Published in Hum Mol Genet on August 07, 2014
Nurses' Health Study (Cardiovascular Component) | NCT00005152
FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis. Am J Clin Nutr (2016) 1.41
Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review. Circulation (2016) 1.13
Gene-Lifestyle Interactions in Complex Diseases: Design and Description of the GLACIER and VIKING Studies. Curr Nutr Rep (2014) 0.91
Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents. Diabetes (2015) 0.85
Milk: an epigenetic amplifier of FTO-mediated transcription? Implications for Western diseases. J Transl Med (2015) 0.85
Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet (2015) 0.84
Multiple novel gene-by-environment interactions modify the effect of FTO variants on body mass index. Nat Commun (2016) 0.82
Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet (2017) 0.78
Advances in exercise, fitness, and performance genomics in 2014. Med Sci Sports Exerc (2015) 0.78
Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype. PLoS One (2016) 0.78
Appetitive traits as behavioural pathways in genetic susceptibility to obesity: a population-based cross-sectional study. Sci Rep (2015) 0.77
Assessing gene-environment interaction effects of FTO, MC4R and lifestyle factors on obesity using an extreme phenotype sampling design: Results from the HUNT study. PLoS One (2017) 0.75
Inverse association between obesity predisposing FTO genotype and completed suicide. PLoS One (2014) 0.75
Interaction between FTO gene variants and lifestyle factors on metabolic traits in an Asian Indian population. Nutr Metab (Lond) (2016) 0.75
FTO gene variation, macronutrient intake and coronary heart disease risk: a gene-diet interaction analysis. Eur J Nutr (2015) 0.75
A comprehensive survey of genetic variation in 20,691 subjects from four large cohorts. PLoS One (2017) 0.75
Interaction between FTO rs9939609 and the Native American-origin ABCA1 rs9282541 affects BMI in the admixed Mexican population. BMC Med Genet (2017) 0.75
Gene-Diet Interaction and Precision Nutrition in Obesity. Int J Mol Sci (2017) 0.75
Association of FTO rs9939609 SNP with Obesity and Obesity- Associated Phenotypes in a North Indian Population. Oman Med J (2016) 0.75
Lack of Association between NYD-SP18 Variant and Obesity. The Health Alcohol and Psychosocial Factors in Eastern Europe Study. Ann Nutr Metab (2016) 0.75
Relation of FTO gene variants to fetal growth trajectories: Findings from the Southampton Women's survey. Placenta (2015) 0.75
Overexpression of the fat mass and obesity associated gene (FTO) in breast cancer and its clinical implications. Int J Clin Exp Pathol (2015) 0.75
FTO association and interaction with time spent sitting. Int J Obes (Lond) (2015) 0.75
Lifestyle precision medicine: the next generation in type 2 diabetes prevention? BMC Med (2017) 0.75
Examining for an association between candidate gene polymorphisms in the metabolic syndrome components on excess weight and adiposity measures in youth: a cross-sectional study. Genes Nutr (2017) 0.75
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. PLoS Genet (2017) 0.75
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science (2007) 37.88
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet (2010) 23.08
Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet (2007) 14.99
Hypothalamic mTOR signaling regulates food intake. Science (2006) 8.62
Sugar-sweetened beverages and genetic risk of obesity. N Engl J Med (2012) 5.98
An obesity-associated FTO gene variant and increased energy intake in children. N Engl J Med (2008) 5.88
Inactivation of the Fto gene protects from obesity. Nature (2009) 5.61
Overexpression of Fto leads to increased food intake and results in obesity. Nat Genet (2010) 4.37
Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med (2011) 3.94
The brain, appetite, and obesity. Annu Rev Psychol (2008) 3.35
The fat mass- and obesity-associated locus and dietary intake in children. Am J Clin Nutr (2008) 3.18
Misreporting of energy and micronutrient intake estimated by food records and 24 hour recalls, control and adjustment methods in practice. Br J Nutr (2009) 2.96
The detection of gene-environment interaction for continuous traits: should we deal with measurement error by bigger studies or better measurement? Int J Epidemiol (2003) 2.89
FTO genotype is associated with phenotypic variability of body mass index. Nature (2012) 2.77
Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. PLoS One (2008) 2.67
