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Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data.

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🔗 View Article (PMC 4091648)

Published in BMJ on July 10, 2014

Authors

Michael V Holmes1, Caroline E Dale2, Luisa Zuccolo3, Richard J Silverwood4, Yiran Guo5, Zheng Ye6, David Prieto-Merino2, Abbas Dehghan7, Stella Trompet8, Andrew Wong9, Alana Cavadino10, Dagmar Drogan11, Sandosh Padmanabhan12, Shanshan Li13, Ajay Yesupriya14, Maarten Leusink15, Johan Sundstrom16, Jaroslav A Hubacek17, Hynek Pikhart18, Daniel I Swerdlow19, Andrie G Panayiotou20, Svetlana A Borinskaya21, Chris Finan19, Sonia Shah22, Karoline B Kuchenbaecker23, Tina Shah19, Jorgen Engmann19, Lasse Folkersen24, Per Eriksson24, Fulvio Ricceri25, Olle Melander26, Carlotta Sacerdote25, Dale M Gamble27, Sruti Rayaprolu28, Owen A Ross28, Stela McLachlan29, Olga Vikhireva18, Ivonne Sluijs30, Robert A Scott6, Vera Adamkova31, Leon Flicker32, Frank M van Bockxmeer33, Christine Power10, Pedro Marques-Vidal34, Tom Meade2, Michael G Marmot35, Jose M Ferro36, Sofia Paulos-Pinheiro37, Steve E Humphries38, Philippa J Talmud38, Irene Mateo Leach39, Niek Verweij39, Allan Linneberg40, Tea Skaaby40, Pieter A Doevendans41, Maarten J Cramer41, Pim van der Harst42, Olaf H Klungel15, Nicole F Dowling14, Anna F Dominiczak12, Meena Kumari19, Andrew N Nicolaides43, Cornelia Weikert11, Heiner Boeing11, Shah Ebrahim2, Tom R Gaunt3, Jackie F Price29, Lars Lannfelt44, Anne Peasey18, Ruzena Kubinova45, Andrzej Pajak46, Sofia Malyutina47, Mikhail I Voevoda48, Abdonas Tamosiunas49, Anke H Maitland-van der Zee15, Paul E Norman50, Graeme J Hankey51, Manuela M Bergmann11, Albert Hofman7, Oscar H Franco7, Jackie Cooper52, Jutta Palmen38, Wilko Spiering53, Pim A de Jong54, Diana Kuh9, Rebecca Hardy9, Andre G Uitterlinden7, M Arfan Ikram7, Ian Ford55, Elina Hyppönen56, Osvaldo P Almeida57, Nicholas J Wareham6, Kay-Tee Khaw58, Anders Hamsten59, Lise Lotte N Husemoen40, Anne Tjønneland60, Janne S Tolstrup61, Eric Rimm62, Joline W J Beulens30, W M Monique Verschuren63, N Charlotte Onland-Moret30, Marten H Hofker64, S Goya Wannamethee65, Peter H Whincup66, Richard Morris65, Astrid M Vicente67, Hugh Watkins68, Martin Farrall68, J Wouter Jukema8, James Meschia27, L Adrienne Cupples69, Stephen J Sharp6, Myriam Fornage70, Charles Kooperberg71, Andrea Z LaCroix71, James Y Dai71, Matthew B Lanktree72, David S Siscovick73, Eric Jorgenson74, Bonnie Spring75, Josef Coresh76, Yun R Li77, Sarah G Buxbaum78, Pamela J Schreiner79, R Curtis Ellison80, Michael Y Tsai81, Sanjay R Patel82, Susan Redline83, Andrew D Johnson84, Ron C Hoogeveen85, Hakon Hakonarson86, Jerome I Rotter87, Eric Boerwinkle88, Paul I W de Bakker89, Mika Kivimaki18, Folkert W Asselbergs90, Naveed Sattar91, Debbie A Lawlor3, John Whittaker92, George Davey Smith3, Kenneth Mukamal93, Bruce M Psaty94, James G Wilson95, Leslie A Lange96, Ajna Hamidovic97, Aroon D Hingorani19, Børge G Nordestgaard98, Martin Bobak18, David A Leon2, Claudia Langenberg6, Tom M Palmer99, Alex P Reiner71, Brendan J Keating100, Frank Dudbridge2, Juan P Casas101, InterAct Consortium

