PubRank

William J Muller

Author PubWeight™ 158.35‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases. Am J Pathol 2003 8.61
2 ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol 2008 5.19
3 Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis. Cell 2006 4.48
4 Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 2004 4.34
5 Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci U S A 2003 3.61
6 Activation of Akt-1 (PKB-alpha) can accelerate ErbB-2-mediated mammary tumorigenesis but suppresses tumor invasion. Cancer Res 2004 2.84
7 Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A 2007 2.64
8 Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Cancer Res 2005 2.63
9 Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol 2002 2.54
10 Syngeneic mouse mammary carcinoma cell lines: two closely related cell lines with divergent metastatic behavior. Clin Exp Metastasis 2005 2.52
11 Insights from transgenic mouse models of ERBB2-induced breast cancer. Nat Rev Cancer 2007 2.41
12 Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo. Role of Cav-1 in cell invasiveness and matrix metalloproteinase (MMP-2/9) secretion. J Biol Chem 2004 2.37
13 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell 2009 2.09
14 Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis. Nat Genet 2007 1.98
15 ShcA signalling is essential for tumour progression in mouse models of human breast cancer. EMBO J 2008 1.82
16 Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure. Genes Dev 2006 1.80
17 Stat1 is a suppressor of ErbB2/Neu-mediated cellular transformation and mouse mammary gland tumor formation. Cell Cycle 2011 1.79
18 Changes in the expression of many Ets family transcription factors and of potential target genes in normal mammary tissue and tumors. J Biol Chem 2003 1.72
19 Distinct biological roles for the akt family in mammary tumor progression. Cancer Res 2010 1.62
20 Celecoxib, a selective cyclooxygenase 2 inhibitor, protects against human epidermal growth factor receptor 2 (HER-2)/neu-induced breast cancer. Cancer Res 2002 1.59
21 Loss of the 14-3-3σ tumor suppressor is a critical event in ErbB2-mediated tumor progression. Cancer Discov 2011 1.57
22 The EGF/CSF-1 paracrine invasion loop can be triggered by heregulin beta1 and CXCL12. Cancer Res 2009 1.56
23 Loss of caveolin-1 gene expression accelerates the development of dysplastic mammary lesions in tumor-prone transgenic mice. Mol Biol Cell 2003 1.53
24 Akt1 and akt2 play distinct roles in the initiation and metastatic phases of mammary tumor progression. Cancer Res 2009 1.53
25 Memo mediates ErbB2-driven cell motility. Nat Cell Biol 2004 1.47
26 Ets2-dependent stromal regulation of mouse mammary tumors. Mol Cell Biol 2003 1.43
27 ErbB2 is required for muscle spindle and myoblast cell survival. Mol Cell Biol 2002 1.39
28 Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu. Oncogene 2002 1.36
29 The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis. Genes Dev 2012 1.32
30 HER2/neu-induced mammary tumorigenesis and angiogenesis are reduced in cyclooxygenase-2 knockout mice. Cancer Res 2005 1.32
31 Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression. Cancer Res 2009 1.32
32 Oncogenes and tumor suppressor genes. Cold Spring Harb Perspect Biol 2010 1.31
33 Integrins in mammary-stem-cell biology and breast-cancer progression--a role in cancer stem cells? J Cell Sci 2009 1.27
34 HER3 is required for HER2-induced preneoplastic changes to the breast epithelium and tumor formation. Cancer Res 2012 1.27
35 HGF converts ErbB2/Neu epithelial morphogenesis to cell invasion. Mol Biol Cell 2004 1.26
36 Signal transduction in transgenic mouse models of human breast cancer--implications for human breast cancer. J Mammary Gland Biol Neoplasia 2008 1.25
37 Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway. Sci Signal 2011 1.24
38 Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden. Neoplasia 2010 1.23
39 The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation. Oncogene 2005 1.22
40 Copy number aberrations in mouse breast tumors reveal loci and genes important in tumorigenic receptor tyrosine kinase signaling. Cancer Res 2005 1.20
41 c-Src associates with ErbB2 through an interaction between catalytic domains and confers enhanced transforming potential. Mol Cell Biol 2009 1.19
42 PTHrP drives breast tumor initiation, progression, and metastasis in mice and is a potential therapy target. J Clin Invest 2011 1.17
43 Targeted disruption of ErbB2/Neu in the mammary epithelium results in impaired ductal outgrowth. Oncogene 2005 1.16
