Tissue-specific methylation of human insulin gene and PCR assay for monitoring beta cell death.

PubWeight™: 1.02‹?› | Rank: Top 15%

🔗 View Article (PMC 3983232)

Published in PLoS One on April 10, 2014

Authors

Mohamed I Husseiny1, Alexander Kaye2, Emily Zebadua2, Fouad Kandeel2, Kevin Ferreri2

Author Affiliations

1: Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of City of Hope, Duarte, California, United States of America; Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
2: Department of Diabetes and Metabolic Diseases Research, Beckman Research Institute of City of Hope, Duarte, California, United States of America.

Articles citing this

β cell death and dysfunction during type 1 diabetes development in at-risk individuals. J Clin Invest (2015) 1.31

Identification of tissue-specific cell death using methylation patterns of circulating DNA. Proc Natl Acad Sci U S A (2016) 1.06

Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes. Diabetes (2015) 0.94

Life and death of β cells in Type 1 diabetes: A comprehensive review. J Autoimmun (2016) 0.81

Methylation of insulin DNA in response to proinflammatory cytokines during the progression of autoimmune diabetes in NOD mice. Diabetologia (2016) 0.81

Plasma GAD65, a Marker for Early β-Cell Loss After Intraportal Islet Cell Transplantation in Diabetic Patients. J Clin Endocrinol Metab (2015) 0.79

Nucleic acid biomarkers of β cell stress and death in type 1 diabetes. Curr Opin Endocrinol Diabetes Obes (2016) 0.78

Biomarkers of β-Cell Stress and Death in Type 1 Diabetes. Curr Diab Rep (2016) 0.77

Applicability of digital PCR to the investigation of pediatric-onset genetic disorders. Biomol Detect Quantif (2016) 0.77

Unmethylated Insulin DNA Is Elevated After Total Pancreatectomy With Islet Autotransplantation: Assessment of a Novel Beta Cell Marker. Am J Transplant (2016) 0.76

Strategies for clinical trials in type 1 diabetes. J Autoimmun (2016) 0.75

Measurement of Differentially Methylated INS DNA Species in Human Serum Samples as a Biomarker of Islet β Cell Death. J Vis Exp (2016) 0.75

Circulating unmethylated insulin DNA as a potential non-invasive biomarker of beta cell death in type 1 Diabetes: a review and future prospect. Clin Epigenetics (2017) 0.75

Epigenetic control of β-cell function and failure. Diabetes Res Clin Pract (2016) 0.75

The effects of C5-substituted 2,4-diaminoquinazolines on selected transcript expression in spinal muscular atrophy cells. PLoS One (2017) 0.75

Articles cited by this

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants. Lancet (2011) 19.21

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet (2009) 16.53

Incidence and trends of childhood Type 1 diabetes worldwide 1990-1999. Diabet Med (2006) 6.71

Type 1 diabetes: new perspectives on disease pathogenesis and treatment. Lancet (2001) 6.14

Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature (2010) 5.16

HLA DR-DQ haplotypes and genotypes and type 1 diabetes risk: analysis of the type 1 diabetes genetics consortium families. Diabetes (2008) 4.94

Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A (2003) 3.75

Type-I diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu Rev Immunol (1990) 3.35

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med (2012) 2.86

Trends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase. Diabetologia (2012) 2.85

Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci U S A (2005) 2.70

Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein. Proc Natl Acad Sci U S A (1990) 2.23

Insulin gene expression is regulated by DNA methylation. PLoS One (2009) 1.97

Detection of β cell death in diabetes using differentially methylated circulating DNA. Proc Natl Acad Sci U S A (2011) 1.77

Beta-cell mass and type 1 diabetes: going, going, gone? Diabetes (2008) 1.69

Validity and reproducibility of measurement of islet autoreactivity by T-cell assays in subjects with early type 1 diabetes. Diabetes (2009) 1.43

Immune therapy and β-cell death in type 1 diabetes. Diabetes (2013) 1.33

First-phase insulin release during the intravenous glucose tolerance test as a risk factor for type 1 diabetes. J Pediatr (2001) 1.29

Predictive value of intravenous glucose tolerance test insulin secretion less than or greater than the first percentile in islet cell antibody positive relatives of type 1 (insulin-dependent) diabetic patients. Diabetologia (1991) 1.27

The peri-islet basement membrane, a barrier to infiltrating leukocytes in type 1 diabetes in mouse and human. Diabetes (2012) 1.27

The prediction of type 1 diabetes by multiple autoantibody levels and their incorporation into an autoantibody risk score in relatives of type 1 diabetic patients. Diabetes Care (2013) 1.23

CD8+ T cells in type 1 diabetes. Adv Immunol (2008) 1.22

Detection of islet β-cell death in vivo by multiplex PCR analysis of differentially methylated DNA. Endocrinology (2013) 1.14

Development of a quantitative methylation-specific polymerase chain reaction method for monitoring beta cell death in type 1 diabetes. PLoS One (2012) 1.14

Pancreatic diabetes manifests when beta cell area declines by approximately 65% in humans. Diabetologia (2012) 1.08

Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Diabetes (2008) 1.06

Autoimmune diabetes and the circle of tolerance. Diabetes (2004) 1.03

Prediction of type 1 diabetes: the natural history of the prediabetic period. Adv Exp Med Biol (2004) 0.90

Clinical evolution of beta cell function in youth with diabetes: the SEARCH for Diabetes in Youth study. Diabetologia (2012) 0.87

Ontogenesis of hepatic and pancreatic stem cells. Stem Cell Rev (2012) 0.80

The Development and Application of HLA Tetramers in the Detection, Characterization and Therapy of Type 1 Diabetes Mellitus. Rev Diabet Stud (2007) 0.78