Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer's disease.

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Published in Neuron on September 18, 2014

Authors

Chia-Chen Liu1, Chih-Wei Tsai2, Ferenc Deak3, Justin Rogers2, Michael Penuliar2, You Me Sung4, James N Maher4, Yuan Fu2, Xia Li2, Huaxi Xu5, Steven Estus6, Hyang-Sook Hoe7, John D Fryer8, Takahisa Kanekiyo2, Guojun Bu9

Author Affiliations

1: Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, China.
2: Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA.
3: Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, Oklahoma City, OK 73104, USA.
4: Department of Neuroscience, Georgetown University, Washington, D.C. 20057, USA.
5: Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, China.
6: Department of Physiology and Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA.
7: Department of Neuroscience, Georgetown University, Washington, D.C. 20057, USA; Convergence Brain Research Department, Korea Brain Research Institute (KBRI), 425, Jungang-daero, Jung-gu, Daegu, Korea.
8: Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Neurobiology of Disease Graduate Program, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA.
9: Department of Neuroscience, Mayo Clinic, Jacksonville, FL 32224, USA; Neurobiology of Disease Graduate Program, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA; Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, College of Medicine, Xiamen University, Xiamen, Fujian, China. Electronic address: bu.guojun@mayo.edu.

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