Fine mapping of the association with obesity at the FTO locus in African-derived populations. Hum Mol Genet (2010) 2.48
The FTO gene and measured food intake in children. Int J Obes (Lond) (2008) 2.42
Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. PLoS Med (2010) 2.25
A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest (2013) 2.23
Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr (2009) 2.13
Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. Diabetes (2008) 1.98
Variation in the FTO gene influences food intake but not energy expenditure. Exp Clin Endocrinol Diabetes (2008) 1.96
The FTO gene rs9939609 obesity-risk allele and loss of control over eating. Am J Clin Nutr (2009) 1.88
Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr (2009) 1.88
FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. J Clin Endocrinol Metab (2009) 1.87
Measuring food intake in studies of obesity. Public Health Nutr (2002) 1.46
Lifestyle interaction with fat mass and obesity-associated (FTO) genotype and risk of obesity in apparently healthy U.S. women. Diabetes Care (2011) 1.44
FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. BMC Med Genet (2010) 1.38
A supersized list of obesity genes. Nat Genet (2009) 1.38
Television watching, leisure time physical activity, and the genetic predisposition in relation to body mass index in women and men. Circulation (2012) 1.33
Adult onset global loss of the fto gene alters body composition and metabolism in the mouse. PLoS Genet (2013) 1.31
Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A (2013) 1.24
A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. J Nutr (2011) 1.20
FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial. Diabetes (2012) 1.16
Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population. Endocr J (2010) 1.13
Challenges in the use of literature-based meta-analysis to examine gene-environment interactions. Am J Epidemiol (2010) 1.10
Association between fat intake, physical activity and mortality depending on genetic variation in FTO. Int J Obes (Lond) (2010) 1.10
Association of FTO gene variants with adiposity in African-American adolescents. Obesity (Silver Spring) (2010) 1.09
Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans. Clin Chim Acta (2010) 1.08
Genes and lifestyle factors in obesity: results from 12,462 subjects from MONICA/KORA. Int J Obes (Lond) (2010) 1.04
Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier. J Obes (2011) 1.02
FTO expression is regulated by availability of essential amino acids. Int J Obes (Lond) (2012) 1.02
A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake. J Nutr (2010) 1.01
Dietary fatty acid distribution modifies obesity risk linked to the rs9939609 polymorphism of the fat mass and obesity-associated gene in a Spanish case-control study of children. Br J Nutr (2011) 0.99
Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. Int J Obes (Lond) (2010) 0.95
FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study. Physiol Res (2010) 0.92
Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans. Int J Obes (Lond) (2009) 0.91
High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults. J Nutr (2012) 0.90
Association between FTO variant and change in body weight and its interaction with dietary factors: the DiOGenes study. Obesity (Silver Spring) (2012) 0.87
Absence of association between specific common variants of the obesity-related FTO gene and psychological and behavioral eating disorder phenotypes. Am J Med Genet B Neuropsychiatr Genet (2011) 0.82
Defining the role of common variation in the genomic and biological architecture of adult human height. Nat Genet (2014) 5.78
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials. Lancet (2014) 3.94
Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol (2014) 2.10
Estimated 10-year cardiovascular mortality seriously underestimates overall cardiovascular risk. Heart (2015) 2.10
EMAS position statement: individualized breast cancer screening versus population-based mammography screening programmes. Maturitas (2014) 2.04
Mendelian randomization of blood lipids for coronary heart disease. Eur Heart J (2014) 1.51
Whole-exome sequencing identifies OR2W3 mutation as a cause of autosomal dominant retinitis pigmentosa. Sci Rep (2015) 1.49
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans. Diabetes (2012) 1.47
Physical activity and menopause-related quality of life - a population-based cross-sectional study. Maturitas (2014) 1.44
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk. Nat Genet (2017) 1.44
