A randomized 2×2 factorial trial, part 1: single-dose rabbit antithymocyte globulin induction may improve renal transplantation outcomes.

PubWeight™: 0.83‹?›

🔗 View Article (PMC 4281164)

Published in Transplantation on January 01, 2015

Authors

R Brian Stevens1, Kirk W Foster, Clifford D Miles, James T Lane, Andre C Kalil, Diana F Florescu, John P Sandoz, Theodore H Rigley, Kathleen J Nielsen, Jill Y Skorupa, Anna M Kellogg, Tamer Malik, Lucile E Wrenshall

Author Affiliations

1: 1 Department of Surgery, Wright State University Boonshoft School of Medicine, Dayton, OH. 2 Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE. 3 Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE. 4 Department of Internal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK. 5 Sigma Analytics, Inc., Anthem, AZ. 6 Department of Surgery, Methodist Hospital, Houston, TX.

Associated clinical trials:

Improved Induction and Maintenance Immunosuppression in Kidney Transplantation | NCT00556933

Safety Trial of Single Versus Multiple Dose Thymoglobulin Induction in Kidney Transplantation (STAT) | NCT00906204

Articles cited by this

A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med (1999) 82.86

The natural history of chronic allograft nephropathy. N Engl J Med (2003) 8.70

The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal homotransplantation. Surg Gynecol Obstet (1967) 7.24

Banff '05 Meeting Report: differential diagnosis of chronic allograft injury and elimination of chronic allograft nephropathy ('CAN'). Am J Transplant (2007) 5.39

Rabbit antithymocyte globulin versus basiliximab in renal transplantation. N Engl J Med (2006) 4.79

Alemtuzumab induction in renal transplantation. N Engl J Med (2011) 4.13

Tolerogenic immunosuppression for organ transplantation. Lancet (2003) 4.09

Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. Am J Transplant (2009) 3.43

Evidence for antibody-mediated injury as a major determinant of late kidney allograft failure. Transplantation (2010) 2.59

Steroid avoidance or withdrawal after renal transplantation increases the risk of acute rejection but decreases cardiovascular risk. A meta-analysis. Transplantation (2010) 2.57

Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets. Am J Transplant (2007) 2.25

De novo donor-specific antibody at the time of kidney transplant biopsy associates with microvascular pathology and late graft failure. Am J Transplant (2009) 2.24

Switch to a sirolimus-based immunosuppression in long-term renal transplant recipients: reduced rate of (pre-)malignancies and nonmelanoma skin cancer in a prospective, randomized, assessor-blinded, controlled clinical trial. Am J Transplant (2010) 2.10

Mechanisms of action of antithymocyte globulin: T-cell depletion and beyond. Leukemia (2007) 2.07

NF-kappaB in renal inflammation. J Am Soc Nephrol (2010) 2.00

Kidney transplantation under minimal immunosuppression after pretransplant lymphoid depletion with Thymoglobulin or Campath. J Am Coll Surg (2005) 1.93

Calcineurin inhibitor minimization in the Symphony study: observational results 3 years after transplantation. Am J Transplant (2009) 1.88

Calcineurin inhibitor nephrotoxicity: longitudinal assessment by protocol histology. Transplantation (2004) 1.82

Antiserum to lymphocytes: prolonged survival of canine renal allografts. Science (1966) 1.81

A prospective, randomized, double-blind, placebo-controlled multicenter trial comparing early (7 day) corticosteroid cessation versus long-term, low-dose corticosteroid therapy. Ann Surg (2008) 1.74

Mechanisms involved in antithymocyte globulin immunosuppressive activity in a nonhuman primate model. Transplantation (2001) 1.68

Inflammation in areas of tubular atrophy in kidney allograft biopsies: a potent predictor of allograft failure. Am J Transplant (2010) 1.65

Prolonged CD4 T cell lymphopenia increases morbidity and mortality after renal transplantation. J Am Soc Nephrol (2010) 1.60

Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase. Immunol Cell Biol (2011) 1.45

Anti-serum to cultured human lymphoblasts: preparation, purification and immunosuppressive properties in man. Ann Surg (1969) 1.37

