Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression.

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Published in Nat Commun on August 06, 2014

Authors

Youhua Tan1, Arash Tajik2, Junwei Chen3, Qiong Jia4, Farhan Chowdhury5, Lili Wang4, Junjian Chen4, Shuang Zhang4, Ying Hong4, Haiying Yi4, Douglas C Wu6, Yuejin Zhang4, Fuxiang Wei4, Yeh-Chuin Poh7, Jihye Seong8, Rishi Singh6, Li-Jung Lin9, Sultan Doğanay10, Yong Li11, Haibo Jia4, Taekjip Ha10, Yingxiao Wang12, Bo Huang13, Ning Wang7

Author Affiliations

1: 1] Laboratory for Cell Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China [2] Department of Mechanical Science and Engineering, College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA [3].
2: 1] Department of Mechanical Science and Engineering, College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA [2].
3: 1] Laboratory for Cell Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China [2].
4: Laboratory for Cell Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China.
5: Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
6: Department of Mechanical Science and Engineering, College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
7: 1] Laboratory for Cell Biomechanics and Regenerative Medicine, Department of Biomedical Engineering, School of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China [2] Department of Mechanical Science and Engineering, College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
8: 1] Department of Mechanical Science and Engineering, College of Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA [2] Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA [3].
9: Department of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
10: 1] Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA [2] Center for Biophysics and Computational Biology and Center for the Physics of Living Cells, Department of Physics, University of Illinois at Urbana-Champaign, Howard Hughs Medical Institute, Urbana, Illinois 61801, USA.
11: Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
12: Department of Bioengineering and Institute of Engineering in Medicine, University of California-San Diego, La Jolla, California 92093, USA.
13: 1] Department of Biochemistry and Molecular Biology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China [2] Department of Immunology, Institute of Basic Medical Sciences of Chinese Academy of Medical Sciences, Beijing 100005, China.

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