2012 ETA Guidelines: The Use of L-T4 + L-T3 in the Treatment of Hypothyroidism.

PubWeight™: 1.32‹?› | Rank: Top 10%

🔗 View Article (PMC 3821467)

Published in Eur Thyroid J on June 13, 2012

Authors

Wilmar M Wiersinga1, Leonidas Duntas2, Valentin Fadeyev3, Birte Nygaard4, Mark P J Vanderpump5

Author Affiliations

1: Department of Endocrinology and Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
2: Endocrine Unit, Evgenidion Hospital, University of Athens Medical School, Athens, Greece.
3: Federal Endocrinological Scientific Center, Moscow, Russia.
4: Department of Endocrinology, Herlev Hospital, Herlev, Denmark.
5: Department of Endocrinology, Royal Free Hampstead NHS Trust, London, UK.

Articles citing this

Guidelines for the treatment of hypothyroidism: prepared by the american thyroid association task force on thyroid hormone replacement. Thyroid (2014) 2.77

2013 ETA Guideline: Management of Subclinical Hypothyroidism. Eur Thyroid J (2013) 1.87

Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine. J Clin Invest (2015) 1.03

Thyroid function and obesity. Eur Thyroid J (2012) 0.98

Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes. J Clin Endocrinol Metab (2015) 0.98

Defending plasma T3 is a biological priority. Clin Endocrinol (Oxf) (2014) 0.97

The chronic autoimmune thyroiditis quality of life selenium trial (CATALYST): study protocol for a randomized controlled trial. Trials (2014) 0.89

The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism. Eur Thyroid J (2015) 0.84

Scope and limitations of iodothyronine deiodinases in hypothyroidism. Nat Rev Endocrinol (2015) 0.82

Variation in the biochemical response to l-thyroxine therapy and relationship with peripheral thyroid hormone conversion efficiency. Endocr Connect (2015) 0.82

Treating Hypothyroidism with Thyroxine/Triiodothyronine Combination Therapy in Denmark: Following Guidelines or Following Trends? Eur Thyroid J (2015) 0.80

An Inverse Relationship Between Weight and Free Thyroxine During Early Gestation Among Women Treated for Hypothyroidism. Thyroid (2015) 0.79

Peripheral markers of thyroid function: the effect of T4 monotherapy vs T4/T3 combination therapy in hypothyroid subjects in a randomized crossover study. Endocr Connect (2013) 0.79

The History and Future of Treatment of Hypothyroidism. Ann Intern Med (2016) 0.77

Recent Advances in Autoimmune Thyroid Diseases. Endocrinol Metab (Seoul) (2016) 0.76

Current recommendations in the management of hypothyroidism: developed from a statement by the British Thyroid Association Executive. Br J Gen Pract (2016) 0.75

DIAGNOSIS OF ENDOCRINE DISEASE: How reliable are free thyroid and total T3 hormone assays? Eur J Endocrinol (2016) 0.75

Intracerebral Bleeding and Massive Pericardial Effusion as Presenting Symptoms of Myxedema Crisis. Case Rep Emerg Med (2017) 0.75

European thyroid association guidelines on L-t4 + L-t3 combination for hypothyroidism: a weary step in the right direction. Eur Thyroid J (2012) 0.75

Pediatric papillary thyroid cancer: current management challenges. Onco Targets Ther (2016) 0.75

Thyroid function: New guidelines for the management of hypothyroidism. Nat Rev Endocrinol (2012) 0.75

Hypothyroidism (primary). BMJ Clin Evid (2014) 0.75

Hypothyroid Patients Encoding Combined MCT10 and DIO2 Gene Polymorphisms May Prefer L-T3 + L-T4 Combination Treatment - Data Using a Blind, Randomized, Clinical Study. Eur Thyroid J (2017) 0.75

Recent advances in understanding autoimmune thyroid disease: the tallest tree in the forest of polyautoimmunity. F1000Res (2017) 0.75

Dual control of pituitary thyroid stimulating hormone secretion by thyroxine and triiodothyronine in athyreotic patients. Ther Adv Endocrinol Metab (2017) 0.75

Neither Baseline nor Changes in Serum Triiodothyronine during Levothyroxine/Liothyronine Combination Therapy Predict a Positive Response to This Treatment Modality in Hypothyroid Patients with Persistent Symptoms. Eur Thyroid J (2017) 0.75

Articles cited by this

The Colorado thyroid disease prevalence study. Arch Intern Med (2000) 7.84

Hyperthyroidism and other causes of thyrotoxicosis: management guidelines of the American Thyroid Association and American Association of Clinical Endocrinologists. Thyroid (2011) 7.17

Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases. Endocr Rev (2002) 5.15

Grading strength of recommendations and quality of evidence in clinical guidelines: report from an american college of chest physicians task force. Chest (2006) 4.77

Treatment guidelines for patients with hyperthyroidism and hypothyroidism. Standards of Care Committee, American Thyroid Association. JAMA (1995) 3.68

American Association of Clinical Endocrinologists medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract (2004) 3.36

