The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis.

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Published in J Infect Dis on July 16, 2014

Authors

John Mair-Jenkins1, Maria Saavedra-Campos2, J Kenneth Baillie3, Paul Cleary4, Fu-Meng Khaw1, Wei Shen Lim5, Sophia Makki1, Kevin D Rooney6, Jonathan S Nguyen-Van-Tam, Charles R Beck7, Convalescent Plasma Study Group

Author Affiliations

1: East Midlands Centre, Public Health England.
2: Field Epidemiology Training Programme, Public Health England, London Field Epidemiology Service, Public Health England, Liverpool.
3: Roslin Institute, University of Edinburgh, Midlothian.
4: Field Epidemiology Service, Public Health England, Liverpool.
5: Respiratory Medicine, Nottingham University Hospitals NHS Trust.
6: Institute of Care and Practice Improvement, University of the West of Scotland, Hamilton, United Kingdom.
7: Division of Epidemiology and Public Health, University of Nottingham, Nottingham.

Associated clinical trials:

Convalescent Plasma as Treatment for Hospitalized Subjects With COVID-19 Infection | NCT04343755

Efficacy and Safety of Novel Treatment Options for Adults With COVID-19 Pneumonia (CCAP) | NCT04345289

Convalescent Plasma in ICU Patients With COVID-19-induced Respiratory Failure | NCT04353206

Convalescent Plasma Compared to the Best Available Therapy for the Treatment of SARS-CoV-2 Pneumonia (COP-COVID-19) | NCT04358783

Efficacy of Convalescent Plasma Therapy in the Early Care of COVID-19 Patients. (PLASCOSSA) | NCT04372979

Convalescent Plasma for Treatment of COVID-19 Patients With Pneumonia | NCT04374565

Effectiveness and Safety of Convalescent Plasma Therapy on COVID-19 Patients With Acute Respiratory Distress Syndrome | NCT04380935

Convalescent Plasma vs Human Immunoglobulin to Treat COVID-19 Pneumonia | NCT04381858

Feasibility Study of Anti-SARS-CoV-2 Plasma Transfusions in COVID-19 Patients With SRD | NCT04411602

Investigational COVID-19 Convalescent Plasma Infusion for Severely or Life-threateningly Ill COVID-19 Patients | NCT04420988

Convalescent Plasma as Treatment for Subjects With Early COVID-19 Infection | NCT04456413

Administration of Anti-SARS-CoV-2 Convalescent Plasma in Hospitalized, Non-ICU Patients With COVID-19 | NCT04467151

Treatment of Critically Ill Patients With Covid-19 With Convalescent Plasma | NCT04468009

Expanded Access to Convalescent Plasma for Treatment of COVID-19 | NCT04472572

Therapeutic Plasmapheresis in Critically Ill Adult Patients With COVID-19 Confirmed Diagnosis (PLASMA) | NCT04480632

Open-label Treatment of Severe Coronavirus Disease 2019 (COVID-19) With Convalescent Plasma (Inova-CCP) | NCT04502472

Convalescent Plasma in the Early Treatment of High-Risk Patients With SARS-CoV-2 (COVID-19) Infection | NCT04513158

SARS-CoV-2 Antibodies Based IVIG Therapy for COVID-19 Patients | NCT04521309

Convalescent Plasma as Adjunct Therapy for COVID-19 (PlaSenTer) | NCT04873414

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