44 The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis. Proc Natl Acad Sci U S A 2004 1.15
45 Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer. Proc Natl Acad Sci U S A 2013 1.14
46 Signaling through ShcA is required for transforming growth factor beta- and Neu/ErbB-2-induced breast cancer cell motility and invasion. Mol Cell Biol 2008 1.14
47 CXCR4 peptide antagonist inhibits primary breast tumor growth, metastasis and enhances the efficacy of anti-VEGF treatment or docetaxel in a transgenic mouse model. Int J Cancer 2010 1.14
48 Gene expression profiling of neu-induced mammary tumors from transgenic mice reveals genetic and morphological similarities to ErbB2-expressing human breast cancers. Cancer Res 2003 1.13
49 Angiogenic acceleration of Neu induced mammary tumor progression and metastasis. Cancer Res 2004 1.12
50 Multifaceted roles of integrins in breast cancer metastasis. J Mammary Gland Biol Neoplasia 2007 1.11
51 Transforming acidic coiled coil 1 promotes transformation and mammary tumorigenesis. Cancer Res 2005 1.10
52 Transcriptional control of the ERBB2 amplicon by ERRalpha and PGC-1beta promotes mammary gland tumorigenesis. Cancer Res 2010 1.10
53 PTEN deficiency in a luminal ErbB-2 mouse model results in dramatic acceleration of mammary tumorigenesis and metastasis. J Biol Chem 2009 1.09
54 β-Catenin signaling is a critical event in ErbB2-mediated mammary tumor progression. Cancer Res 2013 1.08
55 Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors. Proc Natl Acad Sci U S A 2003 1.07
56 Distinct ErbB-2 coupled signaling pathways promote mammary tumors with unique pathologic and transcriptional profiles. Cancer Res 2007 1.06
57 Contribution of CXCL12 secretion to invasion of breast cancer cells. Breast Cancer Res 2012 1.05
58 β1-integrins signaling and mammary tumor progression in transgenic mouse models: implications for human breast cancer. Breast Cancer Res 2011 1.05
59 Conditional deletion of Shp2 in the mammary gland leads to impaired lobulo-alveolar outgrowth and attenuated Stat5 activation. J Biol Chem 2006 1.05
60 Rac-specific guanine nucleotide exchange factor DOCK1 is a critical regulator of HER2-mediated breast cancer metastasis. Proc Natl Acad Sci U S A 2013 1.04
61 Mammary epithelial-specific disruption of c-Src impairs cell cycle progression and tumorigenesis. Proc Natl Acad Sci U S A 2011 1.03
62 PGC-1α promotes the growth of ErbB2/Neu-induced mammary tumors by regulating nutrient supply. Cancer Res 2012 1.01
63 Phosphatase and tensin homologue deleted on chromosome 10 deficiency accelerates tumor induction in a mouse model of ErbB-2 mammary tumorigenesis. Cancer Res 2008 1.01
64 Mammary tumor development is directly inhibited by lifelong n-3 polyunsaturated fatty acids. J Nutr Biochem 2012 1.01
65 A novel role for 14-3-3sigma in regulating epithelial cell polarity. Genes Dev 2010 1.00
66 Genetic instability favoring transversions associated with ErbB2-induced mammary tumorigenesis. Proc Natl Acad Sci U S A 2002 0.99
67 p120-catenin is essential for terminal end bud function and mammary morphogenesis. Development 2012 0.99
68 Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression. Cancer Res 2010 0.98
69 Addressing the role of cell adhesion in tumor cell dormancy. Cell Cycle 2006 0.97
70 Ets2-dependent microenvironmental support of mouse mammary tumors. Oncogene 2005 0.96
71 An interaction map of endoplasmic reticulum chaperones and foldases. Mol Cell Proteomics 2012 0.96
72 Neurologic disease in HIV-infected children and the impact of combination antiretroviral therapy. Rev Med Virol 2014 0.95
73 The immunologic basis for severe neonatal herpes disease and potential strategies for therapeutic intervention. Clin Dev Immunol 2013 0.93
74 An EGR2/CITED1 transcription factor complex and the 14-3-3sigma tumor suppressor are involved in regulating ErbB2 expression in a transgenic-mouse model of human breast cancer. Mol Cell Biol 2007 0.93
75 Estradiol promotes growth and angiogenesis in polyoma middle T transgenic mouse mammary tumor explants. Breast Cancer Res Treat 2003 0.93
76 Transforming growth factor-beta regulator SnoN modulates mammary gland branching morphogenesis, postlactational involution, and mammary tumorigenesis. Cancer Res 2010 0.93
77 Elevated expression of DecR1 impairs ErbB2/Neu-induced mammary tumor development. Mol Cell Biol 2007 0.93
78 HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer. Proc Natl Acad Sci U S A 2011 0.92
79 Functional interaction between herpes simplex virus type 2 gD and HVEM transiently dampens local chemokine production after murine mucosal infection. PLoS One 2011 0.92