Prevalence of resistant hypertension and associated factors for blood pressure control status with optimal medical therapy using Korean ambulatory blood pressure monitoring registry data. Clin Hypertens (2016) 1.40
FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials. BMJ (2016) 1.39
Alterations to chromatin in intestinal macrophages link IL-10 deficiency to inappropriate inflammatory responses. Eur J Immunol (2016) 1.38
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet (2015) 1.28
Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder. JAMA Psychiatry (2015) 1.27
The impact of low-frequency and rare variants on lipid levels. Nat Genet (2015) 1.20
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index. Hum Mol Genet (2014) 1.20
The relative importance of modifiable potential risk factors of type 2 diabetes: a meta-analysis of two cohorts. Eur J Epidemiol (2009) 1.10
Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33. Hum Mol Genet (2014) 1.09
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry (2014) 1.01
Competing targets of microRNA-608 affect anxiety and hypertension. Hum Mol Genet (2014) 0.99
Stratification by smoking status reveals an association of CHRNA5-A3-B4 genotype with body mass index in never smokers. PLoS Genet (2014) 0.97
PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. J Med Genet (2016) 0.95
Genome-wide association analysis identifies three new susceptibility loci for childhood body mass index. Hum Mol Genet (2015) 0.94
Testosterone, sex hormone-binding globulin and the metabolic syndrome in men: an individual participant data meta-analysis of observational studies. PLoS One (2014) 0.90
Discordance between ambulatory versus clinic blood pressure according to global cardiovascular risk group. Korean J Intern Med (2015) 0.89
Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium. Mol Nutr Food Res (2015) 0.89
Fine-mapping identifies two additional breast cancer susceptibility loci at 9q31.2. Hum Mol Genet (2015) 0.88
Genome-wide associations for birth weight and correlations with adult disease. Nature (2016) 0.87
Sex-specific age associations of ankle proprioception test performance in older adults: results from the Baltimore Longitudinal Study of Aging. Age Ageing (2015) 0.86
Effects of Alzheimer's disease-associated risk loci on cerebrospinal fluid biomarkers and disease progression: a polygenic risk score approach. J Alzheimers Dis (2015) 0.86
EMAS position statement: Testosterone replacement therapy in the aging male. Maturitas (2015) 0.85
Strategies to fine-map genetic associations with lipid levels by combining epigenomic annotations and liver-specific transcription profiles. Genomics (2014) 0.85
Gene × dietary pattern interactions in obesity: analysis of up to 68 317 adults of European ancestry. Hum Mol Genet (2015) 0.84
Genome-wide analysis identifies 12 loci influencing human reproductive behavior. Nat Genet (2016) 0.84
Heterogeneous impact of classic atherosclerotic risk factors on different arterial territories: the EPIC-Norfolk prospective population study. Eur Heart J (2015) 0.83
Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behav Genet (2015) 0.83
Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? Am J Med Genet B Neuropsychiatr Genet (2010) 0.82
Adherence to dietary guidelines and cardiovascular disease risk in the EPIC-NL cohort. Int J Cardiol (2014) 0.82
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration. Hum Mol Genet (2015) 0.82
The effects of omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-6 gene promoter. Mol Nutr Food Res (2015) 0.81
Obesity and Age-Related Changes in Markers of Oxidative Stress and Inflammation Across Four Generations. Obesity (Silver Spring) (2016) 0.81
Predictors and long-term reproducibility of urinary phthalate metabolites in middle-aged men and women living in urban Shanghai. Environ Int (2015) 0.81
Transancestral fine-mapping of four type 2 diabetes susceptibility loci highlights potential causal regulatory mechanisms. Hum Mol Genet (2016) 0.81
Metabolic profiling of fatty liver in young and middle-aged adults - cross-sectional and prospective analyses of the Young Finns Study. Hepatology (2016) 0.80
The Relation between Occupational Sitting and Mental, Cardiometabolic, and Musculoskeletal Health over a Period of 15 Years - The Doetinchem Cohort Study. PLoS One (2016) 0.80
EMAS clinical guide: vulvar lichen sclerosus in peri and postmenopausal women. Maturitas (2013) 0.79
DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. Genome Biol (2016) 0.79
