Published in Cold Spring Harb Perspect Med on August 01, 2014
Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity. Cell Syst (2016) 1.44
Pri-Mir-34b/C and Tp-53 Polymorphisms are Associated With The Susceptibility of Papillary Thyroid Carcinoma: A Case-Control Study. Medicine (Baltimore) (2015) 0.88
Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol (2015) 0.88
Integration of the Transcription Factor-Regulated and Epigenetic Mechanisms in the Control of Keratinocyte Differentiation. J Investig Dermatol Symp Proc (2015) 0.83
FLLL12 induces apoptosis in lung cancer cells through a p53/p73-independent but death receptor 5-dependent pathway. Cancer Lett (2015) 0.81
Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder. J Invest Dermatol (2016) 0.81
Role of chromatin and transcriptional co-regulators in mediating p63-genome interactions in keratinocytes. BMC Genomics (2014) 0.79
The homeoprotein DLX3 and tumor suppressor p53 co-regulate cell cycle progression and squamous tumor growth. Oncogene (2015) 0.78
Structural investigations of the p53/p73 homologs from the tunicate species Ciona intestinalis reveal the sequence requirements for the formation of a tetramerization domain. Protein Sci (2015) 0.77
A global analysis of the complex landscape of isoforms and regulatory networks of p63 in human cells and tissues. BMC Genomics (2015) 0.77
Metabolic pathways regulated by TAp73 in response to oxidative stress. Oncotarget (2016) 0.76
Curcumin induces apoptosis of upper aerodigestive tract cancer cells by targeting multiple pathways. PLoS One (2015) 0.76
Mutations in TSPEAR, Encoding a Regulator of Notch Signaling, Affect Tooth and Hair Follicle Morphogenesis. PLoS Genet (2016) 0.75
The p53 family orchestrates the regulation of metabolism: physiological regulation and implications for cancer therapy. Br J Cancer (2016) 0.75
Cbx4: A new guardian of p63's domain of epidermal control. J Cell Biol (2015) 0.75
Epigenetic Regulation of Epidermal Stem Cell Biomarkers and Their Role in Wound Healing. Int J Mol Sci (2015) 0.75
Differential Expression of Stem Cell Markers in Ocular Surface Squamous Neoplasia. PLoS One (2016) 0.75
p53: key conductor of all anti-acne therapies. J Transl Med (2017) 0.75
The DNA-damage response in human biology and disease. Nature (2009) 17.86
p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature (1999) 14.38
p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature (1999) 13.21
A landscape of driver mutations in melanoma. Cell (2012) 12.61
p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol Cell (1998) 11.54
Epidermal homeostasis: a balancing act of stem cells in the skin. Nat Rev Mol Cell Biol (2009) 7.95
p53 isoforms can regulate p53 transcriptional activity. Genes Dev (2005) 6.76
Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature (2005) 6.67
p63 is the molecular switch for initiation of an epithelial stratification program. Genes Dev (2004) 6.40
The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol (2005) 6.27
A skin microRNA promotes differentiation by repressing 'stemness'. Nature (2008) 5.66
Controls of hair follicle cycling. Physiol Rev (2001) 5.49
p53 mutations in cancer. Nat Cell Biol (2013) 5.18
The secret life of the hair follicle. Trends Genet (1992) 4.94
Molecular mechanisms regulating hair follicle development. J Invest Dermatol (2002) 4.16
Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family. Cancer Cell (2005) 4.14
Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev (2006) 3.72
Programming gene expression in developing epidermis. Development (1994) 3.60
TAp63 suppresses metastasis through coordinate regulation of Dicer and miRNAs. Nature (2010) 3.37
SKPs derive from hair follicle precursors and exhibit properties of adult dermal stem cells. Cell Stem Cell (2009) 3.20
TAp63 prevents premature aging by promoting adult stem cell maintenance. Cell Stem Cell (2009) 3.15
Molecular principles of hair follicle induction and morphogenesis. Bioessays (2005) 3.08
The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations. Mol Cell Biol (2003) 3.00
Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63. Hum Mol Genet (2001) 2.95
Perp is a p63-regulated gene essential for epithelial integrity. Cell (2005) 2.58
Bcl-2 and accelerated DNA repair mediates resistance of hair follicle bulge stem cells to DNA-damage-induced cell death. Nat Cell Biol (2010) 2.48
Mechanisms regulating epithelial stratification. Annu Rev Cell Dev Biol (2007) 2.47
p53 Research: the past thirty years and the next thirty years. Cold Spring Harb Perspect Biol (2010) 2.34
p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation. Development (2006) 2.23
p63 in epithelial survival, germ cell surveillance, and neoplasia. Annu Rev Pathol (2010) 2.21
TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol (2009) 2.15
p63-associated disorders. Cell Cycle (2007) 2.05
ΔNp63 knockout mice reveal its indispensable role as a master regulator of epithelial development and differentiation. Development (2012) 1.97
p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ (2011) 1.94
Deconstructing the skin: cytoarchitectural determinants of epidermal morphogenesis. Nat Rev Mol Cell Biol (2011) 1.94
The origins and evolution of the p53 family of genes. Cold Spring Harb Perspect Biol (2009) 1.90