Calcineurin inhibitor-sparing regimens in solid organ transplantation: focus on improving renal function and nephrotoxicity. Clin Transplant (2008) 1.29

Efficacy on renal function of early conversion from cyclosporine to sirolimus 3 months after renal transplantation: concept study. Am J Transplant (2009) 1.24

Association of herpesvirus infections with T-lymphocyte-subset alterations, glomerulopathy, and opportunistic infections after renal transplantation. N Engl J Med (1983) 1.23

A prospective, randomized, clinical trial of intraoperative versus postoperative Thymoglobulin in adult cadaveric renal transplant recipients. Transplantation (2003) 1.19

The transcriptome of the implant biopsy identifies donor kidneys at increased risk of delayed graft function. Am J Transplant (2007) 1.13

Improved scoring system to assess adult donors for cadaver renal transplantation. Am J Transplant (2003) 1.13

Long-term deterioration of kidney allograft function. Am J Transplant (2005) 1.09

A prospective randomized trial of steroid-free maintenance regimens in kidney transplant recipients--an interim analysis. Am J Transplant (2005) 1.09

CD4 cell lymphopenia and atherosclerosis in renal transplant recipients. J Am Soc Nephrol (2003) 1.08

Wound healing complications and the use of mammalian target of rapamycin inhibitors in kidney transplantation: a critical review of the literature. Transplantation (2012) 1.06

Inhibition of nuclear factor-kappaB activation reduces cortical tubulointerstitial injury in proteinuric rats. Kidney Int (1999) 1.05

Long-term immunosuppression, without maintenance prednisone, after kidney transplantation. Ann Surg (2004) 1.04

Polyclonal rabbit antithymocyte globulin exhibits consistent immunosuppressive capabilities beyond cell depletion. Transplantation (2009) 1.04

Heparinase selectively sheds heparan sulphate from the endothelial glycocalyx. Biol Chem (2008) 1.03

Molecular correlates of renal function in kidney transplant biopsies. J Am Soc Nephrol (2009) 1.03

T cells in atherosclerosis. Int Immunol (2013) 1.03

Rabbit antithymocyte globulin (thymoglobulin): 25 years and new frontiers in solid organ transplantation and haematology. Drugs (2010) 1.03

Conversion from calcineurin inhibitors to sirolimus for chronic renal allograft dysfunction: a systematic review of the evidence. Transplantation (2006) 1.02

Do wound complications or lymphoceles occur more often in solid organ transplant recipients on mTOR inhibitors? A systematic review of randomized controlled trials. Transpl Int (2011) 0.98

Single bolus antithymocyte globulin versus basiliximab induction in kidney transplantation with cyclosporine triple immunosuppression: efficacy and safety. Transplantation (2007) 0.96

Focal C4d+ in renal allografts is associated with the presence of donor-specific antibodies and decreased allograft survival. Am J Transplant (2009) 0.96

Randomized trial of single-dose versus divided-dose rabbit anti-thymocyte globulin induction in renal transplantation: an interim report. Transplantation (2008) 0.92

Thymoglobulin and ischemia reperfusion injury in kidney and liver transplantation. Nephrol Dial Transplant (2007) 0.92

Analysis of HLA class I specific antibodies in patients with failed allografts. Transplantation (2007) 0.92

Effect of antilymphocytic serum on suspensions of lymphocytes in vitro. Nature (1951) 0.90

The impact of c4d pattern and donor-specific antibody on graft survival in recipients requiring indication renal allograft biopsy. Am J Transplant (2009) 0.88

Brain heparanase expression is up-regulated during postnatal development and hypoxia-induced neovascularization in adult rats. J Neurochem (2007) 0.88

Minimization of steroids in kidney transplantation. Transpl Int (2008) 0.87

Interleukin-2 directly increases albumin permeability of bovine and human vascular endothelium in vitro. Am J Respir Cell Mol Biol (1992) 0.87

Influence of induction modality on the outcome of deceased donor kidney transplant recipients discharged on steroid-free maintenance immunosuppression. Transplantation (2012) 0.86

Post-renal transplant surgical complications with newer immunosuppressive drugs: mycophenolate mofetil vs. m-TOR inhibitors. Int Urol Nephrol (2009) 0.82

