Role of pancreatic stellate cells in chemoresistance in pancreatic cancer.

Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages. PLoS One (2015) 0.91

Molecular mechanisms underlying the role of microRNAs in the chemoresistance of pancreatic cancer. Biomed Res Int (2014) 0.90

Pancreatic cancer stromal biology and therapy. Genes Dis (2015) 0.87

Thiol-ene hydrogels as desmoplasia-mimetic matrices for modeling pancreatic cancer cell growth, invasion, and drug resistance. Biomaterials (2014) 0.81

ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion. Nat Commun (2016) 0.78

Exploiting base excision repair to improve therapeutic approaches for pancreatic cancer. Front Nutr (2015) 0.78

ATRA modulates mechanical activation of TGF-β by pancreatic stellate cells. Sci Rep (2016) 0.77

Targeting of the P2X7 receptor in pancreatic cancer and stellate cells. Int J Cancer (2016) 0.75

The anti-fibrotic effect of GV1001 combined with gemcitabine on treatment of pancreatic ductal adenocarcinoma. Oncotarget (2016) 0.75

MutY-Homolog (MYH) inhibition reduces pancreatic cancer cell growth and increases chemosensitivity. Oncotarget (2017) 0.75

Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models. Mol Cancer Ther (2016) 0.75

Response. J Natl Cancer Inst (2015) 0.75

Autocrine and Paracrine Mechanisms Promoting Chemoresistance in Cholangiocarcinoma. Int J Mol Sci (2017) 0.75

Retinoids in the pancreas. Hepatobiliary Surg Nutr (2016) 0.75

Modified methods for isolation of pancreatic stellate cells from human and rodent pancreas. J Biomed Res (2016) 0.75

Impact of Angiotensin Receptor Blocker Use on Overall Survival Among Patients Undergoing Resection for Pancreatic Cancer. World J Surg (2017) 0.75

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science (2009) 18.40

Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine. N Engl J Med (2013) 16.24

Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. Cancer Cell (2009) 16.06

Pancreatic cancer. N Engl J Med (2010) 13.88

Accelerated metastasis after short-term treatment with a potent inhibitor of tumor angiogenesis. Cancer Cell (2009) 13.09

Targeting multidrug resistance in cancer. Nat Rev Drug Discov (2006) 10.55

Pancreatic cancer. Lancet (2011) 8.54

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 7.57

Pancreatic cancer biology and genetics. Nat Rev Cancer (2002) 7.36

Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial. J Clin Oncol (2011) 6.16

Cancer-associated stromal fibroblasts promote pancreatic tumor progression. Cancer Res (2008) 5.21

Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J (2001) 5.20

Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol (2006) 4.71

Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer (2008) 4.43

Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res (2009) 4.19

The pancreas cancer microenvironment. Clin Cancer Res (2012) 4.10

Stromal biology and therapy in pancreatic cancer. Gut (2010) 3.80

Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture. Gut (1998) 3.77

Epidemiology of pancreatic cancer: an overview. Nat Rev Gastroenterol Hepatol (2009) 3.67

The pancreatic stellate cell: a star on the rise in pancreatic diseases. J Clin Invest (2007) 3.39

Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. Gut (1999) 3.36

Pancreatic tumors show high levels of hypoxia. Int J Radiat Oncol Biol Phys (2000) 3.22

Pancreatic carcinoma cells induce fibrosis by stimulating proliferation and matrix synthesis of stellate cells. Gastroenterology (2005) 3.18

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer. Gut (2012) 3.13

Decreased blood flow with increased metabolic activity: a novel sign of pancreatic tumor aggressiveness. Clin Cancer Res (2009) 3.01

Recent progress in pancreatic cancer. CA Cancer J Clin (2013) 2.88

Desmoplastic reaction in pancreatic cancer: role of pancreatic stellate cells. Pancreas (2004) 2.85

Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1). J Pathol (2005) 2.70

Pancreatic stellate cells: partners in crime with pancreatic cancer cells. Cancer Res (2008) 2.66

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc Natl Acad Sci U S A (2012) 2.66

