Published in PLoS One on April 10, 2014
AKT1 Activation Promotes Development of Melanoma Metastases. Cell Rep (2015) 1.00
Hyperphosphorylation of ribosomal protein S6 predicts unfavorable clinical survival in non-small cell lung cancer. J Exp Clin Cancer Res (2015) 0.87
miR-185 acts as a tumor suppressor by targeting AKT1 in non-small cell lung cancer cells. Int J Clin Exp Pathol (2015) 0.81
Influence of AKT on progesterone action in endometrial diseases. Biol Reprod (2014) 0.80
Akt isoform specific effects in ovarian cancer progression. Oncotarget (2016) 0.79
Early Steps of Jaagsiekte Sheep Retrovirus-Mediated Cell Transformation Involve the Interaction between Env and the RALBP1 Cellular Protein. J Virol (2015) 0.79
Unique roles of Akt1 and Akt2 in IGF-IR mediated lung tumorigenesis. Oncotarget (2016) 0.78
Downregulation of AKT3 Increases Migration and Metastasis in Triple Negative Breast Cancer Cells by Upregulating S100A4. PLoS One (2016) 0.78
AKT isoforms modulate Th1-like Treg generation and function in human autoimmune disease. EMBO Rep (2016) 0.77
Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells. Cell Death Dis (2015) 0.77
Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation. Sci Rep (2015) 0.76
Up-regulation of thrombospondin-2 in Akt1-null mice contributes to compromised tissue repair due to abnormalities in fibroblast function. J Biol Chem (2014) 0.76
Regulation of PI3K effector signalling in cancer by the phosphoinositide phosphatases. Biosci Rep (2017) 0.75
Trichostatin A attenuates ventilation-augmented epithelial-mesenchymal transition in mice with bleomycin-induced acute lung injury by suppressing the Akt pathway. PLoS One (2017) 0.75
Preferential effect of akt2-dependent signaling on the cellular viability of ovarian cancer cells in response to EGF. J Cancer (2014) 0.75
Akt as a target for cancer therapy: more is not always better (lessons from studies in mice). Br J Cancer (2017) 0.75
Role of RANK and Akt1 activation in human osteosarcoma progression: A clinicopathological study. Exp Ther Med (2017) 0.75
Molecular mechanisms underlying Th1-like Treg generation and function. Cell Mol Life Sci (2017) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
TOR signaling in growth and metabolism. Cell (2006) 35.29
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell (1999) 32.32
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell (1997) 21.42
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
Cellular survival: a play in three Akts. Genes Dev (1999) 17.05
Epidermal growth factor receptor mutations in lung cancer. Nat Rev Cancer (2007) 14.84
Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst (2005) 13.00
Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov (2005) 11.46
Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science (2001) 11.22
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol (2007) 8.07
Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol (2002) 8.04
The renaissance of GSK3. Nat Rev Mol Cell Biol (2001) 7.99
Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications. Cancer Res (2004) 7.76
Akt1/PKBalpha is required for normal growth but dispensable for maintenance of glucose homeostasis in mice. J Biol Chem (2001) 7.10
Diabetes and cancer: a consensus report. Diabetes Care (2010) 6.71
Perturbations of the AKT signaling pathway in human cancer. Oncogene (2005) 6.64
Lung cancer in never smokers--a different disease. Nat Rev Cancer (2007) 6.41
Systemic delivery of genes to striated muscles using adeno-associated viral vectors. Nat Med (2004) 5.59
Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol (2005) 4.00
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell (2006) 3.83
Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. Clin Cancer Res (2006) 3.40
Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J Biol Chem (2003) 3.27
Cigarette smoking is strongly associated with mutation of the K-ras gene in patients with primary adenocarcinoma of the lung. Cancer (2001) 3.22
Akt1 ablation inhibits, whereas Akt2 ablation accelerates, the development of mammary adenocarcinomas in mouse mammary tumor virus (MMTV)-ErbB2/neu and MMTV-polyoma middle T transgenic mice. Cancer Res (2007) 3.13
Never-smokers with lung cancer: epidemiologic evidence of a distinct disease entity. J Clin Oncol (2006) 2.86