Author Affiliations

1: Genetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
2: Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
3: MRC Integrative Epidemiology Unit (IEU) at the Universty of Bristol, Oakfield House, Bristol BS8 2BN, UK.
4: Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK Centre for Statistical Methodology, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK.
5: Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA BGI-Shenzhen, Beishan Industrial Zone, Yantian District, Shenzhen 518083, China.
6: MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.
7: Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands.
8: Department of Cardiology, Leiden University Medical Center, the Netherlands.
9: MRC Unit for Lifelong Health and Ageing at UCL, London, UK.
10: Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK.
11: German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany.
12: Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
13: Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA Juan-P.Casas@lshtm.ac.uk.
14: Office of Public Health Genomics, Office of Epidemiology, Surveillance, and Laboratory Services, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
15: Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
16: Department of Medical Sciences, Uppsala University, Uppsala University Hospital, SE-751 85 Uppsala, Sweden.
17: Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Videnska 1958/9, Prague 4, 14021, Czech Republic.
18: Department of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.
19: Genetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK.
20: Cyprus International Institute for Environmental and Public Health in association with the Harvard School of Public Health, Cyprus University of Technology, 3603 Limassol, Cyprus.
21: Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
22: UCL Genetics Institute, Department of Genetics Environment and Evolution, London, WC1E 6BT, UK.
23: Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
24: Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
25: Unit of Cancer Epidemiology, San Giovanni Battista Hospital and Center for Cancer Prevention (CPO-Piemonte), 10129, Torino, Italy.
26: Department of Clinical Sciences, Lund University, Malmö, Sweden.
27: Mayo Clinic Department of Neurology, Jacksonville, FL 32224, USA.
28: Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, USA.
29: Centre for Population Health Sciences, University of Edinburgh, Edinburgh EH8 9AG, UK.
30: Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands.
31: Department of Preventive Cardiology, Institute for Clinical and Experimental Medicine, Prague 4, 14021, Czech Republic.
32: Western Australian Centre for Health & Ageing, Centre for Medical Research, University of Western Australia, Perth, Australia.
33: Department of Clinical Biochemistry, Royal Perth Hospital and School of Surgery, the University of Western Australia.
34: Department of Internal Medicine, Internal Medicine, CHUV, Lausanne, Switzerland.
35: UCL Institute of Health Equity, Department of Epidemiology & Public Health, London WC1E 7HB, UK.
36: Instituto Medicina Molecular, Faculdade de Medicina Universidade de Lisboa, 1649-028 Lisbon, Portugal Servico Neurologia, Hospital de Santa Maria, 1649-035 Lisbon, Portugal.
37: Instituto Nacional de Saude Doutor Ricardo Jorge, 1649-016 Lisbon, Portugal Faculdade Ciencias Universidade Lisboa, 1749-016 Lisbon, Portugal.
38: Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK.
39: Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands.
40: Research Centre for Prevention and Health, Capital Region of Denmark, Glostrup University Hospital, Glostrup, Denmark.
41: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands.
42: Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands Department of Genetics, University Medical Center Groningen, Groningen, The Netherlands Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands.
43: Vascular Screening and Diagnostic Centre, Ayios Dometios, Nicosia, Cyprus Deparment of Vascular Surgery, Imperial College, London, SW7 2BX, UK Cyprus Cardiovascular Disease Educational and Research trust, Nicosia, Cyprus.
44: Department of Public Health & Caring Sciences, Uppsala University, Uppsala University Hospital, SE-75185 Uppsala, Sweden.
45: Centre for Health Monitoring, National Institute of Public Health, 100 42 Prague, Czech Republic.
46: Department of Epidemiology and Population Studies, Institute of Public Health, Jagiellonian University Medical College, 31-531 Krakow, Poland.
47: Institute of Internal and Preventative Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia, 630089 Dept of Internal Medicine, Novosibirsk State Medical University, Novosibirsk, Russia, 630091.
48: Institute of Internal and Preventative Medicine, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk, Russia, 630089 Faculty of Medicine, Novosibirsk State University, Novosibirsk, Russia, 630090.
49: Department of Population Studies, Institute of Cardiology, Lithuanian University of Health Sciences, Kaunas LT-50161, Lithuania.
50: School of Surgery, University of Western Australia, Perth, Australia.
51: Department of Neurology, Sir Charles Gairdner Hospital, Perth, Australia School of Medicine and Pharmacology, The University of Western Australia, Nedlands, Perth, Australia.
52: Centre for Cardiovascular Genetics, Institute of Cardiovascular Science, University College London, London, UK WC1E 6JF.
