Published in Nat Rev Drug Discov on April 22, 2014
Type I/II cytokines, JAKs, and new strategies for treating autoimmune diseases. Nat Rev Rheumatol (2015) 1.11
Nivolumab in melanoma: latest evidence and clinical potential. Ther Adv Med Oncol (2015) 1.09
IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation, and microbiome in ARV-treated, SIV-infected macaques. Mucosal Immunol (2015) 0.94
Common gamma chain cytokines in combinatorial immune strategies against cancer. Immunol Lett (2015) 0.91
Loss of interleukin-21 receptor activation in hypoxic endothelial cells impairs perfusion recovery after hindlimb ischemia. Arterioscler Thromb Vasc Biol (2015) 0.89
Identification of novel HIV-1 dependency factors in primary CCR4(+)CCR6(+)Th17 cells via a genome-wide transcriptional approach. Retrovirology (2015) 0.85
IL-21 Signaling in Immunity. F1000Res (2016) 0.84
Cytokine-Induced Modulation of Colorectal Cancer. Front Oncol (2016) 0.84
IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells. Nat Commun (2015) 0.84
IL-21: a pleiotropic cytokine with potential applications in oncology. J Immunol Res (2015) 0.83
Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis. Oncotarget (2015) 0.81
Berberine may rescue Fusobacterium nucleatum-induced colorectal tumorigenesis by modulating the tumor microenvironment. Oncotarget (2015) 0.80
Regulation of autoimmune germinal center reactions in lupus-prone BXD2 mice by follicular helper T cells. PLoS One (2015) 0.80
Contribution of enhanced engagement of antigen presentation machinery to the clinical immunogenicity of a human interleukin (IL)-21 receptor-blocking therapeutic antibody. Clin Exp Immunol (2015) 0.79
IL-21 and T Cell Differentiation: Consider the Context. Trends Immunol (2016) 0.79
IL-21 signaling is essential for optimal host resistance against Mycobacterium tuberculosis infection. Sci Rep (2016) 0.78
The Lupus Susceptibility Gene Pbx1 Regulates the Balance between Follicular Helper T Cell and Regulatory T Cell Differentiation. J Immunol (2016) 0.78
Immunophenotyping of rheumatoid arthritis reveals a linkage between HLA-DRB1 genotype, CXCR4 expression on memory CD4(+) T cells, and disease activity. Sci Rep (2016) 0.78
Dual Roles of IL-27 in Cancer Biology and Immunotherapy. Mediators Inflamm (2017) 0.78
Endothelial interleukin-21 receptor up-regulation in peripheral artery disease. Vasc Med (2015) 0.77
Interleukin-21 administration to aged mice rejuvenates their peripheral T-cell pool by triggering de novo thymopoiesis. Aging Cell (2016) 0.77
IL-21 Is Important for Induction of KLRG1+ Effector CD8 T Cells during Acute Intracellular Infection. J Immunol (2015) 0.77
Interleukin-21 signaling in B cells, but not in T cells, is indispensable for the development of collagen-induced arthritis in mice. Arthritis Res Ther (2016) 0.77
Understanding Immune Cells in Tertiary Lymphoid Organ Development: It Is All Starting to Come Together. Front Immunol (2016) 0.76
Phenotype and function of CXCR5+CD45RA-CD4+ T cells were altered in HBV-related hepatocellular carcinoma and elevated serum CXCL13 predicted better prognosis. Oncotarget (2015) 0.76
Interleukin-21 induces migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis. Clin Exp Immunol (2016) 0.75
Translational opportunities for targeting the Th17 axis in acute graft-vs.-host disease. Mucosal Immunol (2016) 0.75
B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity. Front Neurol (2017) 0.75
Forced co-expression of IL-21 and IL-7 in whole-cell cancer vaccines promotes antitumor immunity. Sci Rep (2016) 0.75