Angiotensin inhibition enhances drug delivery and potentiates chemotherapy by decompressing tumour blood vessels. Nat Commun (2013) 2.31

Tumor stroma interactions induce chemoresistance in pancreatic ductal carcinoma cells involving increased secretion and paracrine effects of nitric oxide and interleukin-1beta. Cancer Res (2004) 2.19

Pancreatic cancer: understanding and overcoming chemoresistance. Nat Rev Gastroenterol Hepatol (2010) 2.15

StellaTUM: current consensus and discussion on pancreatic stellate cell research. Gut (2011) 2.07

The activated stroma index is a novel and independent prognostic marker in pancreatic ductal adenocarcinoma. Clin Gastroenterol Hepatol (2008) 2.05

Prognostic significance of tumor oxygenation in humans. Cancer Lett (2003) 1.88

Role of pancreatic stellate cells in pancreatic cancer metastasis. Am J Pathol (2010) 1.87

Stromal disrupting effects of nab-paclitaxel in pancreatic cancer. Br J Cancer (2013) 1.85

Expression of transforming growth factor-beta 1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. Am J Pathol (2002) 1.78

Pancreatic stellate cells and pancreatic cancer cells: an unholy alliance. Cancer Res (2008) 1.77

Enzymatic depletion of tumor hyaluronan induces antitumor responses in preclinical animal models. Mol Cancer Ther (2010) 1.68

Loss of BNIP3 expression is a late event in pancreatic cancer contributing to chemoresistance and worsened prognosis. Oncogene (2005) 1.67

Tumor-stroma interaction of human pancreatic cancer: acquired resistance to anticancer drugs and proliferation regulation is dependent on extracellular matrix proteins. Pancreas (2004) 1.67

Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitis. Gut (2002) 1.66

High expression of HIF1a is a predictor of clinical outcome in patients with pancreatic ductal adenocarcinomas and correlated to PDGFA, VEGF, and bFGF. Neoplasia (2008) 1.56

Characterization of an oxygen/redox-dependent degradation domain of hypoxia-inducible factor alpha (HIF-alpha) proteins. Biochem Biophys Res Commun (1999) 1.55

Current concepts and novel targets in advanced pancreatic cancer. Gut (2012) 1.53

Cancer-stellate cell interactions perpetuate the hypoxia-fibrosis cycle in pancreatic ductal adenocarcinoma. Neoplasia (2009) 1.52

Oxygen consumption can regulate the growth of tumors, a new perspective on the Warburg effect. PLoS One (2009) 1.52

Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancer. Clin Cancer Res (2011) 1.51

Rat pancreatic stellate cells secrete matrix metalloproteinases: implications for extracellular matrix turnover. Gut (2003) 1.47

Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells. Am J Physiol Cell Physiol (2001) 1.45

Hypoxia predicts aggressive growth and spontaneous metastasis formation from orthotopically grown primary xenografts of human pancreatic cancer. Cancer Res (2011) 1.42

Prognostic significance of HIF-1 alpha overexpression in human pancreatic cancer. Anticancer Res (2004) 1.42

Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers. Cell Adh Migr (2012) 1.41

Regulation of gene expression by HIF-1. Novartis Found Symp (2006) 1.38

Expression of hypoxia-inducible factor-1 alpha and associated proteins in pancreatic ductal adenocarcinoma and their impact on prognosis. Int J Oncol (2007) 1.35

Hypoxia stimulates pancreatic stellate cells to induce fibrosis and angiogenesis in pancreatic cancer. Am J Physiol Gastrointest Liver Physiol (2008) 1.34

Tumor microenvironment and progression of pancreatic cancer. Exp Oncol (2010) 1.32

Inhibition of renin-angiotensin system affects prognosis of advanced pancreatic cancer receiving gemcitabine. Br J Cancer (2010) 1.31

Pancreatic stellate cells promote epithelial-mesenchymal transition in pancreatic cancer cells. Biochem Biophys Res Commun (2010) 1.28

The biological kinship of hypoxia with CSC and EMT and their relationship with deregulated expression of miRNAs and tumor aggressiveness. Biochim Biophys Acta (2012) 1.26