T cells in coronary artery disease: different effects of different T-cell subsets. J Am Coll Cardiol (2007) 0.81

Effect of recombinant human interleukin 2 on neutrophil adherence to endothelial cells in vitro. Inflammation (1996) 0.81

Administration of nonanticoagulant heparin inhibits the loss of glycosaminoglycans from xenogeneic cardiac grafts and prolongs graft survival. Transplant Proc (1993) 0.81

Short and long-term results after pretransplant high-dose single ATG-fresenius bolus in cadaveric kidney transplantation. Transplant Proc (1998) 0.80

Prospective randomized trial of maintenance immunosuppression with rapid discontinuation of prednisone in adult kidney transplantation. Am J Transplant (2013) 0.80

Transplantation: To convert or not to convert: lessons from the CONVERT trial. Nat Rev Nephrol (2009) 0.80

The pathogenesis of hyperacute xenograft rejection. Am J Kidney Dis (1992) 0.79

Improved long-term survival after intra-operative single high-dose ATG-Fresenius induction in renal transplantation: a single centre experience. Ann Transplant (2009) 0.79

Steroid minimization for sirolimus-treated renal transplant recipients. Clin Transplant (2010) 0.78

Single-dose rATG induction at renal transplantation: superior renal function and glucoregulation with less hypomagnesemia. Clin Transplant (2011) 0.78

Albuminuria after renal transplantation: maintenance with sirolimus/low-dose tacrolimus vs. mycophenolate mofetil/high-dose tacrolimus. Clin Transplant (2010) 0.77

Graft survival after renal transplantation: agenda for analysis. Kidney Int (1983) 0.77

Results with renal transplants performed after previous solitary pancreas transplants. Transplant Proc (1994) 0.76

Differential regulation of the nuclear factor-κB pathway by rabbit antithymocyte globulins in kidney transplantation. Transplantation (2012) 0.76

Articles by these authors

Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA (2013) 3.78

Guidelines for evaluation of new fever in critically ill adult patients: 2008 update from the American College of Critical Care Medicine and the Infectious Diseases Society of America. Crit Care Med (2008) 3.67

Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit. Crit Care Med (2009) 2.65

West Nile virus-associated encephalitis in recipients of renal and pancreas transplants: case series and literature review. Clin Infect Dis (2004) 1.84

Cryptococcus neoformans in organ transplant recipients: impact of calcineurin-inhibitor agents on mortality. J Infect Dis (2007) 1.78

Lipid formulations of amphotericin B significantly improve outcome in solid organ transplant recipients with central nervous system cryptococcosis. Clin Infect Dis (2009) 1.60

Safety, pharmacokinetics, and pharmacodynamics of drotrecogin alfa (activated) in children with severe sepsis. Pediatrics (2004) 1.60

Interleukin-2 is present in human blood vessels and released in biologically active form by heparanase. Immunol Cell Biol (2011) 1.45

Regional manifestations and control of the immune system. FASEB J (2002) 1.38

Lessons learned: critical care management of patients with Ebola in the United States. Crit Care Med (2015) 1.18

An immune reconstitution syndrome-like illness associated with Cryptococcus neoformans infection in organ transplant recipients. Clin Infect Dis (2005) 1.14

Cutaneous cryptococcosis in solid organ transplant recipients. Med Mycol (2010) 1.09

New-onset diabetes after kidney transplantation: an application of 2003 International Guidelines. Transplantation (2005) 1.06

Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species. Med Mycol (2012) 1.06

Validation and comparison of clinical prediction rules for invasive candidiasis in intensive care unit patients: a matched case-control study. Crit Care (2011) 1.04

Antifungal management practices and evolution of infection in organ transplant recipients with cryptococcus neoformans infection. Transplantation (2005) 1.02

Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia. Cochrane Database Syst Rev (2008) 1.02

Renal thrombotic microangiopathy in mice with combined deletion of endocytic recycling regulators EHD3 and EHD4. PLoS One (2011) 0.99

Efficacy of the oxygen-charged static two-layer method for short-term pancreas preservation and islet isolation from nonhuman primate and human pancreata. Cell Transplant (2002) 0.99

