Maturation stage of T-cell acute lymphoblastic leukemia determines BCL-2 versus BCL-XL dependence and sensitivity to ABT-199.

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Published in Cancer Discov on July 03, 2014

Authors

Triona Ni Chonghaile1, Justine E Roderick2, Cian Glenfield3, Jeremy Ryan1, Stephen E Sallan4, Lewis B Silverman4, Mignon L Loh5, Stephen P Hunger6, Brent Wood7, Daniel J DeAngelo1, Richard Stone1, Marian Harris8, Alejandro Gutierrez9, Michelle A Kelliher10, Anthony Letai11

Author Affiliations

1: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
2: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts.
3: Department of Genetics, The Smurfit Institute, Trinity College, Dublin, Ireland.
4: Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts.
5: Department of Pediatrics, Benioff Children's Hospital, University of California, San Francisco, San Francisco, California.
6: Pediatric Hematology/Oncology/BMT, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, Colorado.
7: Department of Medicine, University of Washington, Seattle, Washington.
8: Department of Pathology, Boston Children's Hospital, Boston, Massachusetts.
9: Division of Hematology/Oncology, Boston Children's Hospital, Boston, Massachusetts. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
10: Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts. anthony_letai@dfci.harvard.edu michelle.kelliher@umassmed.edu.
11: Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts. anthony_letai@dfci.harvard.edu michelle.kelliher@umassmed.edu.

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