Increased frequency of ICOS+ CD4 T cells as a pharmacodynamic biomarker for anti-CTLA-4 therapy.

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Published in Cancer Immunol Res on July 31, 2013

Authors

Derek Ng Tang1, Yu Shen, Jingjing Sun, Sijin Wen, Jedd D Wolchok, Jianda Yuan, James P Allison, Padmanee Sharma

Author Affiliations

1: Authors' Affiliations: Ludwig Center for Cancer Immunotherapy, Memorial Sloan-Kettering Cancer Center, New York, New York.

Associated clinical trials:

Compassionate Use Trial for Unresectable Melanoma With Ipilimumab | NCT00495066

Vaccine Therapy in Treating Patients With Stage IIB, Stage IIC, Stage III, or Stage IV Melanoma | NCT00398073

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