Pooled analysis of mitochondrial DNA copy number and lung cancer risk in three prospective studies. Cancer Epidemiol Biomarkers Prev (2014) 0.79
Genome-wide meta-analyses identify novel loci associated with n-3 and n-6 polyunsaturated fatty acid levels in Chinese and European-ancestry populations. Hum Mol Genet (2016) 0.79
Gene-specific DNA methylation profiles and LINE-1 hypomethylation are associated with myocardial infarction risk. Clin Epigenetics (2015) 0.79
The association of substituting carbohydrates with total fat and different types of fatty acids with mortality and weight change among diabetes patients. Clin Nutr (2015) 0.79
Intraindividual variation and short-term temporal trend in DNA methylation of human blood. Cancer Epidemiol Biomarkers Prev (2014) 0.79
EMAS position statement: The ten point guide to the integral management of menopausal health. Maturitas (2015) 0.79
Breast arterial calcifications: a systematic review and meta-analysis of their determinants and their association with cardiovascular events. Atherosclerosis (2014) 0.79
Genome-wide association studies in East Asians identify new loci for waist-hip ratio and waist circumference. Sci Rep (2016) 0.79
The relationship between the dietary inflammatory index and risk of total cardiovascular disease, ischemic heart disease and cerebrovascular disease: Findings from an Australian population-based prospective cohort study of women. Atherosclerosis (2016) 0.78
A dietary biomarker approach captures compliance and cardiometabolic effects of a healthy Nordic diet in individuals with metabolic syndrome. J Nutr (2014) 0.78
Metabolic profiling of alcohol consumption in 9778 young adults. Int J Epidemiol (2016) 0.78
Anti-Müllerian Hormone as a marker of ovarian reserve in relation to cardio-metabolic health: a narrative review. Maturitas (2015) 0.78
Vasomotor menopausal symptoms are not associated with incidence of breast cancer in a population-based cohort of mid-aged women. Eur J Cancer (2013) 0.78
EMAS recommendations for conditions in the workplace for menopausal women. Maturitas (2015) 0.78
Incidence trends and associated factors of diabetes mellitus in Korean children and adolescents: a retrospective cohort study in Busan and Gyeongnam. Ann Pediatr Endocrinol Metab (2015) 0.77
Famine in the young and risk of later hospitalization for COPD and asthma. PLoS One (2013) 0.77
EMAS position statement: The management of postmenopausal women with vertebral osteoporotic fracture. Maturitas (2014) 0.77
Association between Cognition and Serum Insulin-Like Growth Factor-1 in Middle-Aged & Older Men: An 8 Year Follow-Up Study. PLoS One (2016) 0.77
Metabolic signatures of birthweight in 18 288 adolescents and adults. Int J Epidemiol (2016) 0.77
Urinary isothiocyanates level and liver cancer risk: a nested case-control study in Shanghai, China. Nutr Cancer (2014) 0.77
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer. Gynecol Oncol (2015) 0.77
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nat Genet (2017) 0.77
Association between type 2 diabetes and risk of cancer mortality: a pooled analysis of over 771,000 individuals in the Asia Cohort Consortium. Diabetologia (2017) 0.76
Soluble levels of CD27 and CD30 are associated with risk of non-Hodgkin lymphoma in three Chinese prospective cohorts. Int J Cancer (2015) 0.76
Novel cardiovascular biomarkers in women with a history of early preeclampsia. Atherosclerosis (2014) 0.76
Psychosocial environment in childhood and body mass index growth over 32years. Prev Med (2016) 0.76
Associations of functional alanine-glyoxylate aminotransferase 2 gene variants with atrial fibrillation and ischemic stroke. Sci Rep (2016) 0.75
Pre-diagnostic cruciferous vegetables intake and lung cancer survival among Chinese women. Sci Rep (2015) 0.75
Whole-Exome Sequencing Identifies Novel Somatic Mutations in Chinese Breast Cancer Patients. J Mol Genet Med (2015) 0.75
Trajectories of Metabolic Risk Factors and Biochemical Markers prior to the Onset of Cardiovascular Disease - The Doetinchem Cohort Study. PLoS One (2016) 0.75
Age at menarche and age at natural menopause in East Asian women: a genome-wide association study. Age (Dordr) (2016) 0.75
Higher Glucose and Insulin Levels Are Associated with Risk of Liver Cancer and Chronic Liver Disease Mortality among Men without a History of Diabetes. Cancer Prev Res (Phila) (2016) 0.75
The influence of sex on cardiovascular outcomes associated with diabetes among older black and white adults. J Diabetes Complications (2013) 0.75
rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk. Sci Rep (2016) 0.75