What do we know about adenovirus in renal transplantation? Nephrol Dial Transplant (2013) 0.96

Pulmonary cryptococcosis in solid organ transplant recipients: clinical relevance of serum cryptococcal antigen. Clin Infect Dis (2008) 0.95

Unrecognized pretransplant and donor‐derived cryptococcal disease in organ transplant recipients. Clin Infect Dis (2010) 0.94

Calcineurin inhibitor agents interact synergistically with antifungal agents in vitro against Cryptococcus neoformans isolates: correlation with outcome in solid organ transplant recipients with cryptococcosis. Antimicrob Agents Chemother (2007) 0.94

Delayed graft function and cast nephropathy associated with tacrolimus plus rapamycin use. J Am Soc Nephrol (2003) 0.94

Inhibition of the cardiac angiogenic response to exogenous vascular endothelial growth factor. Surgery (2004) 0.93

Duodenal infusion of feces for recurrent Clostridium difficile. N Engl J Med (2013) 0.93

Randomized trial of single-dose versus divided-dose rabbit anti-thymocyte globulin induction in renal transplantation: an interim report. Transplantation (2008) 0.92

Central nervous system cryptococcosis in solid organ transplant recipients: clinical relevance of abnormal neuroimaging findings. Transplantation (2008) 0.92

Is there a role for oral human immunoglobulin in the treatment for norovirus enteritis in immunocompromised patients? Pediatr Transplant (2011) 0.91

Pancreas transplantation improves vascular disease in patients with type 1 diabetes. Diabetes Care (2004) 0.90

Sitagliptin therapy in kidney transplant recipients with new-onset diabetes after transplantation. Transplantation (2011) 0.90

Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia. Cochrane Database Syst Rev (2012) 0.89

Effects of L-arginine on fibroblast growth factor 2-induced angiogenesis in a model of endothelial dysfunction. Circulation (2005) 0.88

Critical Care for Multiple Organ Failure Secondary to Ebola Virus Disease in the United States. Crit Care Med (2015) 0.88

Severe sepsis: are PROWESS and PROWESS-SHOCK trials comparable? A clinical and statistical heterogeneity analysis. Crit Care (2013) 0.88

Cerebral aspergillosis caused by Aspergillus ustus following orthotopic heart transplantation: case report and review of the literature. Clin Transplant (2008) 0.87

Normalization of coronary microvascular reactivity and improvement in myocardial perfusion by surgical vascular endothelial growth factor therapy combined with oral supplementation of l-arginine in a porcine model of endothelial dysfunction. J Thorac Cardiovasc Surg (2005) 0.87

Evaluation of the coagulation and inflammatory responses in solid organ transplant recipients and donors. Clin Transplant (2009) 0.87

Adenovirus: current epidemiology and emerging approaches to prevention and treatment. Curr Infect Dis Rep (2014) 0.86

Perlecan: a major IL-2-binding proteoglycan in murine spleen. Immunol Cell Biol (2007) 0.86

The importance of detecting cytomegalovirus infections in studies evaluating new therapies for severe sepsis. Crit Care Med (2010) 0.85

The "last breath" of the ventilator-associated pneumonia surveillance definition*. Crit Care Med (2014) 0.84

Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia. Cochrane Database Syst Rev (2014) 0.84

Is cytomegalovirus reactivation increasing the mortality of patients with severe sepsis? Crit Care (2011) 0.83

Linezolid does not show advantages over vancomycin in modulating the pulmonary immune response: how should we conciliate these new findings with the Zephyr trial results? Crit Care Med (2011) 0.83

Unresolved questions with the use of linezolid vs vancomycin for nosocomial pneumonia. Chest (2004) 0.83

Long-term effect of chronic intravenous and inhaled nephrotoxic antibiotic treatment on the renal function of patients with cystic fibrosis. Hemodial Int (2012) 0.83

An international survey of cytomegalovirus prevention and treatment practices in intestinal transplantation. Transplantation (2014) 0.83

An epidemiological analysis of acute flaccid paralysis and its surveillance system in Iraq, 1997-2011. BMC Infect Dis (2014) 0.82