80 Bcl3 selectively promotes metastasis of ERBB2-driven mammary tumors. Cancer Res 2012 0.92
81 Expression, location, and interactions of ErbB2 and its intramembrane ligand Muc4 (sialomucin complex) in rat mammary gland during pregnancy. J Cell Physiol 2005 0.91
82 The catalytic activity of the ErbB-2 receptor tyrosine kinase is essential for embryonic development. Mol Cell Biol 2002 0.91
83 The role of Ink4a/Arf in ErbB2 mammary gland tumorigenesis. Cancer Res 2003 0.91
84 Concomitant targeting of tumor cells and induction of T-cell response synergizes to effectively inhibit trastuzumab-resistant breast cancer. Cancer Res 2012 0.90
85 Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo. Breast Cancer Res 2012 0.90
86 Early viral suppression improves neurocognitive outcomes in HIV-infected children. AIDS 2015 0.89
87 The ShcA adaptor protein is a critical regulator of breast cancer progression. Cell Cycle 2008 0.89
88 Receptor tyrosine kinase signaling favors a protumorigenic state in breast cancer cells by inhibiting the adaptive immune response. Cancer Res 2010 0.89
89 Stromal retinoic acid receptor beta promotes mammary gland tumorigenesis. Proc Natl Acad Sci U S A 2010 0.88
90 Uncoupling of PI3K from ErbB3 impairs mammary gland development but does not impact on ErbB2-induced mammary tumorigenesis. Cancer Res 2012 0.88
91 Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression. Oncogene 2003 0.87
92 p27Kip1 repression of ErbB2-induced mammary tumor growth in transgenic mice involves Skp2 and Wnt/beta-catenin signaling. Cancer Res 2006 0.87
93 Integrins in breast cancer dormancy. APMIS 2008 0.87
94 RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland. Dis Model Mech 2014 0.87
95 Focal adhesion kinase is required for β-catenin-induced mobilization of epidermal stem cells. Carcinogenesis 2012 0.87
96 ErbB2 overexpression in mammary cells upregulates VEGF through the core promoter. Biochem Biophys Res Commun 2005 0.86
97 Dasatinib inhibits mammary tumour development in a genetically engineered mouse model. J Pathol 2013 0.86
98 Selenoproteins reduce susceptibility to DMBA-induced mammary carcinogenesis. Carcinogenesis 2012 0.86
99 Germ-line expression of an oncogenic erbB2 allele confers resistance to erbB2-induced mammary tumorigenesis. Proc Natl Acad Sci U S A 2004 0.85
100 Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis. Biochem Biophys Res Commun 2010 0.84
101 Cooperative signaling between Wnt1 and integrin-linked kinase induces accelerated breast tumor development. Breast Cancer Res 2010 0.84
102 Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development. Development 2004 0.84
103 An identity crisis for fps/fes: oncogene or tumor suppressor? Cancer Res 2005 0.84
104 Herpes simplex virus-2 glycoprotein interaction with HVEM influences virus-specific recall cellular responses at the mucosa. Clin Dev Immunol 2012 0.83
105 Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer Res 2010 0.83
106 Pathogenesis of neonatal herpes simplex 2 disease in a mouse model is dependent on entry receptor expression and route of inoculation. J Virol 2012 0.83
107 Functional rescue of vitamin C synthesis deficiency in human cells using adenoviral-based expression of murine l-gulono-gamma-lactone oxidase. Genomics 2004 0.81
108 BIM, PUMA, and the achilles' heel of oncogene addiction. Sci Signal 2013 0.80
109 Protein-tyrosine phosphatase epsilon regulates Shc signaling in a kinase-specific manner: increasing coherence in tyrosine phosphatase signaling. J Biol Chem 2007 0.80
110 Mammary tumour development is dose-dependently inhibited by n-3 polyunsaturated fatty acids in the MMTV-neu(ndl)-YD5 transgenic mouse model. Lipids Health Dis 2014 0.79
111 Mammary epithelial-restricted expression of activated c-src rescues the block to mammary gland morphogenesis due to the deletion of the C-terminus of Patched-1. Dev Biol 2012 0.79
112 Developmental timing of activated erbB2 expression plays a critical role in the induction of mammary tumors. Cell Cycle 2004 0.77
113 Inducible and coupled expression of the polyomavirus middle T antigen and Cre recombinase in transgenic mice: an in vivo model for synthetic viability in mammary tumour progression. Breast Cancer Res 2014 0.76
114 Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model. BMC Cancer 2014 0.76
115 Transgenic mouse models--a seminal breakthrough in oncogene research. Cold Spring Harb Protoc 2013 0.76
116 Changes in tumor tissue organization in collagen-I sensitize cells to ionizing radiation in an ex vivo model of solid mammary tumor growth and local invasion. Cell Cycle 2011 0.75