Down-regulation of p63 is required for epidermal UV-B-induced apoptosis. Cancer Res (2000) 1.88
Analysis of apoptosis during hair follicle regression (catagen) Am J Pathol (1997) 1.82
MYC in mammalian epidermis: how can an oncogene stimulate differentiation? Nat Rev Cancer (2008) 1.78
TAp63 is a master transcriptional regulator of lipid and glucose metabolism. Cell Metab (2012) 1.77
ΔNp63α is an oncogene that targets chromatin remodeler Lsh to drive skin stem cell proliferation and tumorigenesis. Cell Stem Cell (2011) 1.75
Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell (2010) 1.75
An active role of the DeltaN isoform of p63 in regulating basal keratin genes K5 and K14 and directing epidermal cell fate. PLoS One (2009) 1.69
DNA-damage response in tissue-specific and cancer stem cells. Cell Stem Cell (2011) 1.67
An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest (2007) 1.64
Rescue of key features of the p63-null epithelial phenotype by inactivation of Ink4a and Arf. EMBO J (2009) 1.54
p63, a story of mice and men. J Invest Dermatol (2011) 1.50
ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. Dev Cell (2012) 1.47
TAp73 depletion accelerates aging through metabolic dysregulation. Genes Dev (2012) 1.45
Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389. Mol Cell Biol (2004) 1.44
p63 and p73 transcriptionally regulate genes involved in DNA repair. PLoS Genet (2009) 1.41
p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci U S A (2012) 1.41
ΔNp63 is an ectodermal gatekeeper of epidermal morphogenesis. Cell Death Differ (2010) 1.39
p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis. J Cell Biol (2011) 1.39
p63 steps into the limelight: crucial roles in the suppression of tumorigenesis and metastasis. Nat Rev Cancer (2013) 1.34
Epigenetic regulation of gene expression in keratinocytes. J Invest Dermatol (2012) 1.32
Diverse epigenetic strategies interact to control epidermal differentiation. Nat Cell Biol (2012) 1.29
p53 is essential for chemotherapy-induced hair loss. Cancer Res (2000) 1.29
Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cells. J Invest Dermatol (2010) 1.29
Hairy tale of signaling in hair follicle development and cycling. Semin Cell Dev Biol (2012) 1.22
p53 Involvement in the control of murine hair follicle regression. Am J Pathol (2001) 1.19
Covering the limb--formation of the integument. J Anat (2003) 1.16
Mutant p63 causes defective expansion of ectodermal progenitor cells and impaired FGF signalling in AEC syndrome. EMBO Mol Med (2012) 1.13
iASPP/p63 autoregulatory feedback loop is required for the homeostasis of stratified epithelia. EMBO J (2011) 1.12
The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin. EMBO J (2011) 1.11
Pathobiology of chemotherapy-induced hair loss. Lancet Oncol (2013) 1.08
p63 is a useful marker for cutaneous spindle cell squamous cell carcinoma. J Cutan Pathol (2006) 1.08
A new scenario for the evolutionary origin of hair, feather, and avian scales. J Anat (2009) 1.08
Pattern formation today. Int J Dev Biol (2009) 1.06
p63 Suppresses non-epidermal lineage markers in a bone morphogenetic protein-dependent manner via repression of Smad7. J Biol Chem (2009) 1.04
p63/p73 in the control of cell cycle and cell death. Exp Cell Res (2012) 1.04
DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. J Biol Chem (2011) 1.03
ΔNp63α regulates keratinocyte proliferation by controlling PTEN expression and localization. Cell Death Differ (2011) 1.02
Mutation analysis of P73 and TP53 in Merkel cell carcinoma. Br J Cancer (2000) 1.00
p63 Coordinates anogenital modeling and epithelial cell differentiation in the developing female urogenital tract. Am J Pathol (2002) 0.99
Epigenetic regulation of skin: focus on the Polycomb complex. Cell Mol Life Sci (2012) 0.99
Abnormal hair follicle development and altered cell fate of follicular keratinocytes in transgenic mice expressing DeltaNp63alpha. Development (2010) 0.96
Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition. Dev Cell (2013) 0.95
Development and homeostasis of the sebaceous gland. Semin Cell Dev Biol (2012) 0.94
p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells. Development (2014) 0.92
Induced multipotency in adult keratinocytes through down-regulation of ΔNp63 or DGCR8. Proc Natl Acad Sci U S A (2014) 0.92
Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy. Am J Pathol (2007) 0.92
p63 in skin appendage development. Cell Cycle (2007) 0.91
Chromatin regulators in mammalian epidermis. Semin Cell Dev Biol (2012) 0.91
MicroRNA/mRNA regulatory networks in the control of skin development and regeneration. Cell Cycle (2012) 0.90
Asymmetric cell divisions in the epidermis. Int Rev Cell Mol Biol (2012) 0.88
BRCA1 deficiency in skin epidermis leads to selective loss of hair follicle stem cells and their progeny. Genes Dev (2012) 0.86
Targeting p73 in cancer. Cancer Lett (2011) 0.85
Fas signaling is involved in the control of hair follicle response to chemotherapy. Cancer Res (2004) 0.85
The p53 family grows old. Genes Dev (2012) 0.84
Embryology of the epidermis: ultrastructural aspects. 1. Formation and early development in the mouse with mammalian comparisons. Acta Derm Venereol (1975) 0.83
DNA damage down-regulates ΔNp63α and induces apoptosis independent of wild type p53. Biochem Biophys Res Commun (2012) 0.82