53: Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
54: Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands.
55: Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
56: Centre for Paediatric Epidemiology and Biostatistics, UCL Institute of Child Health, London, UK School of Population Health and Sansom Institute for Health Research, University of South Australia, Adelaide SA 5000, Australia South Australian Health and Medical Research Institute, Adelaide SA5000, Australia.
57: Western Australian Centre for Health & Ageing, Centre for Medical Research, University of Western Australia, Perth, Australia School of Psychiatry & Clinical Neurosciences (M573), University of Western Australia, Perth 6009, Australia Department of Psychiatry, Royal Perth Hospital, Perth, Australia.
58: Department of Primary Care and Public Health and Primary Care, University of Cambridge, Cambridge, UK.
59: Atherosclerosis Research Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.
60: Danish Cancer Society, Strandboulevarden, Copenhagen, Denmark.
61: National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
62: Department of Epidemiology and Department of Nutrition, Harvard School of Public Health, Boston, MA, USA Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
63: National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
64: Dept Pathology and Medical Biology, Medical Biology division, Molecular Genetics, University Medical Center Groningen and Groningen University, Groningen, The Netherlands.
65: Department of Primary Care & Population Health, UCL, London, UK.
66: Population Health Research Institute, St George's, University of London, London, UK.
67: Instituto Nacional de Saude Doutor Ricardo Jorge, 1649-016 Lisbon, Portugal Instituto Gulbenkian Ciencia, P-2780-156 Oeiras, Portugal Biofig - Center for Biodiversity, Functional and Integrative Genomics, Campus da FCUL, 1749-016 Lisboa, Portugal.
68: Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK Department of Cardiovascular Medicine, University of Oxford, Oxford, UK.
69: Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA National Heart, Lung, and Blood Institute's The Framingham Heart Study, Framingham, Massachusetts, USA.
70: Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Texas, USA.
71: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
72: Department of Medicine, McMaster University, Hamilton, Ontario, Canada L8S4L8.
73: New York Academy of Medicine, New York, NY 10021, USA.
74: Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA.
75: Northwestern University, Feinberg School of Medicine, Department of Preventive Medicine, Chicago, IL, USA.
76: Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA.
77: Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA Juan-P.Casas@lshtm.ac.uk.
78: School of Health Sciences, Jackson State University, Jackson, MS, USA.
79: School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
80: Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
81: Department of Laboratory Medicine and Pathology, University of Minnesota, USA.
82: Division of Sleep and Circadian Disorders, Brigham and Women's Hospital; Harvard Medical School, Boston USA Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
83: Division of Sleep and Circadian Disorders, Brigham and Women's Hospital; Harvard Medical School, Boston USA.
84: National Heart, Lung, and Blood Institute's The Framingham Heart Study, Framingham, Massachusetts, USA.
85: Baylor College of Medicine, Department of Medicine, Division of Atherosclerosis & Vascular Medicine, Houston, Texas 77030, USA.
86: Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA.
87: Institute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, Calif, USA.
88: Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Texas, USA.
89: Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands Department of Medical Genetics, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
90: Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands Institute of Cardiovascular Science, Faculty of Population Health Sciences, University College London, London, UK.
91: British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK.
92: Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK Genetics, R&D, GlaxoSmithKline, Stevenage, UK.
93: Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
94: Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA,USA Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA.
95: Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
96: Department of Genetics, University of North Carolina School of Medicine at Chapel Hill, Chapel Hill, North Carolina 27514, USA.
97: College of Pharmacy, The University of New Mexico, Albuquerque, NM, USA.
98: The Copenhagen General Population Study, Herlev Hospital, Copenhagen, Denmark Faculty of Health Sciences, Copenhagen University Hospital, University of Copenhagen,Copenhagen, Denmark Department of Clinical Biochemistry, Herlev Hospital, Copenhagen University Hospital, Denmark.
99: Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, UK.
100: Department of Surgery, Penn Transplant Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA19104, USA Center for Applied Genomics, Abramson Research Center, The Children's Hospital of Philadelphia, Philadelphia, USA.
101: Genetic Epidemiology Group, Institute of Cardiovascular Science, Department of Epidemiology and Public Health, University College London, UK Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK Juan-P.Casas@lshtm.ac.uk.