Prevalence and relative risk of other autoimmune diseases in subjects with autoimmune thyroid disease. Am J Med (2010) 3.24

Psychological well-being in patients on 'adequate' doses of l-thyroxine: results of a large, controlled community-based questionnaire study. Clin Endocrinol (Oxf) (2002) 3.12

Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism. N Engl J Med (1999) 2.72

Combined thyroxine/liothyronine treatment does not improve well-being, quality of life, or cognitive function compared to thyroxine alone: a randomized controlled trial in patients with primary hypothyroidism. J Clin Endocrinol Metab (2003) 2.59

Deiodinases: implications of the local control of thyroid hormone action. J Clin Invest (2006) 2.56

Combined levothyroxine plus liothyronine compared with levothyroxine alone in primary hypothyroidism: a randomized controlled trial. JAMA (2003) 2.44

Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodothyronine therapy in hypothyroid patients. J Clin Endocrinol Metab (2009) 2.31

Triiodothyronine levels in athyreotic individuals during levothyroxine therapy. JAMA (2008) 2.10

Fine adjustment of thyroxine replacement dosage: comparison of the thyrotrophin releasing hormone test using a sensitive thyrotrophin assay with measurement of free thyroid hormones and clinical assessment. Clin Endocrinol (Oxf) (1988) 1.94

Replacement dose, metabolism, and bioavailability of levothyroxine in the treatment of hypothyroidism. Role of triiodothyronine in pituitary feedback in humans. N Engl J Med (1987) 1.87

Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects. J Clin Endocrinol Metab (2003) 1.86

Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function. Am J Hum Genet (2008) 1.77

Thyroxine-triiodothyronine combination therapy versus thyroxine monotherapy for clinical hypothyroidism: meta-analysis of randomized controlled trials. J Clin Endocrinol Metab (2006) 1.69

Hashimoto's thyroiditis affects symptom load and quality of life unrelated to hypothyroidism: a prospective case-control study in women undergoing thyroidectomy for benign goiter. Thyroid (2010) 1.64

TSH may not be a good marker for adequate thyroid hormone replacement therapy. Wien Klin Wochenschr (2005) 1.58

Morbidity, mortality, and quality of life for patients treated with levothyroxine. Arch Intern Med (1990) 1.54

A case for clarity, consistency, and helpfulness: state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system. J Clin Endocrinol Metab (2008) 1.53

Replacement therapy for hypothyroidism with thyroxine alone does not ensure euthyroidism in all tissues, as studied in thyroidectomized rats. J Clin Invest (1995) 1.47

Does a combination regimen of thyroxine (T4) and 3,5,3'-triiodothyronine improve depressive symptoms better than T4 alone in patients with hypothyroidism? Results of a double-blind, randomized, controlled trial. J Clin Endocrinol Metab (2003) 1.47

Combined levotriiodothyronine and levothyroxine therapy for hypothyroidism: are we a step closer to the magic formula? Thyroid (2004) 1.41

Only the combined treatment with thyroxine and triiodothyronine ensures euthyroidism in all tissues of the thyroidectomized rat. Endocrinology (1996) 1.30

Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone. Ann Intern Med (2005) 1.30

Cognitive functioning and well-being in euthyroid patients on thyroxine replacement therapy for primary hypothyroidism. Eur J Endocrinol (2005) 1.29

Are individuals with an autoimmune disease at higher risk of a second autoimmune disorder? Am J Epidemiol (2009) 1.23

Levothyroxine monotherapy cannot guarantee euthyroidism in all athyreotic patients. PLoS One (2011) 1.22

Health status, psychological symptoms, mood, and cognition in L-thyroxine-treated hypothyroid subjects. Thyroid (2007) 1.15

A common variation in deiodinase 1 gene DIO1 is associated with the relative levels of free thyroxine and triiodothyronine. J Clin Endocrinol Metab (2008) 1.15

Thyroidal and peripheral production of 3,5,3'-triiodothyronine in humans by multicompartmental analysis. Am J Physiol (1990) 1.13

Novel insights into thyroid hormones from the study of common genetic variation. Nat Rev Endocrinol (2009) 1.10

Effect of combination therapy with thyroxine (T4) and 3,5,3'-triiodothyronine versus T4 monotherapy in patients with hypothyroidism, a double-blind, randomised cross-over study. Eur J Endocrinol (2009) 1.08

Free triiodothyronine has a distinct circadian rhythm that is delayed but parallels thyrotropin levels. J Clin Endocrinol Metab (2008) 1.07

Thyroid autoimmunity, depression and anxiety; are there any connections? An epidemiological study of a large population. J Psychosom Res (2005) 1.05

A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters. Am J Physiol Endocrinol Metab (2005) 1.04

A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels. Eur J Endocrinol (2011) 1.03

Thyroxine alone or thyroxine plus triiodothyronine replacement therapy for hypothyroidism. Nucl Med Commun (2009) 1.02