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice. Genes Dev (2006) 2.76
Glycogen synthase kinase-3beta participates in nuclear factor kappaB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res (2005) 2.72
Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A (2007) 2.67
Transduction by adeno-associated virus vectors in the rabbit airway: efficiency, persistence, and readministration. J Virol (1997) 2.65
Glycogen synthase kinase 3beta (GSK3beta) in tumorigenesis and cancer chemotherapy. Cancer Lett (2008) 2.57
Insulin-mediated acceleration of breast cancer development and progression in a nonobese model of type 2 diabetes. Cancer Res (2010) 2.13
Akt signaling and cancer: surviving but not moving on. Cancer Res (2006) 2.10
Thiazolidinedione use and cancer incidence in type 2 diabetes: a systematic review and meta-analysis. Diabetes Metab (2012) 2.06
Frequent activation of AKT in non-small cell lung carcinomas and preneoplastic bronchial lesions. Carcinogenesis (2004) 1.92
Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer. Cell Signal (2008) 1.81
Efficient mouse airway transduction following recombination between AAV vectors carrying parts of a larger gene. Nat Biotechnol (2002) 1.69
Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors. J Clin Oncol (2005) 1.64
Sheep retrovirus structural protein induces lung tumours. Nature (2005) 1.61
Increased phospho-AKT (Ser(473)) expression in bronchial dysplasia: implications for lung cancer prevention studies. Cancer Epidemiol Biomarkers Prev (2003) 1.42
Sheep pulmonary adenomatosis: a unique model of retrovirus-associated lung cancer. Trends Microbiol (1997) 1.41
The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation: a 2009 update. Curr Top Med Chem (2010) 1.29
Glycogen synthase kinase-3: a new therapeutic target in renal cell carcinoma. Br J Cancer (2009) 1.29
Epithelial-stromal interaction increases cell proliferation, survival and tumorigenicity in a mouse model of human epithelial ovarian cancer. Gynecol Oncol (2007) 1.21
Expression of the jaagsiekte sheep retrovirus envelope glycoprotein is sufficient to induce lung tumors in sheep. J Virol (2006) 1.19
Akt1 deletion prevents lung tumorigenesis by mutant K-ras. Oncogene (2011) 1.17
Oncogenic transformation by the jaagsiekte sheep retrovirus envelope protein. Oncogene (2006) 1.07
Clinical and molecular mechanisms favoring cancer initiation and progression in diabetic patients. Nutr Metab Cardiovasc Dis (2013) 1.02
Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes. Breast Cancer Res (2012) 1.01
The suppression of lung tumorigenesis by aerosol-delivered folate-chitosan-graft-polyethylenimine/Akt1 shRNA complexes through the Akt signaling pathway. Biomaterials (2009) 0.99
Lung cancer pathology in smokers, ex-smokers and never smokers. Cancer Lett (1995) 0.97
The effect Akt2 deletion on tumor development in Pten(+/-) mice. Oncogene (2011) 0.96
Pathology of human bronchioloalveolar carcinoma and its relationship to the ovine disease. Curr Top Microbiol Immunol (2003) 0.96
Lung cancer induced in mice by the envelope protein of jaagsiekte sheep retrovirus (JSRV) closely resembles lung cancer in sheep infected with JSRV. Retrovirology (2006) 0.96
Poly(ester amine)-mediated, aerosol-delivered Akt1 small interfering RNA suppresses lung tumorigenesis. Am J Respir Crit Care Med (2008) 0.96
Akt1 deficiency delays tumor progression, vascular invasion, and distant metastasis in a murine model of thyroid cancer. Oncogene (2011) 0.92
Activated Akt expression has significant correlation with EGFR and TGF-alpha expressions in stage I NSCLC. Anticancer Res (2004) 0.90
Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma. Lung Cancer (2006) 0.87
Allosteric inhibitors of Akt1 and Akt2: discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity. Bioorg Med Chem Lett (2008) 0.86
New transformation tricks from a barnyard retrovirus: implications for human lung cancer. Proc Natl Acad Sci U S A (2001) 0.85
Hyperinsulinemia promotes metastasis to the lung in a mouse model of Her2-mediated breast cancer. Endocr Relat Cancer (2013) 0.84
Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice. BMC Cancer (2013) 0.84
Adeno-associated virus vector mediated expression of an oncogenic retroviral envelope protein induces lung adenocarcinomas in immunocompetent mice. PLoS One (2012) 0.83