In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer.

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Published in Nat Med on September 14, 2014

Authors

Ramona Rudalska1, Daniel Dauch1, Thomas Longerich2, Katherine McJunkin3, Torsten Wuestefeld4, Tae-Won Kang5, Anja Hohmeyer5, Marina Pesic4, Josef Leibold4, Anne von Thun6, Peter Schirmacher2, Johannes Zuber7, Karl-Heinz Weiss8, Scott Powers9, Nisar P Malek10, Martin Eilers6, Bence Sipos11, Scott W Lowe12, Robert Geffers13, Stefan Laufer14, Lars Zender5

Author Affiliations

1: 1] Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany. [2].
2: Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany.
3: The Watson School of Biological Sciences, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
4: Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany.
5: 1] Division of Translational Gastrointestinal Oncology, Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany. [2] Translational Gastrointestinal Oncology Group within the German Consortium for Translational Cancer Research (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
6: 1] Comprehensive Cancer Center Mainfranken, University of Wuerzburg, Wuerzburg, Germany. [2] Theodor Boveri Institute, Biocenter, University of Wuerzburg, Wuerzburg, Germany.
7: Research Institute of Molecular Pathology, Vienna, Austria.
8: Department of Gastroenterology, University Hospital Heidelberg, Heidelberg, Germany.
9: Cancer Genome Center, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.
10: Department of Internal Medicine I, University of Tuebingen, Tuebingen, Germany.
11: Institute of Pathology, University of Tuebingen, Tuebingen, Germany.
12: 1] Memorial Sloan Kettering Cancer Center, New York, New York, USA. [2] Howard Hughes Medical Institute, New York, New York, USA.
13: Helmholtz Centre for Infection Research, Braunschweig, Germany.
14: Department of Pharmaceutical and Medicinal Chemistry, University of Tuebingen, Tuebingen, Germany.

Associated clinical trials:

A Phase II, Study To Evaluate The Efficacy And Safety Of PH-797804 In Adults With Moderate To Severe Chronic Obstructive Pulmonary Disease (COPD). | NCT00559910

An Oral p38 Inhibitor Investigating Safety, Efficacy, And PK In Subjects With Active Rheumatoid Arthritis | NCT00383188

A Study of ARRY-371797 in Patients With Rheumatoid Arthritis | NCT00729209

A Study of ARRY-371797 in Patients With Osteoarthritis of the Knee | NCT01366014

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