Assessing treatment barriers in young adults with type 1 diabetes. Diabetes Res Clin Pract (2010) 0.82

Cytomegalovirus infections in non-immunocompromised and immunocompromised patients in the intensive care unit. Infect Disord Drug Targets (2011) 0.82

Effects of L-arginine on the endogenous angiogenic response in a model of hypercholesterolemia. Surgery (2005) 0.81

Effectiveness of valganciclovir 900 mg versus 450 mg for cytomegalovirus prophylaxis in transplantation: direct and indirect treatment comparison meta-analysis. Clin Infect Dis (2010) 0.81

Impact of simultaneous pancreas and kidney transplantation on cardiovascular risk factors in patients with type 1 diabetes mellitus. Transplantation (2007) 0.81

Improved islet yields from Macaca nemestrina and marginal human pancreata after two-layer method preservation and endogenous trypsin inhibition. Am J Transplant (2003) 0.81

Risk of cytomegalovirus disease in high-risk liver transplant recipients on valganciclovir prophylaxis: a systematic review and meta-analysis. Liver Transpl (2012) 0.81

Cytomegalovirus viremia in solid organ transplantation: does the initial viral load correlate with risk factors and outcomes? Clin Transplant (2008) 0.81

Adenovirus infections in pediatric small bowel transplant recipients. Transplantation (2010) 0.80

Risk of serious opportunistic infections after solid organ transplantation: interleukin-2 receptor antagonists versus polyclonal antibodies. A meta-analysis. Expert Rev Anti Infect Ther (2014) 0.80

Bloodstream infections during the first year after pediatric small bowel transplantation. Pediatr Infect Dis J (2012) 0.80

Is linezolid superior to vancomycin for complicated skin and soft tissue infections due to methicillin-resistant Staphylococcus aureus? Antimicrob Agents Chemother (2006) 0.79

Donor age and gender are the strongest predictors of marrow recovery from cadaveric vertebral bodies. Cell Transplant (2003) 0.79

Does increasing immunoglobulin levels impact survival in solid organ transplant recipients with hypogammaglobulinemia? Clin Transplant (2014) 0.79

Emerging and resistant infections. Ann Am Thorac Soc (2014) 0.78

Single-dose rATG induction at renal transplantation: superior renal function and glucoregulation with less hypomagnesemia. Clin Transplant (2011) 0.78

Anti-inflammatory effects of rosuvastatin in healthy subjects: a prospective longitudinal study. Curr Pharm Des (2014) 0.78

Identifying predictors of central nervous system disease in solid organ transplant recipients with cryptococcosis. Transplantation (2010) 0.78

Chicken pox after pediatric liver transplantation. Liver Transpl (2005) 0.78

Evaluation of an infrared thermal detection system for fever recognition during the H1N1 influenza pandemic. Infect Control Hosp Epidemiol (2011) 0.77

Albuminuria after renal transplantation: maintenance with sirolimus/low-dose tacrolimus vs. mycophenolate mofetil/high-dose tacrolimus. Clin Transplant (2010) 0.77

Aqueous flow in galactose-fed dogs. Exp Eye Res (2006) 0.77

Is it time to replace L-arginine in severe sepsis? Crit Care Med (2011) 0.77

Does recombinant activated protein C work in patients with severe sepsis? Crit Care Med (2010) 0.77

Heel ultrasonography is not a good screening tool for bone loss after kidney and pancreas transplantation. Clin Transplant (2004) 0.77

Geographic differences in disease expression of cryptococcosis in solid organ transplant recipients in the United States. Ann Transplant (2010) 0.76

Wanted: early goal-directed therapy for septic shock--dead or alive, but not critically ill! Intensive Care Med (2009) 0.76

A silent killer: cytomegalovirus infection in the nonimmunocompromised critically ill patient. Crit Care Med (2008) 0.76

Why valganciclovir should not be indicated for liver recipients and high-dose acyclovir should not be removed from international cytomegalovirus guidelines. Transplantation (2011) 0.76

Risk factors for systemic Candida infections in pediatric small bowel transplant recipients. Pediatr Infect Dis J (2012) 0.76

Blood purification: can we purify our patients from sepsis? Crit Care Med (2013) 0.76