Published in J Cell Biol on August 25, 2014
The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease. Neuron (2015) 2.82
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Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress. Neuron (2015) 1.00
A Ubl/ubiquitin switch in the activation of Parkin. EMBO J (2015) 0.96
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Compartmentalized Regulation of Parkin-Mediated Mitochondrial Quality Control in the Drosophila Nervous System In Vivo. J Neurosci (2016) 0.82
Methylene Blue Reduces Acute Cerebral Ischemic Injury via the Induction of Mitophagy. Mol Med (2015) 0.82
Beyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial health. Antioxid Redox Signal (2015) 0.82
PINK1 disables the anti-fission machinery to segregate damaged mitochondria for mitophagy. J Cell Biol (2016) 0.81
Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson's Disease. Cell Stem Cell (2016) 0.81
Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress. Brain Res (2016) 0.81
Mitochondrial dysfunction in cardiac aging. Biochim Biophys Acta (2015) 0.80
Glutamate excitotoxicity in neurons triggers mitochondrial and endoplasmic reticulum accumulation of Parkin, and, in the presence of N-acetyl cysteine, mitophagy. Neurobiol Dis (2014) 0.80
Parkin structure and function. FEBS J (2015) 0.80
Synaptosomal Mitochondrial Dysfunction in 5xFAD Mouse Model of Alzheimer's Disease. PLoS One (2016) 0.80
Role of glucose metabolism and ATP in maintaining PINK1 levels during Parkin-mediated mitochondrial damage responses. J Biol Chem (2014) 0.79
Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo. Curr Biol (2016) 0.79
Mitochondrial retrograde signaling regulates neuronal function. Proc Natl Acad Sci U S A (2015) 0.79
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Tumor protein Tctp regulates axon development in the embryonic visual system. Development (2016) 0.79
KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses. Dev Cell (2016) 0.79
Impaired Mitochondrial Dynamics and Mitophagy in Neuronal Models of Tuberous Sclerosis Complex. Cell Rep (2016) 0.79
Dynamic recruitment and activation of ALS-associated TBK1 with its target optineurin are required for efficient mitophagy. Proc Natl Acad Sci U S A (2016) 0.78
Signaling Over Distances. Mol Cell Proteomics (2015) 0.78
Mitochondrial dysfunction in Parkinson disease: evidence in mutant PARK2 fibroblasts. Front Genet (2015) 0.78
Pathologic and therapeutic implications for the cell biology of parkin. Mol Cell Neurosci (2015) 0.78
Nix restores mitophagy and mitochondrial function to protect against PINK1/Parkin-related Parkinson's disease. Sci Rep (2017) 0.78
Autophagy core machinery: overcoming spatial barriers in neurons. J Mol Med (Berl) (2016) 0.77
Deletion of mitochondrial anchoring protects dysmyelinating shiverer: implications for progressive MS. J Neurosci (2015) 0.77
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Decreased Energy Capacity and Increased Autophagic Activity in Optic Nerve Axons With Defective Anterograde Transport. Invest Ophthalmol Vis Sci (2015) 0.76
Parkin Regulation and Neurodegenerative Disorders. Front Aging Neurosci (2016) 0.76
Long-distance autophagy. Autophagy (2015) 0.76
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Autophagy and Alzheimer's Disease. Cell Mol Neurobiol (2016) 0.76
mitoLUHMES: An Engineered Neuronal Cell Line for the Analysis of the Motility of Mitochondria. Cell Mol Neurobiol (2016) 0.75
Drosophila clueless is involved in Parkin-dependent mitophagy by promoting VCP-mediated Marf degradation. Hum Mol Genet (2016) 0.75
Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia. J Cell Biol (2017) 0.75
A new method for quantifying mitochondrial axonal transport. Protein Cell (2016) 0.75
Releasing Syntaphilin Removes Stressed Mitochondria from Axons Independent of Mitophagy under Pathophysiological Conditions. Neuron (2017) 0.75
A novel PINK1- and PARK2-dependent protective neuroimmune pathway in lethal sepsis. Autophagy (2016) 0.75
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The effects of variants in the PARK2 (parkin), PINK1, and PARK7 (DJ-1) genes along with evidence for their pathogenicity. Curr Protein Pept Sci (2016) 0.75
A mitochondrial-derived vesicle HOPS to endolysosomes using Syntaxin-17. J Cell Biol (2016) 0.75
Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis. Sci Rep (2016) 0.75
Transporting mitochondria in neurons. F1000Res (2016) 0.75
Miro phosphorylation sites regulate Parkin recruitment and mitochondrial motility. Proc Natl Acad Sci U S A (2016) 0.75
Mitochondrial fission is an acute and adaptive response in injured motor neurons. Sci Rep (2016) 0.75
Inappropriate trafficking of damaged mitochondria in Parkinson's disease. Stem Cell Investig (2017) 0.75
Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation. Nat Commun (2017) 0.75
Seeking an In Vivo Neuronal Context for the PINK1/Parkin Pathway. J Neurosci (2016) 0.75
PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease. Front Mol Neurosci (2017) 0.75
Mechanisms of neuronal homeostasis: Autophagy in the axon. Brain Res (2016) 0.75
Triggering mitophagy with far-red fluorescent photosensitizers. Sci Rep (2015) 0.75
In vivo imaging reveals mitophagy independence in the maintenance of axonal mitochondria during normal aging. Aging Cell (2017) 0.75
Connecting mitochondrial dynamics and life-or-death events via Bcl-2 family proteins. Neurochem Int (2017) 0.75
Induced Pluripotent Stem Cell Neuronal Models for the Study of Autophagy Pathways in Human Neurodegenerative Disease. Cells (2017) 0.75
Assessment of Autophagy in Neurons and Brain Tissue. Cells (2017) 0.75
Parkin overexpression protects retinal ganglion cells against glutamate excitotoxicity. Mol Vis (2017) 0.75
Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes. Exp Neurol (2017) 0.75
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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy. J Cell Biol (2008) 17.81
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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol (2010) 12.26
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature (2006) 11.91
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature (2006) 11.81
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Chronic systemic pesticide exposure reproduces features of Parkinson's disease. Nat Neurosci (2000) 10.62
A microfluidic culture platform for CNS axonal injury, regeneration and transport. Nat Methods (2005) 7.62
PINK1 and Parkin target Miro for phosphorylation and degradation to arrest mitochondrial motility. Cell (2011) 5.98
Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases. Hum Mol Genet (2009) 5.15
Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. J Biol Chem (2009) 4.90
Visualization of retroviral replication in living cells reveals budding into multivesicular bodies. Traffic (2003) 4.61
Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol Biol Cell (2002) 4.48
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem (2003) 4.36
Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent. J Cell Biol (2006) 4.28
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Axonal transport of mitochondria to synapses depends on milton, a novel Drosophila protein. Neuron (2002) 3.52
Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled. J Neurosci (2006) 3.20
Axonal mitochondrial transport and potential are correlated. J Cell Sci (2004) 3.15
Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway. Nat Cell Biol (2003) 2.96
Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control. EMBO J (2014) 2.93
A genetically encoded photosensitizer. Nat Biotechnol (2005) 2.75
A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr Biol (2012) 2.45
Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking. Biochemistry (2009) 2.38
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons. J Cell Biol (2012) 2.30
Mitochondrial trafficking to synapses in cultured primary cortical neurons. J Neurosci (2006) 2.26
Axonal and dendritic endocytic pathways in cultured neurons. J Cell Biol (1992) 2.19
The PINK1-Parkin pathway promotes both mitophagy and selective respiratory chain turnover in vivo. Proc Natl Acad Sci U S A (2013) 2.10
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci (2011) 2.09
Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment. EMBO Rep (2012) 2.08
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Microfluidic local perfusion chambers for the visualization and manipulation of synapses. Neuron (2010) 2.00
Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization. Hum Mol Genet (2010) 1.99
Mitochondrial Parkin recruitment is impaired in neurons derived from mutant PINK1 induced pluripotent stem cells. J Neurosci (2011) 1.98
The mechanism of action of the respiratory inhibitor, antimycin. Biochim Biophys Acta (1973) 1.91
A neo-substrate that amplifies catalytic activity of parkinson's-disease-related kinase PINK1. Cell (2013) 1.84
Mitophagy selectively degrades individual damaged mitochondria after photoirradiation. Antioxid Redox Signal (2011) 1.79
MPTP as a mitochondrial neurotoxic model of Parkinson's disease. J Bioenerg Biomembr (2004) 1.69
Spatial parkin translocation and degradation of damaged mitochondria via mitophagy in live cortical neurons. Curr Biol (2012) 1.64
PINK1 is degraded through the N-end rule pathway. Autophagy (2013) 1.63
ROS-induced mitochondrial depolarization initiates PARK2/PARKIN-dependent mitochondrial degradation by autophagy. Autophagy (2012) 1.63
Mitochondrial membrane potential in axons increases with local nerve growth factor or semaphorin signaling. J Neurosci (2008) 1.51
Regulation of mitochondrial matrix volume. Am J Physiol Cell Physiol (2006) 1.40
Axon degeneration in Parkinson's disease. Exp Neurol (2012) 1.40
The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax. Proc Natl Acad Sci U S A (2012) 1.30
Reconstitution of mitochondria derived vesicle formation demonstrates selective enrichment of oxidized cargo. PLoS One (2012) 1.27
Parkin selectively alters the intrinsic threshold for mitochondrial cytochrome c release. Hum Mol Genet (2009) 1.22
Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell (2014) 1.21
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What causes the death of dopaminergic neurons in Parkinson's disease? Prog Brain Res (2010) 1.12
In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system. J Neurosci (2012) 1.11
Local pruning of dendrites and spines by caspase-3-dependent and proteasome-limited mechanisms. J Neurosci (2014) 1.06
Spatiotemporally controlled initiation of Parkin-mediated mitophagy within single cells. Autophagy (2011) 1.04
Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies. Free Radic Biol Med (2009) 1.03
Live-cell imaging of autophagy induction and autophagosome-lysosome fusion in primary cultured neurons. Methods Enzymol (2009) 0.97
MitoTimer probe reveals the impact of autophagy, fusion, and motility on subcellular distribution of young and old mitochondrial protein and on relative mitochondrial protein age. Autophagy (2013) 0.93
A genetic model to dissect the role of Tsc-mTORC1 in neuronal cultures. Methods Mol Biol (2012) 0.86
A further update on the role of excitotoxicity in the pathogenesis of Parkinson's disease. J Neural Transm (Vienna) (2014) 0.84
Recognizing the cooperative and independent mitochondrial functions of Parkin and PINK1. Cell Cycle (2012) 0.79