Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions.

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Published in Lancet Infect Dis on April 24, 2014

Authors

Jason A Roberts1, Mohd H Abdul-Aziz2, Jeffrey Lipman3, Johan W Mouton4, Alexander A Vinks5, Timothy W Felton6, William W Hope7, Andras Farkas8, Michael N Neely9, Jerome J Schentag10, George Drusano11, Otto R Frey12, Ursula Theuretzbacher13, Joseph L Kuti14, International Society of Anti-Infective Pharmacology and the Pharmacokinetics and Pharmacodynamics Study Group of the European Society of Clinical Microbiology and Infectious Diseases

Author Affiliations

1: Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia. Electronic address: j.roberts2@uq.edu.au.
2: Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia.
3: Burns, Trauma and Critical Care Research Centre, The University of Queensland, Brisbane, QLD, Australia; Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.
4: Nijmegen Medical Centre, Radboud University, Nijmegen, Netherlands.
5: Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH, USA.
6: Faculty of Science, University of Manchester, Manchester, UK.
7: Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
8: Department of Pharmacy, Nyack Hospital, Nyack, NY, USA.
9: Laboratory of Applied Pharmacokinetics, University of Southern California, Los Angeles, CA, USA.
10: School of Pharmacy, University of Buffalo, Buffalo, NY, USA.
11: Institute for Therapeutic Innovation, College of Medicine, Department of Medicine, University of Florida, Gainesville, FL, USA.
12: Department of Pharmacy, Heidenheim Hospital, Heidenheim, Germany.
13: Center for Anti-Infective Agents, Vienna, Austria.
14: Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, CT, USA.

Associated clinical trials:

Bioelectrical Impedance Analysis as a Bedside Tool to Estimate Volume of Distribution of Hydrophilic Antimicrobials in Critically Ill Patients | NCT03410771

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