Epithelialization in Wound Healing: A Comprehensive Review.

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🔗 View Article (PMID 25032064)

Published in Adv Wound Care (New Rochelle) on July 01, 2014

Authors

Irena Pastar1, Olivera Stojadinovic1, Natalie C Yin1, Horacio Ramirez1, Aron G Nusbaum1, Andrew Sawaya1, Shailee B Patel1, Laiqua Khalid2, Rivkah R Isseroff3, Marjana Tomic-Canic1

Author Affiliations

1: Wound Healing and Regenerative Medicine Research Program, Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine , Miami, Florida.
2: Department of Surgery, University of Miami Miller School of Medicine , Miami, Florida.
3: Department of Dermatology, UC Davis , Sacramento, California.

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The functions of animal microRNAs. Nature (2004) 64.85

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The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol (2009) 8.63

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Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med (2005) 8.01

Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet (2008) 7.55

Growth factors and cytokines in wound healing. Wound Repair Regen (2009) 7.14

The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine. Science (2011) 7.07

Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell (2000) 6.93

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Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet (2006) 6.30

A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66

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Hair follicle stem cells are specified and function in early skin morphogenesis. Cell Stem Cell (2008) 5.02

A structural scaffolding of intermediate filaments in health and disease. Science (1998) 4.70

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Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol (2002) 4.22

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Release of the angiogenic cytokine vascular endothelial growth factor (VEGF) from platelets: significance for VEGF measurements and cancer biology. Br J Cancer (1998) 3.93

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Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury. Nat Med (2009) 3.32

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Epidermal stem cells: an update. Curr Opin Genet Dev (2006) 1.87

Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 release. Biochem J (1997) 1.85

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Current insights into the formation and breakdown of hemidesmosomes. Trends Cell Biol (2006) 1.79

The skin of domestic mammals as a model for the human skin, with special reference to the domestic pig. Curr Probl Dermatol (1978) 1.74

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Steroidogenesis in the skin: implications for local immune functions. J Steroid Biochem Mol Biol (2013) 1.71

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Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis. Br J Dermatol (2003) 1.56

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Angiogenesis, vasculogenesis, and induction of healing in chronic wounds. Vasc Endovascular Surg (2005) 1.50

De novo sterologenesis in the skin. II. Regulation by cutaneous barrier requirements. J Lipid Res (1985) 1.47

Rat models of skin wound healing: a review. Wound Repair Regen (2004) 1.46

Differential expression of a cutaneous corticotropin-releasing hormone system. Endocrinology (2003) 1.46

Structure, function, and differentiation of the keratinocyte. Physiol Rev (1989) 1.45

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Activated mesenchymal stem cells increase wound tensile strength in aged mouse model via macrophages. J Surg Res (2012) 1.44

Epidermal stem cells: the cradle of epidermal determination, differentiation and wound healing. Biol Cell (2005) 1.43

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Cortisol synthesis in epidermis is induced by IL-1 and tissue injury. J Biol Chem (2011) 1.36

Regulatory roles of sex hormones in cutaneous biology and immunology. J Dermatol Sci (2004) 1.35

The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells. Mol Biol Cell (2000) 1.35

Modulation of JE/MCP-1 expression in dermal wound repair. Am J Pathol (1995) 1.33

Epigenetic Silencing of miR-203 Upregulates SNAI2 and Contributes to the Invasiveness of Malignant Breast Cancer Cells. Genes Cancer (2011) 1.32

Epigenetic regulation of gene expression in keratinocytes. J Invest Dermatol (2012) 1.32

The mouse excisional wound splinting model, including applications for stem cell transplantation. Nat Protoc (2013) 1.32

Interactions of methicillin resistant Staphylococcus aureus USA300 and Pseudomonas aeruginosa in polymicrobial wound infection. PLoS One (2013) 1.32

The neuropathic diabetic foot ulcer microbiome is associated with clinical factors. Diabetes (2012) 1.31

Keratinocyte migration, proliferation, and differentiation in chronic ulcers from patients with diabetes and normal wounds. J Histochem Cytochem (2008) 1.29

Stress-mediated increases in systemic and local epinephrine impair skin wound healing: potential new indication for beta blockers. PLoS Med (2009) 1.28

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