Published in Proc Natl Acad Sci U S A on August 18, 2014
Mutant bacterial sodium channels as models for local anesthetic block of eukaryotic proteins. Channels (Austin) (2016) 0.95
Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants. J Gen Physiol (2017) 0.87
Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory. J Membr Biol (2015) 0.79
Theoretical and simulation studies on voltage-gated sodium channels. Protein Cell (2015) 0.77
Molecular dynamics simulations of biological membranes and membrane proteins using enhanced conformational sampling algorithms. Biochim Biophys Acta (2016) 0.77
Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway. Front Pharmacol (2015) 0.75
Important Role of Asparagines in Coupling the Pore and Votage-Sensor Domain in Voltage-Gated Sodium Channels. Biophys J (2015) 0.75
Effect of phenytoin on sodium conductances in rat hippocampal CA1 pyramidal neurons. J Neurophysiol (2016) 0.75
Structural Insights into the Atomistic Mechanisms of Action of Small Molecule Inhibitors Targeting the KCa3.1 Channel Pore. Mol Pharmacol (2017) 0.75
Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. J Physiol (2016) 0.75
Thermal Stability of Phase-Separated Domains in Multicomponent Lipid Membranes with Local Anesthetics. Membranes (Basel) (2017) 0.75
Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49
All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B (1998) 54.00
Jalview Version 2--a multiple sequence alignment editor and analysis workbench. Bioinformatics (2009) 31.84
CHARMM: the biomolecular simulation program. J Comput Chem (2009) 27.71
The Jalview Java alignment editor. Bioinformatics (2004) 21.74
Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol (1977) 12.38
CHARMM general force field: A force field for drug-like molecules compatible with the CHARMM all-atom additive biological force fields. J Comput Chem (2010) 8.79
The crystal structure of a voltage-gated sodium channel. Nature (2011) 7.82
Molecular determinants of state-dependent block of Na+ channels by local anesthetics. Science (1994) 5.62
Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA. J Pharmacol Exp Ther (1975) 5.07
pi-Stacking interactions. Alive and well in proteins. J Biol Chem (1998) 3.92
Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature (2012) 2.97
Crystal structure of a voltage-gated sodium channel in two potentially inactivated states. Nature (2012) 2.78
Estimates of the ab initio limit for pi-pi interactions: the benzene dimer. J Am Chem Soc (2002) 2.53
Automation of the CHARMM General Force Field (CGenFF) II: assignment of bonded parameters and partial atomic charges. J Chem Inf Model (2012) 2.20
Automation of the CHARMM General Force Field (CGenFF) I: bond perception and atom typing. J Chem Inf Model (2012) 2.17
Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing. Nat Commun (2012) 2.01
Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block. J Biol Chem (2002) 1.95
Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons. Mol Pharmacol (1994) 1.68
Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels. J Physiol (2007) 1.57
Molecular action of lidocaine on the voltage sensors of sodium channels. J Gen Physiol (2003) 1.56
Electrostatic contributions of aromatic residues in the local anesthetic receptor of voltage-gated sodium channels. Circ Res (2007) 1.50
A molecular basis for the different local anesthetic affinities of resting versus open and inactivated states of the sodium channel. Mol Pharmacol (1999) 1.48
A common anticonvulsant binding site for phenytoin, carbamazepine, and lamotrigine in neuronal Na+ channels. Mol Pharmacol (1998) 1.41
Prokaryotic NavMs channel as a structural and functional model for eukaryotic sodium channel antagonism. Proc Natl Acad Sci U S A (2014) 1.24
Sodium channel molecular conformations and antiarrhythmic drug affinity. Trends Cardiovasc Med (2010) 1.20
Local anesthetics disrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol (2008) 1.18
Mechanism of local anesthetic drug action on voltage-gated sodium channels. Curr Pharm Des (2005) 1.16
Subtype-selective targeting of voltage-gated sodium channels. Br J Pharmacol (2009) 1.13
Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels. J Physiol (2000) 1.06
Exploring volatile general anesthetic binding to a closed membrane-bound bacterial voltage-gated sodium channel via computation. PLoS Comput Biol (2013) 1.01
Local anesthetic inhibition of a bacterial sodium channel. J Gen Physiol (2012) 0.99
Ion conduction and conformational flexibility of a bacterial voltage-gated sodium channel. Proc Natl Acad Sci U S A (2014) 0.99
The enigmatic drug binding site for sodium channel inhibitors. Curr Mol Pharmacol (2010) 0.98
The perturbation of lipid bilayers by general anesthetics: a quantitative test of the disordered lipid hypothesis. Mol Pharmacol (1980) 0.93
Molecular mechanism of allosteric modification of voltage-dependent sodium channels by local anesthetics. J Gen Physiol (2010) 0.93
Modulation of a voltage-gated Na+ channel by sevoflurane involves multiple sites and distinct mechanisms. Proc Natl Acad Sci U S A (2014) 0.92
Determination of the active form of phenytoin. J Pharmacol Exp Ther (1984) 0.91
Lidocaine reduces the transition to slow inactivation in Na(v)1.7 voltage-gated sodium channels. Br J Pharmacol (2011) 0.90
Slow sodium channel inactivation and use-dependent block modulated by the same domain IV S6 residue. J Membr Biol (2005) 0.86
Drug-membrane interactions studied in phospholipid monolayers adsorbed on nonporous alkylated microspheres. J Biomol Screen (2007) 0.79
Novel molecular determinants in the pore region of sodium channels regulate local anesthetic binding. Mol Pharmacol (2009) 0.79
Thermodynamics of partitioning of benzocaine in some organic solvent/buffer and liposome systems. Chem Pharm Bull (Tokyo) (2003) 0.77
Rational design and validation of a vanilloid-sensitive TRPV2 ion channel. Proc Natl Acad Sci U S A (2016) 0.78