Hepatitis C virus cell-cell transmission and resistance to direct-acting antiviral agents.

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Published in PLoS Pathog on May 15, 2014

Authors

Fei Xiao1, Isabel Fofana1, Laura Heydmann1, Heidi Barth2, Eric Soulier1, François Habersetzer3, Michel Doffoël3, Jens Bukh4, Arvind H Patel5, Mirjam B Zeisel1, Thomas F Baumert6

Author Affiliations

1: Inserm, U1110, Strasbourg, France; Université de Strasbourg, Strasbourg, France.
2: Inserm, U1110, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Laboratoire de Virologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
3: Inserm, U1110, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Pôle Hépato-digestif, Hôpitaux Universitaires de Strasbourg, Strasbourg, France.
4: Copenhagen Hepatitis C Program (CO-HEP), Department of Infectious Diseases and Clinical Research Centre, Hvidovre Hospital and Department of International Health, Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
5: MRC-University of Glasgow Centre for Virus Research, Glasgow, United Kingdom.
6: Inserm, U1110, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Pôle Hépato-digestif, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America.

Associated clinical trials:

French Cohort of Therapeutic Failure and Resistances in Patients Treated With a Protease Inhibitor (Telaprevir or Boceprevir), Pegylated Interferon and Ribavirin (CUPIC) | NCT01514890

Clinical Investigation of Erlotinib as an HCV Entry Inhibitor | NCT01835938

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