 as a therapeutic agent for tolerance induction. Immunotherapy (2011) 0.78
Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice. Blood (2014) 0.78
Expansion of a restricted residual host T reg-cell repertoire is dependent on IL-2 following experimental autologous hematopoietic stem transplantation. Eur J Immunol (2011) 0.78
Therapeutic limitations in tumor-specific CD8+ memory T cell engraftment. BMC Cancer (2003) 0.77