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Genetic studies of body mass index yield new insights for obesity biology. Nature (2015) 8.27

Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet (2014) 5.78

HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet (2014) 3.94

Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study. Lancet (2013) 3.87

Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol (2014) 3.61

New genetic loci link adipose and insulin biology to body fat distribution. Nature (2015) 3.38

Reproducibility of telomere length assessment: an international collaborative study. Int J Epidemiol (2014) 2.91

The polygenic nature of hypertriglyceridaemia: implications for definition, diagnosis, and management. Lancet Diabetes Endocrinol (2013) 2.60

Increasing Prevalence of Myopia in Europe and the Impact of Education. Ophthalmology (2015) 2.19

Lifelong patterns of BMI and cardiovascular phenotype in individuals aged 60-64 years in the 1946 British birth cohort study: an epidemiological study. Lancet Diabetes Endocrinol (2014) 2.14

Estimated 10-year cardiovascular mortality seriously underestimates overall cardiovascular risk. Heart (2015) 2.10

Validity of a short questionnaire to assess physical activity in 10 European countries. Eur J Epidemiol (2011) 1.95

Metformin for non-diabetic patients with coronary heart disease (the CAMERA study): a randomised controlled trial. Lancet Diabetes Endocrinol (2013) 1.95

Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct. Diabetologia (2013) 1.93

Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature (2014) 1.88

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. Am J Hum Genet (2014) 1.86

The effect of statin therapy on heart failure events: a collaborative meta-analysis of unpublished data from major randomized trials. Eur Heart J (2015) 1.83

Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies. Diabetologia (2015) 1.69

The Genome of the Netherlands: design, and project goals. Eur J Hum Genet (2013) 1.68

Long-term risk of incident type 2 diabetes and measures of overall and regional obesity: the EPIC-InterAct case-cohort study. PLoS Med (2012) 1.67

The prospective association between total and type of fish intake and type 2 diabetes in 8 European countries: EPIC-InterAct Study. Am J Clin Nutr (2012) 1.66

Prognostic significance of infarct core pathology revealed by quantitative non-contrast in comparison with contrast cardiac magnetic resonance imaging in reperfused ST-elevation myocardial infarction survivors. Eur Heart J (2015) 1.62

Fetal exposure to maternal and paternal smoking and the risks of wheezing in preschool children: the Generation R Study. Chest (2011) 1.58

A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes. Diabetes (2015) 1.52

Mendelian randomization of blood lipids for coronary heart disease. Eur Heart J (2014) 1.51

Genetic basis of blood pressure and hypertension. Trends Genet (2012) 1.51

Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. PLoS Genet (2013) 1.51

Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis. Lancet Diabetes Endocrinol (2016) 1.49

Identification of six new susceptibility loci for invasive epithelial ovarian cancer. Nat Genet (2015) 1.47

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. Am J Hum Genet (2014) 1.47

Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis. Eur J Clin Nutr (2012) 1.46

The effect of QRS duration on cardiac resynchronization therapy in patients with a narrow QRS complex: a subgroup analysis of the EchoCRT trial. Eur Heart J (2015) 1.45

Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet (2017) 1.44

Bradycardia and atrial fibrillation in patients with stable coronary artery disease treated with ivabradine: an analysis from the SIGNIFY study. Eur Heart J (2015) 1.42

Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts. Circ Cardiovasc Genet (2009) 1.41

The importance of patient-reported outcomes: a call for their comprehensive integration in cardiovascular clinical trials. Eur Heart J (2014) 1.40

Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. Diabetes Care (2011) 1.39

Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study. Diabetologia (2012) 1.29

Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet (2015) 1.28

The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study. Diabetologia (2012) 1.28

The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study. Am J Clin Nutr (2012) 1.24

Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC-InterAct Study. Diabetologia (2012) 1.17

A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Ann Rheum Dis (2013) 1.16

Assessing methods to specify the target difference for a randomised controlled trial: DELTA (Difference ELicitation in TriAls) review. Health Technol Assess (2014) 1.16

Age at menarche and type 2 diabetes risk: the EPIC-InterAct study. Diabetes Care (2013) 1.13

A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. Genet Epidemiol (2013) 1.12

Genome-wide association analysis identifies six new loci associated with forced vital capacity. Nat Genet (2014) 1.07

Unraveling divergent gene expression profiles in bicuspid and tricuspid aortic valve patients with thoracic aortic dilatation: the ASAP study. Mol Med (2011) 1.07

Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. Nat Genet (2014) 1.07

Modifiable etiological factors and the burden of stroke from the Rotterdam study: a population-based cohort study. PLoS Med (2014) 1.05

BMI, total and abdominal fat distribution, and cardiovascular risk factors in school-age children. Pediatr Res (2015) 1.02

Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry (2014) 1.01

Depression, frailty, and all-cause mortality: a cohort study of men older than 75 years. J Am Med Dir Assoc (2014) 1.01

Adherence to predefined dietary patterns and incident type 2 diabetes in European populations: EPIC-InterAct Study. Diabetologia (2013) 0.98

Age at menopause, reproductive life span, and type 2 diabetes risk: results from the EPIC-InterAct study. Diabetes Care (2012) 0.97

Characterization of large structural genetic mosaicism in human autosomes. Am J Hum Genet (2015) 0.96

Dietary protein intake and incidence of type 2 diabetes in Europe: the EPIC-InterAct Case-Cohort Study. Diabetes Care (2014) 0.96

Atherosclerotic calcification is related to a higher risk of dementia and cognitive decline. Alzheimers Dement (2014) 0.95

Functional and computed tomographic evolution and survival of restrictive allograft syndrome after lung transplantation. J Heart Lung Transplant (2013) 0.94

Tea consumption and incidence of type 2 diabetes in Europe: the EPIC-InterAct case-cohort study. PLoS One (2012) 0.93

Smoking and long-term risk of type 2 diabetes: the EPIC-InterAct study in European populations. Diabetes Care (2014) 0.93

Cross-cancer pleiotropic analysis of endometrial cancer: PAGE and E2C2 consortia. Carcinogenesis (2014) 0.93

Parental psychological distress during pregnancy and wheezing in preschool children: the Generation R Study. J Allergy Clin Immunol (2013) 0.92

PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. Lancet Diabetes Endocrinol (2016) 0.92

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170. Nat Genet (2016) 0.92

Genome-wide association study of kidney function decline in individuals of European descent. Kidney Int (2014) 0.91

Automated coronary artery calcification scoring in non-gated chest CT: agreement and reliability. PLoS One (2014) 0.90

Association of TERC and OBFC1 haplotypes with mean leukocyte telomere length and risk for coronary heart disease. PLoS One (2013) 0.90

Mortality among people with severe mental disorders who reach old age: a longitudinal study of a community-representative sample of 37,892 men. PLoS One (2014) 0.90

Incremental value of a genetic risk score for the prediction of new vascular events in patients with clinically manifest vascular disease. Atherosclerosis (2015) 0.90

Global variations and time trends in the prevalence of childhood myopia, a systematic review and quantitative meta-analysis: implications for aetiology and early prevention. Br J Ophthalmol (2016) 0.89

Diagnostic and short-term prognostic utility of plasma pro-enkephalin (pro-ENK) for acute kidney injury in patients admitted with sepsis in the emergency department. J Nephrol (2014) 0.88

Body mass index in early and middle adult life: prospective associations with myocardial infarction, stroke and diabetes over a 30-year period: the British Regional Heart Study. BMJ Open (2015) 0.88

Meta-analysis of loci associated with age at natural menopause in African-American women. Hum Mol Genet (2014) 0.88

Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body size The EPIC-InterAct study. J Intern Med (2012) 0.88

Normal values of the electrocardiogram for ages 16-90 years. J Electrocardiol (2014) 0.88

Cohort Profile Update: The British Regional Heart Study 1978-2014: 35 years follow-up of cardiovascular disease and ageing. Int J Epidemiol (2015) 0.87

Annotation of loci from genome-wide association studies using tissue-specific quantitative interaction proteomics. Nat Methods (2014) 0.86

Computed tomography of aortic wall calcifications in aortic dissection patients. PLoS One (2014) 0.85

Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. Int J Epidemiol (2015) 0.85

Incidental findings on chest CT imaging are associated with increased COPD exacerbations and mortality. Thorax (2015) 0.84

Cardiovascular and metabolic effects of metformin in patients with type 1 diabetes (REMOVAL): a double-blind, randomised, placebo-controlled trial. Lancet Diabetes Endocrinol (2017) 0.83

Endovascular therapy for acute ischaemic stroke: the Pragmatic Ischaemic Stroke Thrombectomy Evaluation (PISTE) randomised, controlled trial. J Neurol Neurosurg Psychiatry (2016) 0.83

The interdependence between cardiovascular calcifications in different arterial beds and vascular risk factors in patients at high cardiovascular risk. Atherosclerosis (2014) 0.83

Maternal LC-PUFA status during pregnancy and child problem behavior: the Generation R Study. Pediatr Res (2014) 0.82

Pubertal timing and bone phenotype in early old age: findings from a British birth cohort study. Int J Epidemiol (2016) 0.82