Increased Frequency of T Follicular Helper Cells and Elevated Interleukin-27 Plasma Levels in Patients with Pemphigus. PLoS One (2016) 0.75
Astrocyte-specific overexpressed gene signatures in response to methamphetamine exposure in vitro. J Neuroinflammation (2017) 0.75
Activation of the FcgammaReceptorIIIa on human natural killer cells leads to increased expression of functional interleukin-21 receptor. Oncoimmunology (2017) 0.75
Mechanism involved in interleukin-21-induced phagocytosis in human monocytes and macrophages. Clin Exp Immunol (2016) 0.75
Interleukin-21 promotes osteoclastogenesis in RAW264.7 cells through the PI3K/AKT signaling pathway independently of RANKL. Int J Mol Med (2016) 0.75
Impaired coronary microcirculation in type 2 diabetic patients is associated with elevated circulating regulatory T cells and reduced number of IL-21R(+) T cells. Cardiovasc Diabetol (2016) 0.75
IL-15 enhances the antitumor effect of human antigen-specific CD8(+) T cells by cellular senescence delay. Oncoimmunology (2016) 0.75
Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells. Nat Immunol (2016) 0.75
Reinvigorating Exhausted T Cells by Blockade of the PD-1 Pathway. For Immunopathol Dis Therap (2015) 0.75
Activated Circulating T Follicular Helper Cells Are Associated with Disease Severity in Patients with Psoriasis. J Immunol Res (2016) 0.75
Advances of the interleukin-21 signaling pathway in immunity and angiogenesis. Biomed Rep (2016) 0.75
CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells are positively correlated with levels of IL-21 in active and transitional cystic echinococcosis patients. BMC Infect Dis (2015) 0.75
Observational study of Interleukin-21 (IL-21) does not distinguish Kawasaki disease from other causes of fever in children. Pediatr Rheumatol Online J (2017) 0.75
JAK-STAT-mediated chronic inflammation impairs cytotoxic T lymphocyte activation to decrease anti-PD-1 immunotherapy efficacy in pancreatic cancer. Oncoimmunology (2017) 0.75
TOWARDS THE DEVELOPMENT OF NOVEL THERAPEUTICS FOR PERIPHERAL ARTERY DISEASE. Trans Am Clin Climatol Assoc (2016) 0.75
Inflammatory mechanisms in tendinopathy - towards translation. Nat Rev Rheumatol (2017) 0.75
Phenotypic and functional characteristics of IL-21-expressing CD8(+) T cells in human nasal polyps. Sci Rep (2016) 0.75
Disruption of Pathogenic Cellular Networks by IL-21 Blockade Leads to Disease Amelioration in Murine Lupus. J Immunol (2017) 0.75
Peripheral inflammatory markers indicate microstructural damage within periventricular white matter hyperintensities in Alzheimer's disease: A preliminary report. Alzheimers Dement (Amst) (2017) 0.75
Are Peripheral Natural Killer Cells and Interleukin-21 Interrelated in Psoriasis Pathogenesis? Ann Dermatol (2017) 0.75
Identification of the novel 3' UTR sequences of human IL-21 mRNA as potential targets of miRNAs. Sci Rep (2017) 0.75
Loss of thymic innate lymphoid cells leads to impaired thymopoiesis in experimental graft vs. host disease. Blood (2017) 0.75
IL-21 Is Positively Associated with Intervertebral Disc Degeneration by Interaction with TNF-α Through the JAK-STAT Signaling Pathway. Inflammation (2017) 0.75
Citrobacter rodentium: a model enteropathogen for understanding the interplay of innate and adaptive components of type 3 immunity. Mucosal Immunol (2017) 0.75
Interleukin 21 inhibits cancer-mediated FOXP3 induction in naïve human CD4 T cells. Cancer Immunol Immunother (2017) 0.75
Human mucosal-associated invariant T (MAIT) cells possess capacity for B-cell help. J Leukoc Biol (2017) 0.75
The circadian gene Arntl2 on distal mouse chromosome 6 controls thymocyte apoptosis. Mamm Genome (2016) 0.75