RasGRP Ras guanine nucleotide exchange factors in cancer.

PubWeight™: 1.04‹?› | Rank: Top 15%

🔗 View Article (PMID 24744772)

Published in Front Biol (Beijing) on October 01, 2013

Authors

Olga Ksionda1, Andre Limnander1, Jeroen P Roose1

Author Affiliations

1: Department of Anatomy, University of California, San Francisco, San Francisco, CA 94143, USA.

Articles citing this

RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nat Cell Biol (2015) 1.03

Regulation of ras exchange factors and cellular localization of ras activation by lipid messengers in T cells. Front Immunol (2013) 0.95

The role of wild type RAS isoforms in cancer. Semin Cell Dev Biol (2016) 0.81

Nuclear EGFR impairs ASPP2-p53 complex-induced apoptosis by inducing SOS1 expression in hepatocellular carcinoma. Oncotarget (2015) 0.80

8-Oxoguanine DNA glycosylase-1-driven DNA base excision repair: role in asthma pathogenesis. Curr Opin Allergy Clin Immunol (2015) 0.79

RasGRP1 overexpression in T-ALL increases basal nucleotide exchange on Ras rendering the Ras/PI3K/Akt pathway responsive to protumorigenic cytokines. Oncogene (2015) 0.77

Lost GRP on cytotoxicity? Nat Immunol (2016) 0.76

RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell (2017) 0.76

Blood miRNomes and transcriptomes reveal novel longevity mechanisms in the long-lived bat, Myotis myotis. BMC Genomics (2016) 0.75

Dysregulation of RasGRP1 in rheumatoid arthritis and modulation of RasGRP3 as a biomarker of TNFα inhibitors. Arthritis Res Ther (2015) 0.75

Distinct oncogenic Ras signals characterized by profound differences in flux through the RasGDP/RasGTP cycle. Small GTPases (2016) 0.75

Protein kinase C in cancer: The top five unanswered questions. Mol Carcinog (2017) 0.75

Flavors of EGFR-Ras signals impacting intestinal homeostasis. Cell Cycle (2015) 0.75

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1. Elife (2017) 0.75

Articles cited by this

(truncated to the top 100)

Cancer genome landscapes. Science (2013) 25.33

Mammalian MAP kinase signalling cascades. Nature (2001) 18.89

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84

The development of androgen-independent prostate cancer. Nat Rev Cancer (2001) 11.88

Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature (2012) 10.39

The genetic basis of early T-cell precursor acute lymphoblastic leukaemia. Nature (2012) 9.89

The guanine nucleotide-binding switch in three dimensions. Science (2001) 9.34

Positive and negative selection of T cells. Annu Rev Immunol (2002) 8.32

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature (2012) 8.13

T cell activation. Annu Rev Immunol (2009) 7.40

GEFs and GAPs: critical elements in the control of small G proteins. Cell (2007) 7.32

In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell (1997) 7.18

NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc Natl Acad Sci U S A (2006) 6.80

Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell (2002) 6.64

Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med (2007) 6.55

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev (2006) 6.19

Sequential application of anticancer drugs enhances cell death by rewiring apoptotic signaling networks. Cell (2012) 5.92

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature (2007) 5.65

Calcium signalling in lymphocyte activation and disease. Nat Rev Immunol (2007) 5.62

Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood (2001) 5.17

Thymic selection threshold defined by compartmentalization of Ras/MAPK signalling. Nature (2006) 5.05

Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia. Lancet Oncol (2009) 4.89

Nucleophosmin and cancer. Nat Rev Cancer (2006) 4.82

RasGRP is essential for mouse thymocyte differentiation and TCR signaling. Nat Immunol (2000) 4.28

New genes involved in cancer identified by retroviral tagging. Nat Genet (2002) 4.14

Induction of self-tolerance in mature peripheral B lymphocytes. Nature (1989) 4.02

Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer (2006) 3.89

High-throughput retroviral tagging to identify components of specific signaling pathways in cancer. Nat Genet (2002) 3.81

Structures and metal-ion-binding properties of the Ca2+-binding helix-loop-helix EF-hand motifs. Biochem J (2007) 3.69

Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature (2003) 3.66

Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy? Nat Rev Cancer (2010) 3.59

B cell antigen receptor signaling 101. Mol Immunol (2004) 3.58

Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol (2008) 3.57

The earliest thymic progenitors for T cells possess myeloid lineage potential. Nature (2008) 3.48

Digital signaling and hysteresis characterize ras activation in lymphoid cells. Cell (2009) 3.47

Adult T-cell progenitors retain myeloid potential. Nature (2008) 3.41

Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation. Proc Natl Acad Sci U S A (2002) 3.28

RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. Science (1998) 3.20

Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applications. Nat Protoc (2009) 3.14

Antigen presentation in the thymus for positive selection and central tolerance induction. Nat Rev Immunol (2009) 3.13

Myelodysplastic syndromes: the complexity of stem-cell diseases. Nat Rev Cancer (2007) 3.10

Compartmentalized Ras/MAPK signaling. Annu Rev Immunol (2006) 3.03

CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation. Nat Med (2004) 3.03

High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia. Blood (2009) 3.02

Aberrant B cell development and immune response in mice with a compromised BCR complex. Science (1996) 3.01

Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol (2011) 2.81

The follicular versus marginal zone B lymphocyte cell fate decision. Nat Rev Immunol (2009) 2.80

Genetic analysis of B cell antigen receptor signaling. Annu Rev Immunol (1999) 2.73