Pancreatic cancer: pathobiology, treatment options, and drug delivery. AAPS J (2010) 1.25

Pancreatic stellate cells are an important source of MMP-2 in human pancreatic cancer and accelerate tumor progression in a murine xenograft model and CAM assay. J Cell Sci (2007) 1.22

Expression of glycolytic enzymes is increased in pancreatic cancerous tissues as evidenced by proteomic profiling by two-dimensional electrophoresis and liquid chromatography-mass spectrometry/mass spectrometry. Int J Oncol (2007) 1.22

SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice. Gut (2013) 1.21

Radiosensitization and stromal imaging response correlates for the HIF-1 inhibitor PX-478 given with or without chemotherapy in pancreatic cancer. Mol Cancer Ther (2010) 1.20

Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells. Am J Physiol Cell Physiol (2005) 1.19

Connective tissue growth factor (CCN2) in rat pancreatic stellate cell function: integrin alpha5beta1 as a novel CCN2 receptor. Gastroenterology (2005) 1.17

"Contextual" synthetic lethality and/or loss of heterozygosity: tumor hypoxia and modification of DNA repair. Clin Cancer Res (2010) 1.11

Cell migration: a novel aspect of pancreatic stellate cell biology. Gut (2003) 1.08

Hypoxia triggers hedgehog-mediated tumor-stromal interactions in pancreatic cancer. Cancer Res (2013) 1.08

The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling. Ann Surg Oncol (2007) 1.07

Tumor hypoxia correlates with metastatic tumor growth of pancreatic cancer in an orthotopic murine model. J Surg Res (2004) 1.07

Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells. Cancer Res (2013) 1.06

The role of inflammatory cells in fostering pancreatic cancer cell growth and invasion. Front Physiol (2012) 1.05

Cancer stem cell marker expression in hepatocellular carcinoma and liver metastases is not sufficient as single prognostic parameter. Cancer Lett (2008) 1.05

Pancreatic stellate cells increase the invasion of human pancreatic cancer cells through the stromal cell-derived factor-1/CXCR4 axis. Pancreatology (2010) 1.05

Isolation of quiescent human pancreatic stellate cells: a promising in vitro tool for studies of human pancreatic stellate cell biology. Pancreatology (2010) 1.02

Existence of autocrine loop between interleukin-6 and transforming growth factor-beta1 in activated rat pancreatic stellate cells. J Cell Biochem (2006) 1.01

Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis. Gut (2003) 1.01

Advanced pancreatic ductal cancer: fibrotic focus and beta-catenin expression correlate with outcome. Pancreas (2003) 0.98

Differential and synergistic effects of platelet-derived growth factor-BB and transforming growth factor-beta1 on activated pancreatic stellate cells. Pancreas (2005) 0.97

Emerging targets in pancreatic cancer: epithelial-mesenchymal transition and cancer stem cells. Onco Targets Ther (2013) 0.97

Battle-scarred pancreas: role of alcohol and pancreatic stellate cells in pancreatic fibrosis. J Gastroenterol Hepatol (2006) 0.96

Review. Molecular background of chemoresistance in pancreatic cancer. In Vivo (2007) 0.93

Tumor-stromal interactions in pancreatic cancer. Pancreatology (2012) 0.92

A multicenter phase II trial of gemcitabine and candesartan combination therapy in patients with advanced pancreatic cancer: GECA2. Invest New Drugs (2013) 0.89

Glucose metabolism gene polymorphisms and clinical outcome in pancreatic cancer. Cancer (2010) 0.88

Pancreatic islet and stellate cells are the main sources of endocrine gland-derived vascular endothelial growth factor/prokineticin-1 in pancreatic cancer. Pancreatology (2008) 0.87

Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor. J Surg Res (2012) 0.86

Candesartan, an angiotensin II receptor antagonist, suppresses pancreatic inflammation and fibrosis in rats. J Pharmacol Exp Ther (2003) 0.85

Alteration of pancreatic cancer cell functions by tumor-stromal cell interaction. Front Physiol (2013) 0.82