Testing chemotherapeutic agents in the feather follicle identifies a selective blockade of cell proliferation and a key role for sonic hedgehog signaling in chemotherapy-induced tissue damage.

PubWeight™: 0.79‹?›

🔗 View Article (PMID 25233072)

Published in J Invest Dermatol on September 18, 2014

Authors

Guojiang Xie1, Hangwei Wang1, Zhipeng Yan1, Linyan Cai1, Guixuan Zhou1, Wanzhong He2, Ralf Paus3, Zhicao Yue1

Author Affiliations

1: Institute of Life Sciences, Fuzhou University, Fuzhou, China.
2: National Institute of Biological Sciences, Beijing, China.
3: 1] Institute of Inflammation and Repair, University of Manchester, Manchester, UK, [2] Department of Dermatology, University of Muenster, Muenster, Germany.

Articles citing this

Cellular Senescence as the Causal Nexus of Aging. Front Genet (2016) 0.80

Feather on the Cap of Medicine. J Invest Dermatol (2015) 0.75

Drug discovery for alopecia: gone today, hair tomorrow. Expert Opin Drug Discov (2015) 0.75

Articles cited by this

Apoptosis: a review of programmed cell death. Toxicol Pathol (2007) 17.92

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature (2009) 7.24

Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs. Cancer Cell (2008) 6.62

Sonic hedgehog signaling is essential for hair development. Curr Biol (1998) 5.58

Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration. Nature (2008) 4.67

The biology of hair follicles. N Engl J Med (1999) 4.46

Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol (1999) 3.62

PARP is important for genomic stability but dispensable in apoptosis. Genes Dev (1997) 3.20

The hair follicle as a dynamic miniorgan. Curr Biol (2009) 2.52

Theory of the growth and evolution of feather shape. J Exp Zool (2001) 2.38

Hair cycle regulation of Hedgehog signal reception. Dev Biol (2003) 2.21

Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17

Self-organizing and stochastic behaviors during the regeneration of hair stem cells. Science (2011) 1.96

Noggin is required for induction of the hair follicle growth phase in postnatal skin. FASEB J (2001) 1.95

The morphogenesis of feathers. Nature (2002) 1.91

Analysis of apoptosis during hair follicle regression (catagen) Am J Pathol (1997) 1.82

Expression of cell-adhesion molecules in embryonic induction. II. Morphogenesis of adult feathers. J Cell Biol (1985) 1.66

NF-kappaB transmits Eda A1/EdaR signalling to activate Shh and cyclin D1 expression, and controls post-initiation hair placode down growth. Development (2006) 1.66

Hair loss pattern due to chemotherapy-induced anagen effluvium: a cross-sectional observation. Dermatology (2007) 1.61

Shh-Bmp2 signaling module and the evolutionary origin and diversification of feathers. J Exp Zool (2002) 1.53

Sonic Hedgehog in feather morphogenesis: induction of mesenchymal condensation and association with cell death. Dev Dyn (1996) 1.45

Mapping stem cell activities in the feather follicle. Nature (2005) 1.44

The biology of feather follicles. Int J Dev Biol (2004) 1.41

The role of the hairless (hr) gene in the regulation of hair follicle catagen transformation. Am J Pathol (1999) 1.38

Chemotherapy-induced alopecia. Semin Cutan Med Surg (2009) 1.32

Chemotherapy-induced alopecia in mice. Induction by cyclophosphamide, inhibition by cyclosporine A, and modulation by dexamethasone. Am J Pathol (1994) 1.30

p53 is essential for chemotherapy-induced hair loss. Cancer Res (2000) 1.29

Modulation of hair growth with small molecule agonists of the hedgehog signaling pathway. J Invest Dermatol (2005) 1.25

Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell (2005) 1.24

Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia. Proc Natl Acad Sci U S A (2006) 1.23

Protection against chemotherapy-induced alopecia. Pharm Res (2006) 1.22

Sonic hedgehog opposes epithelial cell cycle arrest. J Cell Biol (1999) 1.20

Chemotherapy-induced alopecia: psychosocial impact and therapeutic approaches. Support Care Cancer (2004) 1.16

Sculpting skin appendages out of epidermal layers via temporally and spatially regulated apoptotic events. J Invest Dermatol (2004) 1.09

Pathobiology of chemotherapy-induced hair loss. Lancet Oncol (2013) 1.08

Prevention of chemotherapy-induced alopecia in rodent models. Cell Stress Chaperones (2008) 1.06

Distinct patterns of NCAM expression are associated with defined stages of murine hair follicle morphogenesis and regression. J Histochem Cytochem (1998) 1.05

Patterns of proliferation and apoptosis during murine hair follicle morphogenesis. J Invest Dermatol (2001) 1.02

Protection from chemotherapy-induced alopecia in a rat model. Science (1990) 0.96

Feather regeneration as a model for organogenesis. Dev Growth Differ (2013) 0.94

Chemotherapy-induced alopecia. J Am Acad Dermatol (2011) 0.93

Caveolin-1 is expressed on multipotent cells of hair follicles and might be involved in their resistance to chemotherapy. Br J Dermatol (2005) 0.92

Dissecting the impact of chemotherapy on the human hair follicle: a pragmatic in vitro assay for studying the pathogenesis and potential management of hair follicle dystrophy. Am J Pathol (2007) 0.92

Identification of an unexpected link between the Shh pathway and a G2/M regulator, the phosphatase CDC25B. Dev Biol (2006) 0.90

Effect of adenovirus-mediated expression of Sonic hedgehog gene on hair regrowth in mice with chemotherapy-induced alopecia. J Natl Cancer Inst (2001) 0.88

PARP-1 enhances the mismatch-dependence of 5'-directed excision in human mismatch repair in vitro. DNA Repair (Amst) (2011) 0.87

p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. FEBS Lett (2010) 0.86

Fas signaling is involved in the control of hair follicle response to chemotherapy. Cancer Res (2004) 0.85

Doxorubicin-induced alopecia is associated with sebaceous gland degeneration. J Invest Dermatol (2006) 0.85

Cutaneous toxicities of cancer therapy. Curr Opin Oncol (2002) 0.83

Dissecting the molecular mechanism of ionizing radiation-induced tissue damage in the feather follicle. PLoS One (2014) 0.81

Pretreatment of epidermal growth factor promotes primary hair recovery via the dystrophic anagen pathway after chemotherapy-induced alopecia. Exp Dermatol (2013) 0.80

Modulation of chemotherapy-induced human hair follicle damage by 17-beta estradiol and prednisolone: potential stimulators of normal hair regrowth by "dystrophic catagen" promotion? J Invest Dermatol (2008) 0.80

Expression of two Ig family adhesion molecules in the murine hair cycle: DCC in the bulge epithelia and NCAM in the follicular papilla. J Invest Dermatol (1997) 0.79

Role for the epidermal growth factor receptor in chemotherapy-induced alopecia. PLoS One (2013) 0.78

Modeling heterogeneous responsiveness of intrinsic apoptosis pathway. BMC Syst Biol (2013) 0.77

Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia. BMC Pharmacol Toxicol (2013) 0.77

Dkk2/Frzb in the dermal papillae regulates feather regeneration. Dev Biol (2014) 0.77

Articles by these authors

Electron tomography for organelles, cells, and tissues. Methods Mol Biol (2014) 0.75