Twenty-four hour hormone profiles of TSH, Free T3 and free T4 in hypothyroid patients on combined T3/T4 therapy. Exp Clin Endocrinol Diabetes (2007) 1.01

Partial substitution of thyroxine (T4) with tri-iodothyronine in patients on T4 replacement therapy: results of a large community-based randomized controlled trial. J Clin Endocrinol Metab (2004) 1.01

Thyroxine vs thyroxine plus triiodothyronine in treatment of hypothyroidism after thyroidectomy for Graves' disease. Endocrine (2002) 0.98

Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio 14 : 1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism. Clin Endocrinol (Oxf) (2004) 0.98

Type 2 deiodinase polymorphism (threonine 92 alanine) predicts L-thyroxine dose to achieve target thyrotropin levels in thyroidectomized patients. J Clin Endocrinol Metab (2007) 0.98

Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial. J Clin Endocrinol Metab (2005) 0.97

The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients. Clin Endocrinol (Oxf) (2010) 0.96

Controlled clinical trial of combined triiodothyronine and thyroxine in the treatment of hypothyroidism. Br Med J (1970) 0.96

Psychological well-being correlates with free thyroxine but not free 3,5,3'-triiodothyronine levels in patients on thyroid hormone replacement. J Clin Endocrinol Metab (2006) 0.96

Thyroid function tests and hypothyroidism. BMJ (2003) 0.95

Are autoimmune thyroid dysfunction and depression related? J Clin Endocrinol Metab (1998) 0.95

Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy. J Clin Endocrinol Metab (2009) 0.95

Thr92Ala polymorphism in the type 2 deiodinase is not associated with T4 dose in athyroid patients or patients with Hashimoto thyroiditis. Clin Endocrinol (Oxf) (2008) 0.92

Do we need still more trials on T4 and T3 combination therapy in hypothyroidism? Eur J Endocrinol (2009) 0.92

Diseases associated with thyroid autoimmunity: explanations for the expanding spectrum. Clin Endocrinol (Oxf) (2011) 0.92

Small changes in thyroxine dosage do not produce measurable changes in hypothyroid symptoms, well-being, or quality of life: results of a double-blind, randomized clinical trial. J Clin Endocrinol Metab (2006) 0.92

Thyroxine monotherapy after thyroidectomy: coming full circle. JAMA (2008) 0.92

Thyroxine plus low-dose, slow-release triiodothyronine replacement in hypothyroidism: proof of principle. Thyroid (2004) 0.91

Polymorphisms in the brain-specific thyroid hormone transporter OATP1C1 are associated with fatigue and depression in hypothyroid patients. Clin Endocrinol (Oxf) (2008) 0.91

Polymorphisms in type 2 deiodinase are not associated with well-being, neurocognitive functioning, and preference for combined thyroxine/3,5,3'-triiodothyronine therapy. J Clin Endocrinol Metab (2005) 0.90

A paradoxical difference in relationship between anxiety, depression and thyroid function in subjects on and not on T4: findings from the HUNT study. Clin Endocrinol (Oxf) (2009) 0.90

REVIEW: Treatment of hypothyroidism with combinations of levothyroxine plus liothyronine. J Clin Endocrinol Metab (2005) 0.90

A meta-analysis of the associations between common variation in the PDE8B gene and thyroid hormone parameters, including assessment of longitudinal stability of associations over time and effect of thyroid hormone replacement. Eur J Endocrinol (2011) 0.89

Absorption of oral thyroxine in hypothyroid and normal man. J Clin Endocrinol Metab (1970) 0.89

Contribution fron local conversion of thyroxine to 3,5,3'-triiodothyronine to intracellular 3,5,3'-triiodothyronine in several organs in hypothyroid rats at isotope equilibrium. Acta Endocrinol (Copenh) (1982) 0.88

Psychological wellbeing in patients. Clin Endocrinol (Oxf) (2002) 0.85

Combined therapy with L-thyroxine and L-triiodothyronine compared to L-thyroxine alone in the treatment of primary hypothyroidism. Hormones (Athens) (2010) 0.84

The bioavailability of thyroxine and 3,5,3'-triiodothyronine in normal subjects and in hyper- and hypothyroid patients. Acta Endocrinol (Copenh) (1985) 0.83

The effect of genetic variation in the type 1 deiodinase gene on the interindividual variation in serum thyroid hormone levels: an investigation in healthy Danish twins. Clin Endocrinol (Oxf) (2008) 0.83

Substitution of liothyronine at a 1:5 ratio for a portion of levothyroxine: effect on fatigue, symptoms of depression, and working memory versus treatment with levothyroxine alone. Endocr Pract (2005) 0.81

Human thyroxine absorption: age effects and methodological analyses. Thyroid (1994) 0.78

Whose thyroid hormone replacement is it anyway? Clin Endocrinol (Oxf) (2006) 0.77

For some, L-thyroxine replacement might not be enough: a genetic rationale. J Clin Endocrinol Metab (2009) 0.76

Patients on appropriate T(4) replacement are as content as they would be on any thyroid hormone. J Clin Endocrinol Metab (2004) 0.76