Endogenous antigen tunes the responsiveness of naive B cells but not T cells. Nature (2012) 2.64

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. Proc Natl Acad Sci U S A (1998) 2.47

RasGRP links T-cell receptor signaling to Ras. Blood (2000) 2.46

CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors. Leukemia (2006) 2.40

Stem-cell hierarchy in skin cancer. Nat Rev Cancer (2003) 2.36

Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells. J Exp Med (2004) 2.32

Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia. Nat Genet (2011) 2.32

Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia. Blood (2007) 2.29

Selective hypersensitivity to granulocyte-macrophage colony-stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors. Blood (1991) 2.22

A diacylglycerol-protein kinase C-RasGRP1 pathway directs Ras activation upon antigen receptor stimulation of T cells. Mol Cell Biol (2005) 2.16

Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity (2008) 2.16

B-cell anergy: from transgenic models to naturally occurring anergic B cells? Nat Rev Immunol (2007) 2.08

Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in lymphocytes. Mol Cell Biol (2007) 2.05

Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III. J Clin Invest (2007) 2.05

From keratinocyte to cancer: the pathogenesis and modeling of cutaneous squamous cell carcinoma. J Clin Invest (2012) 2.01

Ras oncogenes and their downstream targets. Biochim Biophys Acta (2007) 2.00

Structural basis for diversity of the EF-hand calcium-binding proteins. J Mol Biol (2006) 1.92

Cytogenetics and molecular genetics of T-cell acute lymphoblastic leukemia: from thymocyte to lymphoblast. Leukemia (2006) 1.90

Targeting nonclassical oncogenes for therapy in T-ALL. Cancer Cell (2012) 1.86

Positive and negative selection invoke distinct signaling pathways. J Exp Med (1996) 1.86

Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes. Nat Immunol (2011) 1.84

Network medicine. FEBS Lett (2008) 1.84

Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection. Cell (1998) 1.78

Cell of origin strongly influences genetic selection in a mouse model of T-ALL. Blood (2011) 1.78

BCR ligation induces receptor editing in IgM+IgD- bone marrow B cells in vitro. Immunity (1997) 1.76

K-ras as a target for cancer therapy. Biochim Biophys Acta (2005) 1.74

RasGRP1 transduces low-grade TCR signals which are critical for T cell development, homeostasis, and differentiation. Immunity (2002) 1.73

Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras. Nature (2009) 1.72

Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. Nat Genet (2011) 1.71

RasGRP1 and RasGRP3 regulate B cell proliferation by facilitating B cell receptor-Ras signaling. J Immunol (2005) 1.70

Regulation of ras signaling dynamics by Sos-mediated positive feedback. Curr Biol (2006) 1.70

Targeting oncogenic Ras signaling in hematologic malignancies. Blood (2012) 1.67

B cell development: signal transduction by antigen receptors and their surrogates. Curr Opin Immunol (1999) 1.55

Alterations of the p53, p21, p16, p15 and RAS genes in childhood T-cell acute lymphoblastic leukemia. Leuk Res (1999) 1.54

Autocrine secretion of GM-CSF in acute myeloblastic leukemia. Blood (1986) 1.53

Leukemia-associated NF1 inactivation in patients with pediatric T-ALL and AML lacking evidence for neurofibromatosis. Blood (2008) 1.51

Transitional B cells: step by step towards immune competence. Trends Immunol (2003) 1.50

Role of protein kinase C in T-cell antigen receptor regulation of p21ras: evidence that two p21ras regulatory pathways coexist in T cells. Mol Cell Biol (1992) 1.48

Genome-based identification of cancer genes by proviral tagging in mouse retrovirus-induced T-cell lymphomas. J Virol (2003) 1.47

Requirement for Ras guanine nucleotide releasing protein 3 in coupling phospholipase C-gamma2 to Ras in B cell receptor signaling. J Exp Med (2003) 1.44

CalDAG-GEFI and protein kinase C represent alternative pathways leading to activation of integrin alphaIIbbeta3 in platelets. Blood (2008) 1.41

Phosphorylation of RasGRP3 on threonine 133 provides a mechanistic link between PKC and Ras signaling systems in B cells. Blood (2005) 1.41

Essential role for Rap1 GTPase and its guanine exchange factor CalDAG-GEFI in LFA-1 but not VLA-4 integrin mediated human T-cell adhesion. Blood (2007) 1.41

CalDAG-GEFIII activation of Ras, R-ras, and Rap1. J Biol Chem (2000) 1.40

STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development. Nat Immunol (2011) 1.37

Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3. Blood (2003) 1.37

Signaling in transitional type 2 B cells is critical for peripheral B-cell development. Immunol Rev (2004) 1.34

The chosen few? Positive selection and the generation of naive B lymphocytes. Immunity (1999) 1.32

Targeted Sos1 deletion reveals its critical role in early T-cell development. Proc Natl Acad Sci U S A (2011) 1.30

RasGRP4, a new mast cell-restricted Ras guanine nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. Identification of defective variants of this signaling protein in asthma, mastocytosis, and mast cell leukemia patients and demonstration of the importance of RasGRP4 in mast cell development and function. J Biol Chem (2002) 1.29

Dual inhibition of class IA phosphatidylinositol 3-kinase and mammalian target of rapamycin as a new therapeutic option for T-cell acute lymphoblastic leukemia. Cancer Res (2009) 1.29

Positive selection and lineage commitment during peripheral B-lymphocyte development. Immunol Rev (2004) 1.29

Articles by these authors

RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma. Cancer Cell (2017) 0.76