Selective chemical inhibition of agr quorum sensing in Staphylococcus aureus promotes host defense with minimal impact on resistance.

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Published in PLoS Pathog on June 12, 2014

Authors

Erin K Sully1, Natalia Malachowa2, Bradley O Elmore3, Susan M Alexander4, Jon K Femling5, Brian M Gray6, Frank R DeLeo2, Michael Otto7, Ambrose L Cheung8, Bruce S Edwards9, Larry A Sklar9, Alexander R Horswill10, Pamela R Hall3, Hattie D Gresham1

Author Affiliations

1: Research Service, New Mexico Veterans Affairs Medical Center, Albuquerque, New Mexico, United States of America; Division of Infectious Diseases, Department of Internal Medicine, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America.
2: Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America.
3: College of Pharmacy, University of New Mexico, Albuquerque, New Mexico, United States of America.
4: Research Service, New Mexico Veterans Affairs Medical Center, Albuquerque, New Mexico, United States of America.
5: Department of Emergency Medicine, University of New Mexico, Albuquerque, New Mexico, United States of America.
6: Research Service, New Mexico Veterans Affairs Medical Center, Albuquerque, New Mexico, United States of America; College of Pharmacy, University of New Mexico, Albuquerque, New Mexico, United States of America.
7: Laboratory of Human Bacterial Pathogenesis, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America.
8: Department of Microbiology, Dartmouth Medical School, Hanover, New Hampshire, United States of America.
9: Center for Molecular Discovery and Department of Pathology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America.
10: Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, United States of America.

Associated clinical trials:

Uncomplicated Skin and Soft Tissue Infections Caused by Community-Associated Methicillin-Resistant Staphylococcus Aureus | NCT00730028

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